@article { author = {Tamaddonfard, Esmaeal and Farshid, Amir Abbas and Hosseini, Leila}, title = {Crocin alleviates the local paw edema induced by histamine in rats}, journal = {Avicenna Journal of Phytomedicine}, volume = {2}, number = {2}, pages = {97-104}, year = {2012}, publisher = {Mashhad University of Medical Sciences}, issn = {2228-7930}, eissn = {2228-7949}, doi = {10.22038/ajp.2012.40}, abstract = {Objective: Crocin, as an active constituent of saffron, has many biological functions including antioxidant and anti-inflammatory activities. The present study was aimed to investigate the effects of crocin and chlorpheniramine on local edema induced by histamine. Materials and Methods: Local edema was induced by subcutaneous injection of histamine (100 μl, 0.1%) in ventral surface of right hind paw. The thickness of paw was measured at 1 h before and 1, 2, 3 h after injection of histamine, using a fine caliper. The number of neutrophils in paw tissue sections was counted 3 h after intraplantar injection of histamine. Results: Intraperitoneal injection of crocin at doses of 100 and 200 mg/kg and chlorpheniramine at a dose of 10 mg/kg significantly (p<0.05) decreased both paw thickness and infiltration of neutrophils in paw tissues. In a combined treatment, intraperitoneal injection of an effective dose of crocin (100 mg/kg) with an ineffective dose of chlorpheniramine (2.5 mg/kg) produced a more documented response in comparison with crocin (100 mg/kg) and chlorpheniramine (2.5 mg/kg) used alone. Conclusion: The results suggested that both crocin and chlorpheniramine suppressed histamine-induced local paw edema. Moreover, histamine H1 receptors function may be affected by crocin.  }, keywords = {Crocin,Chlorpheniramine,Histamine,Paw edema,Rats}, url = {https://ajp.mums.ac.ir/article_40.html}, eprint = {https://ajp.mums.ac.ir/article_40_f8723c8bc8d65036582048a924ae45c4.pdf} }