@article { author = {Tamaddonfard, Esmaeal and Erfanparast, Amir and Hamzeh-Gooshchi, Nasrin and Yousofizadeh, Shahnaz}, title = {Effect of curcumin, the active constituent of turmeric, on penicillin-induced epileptiform activity in rats}, journal = {Avicenna Journal of Phytomedicine}, volume = {2}, number = {4}, pages = {196-205}, year = {2012}, publisher = {Mashhad University of Medical Sciences}, issn = {2228-7930}, eissn = {2228-7949}, doi = {10.22038/ajp.2012.109}, abstract = {Objective: Curcumin is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. The present study was conducted to investigate the effects of curcumin and diazepam in separate and combined treatments on penicillin-induced seizures in rats. Materials and Methods: In urethane-anesthetized rats, epileptiform activity was induced by intracortical (i.c.) administration of penicillin (200 IU, 1 µl), and frequency and amplitude of spike waves were analyzed using electrocorticographic recordings. Results: Intraperitoneal (i.p.) injections ofcurcumin at doses of 100 and 200 mg/kg, and intracerebroventricular (i.c.v.) injection of diazepam at a dose of 5 µg significantly (p<0.05) reduced both frequency and amplitude of spike waves. Co-administrations of curcumin (50 mg/kg, i.p.) with diazepam (5 µg, i.c.v.) enhanced the antiepileptic effect of diazepam (5 µg, i.c.v.).  Conclusion: The results suggested that both curcumin and diazepam suppressed penicillin-induced epileptiform activity. A potentiation effect was observed between curcumin and diazepam in reducing penicillin-induced seizures. }, keywords = {Curcumin,Diazepam,Penicillin-Induced Seizures,Rats}, url = {https://ajp.mums.ac.ir/article_109.html}, eprint = {https://ajp.mums.ac.ir/article_109_557710a0af18c607818d4df91928bf85.pdf} }