Effect of Apium graveolens and Trachyspermum copticom on clinical symptoms of patients with functional dyspepsia

Document Type : Original Research Article

Authors

1 Department of Traditional Medicine, School of Traditional Medicine, Kerman University of Medical Sciences, Kerman, Iran

2 Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran

3 Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran

4 Associate Professor of Biostatistics Modeling in Health Research Center Institute for Futures Studies in Health Kerman University of Medical Sciences, Kerman, Iran

5 Biostatistics and Epidemiology Department, Modeling in Health Research Center, Institute for Futures Studies in Health Kerman University of Medical Sciences, Kerman, Iran

6 Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran

7 Herbal and Traditional Medicines Center, Kerman University of Medical Science, Kerman, Iran

Abstract

Objectives:This study aimed at investigating the effect of Iranian traditional remedy prepared from Apium graveolens and Trachyspermum copticom (AT) on the severity and frequency of symptoms in patients with functional dyspepsia (FD).
Material and Methods:In total, 150 FD patients were included in this randomized double-blind trial, based on the ROME III diagnostic criteria, and they were divided into three intervention groups namely, AT, Placebo and omeprazole. Then, severity and frequency of symptoms during this eight-week trial were measured. Obtained information was analyzed using Chi-square test and repeated measures test.
Result:In general, the severity and frequency of symptoms after the 4th week significantly decreased in the AT group as compared to the omeprazole and placebo groups, and continued to reduce by the end of the eighth week. General reduction of symptom severity and frequency in the omeprazole group was significantly different from the placebo group by the end of the 4th and 8th weeks. With respect to each individual symptom, AT markedly improved symptoms, such as burning, pain, early satiation, fullness, bloating, belching and nausea, as compared to placebo-treated group. Moreover, AT significantly improved symptoms, like vomiting, and nausea, except for pain, as compared to omeprazole-treated subjects.
Conclusion:According to the results, AT, as Iranian traditional remedy, was more effective than omeprazole and placebo in reducing the symptoms in FD patients.

Keywords

Main Subjects

References

Alavinezhad A, Boskabadi MH. 2014. Ant-inflammatory, Antioxidant, and Immunological Effects of Carum copticum L. and Some of Its Constituents. Phytother Res, 28: 1739-1748.
Aliasl F. 2015. Nausea and Vomiting Remedies in Iranian Traditional Medicine (ITM). Iran J Public Health, 44: 1164-1165
Amini E, Keshteli A. 2012. Dyspepsia in Iran: SEPAHAN Systematic Review. Int J Prev Med, 3: 18-25.
Ashraffodin Ghoshegir S, Ghannadi A, Feizi A, Babaeian M, Tanhaee M, Karimi M. 2015. Pimpinella anisum in the treatment of functional dyspepsia: A double-blind, randomized clinical trial. J Res Med Sci., 20: 13-21.
Balaji G, Chalamaian M, Ramesh B. 2012. Antidiarrheal activity of ethanol and aqueous extracts of Carum copticum seeds in experimental rats. APJTB, 2: 1151-1155.
Baohai L, Xuehua P, Lianyi G. 2013. Effect of herbal formula XiaoPi-II on functional dyspepsia. J Tradit Chin Med, 33:298-302
Dashti-Rahmatabadi MH, Morshedi A, Rafati A. 2007. The analgesic effect of Carum copticum extract and morphine on phasic pain in mice. J Ethnopharmacol, 109: 226–22.
Hejazian S, Morowati sharifabad M, Mahdavi SM. 2007. Relaxant Effect of Carum copticum on Intestinal Motility in Ileum of Rat. WJZ, 2: 15-18.
Hirakawa K AK, Amano K, Katsube T, Ishihara S. 1999. Prevalence of non-ulcer dyspepsia in the Japanese Population. J Gastrointerol Hepatol, 14: 1083-87.
Hoky KJ, Seow A. 1998. Prevalence of gastrointestinal symptoms in a multiracial Asian population with particular reference to reflux-type symptom. Am J Gastroenterol, 93: 1816-22.
Jones RH. 2002. Approach to uninvestigated dyspepsia. Gut, 50: 42-46.
Kazemi M. 2014. Chemical Composition, Antimicrobial, Antioxidant and Anti-inflammatory Activity of Carum copticum L. Essential Oil. J ESSENT OIL BEAR PL, 17: 2040-2045.
Khademolhosseini F, Zare N, Salehi M. 2010. Prevalence of Dyspepsia and its Correlation with Demographic Factors and Lifestyle in Shiraz, Southern Iran. Middle East J Dig Dis, 2: 24-30.
Khosravi AR, Salari R., Yahyaraeyat R. 2015. Chemical Composition and Antifungal Activity of Trachyspermum copticum Essential Oil Against Alternaria alternata (In-Vitro Study). J Med Plant Res, 14: 82-88.
Kooti W, Asadi-Samani M, Ghadery H, Ashtary-Larky D. 2014. A review on medicinal plant of Apium graveolens. Advanced Herbal Medicine, 1: 48-59.
Lewis ML PO, Whitehead WE, van Tilburg MA. 2016. Prevalence of Functional Gastrointestinal Disorders in Children and Adolescents. J Pediatr, 177: 39-43.
Longo D, Fauci A, Logford C. 2013. Harrison 12s gastroenterology and hepatology. 128-155, Newyork.
Madisch A, Labenz J. 2005. Management of functional dyspepsia: unsolved problems and new perspectives. World J Gastroenterol, 11: 6577-6581.
Malekinejad H, Bazargani-Gilani B, Tukmechi A, Ebrahimi H. 2012. A cytotoxicity and comparative antibacterial study on the effect of Zataria multiflora Boiss, Trachyspermum copticum essential oils, and Enrofloxacin on Aeromonas hydrophila. Avicenna J Phytomed, 2: 188–195.
Masoumi SJ, Mehrabani D, Moradi F, Zare N. 2015. The prevalence of dyspepsia symptoms and its correlation with the quality of life among Qashqai Turkish migrating nomads in Fars Province, Southern Iran. PAK J Med Sci, 31: 325-30.
Melzer J, Reichling J., Brignoli R. 2004. Meta-analysis: phytotherapy of functional dyspepsia with the herbal drug preparation STW 5 (Iberogast). Aliment Pharmacol Ther, 20: 1279-1287.
Mohtashami R, Husseini H, Heidari M, Amini M. 2015. Efficacy and safety of honey based formulation of Nigella sativa seed oil in functional dyspepsia: A double blind randomized controlled clinical trial. J Ethnopharmacol, 175: 147-152.
Nariman F, Eftekhar F, Falsafi T, Habibi Z. 2004. Anti-Helicobacter pylori Activities of Six Iranian Plants. Helicobacter, 9: 146-151.
NG I. Inhibitors of proton pump in the treatment of non-ulcer functional dyspepsia of the reflux-like type. Eksp Klin Gastroenterol. 2002; 2:35-6.
Nguyen S, Foster BC, Tam TW, Xing T, Smith ML, Arnason JT, Akhtar H. 2014. Antimicrobial and P450 inhibitory properties of common functional foods. J Pharm Pharm Sci, 17: 254-265.
Ottillinger, B. 2013. STW 5 (Iberogast®)—a safe and effective standard in the treatment of functional gastrointestinal disorders. Wien Med Wochenschr, 163: 65-72.
Pasalar M, Choopani R, Mosadegh M. 2015. Efficacy and safety of jollab to treat functional dyspepsia: a randomized placebo-controlled clinical trial, J Ethnopharmol, , 11: 199-207.
Powanda MC, Whitehouse M, Rainsford KD. 2015. Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities. Prog Drug Res, 70: 133-153.
Rafieian-kopaei M, Hosseini K. 2005. Effects of Ocimum Basilicum on Functional Dyspepsia: a Double-Blind Placebo-Controlled Study. Iran J Med Sci., 30: 134-137.
Raveendra K, SrinivasaV, Joshua J, Shankargouda K, Nagarajappa H, Kudiganti. 2012. An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. Evidence-Based Complementary and Alternative Medicine, 2012: 1-9.
SharifzadehA, Shokri H. 2016. Antifungal activity of essential oils from Iranian plants against fluconazole-resistant and fluconazole-susceptible Candida albicans. Avicenna J Phytomed. 6: 215–222.
Sowbhagya H. 2014. Chemistry, Technology, and Nutraceutical Functions of Celery (Apium graveolens L.): An Overview. Comp Clin Path, 54: 389-395.
Tack J, Talley N. J. 2006. Functional Gastroduodenal Disorders. Gastroenterology, 130: 1466-79.
Tack J. 2005. Pathophysiology and treatment of functional dyspepsia. J. Clin Gastroenterol, 39: 211-216.
Tajik J, Azizi S, Amanollahi R. 2016. the effects of aqueous extracts of Lippia citriodora, Trachyspermum copticum, Dracocepalum polychaetum on repair of ethanol induced gastric ulcer in rats. Comp Clin Path, 25: 119-123.
Talley NJ. 1998. Scope of the problem of functional digestive disorders. Eur. J. Surg, 582: 35–41.
Talley NJ, Duckworth P, Kordecki R. 1998. Efficacy of omeprazole in functional dyspepsia: double-blind, randomized, placebo-controlled trials (the Bond and Opera studies. Aliment Pharmacol Ther, 12: 1055–1065       
UNESCO (2009). 〈http://www.unesco.org)
Wegener T, Wagner H. 2006. The active components and the pharmacological multi-target principle of STW 5 (Iberogast®). Phytomedicine, 13: 20-35.
Zheng H, Li Y, Liang F, Yu SG. 2009. Acupuncture as a treatment for functional dyspepsia: design and methods of a randomized controlled trial. Trials, 10: 10-75.
Zomorodian K; Ghadiri P. 2015. Antimicrobial Activity of Seven Essential Oils From Iranian Aromatic Plants Against Common Causes of Oral Infections. Jundishapur J Microbiol, 8: 1-6.
Zomorodian K, Ghadiri P, Saharkhiz MJ. (2015). Antimicrobial Activity of Seven Essential Oils from Iranian Aromatic Plants Against Common Causes of Oral Infections.  Jundishapur J Microbiol, 8: e17766
Zohalinezhad ME, Akrami R, Nimrouzi M, Salehi A, Zarshenas MM. 2016. Myrtus communis L. Freeze-Dried Aqueous Extract Versus Omeprazol in Gastrointestinal Reflux Disease: A Double-Blind Randomized Controlled Clinical Trial. J Evid Based Complementary Altern Med, 21: 23-29.
Zohalinezhad ME, Mohammadi S, Abdolali Mohagheghzadeh S. 2015. Effects of Quince syrup on clinical symptoms of children with symptomatic gastroesophageal reflux disease: A double-blind randomized controlled clinical trial. Complement Ther Clin Pract, 21: 268-276.
Avicenna Journal of Phytomedicine
Volume 7, Issue 6
November and December 2017
Pages 554-564

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