Bast T, Feldon J. 2003. Hippocampal
modulation of sensorimotor processes. Prog
Neurobiol, 70: 319-345.
Bellesi M, Vyazovskiy VV, Tononi G, Cirelli
C, Conti F. 2012. Reduction of EEG theta
power and changes in motor activity in rats
treated with ceftriaxone. PLoS One, 7:
e34139.
BenSaad LA, Kim KH, Quah CC, Kim WR,
Shahimi M. 2017. Anti-inflammatory
potential of ellagic acid, gallic acid and
punicalagin A&B isolated from punica
granatum. BMC Complement Altern Med,
17: 47.
Bezerianos A, Tong S, Thakor N. 2003. Timedependent entropy estimation of EEG
rhythm changes following brain ischemia.
Ann Biomed Eng, 31: 221-232.
Bhandary SKB, Sharmila KP, Suchetha
Kumari N, Vadisha Bahat S. 2013. Acute
and sub-acute toxicity study of the ethanol
extract of punica granatum (LINN). Whole
fruit and seeds and synthetic ellagic acid in
Swiss albino. Asian J Pharm Clin Res, 6:
192-198.
Bhardwaj A, Alkayed NJ, Kirsch JR, Hurn
PD. 2003. Mechanisms of ischemic brain
damage. Cur Cardiol Report, 5: 160.
Bin J, Wang Q, Zhuo YY, Xu JP, Zhang HT.
2012. Piperphentonamine (PPTA)
attenuated cerebral ischemia-induced
memory deficits via neuroprotection
associated with anti-apoptotic activity.
Metab Brain Dis, 27: 495-505.
Buzsaki G, Freund TF, Bayardo F, Somogyi P.
1989. Ischemia-induced changes in the
electrical activity of the hippocampus. Exp
Brain Res, 78: 268-278.
Calapai G, Crupi A, Firenzuoli F, Marciano
MC, Squadrito F, Inferrera G, Parisi
A, Rizzo A, Crisafulli C, Fiore A, Caputi
AP. 2000. Neuroprotective effects of
ginkgo biloba extract in brain ischemia are
mediated by inhibition of nitric oxide
synthesis. Life Sci, 67: 2673-2683.
Carden DL, Granger DN. 2000.
Pathophysiology of ischemia–reperfusion
injury. J pathol, 190: 255-266.
Ceci C, Lacal PM, Tentori L, De Martino MG,
Miano R, Graziani G. 2018. Experimental
evidence of the ant-itumor, ant-imetastatic
and ant-iangiogenic activity of ellagic acid.
Nutrients, 10: 1756.
Chen H, Yoshioka H, Kim GS, Jung JE,
Okami N, Sakata H, Maier CM,
Narasimhan P, Goeders CE, Chan PH.
2011. Oxidative stress in ischemic brain
damage: mechanisms of cell death and
potential molecular targets for
neuroprotection. Antioxid Redox Signal,
14: 1505-1517.
Crawley JN. 2003. Behavioral phenotyping of
rodents. Comp Med, 53: 140-146.
de Leon MJ, Convit A, Wolf O, Tarshish CV,
DeSanti S, Rusinek H. 2001. Prediction of
cognitive decline in normal elderly subjects
with 2-[18F]fluoro-2-deoxy-Dglucose/positron-emission tomography
(FDG/PET). PNAS, 98: 10966-10971.
de Oliveira MR. 2016. The effects of ellagic
acid upon brain cells: A mechanistic view
and future directions. Neurochem Res, 41:
1219-1228.
Goth L. 1991. A simple method for
determination of serum catalase activity
and revision of reference range. Clin Chim
Acta, 196: 143-151.
Guo Y, Li P, Guo Q, Shang K, Yan D, Du S,
Lu Y. 2013. Pathophysiology and
biomarkers in acute ischemic stroke–a
review. Trop J Pharm Res, 12: 1097-
1105.
Han DH, Lee MJ, Kim JH. 2006. Antioxidant
and apoptosis-inducing activities of ellagic
acid. Anticancer Res, 26: 3601-3606.
Hassanzadeh KR. 2018. Oxidative stress and
neuroinflammation in the story of
Parkinson’s disease: Could targeting these
pathways write a good ending? J Cell
Physiol, 234: 23-32.
Hong JH, Kim MJ, Park MR, Kwag OG, Lee
IS, Byun BH, Lee SC, Lee KB, Rhee SJ.
2004. Effects of vitamin E on oxidative
stress and membrane fluidity in brain of
streptozotocin-induced diabetic rats. Clin
ChimActa, 340: 107-115.
Hassonizadeh Falahieh KH, Sarkaki A,
Edalatmanesh MA, Gharib Naseri MK,
Farbood Y. 2020. Ellagic acid attenuates
post-cerebral ischemia and reperfusion
behavioral deficits by decreasing brain
tissue inflammation in rats. Iran J Basic
Med Sci. 23: 645-653.
Hou S, Hao L, Wei J, Zhou Y. 2016. Propofol
EA alleviates behaviors and EEG in 2VO brain I/R
AJP, Vol. 13, No. 6, Nov-Dec 2023 663
pretreatment combined with umbilical
blood mesenchymal stem cell
transplantation improves cerebral ischemiareperfusion injuries. Chin J of Tissue Eng
Res, 20: 2810-2816.
Kearse LA, Martin D, McPeck K, LopezBresnahan M. 1993. Computer-derived
density spectral array in detection of mild
analog electroencephalographic ischemic
pattern changes during carotid
endarterectomy. J Neurosurg, 78: 884-890.
Labrousse VF, Costes L, Aubert A,
Darnaudéry M, Ferreira G, Amédée T.
Layé S. 2009. Impaired interleukin-1β and
c-Fos expression in the hippocampus is
associated with a spatial memory deficit in
P2X7 receptor-deficient mice. PLoS One,
4: e6006.
Lakhan SE, Kirchgessner A, Hofer M. 2009.
Inflammatory mechanisms in ischemic
stroke: therapeutic approaches. J Transl
Med, 7: 97.
Liu HP, Ren TW, Yan WJ, Liu J, Liu RB.
2016. Ellagic acid alleviates inflammatory
pain and paclitaxel-induced neuropathic
pain in murine models. Int J Clin Exp Med,
9: 12514-12520.
Liu T, McDonnell PC, Young PR, White RF,
Sirèn AL, Hallenbeck JM, Barone FC,
Feurestein GZ. 1993. Interleukin-1 beta
mRNA expression in ischemic rat cortex.
Stroke, 24: 1746-1750.
Mansouri MT, Farbood Y, Sameri MJ, Sarkaki
A, Naghizadeh B, Rafeirad M. 2013.
Neuroprotective effects of oral gallic acid
against oxidative stress induced by 6-
hydroxydopamine in rats. Food Chem, 138:
1028-1033.
Maurya PK, Rizvi SI. 2009. Protective role of
tea catechins on erythrocytes subjected to
oxidative stress during human aging. Nat
Prod Res, 23: 1072-1079.
Meier K, Merseburg A, Isbrandt D, Marguet
SL, Morellini F. 2020. Dentate gyrus sharp
waves, a local field potential correlate of
learning in the dentate gyrus of mice. J
Neurosci, 40: 7105-7118.
Nascimento LR, de Menezes KKP, Faria CD,
Avelino PR, Scianni AA, Fortini IF, Polese
JC, Teixeira-Salmela LF. 2020. Deficits in
motor coordination of the paretic lower
limb best explained activity limitations
after stroke. Physiother Theory Pract, 36:
417-423.
Mitchell AJ, Sheth B, Gill J, Yadegarfar M,
Stubbs B, Meader N. 2017. Prevalence and
predictors of post-stroke mood disorders: A
meta-analysis and meta-regression of
depression, anxiety and adjustment
disorder. Gen Hosp Psychiatry, 47: 48-60.
Mohammadi H. 2017. The effects of
hydroalcoholic extract of raspberry fruit on
pain and passive avoidance memory
following transient global
ischemia/reperfusion in wistar Rats. J Med
Plants, 16: 137-146.
Moretti DV, Pievani M, Fracassi C, Binetti G,
Rosini PM, Zanetti O, Geroldi C, Sosta K,
Frisoni GB. 2009. Increase of theta/gamma
and alpha3/alpha2 ratio is associated with
amygdalo-hippocampal complex atrophy. J
Alzheimers Dis, 17: 349-357.
Moskowitz MA, Lo EH, Ladecola C. 2010.
The science of stroke: mechanisms in
search of treatments. Neuron, 67: 181-198.
Nagababu E, Rifkind JM, Boindala S, Nakka
L. 2010. Assessment of antioxidant activity
of eugenol in vitro and in vivo Free radicals
and antioxidant protocols. Methods Mol
Biol, 610: 165-180.
Hoseinynejad K, Gharib-Naseri MK, Sarkaki
A, Dianat M, Badavi M, Farbood Y. 2017.
Effects of ellagic acid pretreatment on renal
functions disturbances induced by global
cerebral ischemic-reperfusion in rat. Iran J
Basic Med Sci, 20: 75-82.
Nita DA, Nita V, Spulber S, Moldovan M,
Popa DP, Zagrean AM, Zagrean L. 2001.
Oxidative damage following cerebral
ischemia depends on reperfusion‐a
biochemical study in rat. J Cell Mol Med,
5: 163-170.
Oke F, Aslim B, Ozturk S, Altundag S. 2009.
Essential oil composition, antimicrobial
and antioxidant activities of Satureja
cuneifolia Ten. Food Chem, 112: 874-879.
Orsucci D, Mancuso M, Ienco EC, LoGerfo A,
Siciliano G. 2011. Targeting mitochondrial
dysfunction and neurodegeneration by
means of coenzyme Q10 and its analogues.
Curr Med Chem, 18: 4053-4064.
Pan X, Jiang T, Zhang L, Zheng H, Luo J, Hu
X. 2017. Physical exercise promotes novel
object recognition memory in
spontaneously hypertensive rats after
ischemic stroke by promoting neural
plasticity in the entorhinal cortex. Front
Behav Neurosci. 11: 1-12.
Pandey KB, Rizvi SI. 2009. Plant polyphenols
as dietary antioxidants in human health and
Hassonizadeh Falahieh et al.
AJP, Vol. 13, No. 6, Nov-Dec 2023 664
disease. Oxid Med Cell Longev, 2: 270-
278.
Paxino’s G, Watson’s C. 2007. The rat brain in
stereotaxic coordinations., 6th edition.
Perez-Hernandez J, Zaldivar-Machorro VJ,
Villanueva-Porras D, Vega-Avila E,
Chavarria A. 2016. A potential alternative
against neurodegenerative diseases:
phytodrugs. Oxid Med Cell Longev,
8378613.
Rabiei Z, Bigdeli M, Asadi-Samani M. 2013.
The effect of dietary virgin olive oil on
brain lipid levels and brain edema in rat
stroke models. J Adv Med Biomed Res,
21: 56-64.
Rabiller G, He JW, Nishijima Y, Wong A, Liu
J. 2015. Perturbation of brain oscillations
after ischemic stroke: a potential biomarker
for post-stroke function and therapy. Int J
Mol Sci, 16: 25605-25640.
Ravindran SK. 2019. Eventual analysis of
global cerebral ischemia-reperfusion injury
in rat brain: a paradigm of a shift in stress
and its influence on cognitive functions.
Cell Stress Chaperones, 24: 581-594.
Rios JL, Giner RM, Marin M, Recio MC.
2018. A pharmacological update of ellagic
acid. Planta Med, 84: 1068-1093.
Rosenfeldt F, Wilson M, Lee G, Kure C, Ou
R, Braun I, de Haan J. 2013. Oxidative
stress in surgery in an ageing population:
pathophysiology and therapy. Exp
Gerontol, 48: 45-54.
Sánchez EC. 2013. Mechanisms of action of
hyperbaric oxygenation in stroke: a review.
Crit Care Nurs Q, 36: 290-298.
Tamburella A, Micale V, Mazzola C,
Salomone S, Drago F. 2012. The selective
norepinephrine reuptake inhibitor
atomoxetine counteracts behavioral
impairments in trimethyltin-intoxicated
rats. Eur J Pharmacol, 683: 148-154.
Tancheva L, Popatanasov A, Dragomanova S,
Tzvetanova E, Aleksandrova S, Alova L,
Stefanova S, Kalfin R. 2018. New
mechanisms in preventive effect of ellagic
acid on cognition in mice with Alzheimer’s
disease type dementia. Bulg Chem
Commun, 50: 20-24.
Tsolaki A, Kazis D, Kompatsiaris I, Kosmidou
V, Tsolaki M. 2014. Electroencephalogram
and Alzheimer’s disease: clinical and
research approaches. Int J Alzheimers Dis,
40: 1-10.
Visioli F, Poli A, Gall C. 2002. Antioxidant
and other biological activities of phenols
from olives and olive oil. Med Res Rev, 22:
65-75.
West C, Bowen A, Hesketh A, Vail A. 2008.
Interventions for motor apraxia following
stroke. Cochrane Database Syst Rev, 23:
CD004132.
Widlansky ME, Gutterman DD. 2011.
Regulation of endothelial function by
mitochondrial reactive oxygen species.
Antioxid Redox Signal, 15: 1517-1530.
Yu T, Chen QE, Chen ZW, Xiong Z, Ye M.
2009. Protective effects of total flavones of
rhododendra against global cerebral
ischemia reperfusion injury. Am J Chin
Med, 37: 877-887.
Zarrindast MR, Bakhsha A, Rostami P,
Shafaghi B. 2002. Effects of
intrahippocampal injection of GABAergic
drugs on memory retention of passive
avoidance learning in rats. J
Psychopharmacol, 16: 313-319.
Zhang S, Qi Y, Xu Y, Han X, Peng J, Liu KC,
Sun K. 2013. Protective effect of flavonoidrich extract from Rosa laevigata michx on
cerebral ischemia-reperfusion injury
through suppression of apoptosis and
inflammation. Neurochem Int, 63: 522-532