1School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
2Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
3Targeted Drug Delivery Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Objective: The effect of linalool, a terpene alcohol found in many plants, which inhibits NMDA receptors, on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) was evaluated in mice. Material and Methods: The effects of different doses of linalool (12.5, 25 and 50 mg/kg, i.p.), memantine (20 mg/kg, an NMDA receptor antagonist) and saline, in CPP induced by 40 mg/kg of morphine were investigated in mice. In another experiment, a single injection of morphine (10 mg/kg) reinstated the place reference following extinction of a place preference induced by morphine (40 mg/kg). Linalool (12.5, 25 and 50 mg/kg, i.p.), memantine (20 mg/kg) and saline were administrated 30 min before this priming dose of morphine. Results: In the first experiment, linalool (12.5 and 50 mg/kg) was able to decrease morphine-induced CPP. In the second part, linalool (25 and 50 mg/kg) reduced morphine-induced reinstatement of place preference. Both acquisition and reinstatement of morphine-induced CPP, were considerably decreased by memantine. Conclusion: The present study showed that linalool is able to reduce the acquisition and reinstatement of morphine-induced CPP which might be due tothrough NMDA receptors blocking.
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