1Department of Animal Sciences, College of Agriculture, Ferdowsi University of Mashhad, Mashhad, I. R. Iran
2Department of Pathology, College of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, I. R. Iran
Objective: Turmeric (Curcuma Longa Linn) is a medicinal plant that contains curcumin. There is a growing interest in using curcumin powder (CP) as feed additives for antioxidative and antimicrobial properties to improve human health. This study was conducted to determine the appropriate levels of CP on blood parameters, immunity, and histology of jejunum in hens. Materials and Methods: A total of 200, 58-wk-old Hy-line hens were randomly distributed into 4 treatments (0%, 0.5%, 1.5%, and 2.5% CP or 0, 5, 15, and 25 g/kg feed, respectively) with 5 replicates (10 birds each) for 8 weeks using the completely randomized design. Blood samples were taken from 2 birds per replicate at weeks 61 and 65 to evaluate blood parameters. On weeks 63 and 65, two birds from each replicate received 0.5 ml SRBC (25%) injection in breast muscle and 7 days later, blood samples were collected to evaluate total Ig, IgG, and IgM titers in serum. Two hens were sacrificed at week 65 for the histological study of jejunum. Results: Curcumin reduced triglycerides at 1.5% and 2.5% and cholesterol and LDL at 2.5% (p<0.05). Improvement of total Ig and IgG titers after the 1st and 2nd injections were observed. Muscle thickness in jejunum increased (p<0.05) at 1.5% curcumin and the length and surface area of villus were enhanced as well. Conclusion: Our results demonstrate that curcumin can be used as an antioxidant at 1.5% and antilipidemic agent at 2.5% in diet.
Antony S, Kuttan R, Kutta G. 1999. Immunomodulatory activity of curcumin. Immunol. Invest, 28: 291-303.
Arshami J, Ruttle JL. 1988. Effects of diets containing gossypol on spermatogenic tissues of young bulls. Theriogenol,30: 507-516.
Arun N, Nalini N. 2002. Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Food Hum Nut, 57: 41-52.
Awad WA, Bohm J, Razzazi-Fazeli E, Zentek J. 2005a. In vitro effects of deoxynivalenol on electrical properties of intestinal mucosa of laying hens. Poult Sci, 84: 921-927.
Chandra D, Gupta SS. 1972. Anti-inflammatory and anti-arthritic activity of volatile oil of Curcumalonga (Haldi). Indian J Med Res, 60: 138-142.
Cheema MA, Qureshi MA, Havenstein GB. 2003. A comparison of the immune response of a 2001 commercial broiler with a 1957 randombred broiler strain when fed representative 1957 and 2001 broiler diets. Poult Sci, 82: 1519-1529.
Churchill M, Chadburn A, Bilinski RT, Bertagnolli MM. 2000. Inhibition of intestinal tumours by curcumin is associated with changes in the intestinal immune cell proﬁle. J Surg Res, 89: 169-175.
Emadi M, Kermanshahi H. 2007. Effect of turmeric rhizome powder on activity of some blood enzymes in broiler chickens. Int J Poult Sci, 6: 48-51.
Gomez DC, Alegrio LV, Leon LL, Lima ME. 2002. Total synthesis and anti-leishmanial activity of some curcumin analogues. Arzneimittel-Forsch, 52: 695-698.
Gowda NKS, Ledoux DR, Rottinghaus GE, Bermudez AJ, Chen YC. 2008. Efficacy of turmeric (Curcuma longa), containing a known level of curcumin, and a hydrated sodium calcium aluminosilicate to ameliorate the adverse effects of aflatoxin in broiler chicks. Poult Sci, 87: 1125-1130.
Iqbal M, Sharma SD, Okazaki Y, Fujisawa M, Okada S. 2003. Dietary supplementation of curcumin enhances antioxidant and phase II metabolizing enzymes in ddy male mice: possible role in protection against chemical carcinogenesis and toxicity. Pharmacol Toxicol, 92: 33-38.
Jamroz D, Orda J, Kamel C, Williczkiewicz A, Wertelecki T, Skorupin’Ska J. 2003. The influence of phytogenic extracts on performance, nutrients digestibility, carcass characteristic, and gut microbial status in broiler chickens. J Anim Feed Sci, 12: 583-596.
Kermanshahi H, Riasi A. 2006. Effect of turmeric rhizome powder (Curcuma longa) and soluble NSP degrading enzyme on some blood parameters of laying hens. Int J Poult Sci, 5: 494-498.
Kijparkorn S, Angkanaporn K. 2003. Effect of turmeric (Curcuma Longa Linn.) as an antioxidant on immune status and growth performances of stressed broilers. M.Sc. Thesis, The Chulalongkorn University, Faculty of Veterinary Science.
Kuttan R, Bhanumathy P, Nirmala K, George MC. 1985. Potential anticancer activity of turmeric (Curcuma longa). Cancer Lett, 29: 197-202.
Lee S-H, Jang S, Kim D, Park M, Ionescu C, Bravo D, Lillehoj H. 2009. Effect of dietary cinnamomum cassia and curcuma longa on Eimeria tenella infection in broiler chickens. Poult Sci Assoc, 98th Annual Meeting.
Mohammadi A, Sahebkar A, Iranshahi M, Amini M, Khojasteh R, Ghayour-Mobarhan M, Ferns GA. 2012. Effects of supplementation with curcuminoids on dyslipidemia in obese patients: A randomized crossover trial. Phytother Res, 26 (11). ISSN 0951-418X.
Nishiyama T, Mae T, Kishida H, Tsukagawa M, Mimaki Y, Kuroda M, Sashida Y, Takahashi K, Kawada T, Nakagawa K, Kitahara M. 2005. Curcuminoids and sesquiterpenoids in turmeric (Curcuma longa L.) suppress an increase in blood glucose level in type 2 diabetic KK-Ay mice. J Agric Food Chem, 53:959-963.
Osawa T, Sugiyama Y, Inayoshi M, Kawakisi S. 1995. Antioxidative activity of tetrahydrocurcuminoids. Biosci Biotechnol Biochem, 59: 1609-1612.
Park SY, Kim DS. 2002. Discovery of natural products from Curcuma longa that protect cells from Beta-amyloid Insult: a drug discovery effort against Alzheimer's disease. J Nat Prod, 65: 1227-1231.
Pilevar M, Arshami J, Golian A, Basami MR. 2011. Effects of dietary n-6: n-3 ratio on immune and reproductive systems of pullet chicks. Poult Sci, 90: 1758-1766.
Platel K, Srinivasan K. 2000. Influence of dietary spices and their active principles on pancreatic digestive enzymes in albino rats. Nahrung, 44: 42-46.
Radwan NL, Hassan RA, Qota EM, Fayek HM. 2008. Effect of natural antioxidant on oxidative stability of eggs and productive and reproductive performance of laying hens. Int J Poult Sci, 7: 134-150.
Sakamoto T, Danzmann RG, Gharbi K, Howard P, Ozaki A, Kean Khoo S, Woram RA, Okamoto N, Ferguson MM, Holm LE, Guyomard R, Hoyheim B. 2000. A microsatellite linkage map of rainbow trout (Oncorhynchus mykiss) characterized by large sex-specific differences in recombination rates. Genetics, 155: 1331-1345.
Shankar TNB, Shantha NV, Ramesh HP. 1980. Toxicity studies on turmeric (Curcuma longa): Acute toxicity studies in rats, guinea pigs & monkeys. Indian J Exp Biol, 18: 73-75.
Sharma RA, Gescher AJ, Stewart WP. 2005. Curcumin: the story so far. Eur J Cancer, 41: 1955-1968.
Sharma V, Sharma C, Sharma S. 2011. Influence of Curcuma Longa and Curcumin on blood profile in mice subjected to aflatoxin B1. Int J Pharma Sci Res, 2: 1740-1745.
Singh RK, Rai D, Yadav D, Bhargava A, Balzarini J, Clercq ED. 2010. Synthesis, antibacterial and antiviral properties of curcumin bioconjugates bearing dipeptide, fatty acids and folic acid. Eur J Med Chem, 45: 1078-1086.
South EH, Exon JH, Hendrix K. 1997. Dietary curcumin enhances antibody response in rats. Immunopharmacol Immunotoxicol, 19: 105-119.
Srinivasan K. 2005. Spices as influencers of body metabolism: an overview of three decades of research. Food Res Int, 38: 77-86.
Srinivasan, M. 1972. Effect of curcumin on blood sugar as seen in a diabetic subject. Indian J Med Sci, 26: 269-270.
Toda S, Miyase T, Arichi H, Tanizawa H, Takino Y. 1985. Natural antioxidant III. Antioxidative components isolated from rhizome of Curcumalonga L. Chem and Pharma Bull, 33: 1725-1728.
Wuthi-Udomler M, Grisanapan W, Luanratana O, Caichompoo W. 2000. Anti-fungal activities of plant extracts. South East Asian J Trop Med Public Health,31 Suppl, 1: 178-182.