Effect of Coriandrum sativum hydroalcoholic extract and its essential oil on acetic acid- induced acute colitis in rats

Document Type: Original Research Article

Authors

1 Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

2 Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

3 Department of Pharmacology and Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Objective: The aim of this study was to determine the protective effects of Coriandrum sativum on acetic acid-inducedcolitis in rats. C. sativum (Coriander) has long been used in Iranian traditional medicine and its use as an anti-inflammatory agent is still common in some herbal formulations.
 Materials and Methods: Colitis was induced by intra-rectal administration of 2ml acetic acid 4% in fasted male Wistar rats. Treatment was carried out using three increasing doses of extract (250, 500, 1000 mg/kg) and essential oil (0.25, 0.5, 1 ml/kg) of coriander started 2 h before colitis induction and continued for a five-day period. Colon biopsies were taken for weighting, macroscopic scoring of injured tissue, histopathological examination and measuring myeloperoxidase (MPO) activity.
 Results: Colon weight was decreased in the groups treated with extract (500 and 1000 mg/kg) and essential oil (0.5 ml/kg) compared to the control group. Regarding MPO levels, ulcer severity and area as well as the total colitis index, same results indicating meaningful alleviation of colitis was achieved after treatment with oral extract and essential oil.
 Conclusion: Since the present experiment was made by oral fractions of coriander thus the resulting effects could be due to both the absorption of the active ingredients and/or the effect of non-absorbable materials on colitis after reaching the colon. In this regard, we propose more toxicological and clinical experiments to warranty its beneficial application in human inflammatory bowel diseases.

Keywords

Main Subjects


Al-Mofleh IA , Alheidar AA , Mossa JS , Al-Sohaibani AL , Rafatullah S , Qoreishi S.2006. Protection of gastric mucosal damage by Coriandrum sativum L. pretreatment in Wistar albino rats. Envi Toxicol Pharmacol, 22:64-69.

Asgarpanah J, Kazemivash N.2012. Phytochemistry, pharmacology and medicinal properties of Coriandrum sativum L. African J Pharma  Pharmacol, 6:2340-2345.

Al Rowais NA.2002. Herbal medicine in the treatment of diabetes mellitus. Saudi Med J, 23: 1327–1331.

Bouma C, Strober W.2003. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol, 3:521–533.

Burdock GA, Carabin IG. 2009. Safety assessment of coriander (Coriandrum sativum L.) essential oil as a food ingredient. Food Chem Toxicol, 47: 22-34.

Chithra V, Leelamma S.1999. Coriandrum sativum mechanism of hypoglycemic action. Food Chem, 67: 229–231.

Chithra V, Leelamma S.1997. Hypolipidemic effect of coriander seeds (Coriandrum sativum L.): mechanism of action. Plant Foods Hum Nutr, 51:167-72.

Cooper H, Murthy S, Shah R, Sedergran D.1993. Clinicopathologic study of dextran sulfate sodium experimental murine colitis. Lab Invest,69:238-249.

Delaquis PJ, Stanich K, Girard B, Mazza G.2002. Antimicrobial activity of individual and mixed fractions of dill, cilantro, coriander and eucalyptus essential oils. Int J Food Microbiol, 25:101-109.

Dieleman L, Palmen M, Akol H, Bloemena E, Pena A, Meuwissen S.1998. Chronic experimental colitis induced by dextran sulfate sodium (DSS) is characterized by Th1 and Th2 cytokines. Clin Exp Immuno, 114:385-391.

George P, Chrousos GP. 2009. Adrenocorticosteroids and adrenocortical antagonists. In: Katzung BG. (Ed.) Basic and Clinical Pharmacology. pp. 685-687, New York, McGraw Hill Companies.

Ghannadi AR, Sajjadi SE, Beigihassan A.2002. Composition of the essential oil of Ferula ovina (Bioss.) Bioss. from Iran. Daru, 10:165–167.

Goswami  S, Singhai A. 2012. Phytochemical and pharmacological investigation on Coriandrum sativum . Asian J Pharma Educ Res,1:2278-96.

Hashim MS, Ling S, Remya R, Teena M, Anila L. 2005. Effect of polyphenolic compounds from Coriandrum sativum on H2O2- induced oxidative stress in human lymphocytes. Food Chem, 92: 653–660.

Hwang E, Lee DG, Park SH, Oh MS, Kim SY. 2014. Coriander leaf extract exerts antioxidant activity and protects against UVB-induced photoagaing of skin by regulation of procollagen type I and MMP-1 expression. J Med Food, 17: 985-995.

Iranian Herbal Pharmacopoeia.2002.Tehran: Food and Drug Deputy of Health Ministry,1: 387-396.

Laribi B, Kouki K, M'Hamid M, Bettaieb T. 2015. Coriander (Corindrum sativum L.) and its bioactive constituents. Fitoterapia, 103: 9-26.

Mascolo N, Izzo A, Autore G, Maiello F, Dicarlo G, Capsso F. 1995. Acetic acid-induced colitis in normal and essential fatty acid deficient rats. J Pharmacol Exp Ther, 272: 469-475.

MaPherson BP, Pfeiffer CJ.1978. Experimental production of diffuse colitis in rats. Digestion,17: 135-150

McQuaid KR. 2009. Drugs used in the treatment of gastrointestinal diseases. In: Katzung BG. (Ed.) Basic and Clinical Pharmacology. pp. 1089-1090, New York, McGraw Hill Companies.

Huo M, Cui X, Xue J, Chi G, Gao R, Deng X, et al. 2013. Anti-inflammatory effect of linalool in RAW 264.7 macrophages and lipopolysaccharide-induced lung injury model, J Surg Res 180: 47-54.

Minaiyan M, Ghannadi AR, Karimzadeh A. 2006. Antiulcerogenic effects of ginger (Zingiber officinale Roscoe.) on cysteamine induced duodenal ulcer in rats. Daru, 14: 97-101.

Minaiyan M, Sajjadi SE, Naderi N, Taheri D. 2014. Anti-Inflammatory Effect of Kelussia odoratissima Mozaff. hydroalcoholic extract on acetic acid- induced acute colitis in rats, J Res Pharm Sci; 3.1.

Morris GP, Beck PL, Herridge MS, Depew WT, Szewczuck MR, Wallace JL.1989. Hapten induced mode of inflammation and ulceration in rat colon. Gastroenterology, 96: 795-803.

Motavallian Naeini A, Minaiyan M, Rabbani M, Mahzouni P. 2012. Anti-inflammatory effect of ondansetron through 5-HT3 receptors on TNBS induced colitis in Rat. EXCLI J, 11:30-44.

Nair V, Singh S, Gupta YK. 2013. Anti-granuloma activity of Coriandrum sativum in experimental models. J Ayurveda Integr Med, 4:13-18.

Pandey A, Bigoniya P, Raj V, Patel KK. 2011. Pharmacological screening of Coriandrum sativum L. for hepatoprotective activity. J Pharm Bioall Sci, 3: 435–441.

Peana  A.T , Marzocco S , Popolo A, Pinto A. 2006. (-)Linalooln inhibits in vitro NO formation: probable involvement in the antinociceptive activity of this monoterpene compound. Life Sci,78 :719-723

Sahib NG, Anwar F, Gilani AH, Abdul Hamid A, Saari N, Alkharfy  KHM. 2013. Coriander  (Coriandrum sativum L.):A potential source of High-Value components for functional  food and nutraceuticals. Phytother Res, 27: 1439-1456.

Sartor RB. 1997. Pathogenesis and immune mechanism of chronic inflammatory bowel diseases. Am J Gastroenterol, 92: 5–11.

Sellin JH, Pasricha PJ. 2006. Pharmacotherapy of inflammatory bowel diseases. In: Brunton LL, Lazo JS, Parker KL, editors. Goodman & Gilmans the pharmacological basis of therapeutics. 10th ed. New York: McGraw-Hill Companies,10: 1009–1011.

Thabrew ML, Dharmasiri MG, Senaratne L. 2003. Anti-inflammatory and analgesic activity in the polyherbal formulation Maharasnadhi Quathar. J Ethnopharmacol, 85: 261–267

Varier PS. Coriandrum sativum in Indian medicinal plants. 1994. a compendium of 500 species .Orient Longman LtD, 2:416–417.

Wu TT, Tsai CW, Yao HT, Lii CK, Chen HW, Wu YL et al. 2010. Suppressive effects of extracts from the aerial part of Coriandrum sativum L. on LPS-induced inflammatory responses in murine RAW 264.7 macrophages, 90: 1846-1854.