1Department of Anatomy and Cell biology, Birjand University of Medical Sciences, Birjand, Iran.
2Pharmacological Research Center of Medicinal Plant, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
3Biochemistry of Nutrition Research Center, School of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
4Institute of Genetics and Developmental Biology, University of Chinese Academy of Sciences, Beijing, China.
5Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Science, Mashhad, Iran.
6Division of Medical Education, Brighton & Sussex Medical School, Rm 342, Mayfield House, University of Brighton, BN1 9PH, United Kingdom
Objectives: We have investigated the effect of a saffron supplement, given at a dose of 100 mg/kg, on prooxidant-antioxidant balance (PAB) in individuals with metabolic syndrome. Materials and Methods: A randomized, placebo-controlled trial design was used in 75 subjects with metabolic syndrome who were randomly allocated to one of two study groups: (1) the case group received 100mg/kg saffron and (2) the placebo control group received placebo for 12 weeks. The serum PAB assay was applied to all subjects before (week 0) and after (weeks 6 and 12) the intervention. Results: There was a significant (p=0.035) reduction in serum PAB between week 0 to week 6 and also from week 0 to week 12. Conclusion: Saffron supplements can modulate serum PAB in subjects with metabolic syndrome, implying an improvement in some aspects of oxidative stress or antioxidant protection.
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