Phytochemical and pharmacological aspects of Descurainia sophia Webb ex Prantl: modern and traditional applications

Document Type: Mini Review Article

Authors

1 Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran

2 Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran

Abstract

Seed of Descurainia sophia  Webb ex Prantl has been traditionally prescribed as treatment for palpitation, varicose vein, varicocele, constipation, hemorrhoid, skin eruptions, and impotence. To outline a view for further approaches, current work compiled a survey on all relevant clinical properties of this medicament in addition to the traditional reports. To do this, databases as PubMed, Scopus, EMBASE, IranMedex and Science information databases (SID) were searched by keywords, i.e., “Descurainia sophia”, “Khaksheer”, and “Flixweed” as well as “pharmacology” and “phytochemistry”. According to the findings, scant experimental evaluation and clinical assessment have been performed on this medicament. Of those, only anti-inflammatory, analgesic, and antipyretic effects as well as antioxidant and anthelmintic activities were assessed and confirmed in experimental studies. Despite broad administration of this herb in folk and traditional medicine, only two human clinical trials in bowel discomfort and pregnant subjects were conducted. Taken as a whole, more comprehensive clinical evaluations should be conducted on respective applications to support those traditional and folk uses.

Keywords

Main Subjects


Ahmadieh A. 2007. Raz-e-Darman(Secret of treatment), pp.171-172, Tehran, Iran, Eghbal press (In Persian).

Akbari N, Parvin N, Sereshti M, Safdari F. 2011. Study about different types of medicinal plants used by elderly people in Shahrekord city. J Shahrekord Univ Med Sci, 12: 26-32.

Arzani MA. 1870. Mīzān al-Tibb(Handbook of medicine for beginners), p. 238, India, Nūl Kishūr press (In Persian).

Arzani MA. 1915. Mofareh Al-Gholub, pp. 103 Lahoor, Salim lahoor press (In Persian).

yoobi F, Kamali B, Shamsizadeh A, Sajadi MA, Roohbakhsh A, Vazirinejad R, Hakimi E, Rezazadeh HA, Rahmani MR, Allahtavakili M. 2013. Effect of Aqueous Extract of Descurainia Sophia on Castor Oil-Induced Diarrhea in Male Rat. J Rafsenjan Univ Med Sci, 12: 149-156.

Behbahani MS, Abbasi S, Using shear reversible gels to stabilize the Flixweed (Descurainia sophia L.) syrup. 2013, 1stInternational e-Conference on novel Food Processing, Mashhad, Iran.

Buck WB, Osweiter GD, Van Gelder AG. 1976. Clinical and diagnostic veterinary toxicology. 2nd Ed. Iowa, Kendall/ Hunt Publishing Company.

Mirheidar H. 2005. Maaref giahi (Plant Knowledge), pp. 172-173, Tehran, Iran, Daftare Nashre Farhange Eslami.

Hossaini-Tabib, M. 1959. Tuhfat al-mu'minīn(Present for the faithful), pp. 342-346 Tehran and Qum, Iran, Mostafavi Press (In Persian).

Kai S, Xian L. 2003. Study on the chemical constituents of Descurainia sophia (L.) Webb ex Prantl. Shenyang Yao Ke Da Xue Xue Bao (Journal of Shenyang Pharmaceutical University), 6: 8-8.

Khorasani MA. 2001. Makhzan al Advieh (The storehouse of medicaments), p. 351, Research institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran, Bavardaran Press  (In Persian).

Lee YJ, Kim NS, Kim H, Yi JM, Oh SM, Bang OS, Lee J. 2013. Cytotoxic and anti-inflammatory constituents from the seeds of Descurainia sophia. Arch Pharm Res, 36: 536-541.

Li J, Liu X, Dong F, Xu J, Zheng Y, Shan W. 2010. Determination of the volatile composition in essential oil of Descurainia sophia (L.) Webb ex Prantl (Flixweed) by gas chromatography/mass spectrometry (GC/MS). Molecules, 15: 233-240.

Li W, Liu X, Khan MA, Kamiya Y, Yamaguchi S. 2005. Hormonal and environmental regulation of seed germination in flixweed (Descurainia sophia). Plant Growth Regul, 45: 199-207.

Maraghi S, Torfi Jabrpoor N. 2002. Study of in vitro and in vivo effects of Descurainia sophia extract on Hymenolepis nana in comparison with niclosamide. Hakim, 5: 57-62.

Mirzaei A, Mohammadi J, Mirzaei N, Mirzaei M. 2011. The Antioxidant Capacities and Total Phenolic Contents of Some Medicinal Plants in Iran. J Fasa Univ Med Sci, 1: 160-167.

Mohamed NH, Mahrous AE. 2009. Chemical constituents of Descurainia sophia L. and its biological activity. Rec Nat Prod, 3: 58-67.

Mohammadinia N, Rezaei MA, Loripour M, Heydari N. 2012. The Effect of Consumption of Sisymbrium-Seeds at the End of Pregnancy on the Rate of Cesarean Delivery and Apgar Score. Iran J Obstet Gynecol Infertil, 15: 8-13.

Pasalar M, Bagheri Lankarani K, Mehrabani D, Tolidei HR, Naseri M. 2013. The effect of Descureania Sophia L. and Prunus Domestica L. in prevention of constipation among Iranian Hajj Pilgrims, Saudi Arabia. Res J Pharm Biol Chem Sci, 4: 1195-1204.

Peng L, Yi Y, Fu-li G, Ze-qü L. 1997. A preliminary study on the introduction of Descurainia sophia, an oil plant species for industrial uses. Acta Botanica Sinica, 39: 447-479.

Sun K, Li X, Li W, Liu JM, Wang JH, Sha Y. 2006. A new nor-lignan from the seeds of Descurainia sophia. Nat Prod Res, 20: 519-522.

Sun K, Li X, Li W, Wang J, Liu J, Sha Y. 2004. Two new lactones and one new aryl-8-oxa-bicyclo[3,2,1]oct-3-en-2-one from Descurainia sophia. Chem Pharm Bull (Tokyo), 52: 1483-1486.

Sun K, Li X, Liu JM, Wang JH, Li W, Sha Y. 2005. A novel sulphur glycoside from the seeds of Descurainia sophia (L.). J Asian Nat Prod Res, 7: 853-856.

Tavakoli R, Mohadjerani M, Hosseinzadeh R, Tajbakhsh M, Naqinezhad A 2012. Chemical Composition of Fatty Acid from Different Parts of Descurainia Sophia L. Growing Wild in North of Iran. Anal Chem Lett, 2: 363-366.

Wang AQ, Wang XK, Li JL, Cui XY. 2004. Isolation and structure identification of chemical constituents from the seeds of Descurainia sophia (L.) Webb ex Prantl. Yao Xue Xue Bao (Acta Pharmaceutica Sinica), 39: 46-51.

Zarshenas MM, Petramfar P, Firoozabadi A, Moein MR, Mohagheghzadeh, A. 2013. Types of headache and those remedies in traditional persian medicine. Pharmacogn Rev, 7: 17-26.

Zhongfeng X. 2007. Determination of Trace Elements in Descurainia sophia by FAAS. Anhui Nong Ye Ke Xue (Journal of Anhui Agricultural Sciences), 35: 10575.