Home Articles List Article Information
Avicenna Journal of Phytomedicine
Journal Archive
Volume Volume 9 (2019)
Volume Volume 8 (2018)
Volume Volume 7 (2017)
Volume Volume 6 (2016)
Volume Volume 5 (2015)
Volume Volume 4 (2014)
Volume Volume 3 (2013)
Volume Volume 2 (2012)
Volume Volume 1 (2011)
Avicenna  Journal of Phytomedicine
Rejection Rate 52.63%
Average time to first decision (days) 34.58
Najafi, H., Changizi Ashtiyani, S., Sayedzadeh, S., Mohamadi yarijani, Z., Fakhri, S. (2015). Therapeutic effects of curcumin on the functional disturbances and oxidative stress induced by renal ischemia/reperfusion in rats. Avicenna Journal of Phytomedicine, 5(6), 576-586. doi: 10.22038/ajp.2015.4451
Houshang Najafi; Saeed Changizi Ashtiyani; Sayed Abolhasan Sayedzadeh; Zeynab Mohamadi yarijani; Sajad Fakhri. "Therapeutic effects of curcumin on the functional disturbances and oxidative stress induced by renal ischemia/reperfusion in rats". Avicenna Journal of Phytomedicine, 5, 6, 2015, 576-586. doi: 10.22038/ajp.2015.4451
Najafi, H., Changizi Ashtiyani, S., Sayedzadeh, S., Mohamadi yarijani, Z., Fakhri, S. (2015). 'Therapeutic effects of curcumin on the functional disturbances and oxidative stress induced by renal ischemia/reperfusion in rats', Avicenna Journal of Phytomedicine, 5(6), pp. 576-586. doi: 10.22038/ajp.2015.4451
Najafi, H., Changizi Ashtiyani, S., Sayedzadeh, S., Mohamadi yarijani, Z., Fakhri, S. Therapeutic effects of curcumin on the functional disturbances and oxidative stress induced by renal ischemia/reperfusion in rats. Avicenna Journal of Phytomedicine, 2015; 5(6): 576-586. doi: 10.22038/ajp.2015.4451

Therapeutic effects of curcumin on the functional disturbances and oxidative stress induced by renal ischemia/reperfusion in rats

Article 11, Volume 5, Issue 6, October 2015, Page 576-586  XML PDF (633 K)
Document Type: Original Research Article
DOI: 10.22038/ajp.2015.4451
Authors
Houshang Najafi 1; Saeed Changizi Ashtiyani2; Sayed Abolhasan Sayedzadeh3; Zeynab Mohamadi yarijani1; Sajad Fakhri4
1Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran.
2Department of Physiology, School of Medicine, Arak University of Medical Sciences, Arak, Iran.
3Department of Nephrology, Emam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
4School of pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Abstract
Objectives: Curcumin has anti-inflammatory and antioxidative properties. The objective of this study was to investigate the therapeutic effects of curcumin on functional disturbances, oxidative stress, and leukocyte infiltration induced by renal ischemia/reperfusion (I/R).
Materials and Methods: Animals were randomly divided into 9 groups. The groups with 24-h reperfusion consisted of sham-24h, I/R-24h, and three I/R groups treated with curcumin at 10, 20, or 30 mg kg-1, i.p. after the ischemic period. The 72-h reperfusion groups also included Sham-72h, I/R-72h, I/R treated with curcumin at single dose of 20 mg kg-1, i.p., and I/R group which received three doses of curcumin at 20 mg kg-1, i.p., consecutively. Renal functional injury was assessed by measuring serum creatinine and urea-nitrogen concentrations. Oxidative stress was evaluated by assessment tissue malondialdehyde (MDA) and the ferric reducing/antioxidant power (FRAP) levels. Moreover, renal tissue leukocyte infiltration was measured by histopathology examination.
Results: Ischemia/reperfusion resulted in a significant increase in serum concentration of creatinine, urea-nitrogen, tissue MDA level, and leukocytes infiltration as well as reduced FRAP level. Treatment with curcumin in 24-h reperfusion groups could only lead to a significant change in the levels of MDA and FRAP. However, in 72-h reperfusion groups, curcumin was able to correct all functional disturbances, oxidative stress, and leukocytes infiltration with more effectiveness in groups that received three doses of curcumin.
Conclusion: The administration of curcumin during 72-h reperfusion following 30 minutes of ischemia can decrease renal oxidative stress and leukocytes infiltration as well as improve kidney function. However, during first 24-h reperfusion, curcumin only decreased oxidative stress.
Keywords
Curcumin; Acute renal failure; Oxidative stress; Ischemia/Reperfusion
Main Subjects
Physiology
References
Ammon HP, Safayhi H, Mack T, Sabieraj J. 1993. Mechanism of antiinflammatory actions of curcumine and boswellic acids. J Ethnopharmacol, 38: 113-119.

Ammon HP, Wahl MA. 1991. Pharmacology of Curcuma longa. Planta Med, 57: 1-7.

Ashtiyani SC, Najafi H, Firouzifar MR, Shafaat O. 2013. Grape seed extract for reduction of renal disturbances following reperfusion in rats. Iran J Kidney Dis, 7: 28-35.

Ashtiyani SC, Najafi H, Kabirinia K, Vahedi E, Jamebozorky L. 2012. Oral omega-3 fatty acid for reduction of kidney dysfunction induced by reperfusion injury in rats. Iran J Kidney Dis, 6: 275-283.

Awad AS, El-Sharif AA. 2011. Curcumin immune-mediated and anti-apoptotic mechanisms protect against renal ischemia/reperfusion and distant organ induced injuries. Int Immunopharmacol, 11: 992-996.

Baek SM, Makabali GG, Brown RS, Shoemaker WC. 1975. Free-water clearance patterns as predictors and therapeutic guides in acute renal failure. Surgery, 77: 632-640.

Balogun E, Hoque M, Gong P, Killeen E, Green CJ, Foresti R, Alam J, Motterlini R. 2003. Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem Journal, 371: 887-895.

Bayrak O, Uz E, Bayrak R, Turgut F, Atmaca AF, Sahin S, Yildirim ME, Kaya A, Cimentepe E, Akcay A. 2008. Curcumin protects against ischemia/reperfusion injury in rat kidneys. World J Urol, 26: 285-291.

Benzie IF, Strain JJ. 1999. Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods Enzymol, 299: 15-27.

Changizi Ashtiyani S, Najafi H, Jalalvandi S, Hosseinei F. 2013. Protective effects of Rosa canina L fruit extracts on renal disturbances induced by reperfusion injury in rats. Iran J Kidney Dis, 7: 290-298.

Chatterjee PK, Patel NS, Sivarajah A, Kvale EO, Dugo L, Cuzzocrea S, et al. 2003. GW274150, a potent and highly selective inhibitor of iNOS, reduces experimental renal ischemia/reperfusion injury. Kidney Int, 63: 853-865.

Clarkson M, Friedewald J, Eustace J, Rabb H. 2008. Acute kidney injury. In: Brenner & Rector’s The Kidney. 8th ed. Philadelphia, Pennsylvania, USA: Saunders, Elsevier: 943-986.

Deodhar SD, Sethi R, Srimal RC. 1980. Preliminary study on antirheumatic activity of curcumin (diferuloyl methane). Indian J Med Res, 71: 632-634.

Granger DN. 1988. Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am J Physiol, 255: H1269-1275.

Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. 2008. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci, 65: 1631-1652.

Jafarey M, Changizi Ashtiyani S, Najafi H. 2014. Calcium dobesilate for prevention of gentamicin-induced nephrotoxicity in rats. Iran J Kidney Dis, 8: 46-52.

Jayaprakasha GK, Jagan Mohan Rao L, Sakariah KK. 2002. Improved HPLC method for the determination of curcumin, demethoxycurcumin, and bisdemethoxycurcumin. J Agric Food Chem, 50: 3668-3672.

Kanai M. 2014. Therapeutic applications of curcumin for patients with pancreatic cancer. World J Gastroenterol, 20: 9384-9391.

Kim YS, Kwon JS, Cho YK, Jeong MH, Cho JG, Park JC, Kang JC, AHN Y. 2012. Curcumin reduces the cardiac ischemia-reperfusion injury: involvement of the toll-like receptor 2 in cardiomyocytes. J Nutr Biochem, 23: 1514-1523.

Kribben A, Edelstein CL, Schrier RW. 1999. Pathophysiology of acute renal failure. J Nephrol, 12 (Suppl 2): S142-151.

Kuhad A, Pilkhwal S, Sharma S, Tirkey N, Chopra K. 2007. Effect of curcumin on inflammation and oxidative stress in cisplatin-induced experimental nephrotoxicity. J Agric Food Chem, 55: 10150-10155.

Lal B, Kapoor AK, Agrawal PK, Asthana OP, Srimal RC. 2000. Role of curcumin in idiopathic inflammatory orbital pseudotumours. Phytother Res, 14: 443-447.

Lao CD, Ruffin MTt, Normolle D, Heath DD, Murray SI, Bailey JM, et al. 2006. Dose escalation of a curcuminoid formulation. BMC Complement Altern Med, 6: 10.

Masuda T, Hidaka K, Shinohara A, Maekawa T, Takeda Y, Yamaguchi H. 1999. Chemical studies on antioxidant mechanism of curcuminoid: analysis of radical reaction products from curcumin. J Agric Food Chem, 47: 71-77.

Moosavi SM, Ashtiyani SC, Hosseinkhani S. 2011. L-carnitine improves oxidative stress and suppressed energy metabolism but not renal dysfunction following release of acute unilateral ureteral obstruction in rat. Neurourol Urodyn, 30: 480-487.

Moosavi SM, Ashtiyani SC, Hosseinkhani S, Shirazi M. 2010. Comparison of the effects of L-carnitine and alpha-tocopherol on acute ureteral obstruction-induced renal oxidative imbalance and altered energy metabolism in rats. Urol Res, 38: 187-194.

Najafi H, Firouzifar MR, Shafaat O, Changizi Ashtiyani S, Hosseini N. 2014. Protective effects of Tribulus terrestris L extract against acute kidney injury induced by reperfusion injury in rats. Iran J Kidney Dis, 8: 292-298.

Ohkawa H, Ohishi N, Yagi K. 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem, 95: 351-358.

Okudan N, Belviranli M, Gokbel H, Oz M, Kumak A. 2013. Protective effects of curcumin supplementation on intestinal ischemia reperfusion injury. Phytomedicine, 20: 844-848.

Prodjosudjadi W, Gerritsma JS, Klar-Mohamad N, Gerritsen AF, Bruijn JA, Daha MR, Van Es La. 1995. Production and cytokine-mediated regulation of monocyte chemoattractant protein-1 by human proximal tubular epithelial cells. Kidney Int, 48: 1477-1486.

Rogers NM, Stephenson MD, Kitching AR, Horowitz JD, Coates PT. 2012. Amelioration of renal ischaemia-reperfusion injury by liposomal delivery of curcumin to renal tubular epithelial and antigen-presenting cells. Br J Pharmacol, 166: 194-209.

Satoskar RR, Shah SJ, Shenoy SG. 1986. Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with postoperative inflammation. Int J Clin Pharmacol Ther Toxicol, 24: 651-654.

Slofstra SH, Bijlsma MF, Groot AP, Reitsma PH, Lindhout T, Ten Cate H, et al. 2007. Protease-activated receptor-4 inhibition protects from multiorgan failure in a murine model of systemic inflammation. Blood, 110: 3176-3182.

Srimal RC, Dhawan BN. 1973. Pharmacology of diferuloyl methane (curcumin), a non-steroidal anti-inflammatory agent. J Pharm Pharmacol, 25: 447-452.

Thadhani R, Pascual M, Bonventre JV. 1996. Acute renal failure. N Engl J Med, 334: 1448-1460.

Tirkey N, Kaur G, Vij G, Chopra K. 2005. Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys. BMC pharmacol, 50: 15.

Trujillo J, Chirino YI, Molina-Jijon E, Anderica-Romero AC, Tapia E, Pedraza-Chaverri J. 2013. Renoprotective effect of the antioxidant curcumin: Recent findings. Redox Biol, 1: 448-456.

Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. 2007. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol, 39: 44-84.

Winther K, Rein E, Kharazmi A. 1999. The anti-inflammatory properties of rose-hip. Inflammopharmacology, 7: 63-68.

Xu YX, Pindolia KR, Janakiraman N, Noth CJ, Chapman RA, Gautam SC. 1997. Curcumin, a compound with anti-inflammatory and anti-oxidant properties, down-regulates chemokine expression in bone marrow stromal cells. Exp Hematol, 25: 413-422.

Youn GS, Kwon DJ, Ju SM, Choi SY, Park J. 2013. Curcumin ameliorates TNF-alpha-induced ICAM-1 expression and subsequent THP-1 adhesiveness via the induction of heme oxygenase-1 in the HaCaT cells. BMB Rep, 46: 410-415.

Ysebaert DK, De Greef KE, Vercauteren SR, Ghielli M, Verpooten GA, Eyskens EJ, DE Broe ME. 2000. Identification and kinetics of leukocytes after severe ischaemia/reperfusion renal injury. Nephrol Dial Transplant, 15: 1562-1574.

Statistics
Article View: 10,298
PDF Download: 4,803