Document Type: Original Research Article
Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
Objective: In the present study, the effects of aqueous saffron extract (Crocus sativus L.) on the acquisition and reinstatement of morphine-induced conditioned place preference (CPP) in mice were investigated.
Materials and Methods: Subcutaneous administration of morphine (40 mg/kg for four days) produced place preference. Intraperitoneal administration of aqueous extract (40 and 80 mg/kg for four days) 30 min before the morphine administration decreased the acquisition of morphine CPP. In other groups of animal, following extinction of a place preference induced by morphine (40 mg/kg), single administration of morphine (10 mg/kg) reinstated the place reference. The aqueous extract (80 mg/kg) 30 min before this priming dose of morphine blocked morphine-induced reinstatement of place preference.
Results: These results show that aqueous saffron extract can reduce the acquisition and reinstatement of morphine-induced conditioned place preference.