Department of Pharmaceutical Technology, Faculty of Pharmacy, Omdurman Islamic University, Omdurman, Sudan
Objective: Tribes in Nubia Mountains regions of Sudan used Monechma ciliatum seeds for common cold and other chest allergic conditions as a traditional medicine. The aim of this paper is to validate this traditional practice scientifically. Materials and Methods: Monechma ciliatum seeds were screened for major phytochemical groups using standard methods. Different extracts were bioassayed in- vitro for their bioactivity to inhibit the growth of pathogenic bacteria and fungi. Results: Phytochemical screening results showed the presence of flavonoids, tannins, triterpens, and anthraquinones. Staphylococcusaureus was found to be sensitive to both water extract with zones of inhibition 22 – 26 mm at concentrations of 50 and 100mg/ml and ethanol extract 17 mm at concentration of 100 mg/ml. The growth of Klebsiella pneumoniae was inhibited by ethanol extract with zones of inhibition equal to 16, 26, and 33 mm at concentrations of 50, 100, and 150 mg/ml, respectively. Pseudomonas aeruginosa was insensitive to all extracts used. Similarly, all used fungi were found to be insensitive to extracts used. The minimum inhibitory concentrations of the extracts against microorganisms were ranged from 12.5 to 25 mg/ml. Conclusion: The findings of the current study support the traditional uses of the plant's seed in the therapy of respiratory tract infections caused by Staphylococcusaureus and Klebsiellapneumoniae.
Ahmed I, Agil F, Owais M. 2006. Modern Phytomedicine: Turning Medicinal Plants into Drugs, pp. 200, Wieleyvch Verlag GmbH & Co. KGaA, Weinheim.
Anas K, Jayasree PR, Vijayakumar T, Manish- Kumar PR. 2008. In- vitro antibacterial activity of Psidium guajava Linn leaf extract on clinical isolates of multidrug resistant Staphylococcus aureus. Indian J Exp Biol, 46: 41- 46.
Ayoub SM. 1981. Component fatty acids from the oils from Monechmaciliatum. Fitoterapia, 2: 251- 253.
Harvey RA, Champe PC. 2000. Pharmacology, pp.337, New York, Lippincott Williams and Wilkins.
Hassan SA, Sirat HM, Sakina M, Yagi A, Waleed SK et al. 2011. In vitro Antimicrobial activities of chloroformic, hexane and ethanolic extracts of Citrullus lanatus var. citroides (Wild melon). J Med. Plants Res, 5: 1338-1344.
Fabry W, Okemo P, Ansorg R. 1996. Fungistatic and fungicidal activity of East African medicinal plants. Mycoses, 39: 67-70.
Fathi E, Sefidkon F. 2012. Influence of Drying and Extraction Methods on Yield and Chemical Composition of the Essential Oil of Eucalyptus sargentii. J Agri Sci and Tech, 14: 1035-1042.
Jonathan SG, Fasidi IO. 2003. Antimicrobial activities of two Nigerian Edible Macro- Fungi Lycoperdon pusilum (Bat. Ex) and L.giganteum. Afr J of Biomed Res, 6: 85- 90.
Kumar P, Clark M. 2002. Basic Clinical Medicine, pp. 21, London W.B. Saunders, by path press Limited.
Lopez CM, Nitisinprasert S, Wanchaitanawong P, Poovarodom N. 2003.Antimicrobial activity of medicinal plant extract against food borne spoilage and pathogenic microorganisms. Kasetsart J Nat Sci, 37: 460-467.
Mariod AA, Aseel KM, Mustafa AA, Ibrahim S. 2009. Characterization of the Seed Oil and Meal from Monechma ciliatum and Prunus mahaleb Seeds. J Am Oil Chem Soc, 86: 749-755.
Okunlola A, Adewoyin BA, Odeku OA. 2003. Evaluation of Pharmaceutical and Microbial Qualities of Some Herbal Medicinal Products in South Western Nigeria. Trop. J Pharm Res, 6: 661-670.
Omolola O. 2011. The Isolation of Pseudomonas aeruginosa From Septic Sore Using Some Biological Tests. Int J Food Safety, 13: 188-190.
Padmanabhan P, Jangle SN. 2012. Evaluation of in- vitro anti- inflammatory activity of herbal preparation, a combination of four medicinal plants. Int J App Basic Med Res, 2: 109-116.
Sheng GW, Hua JD, Hui YM, Min SH, Bo LI. 2012. Mechanisms, clinically curative effects and antifungal activities of cinnamon oil and pogostemon oil complex against three species of Candida. J Trad Chinese Med, 32: 1-2.
Sofowora A. 1993. Medicinal Plants and Traditional Medicine in Africa, pp. 289, Ibadan, Spectrum Books Ltd., Sunshine House.
Tatiya A, Tapadiya G, Kotecha S, Surana S. 2011. Effect of solvents on total phenolics, antioxidant and antimicrobial properties of Bridelia retusa Spreng stem bark. Indian J Nat Pro and Res, 2: 442-447.
Uguru MO, Evan F. 2002. Phytochemical and pharmacological studies on Monechma ciliatum. J Ethnopharmacol, 73: 289- 292.