1Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, I. R. Iran
2Department of Traditional Medicine, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, I. R. Iran
3Department of Pharmacognosy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, I. R. Iran
4Department of Nutrition, School of Medicine, Biochemistry and Nutrition, Endoscopic and Minimally Invasive Surgery and Cancer Research Centers, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
5School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
Objectives: Considering the increasing prevalence of depression in modern societies and the positive effects of omega-3 polyunsaturated fatty acids on depression, this study aims to investigate the omega-3 and omega-6 content of various foodstuffs, prescribed or prohibited by Iranian Traditional Medicine (ITM). Materials and Methods: Firstly, reliable sources of Iranian Traditional Medicine were reviewed in order to identify the prescribed and prohibited foodstuffs for depressed patients. Afterwards, according to the online database of United States Department of Agriculture (URL: http://ndb.nal.usda.gov/ndb/search/list), the ratio of linoleic acid to alpha linolenic acid (as representatives of omega-6 and omega-3, respectively) was identified in each foodstuff. Finally, the ratios of omega-6 to omega-3 were compared between seven food groups of vegetables, fruits, dry goods, high protein products, dairies, breads, and spices. Results: Based on the resources of Iranian Traditional Medicine, the following foods are prescribed for depressed patients: basil, coriander, spinach, lettuce, squash, peppermint, dill, chicory, celery, beet, quince, cucumber, watermelon, grape, peach, pomegranate, banana, apple, currant, pistachio, dried fig, almond, egg, chicken, lamb, trout, milk, bread without bran,saffron, oregano, and coriander seeds. On the other hand, cabbage, eggplant, onion, garlic, broad beans, lentils, beef, whole wheat bread, and mustard are prohibited. It should be noted that omega-3 content in some prescribed foods is more than that of the prohibited ones. Conclusion: The present study showed that mint, basil, spinach, lettuce, squash, lamb, saffron, oregano, cucumber, pistachio, milk, and also wild trout can be considered as medicinal foods for depressed patients.
Ahwazi Arjani AA. 1973. Kamel al-Sanaah al-Tibbiyah (The Perfect Art of the Medicine), pp. 297-299, Lithograph edition of Astan-e Quds-e Razavi.
Antonogeorgos G, Panagiotakos DB, Pitsavos C, Papageorgiou C, Chrysohoou C, Papadimitriou GN, Stefanadis C. 2012. Understanding the role of depression and anxiety on cardiovascular disease risk, using structural equation modeling; the mediating effect of the Mediterranean diet and physical activity: the ATTICA study. Ann Epidemiol, 22: 630-637.
Appleton KM, Rogers PJ, Ness AR. 2010. Updated systematic review and meta-analysis of the effects of omega-3 long-chain polyunsaturated fatty acids on depressed mood. Am J Clin Nutr, 91: 757-770.
Bountziouka V, Polychronopoulos E, Zeimbekis A, Papavenetiou E, Ladoukaki E, Papairakleous N, et al. 2009. Long-term fish intake is associated with less severe depressive symptoms among elderly men and women: the MEDIS (MEDiterranean ISlands Elderly) epidemiological study. J Aging Health, 21: 864-880.
Dhingra D, Kumar V. 2008. Evidences for the involvement of monoaminergic and GABAergic systems in antidepressant-like activity of garlic extract in mice. Indian J Pharmacol, 40: 175-179.
Esfahani MM, Zolfaghari B, Karimi H, Gannadi AR. 2011. Doctrine of Iranian traditional medicine a valuable source for introduction and presentation of functional foods. J Trad Med Islam Iran, 3: 77-94. (Persian)
Ibn-e Sina AAH. 2005. Shams al-Din E (Ed), Al-Qanun fi al-Tibb (The Canon of Medicine), vol. 2, pp. 294-301, Lebanon, Alamy le-al-Matbooat institute.
Jacka FN, Pasco JA, Mykletun A, Williams LJ, Hodge AM, O'Reilly SL, et al. 2010. Association of Western and traditional diets with depression and anxiety in women. Am J Psychiatry, 167: 305-311.
JorJani SI. 1976. Saeedi Sirjani AA (Ed), Zakhireh Kharazmshahi (Treasure of Kharazmshah), pp. 297-302, Tehran, the Iranian Culture Foundation.
Kraguljac NV, Montori VM, Pavuluri M, Chai HS, Wilson BS, Unal SS. 2009. Efficacy of omega-3 fatty acids in mood disorders - a systematic review and meta-analysis. Psychopharmacol Bull, 42:39-54.
Li Y, Dai Q, Ekperi LI, Dehal A, Zhang J. 2011. Fish consumption and severely depressed mood, findings from the first national nutrition follow-up study. Psychiatry Res, 190:103-109.
Logan AC. 2006. Dietary fiber, mood, and behavior. Nutrition, 22:213-214.
Mahan LK, Escott-Stump S. 2008. Mahan LK, Escott-Stump S (Ed), 12th Ed, Krause’s food and nutrition therapy, pp. 55, Elsevier Saunders.
Murakami K, Miyake Y, Sasaki S, Tanaka K, Arakawa M. 2010. Fish and n-3 polyunsaturated fatty acid intake and depressive symptoms: Ryukyus Child Health Study. Pediatrics, 126: e623-630.
Nemeroff CB, Goldschmidt-Clermont PJ. 2012. Heartache and heartbreak-the link between depression and cardiovascular disease. Nat Rev Cardiol, 9: 526-539.
Richards D. 2011. Prevalence and clinical course of depression: a review. Clin Psychol Rev, 31: 1117-1125.
Sadock BJ, Sadock VA, Kaplan HI. 2007. 10th Ed, Kaplan & Sadock's synopsis of psychiatry: behavioral sciences/clinical psychiatry, Philadelphia, Wolter Kluwer/Lippincott Williams & Wilkins.
Sánchez-Villegas A, Henríquez P, Bes-Rastrollo M, Doreste J. 2006. Mediterranean diet and depression. Public Health Nutr, 9: 1104-1109.
Silva N, Atlantis E, Ismail K. 2012. A review of the association between depression and insulin resistance: pitfalls of secondary analyses or a promising new approach to prevention of type 2 diabetes? Curr Psychiatry Rep, 14: 8-14.
Su KP. 2009. Biological mechanism of antidepressant effect of omega-3 fatty acids: how does fish oil act as a mind-body interface? Neurosignals, 17: 144-152.
Suares NC, Ford AC. 2011. Prevalence of, and risk factors for, chronic idiopathic constipation in the community: systematic review and meta-analysis. Am J Gastroenterol, 106:1582-1591; quiz 1, 92.
Suominen-Taipale AL, Partonen T, Turunen AW, Männistö S, Jula A, Verkasalo P. 2010. Fish consumption and omega-3 polyunsaturated fatty acids in relation to depressive episodes: a cross-sectional analysis. PLoS One, 5: e10530.
Timonen M, Horrobin D, Jokelainen J, Laitinen J, Herva A, Räsänen P. 2004. Fish consumption and depression: the Northern Finland 1966 birth cohort study. J Affect Disord, 82: 447-452.
United States Department of Agriculture. USDA website 2011 [cited 2012 November]. Available from: URL: http://ndb.nal.usda.gov/ndb/search/list.
Wint D. 2011. Depression: a shared risk factor for cardiovascular and Alzheimer disease. Cleve Clin J Med, 78 Suppl: S44-46.