1Department of Physiology, School of Medicine, Bojnurd University of Medical Sciences, Bojnurd, I. R. Iran
2Student Research Committee, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, I. R. Iran
3Department of Physiology, North Khorasan University of Medical Sciences, Bojnurd, I. R. Iran
4Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
Objective: Gut–brain axis (GBA) is very important in creation and modulation of gastrointestinal problems. Aloe vera gel has gastroprotective properties. The purpose of this study was to evaluate the effect of aqueous extract of Aloe vera leaves on the gastric acid secretion and brain and intestinal water content following acetic acid gastric ulcer induction. Materials and Methods: Gastric ulcer was induced by injection of 20% acetic acid into the subserosal layer in male rats. Rats were randomly assigned into three groups: intact group, gastric ulcer group and Aloe vera group (treatment with Aloe vera following gastric ulcer induction). The acid levels and brain and intestinal water content of each sample were measured eight days after the gastric ulcer induction. Results: Gastric acid levels were significantly decreased in Aloe vera group when compared with gastric ulcer group (p<0.05). However, there were no differences in acid output between gastric ulcer and Aloe vera groups with intact group. After Aloe vera administration, the amount of brain water content had no difference with intact and gastric ulcer groups (p<0.05). The duodenal water content in Aloe vera group was significantly reduced compared with intact group (p<0.05) but gastric ulcer group had no significant difference with intact and Aloe vera group. Conclusions: The administration of Aloe vera has an inhibitory effect on the gastric acid output.
Akhtar S, Li X, ChaudryIH, Choudhry MA. 2009. Neutrophil chemokines and their role in IL-18-mediated increase in neutrophil O2− production and intestinal edema following alcohol intoxication and burn injury. Am J PhysiolGastrointest Liver Physiol, 297: G340-G347.
Borovikova LV, Ivanova S, Zhang M, Yang H, Botchkina GI, Watkins LR, et al. 2000. Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin. Nature, 405: 458-462.
Blitz JJ, Smith JW, Gerard JR. 1963. Aloe vera gel in peptic ulcer therapy: preliminary report. J Am Osteopath Assoc, 62: 731-735.
Bureau I, Gueux E, Mazur A, Rock E, Roussel AM, Rayssiguier Y. 2003. Female rats are protected against oxidative stress during copper deficiency. J Am Coll Nutr, 22: 239-246.
Cheng Y, Macera CA, Davis DR, Blair SN. 2000. Physical activity and peptic ulcers. West J Med, 173: 101-107.
Davidson MT, Deitch EA, Lu Q, Osband A, Feketeova E, Nemeth ZH, Hasko G, Xu DZ. 2004. A study of the biologic activity of trauma-hemorrhagic shock mesenteric lymph over time and the relative role of cytokines. Surgery, 136: 32-41.
Davis RH, Donato JJ, Hartman GM, Hass RC. 1994. Anti-inflammatory and wound healing activity of a growth substance in Aloe vera. J Am Podiatr Med Assoc, 84: 77-81.
Davis RH, Leitner MG, Russo JM, Byrne ME. 1989. Wound healing, Oral and topical activity of Aloe vera. J Am Podiatr Med Assoc, 79: 559-562.
Duansak D, Somboonwong J, Patumraj S. 2003. Effects of Aloe vera on leukocyte adhesion and TNF-alpha and IL-6 levels in burn wounded rats. Clin Hemorheol Microcirc, 29: 239-246.
Eamlamnam k, Patumraj S, Visedopas N, Thong-Ngam d. 2006. Effects of Aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats. World J Gastroenterol, 12: 2034-2039.
Grindlay D, Reynolds T. 1986. The Aloe vera phenomenon: a review of the properties and modern uses of the leaf parenchyma gel. J Ethnopharmacol, 16: 117-151.
Hamman JH. 2008. Composition and Applications of Aloe vera Leaf Gel.Molecules, 13: 1599-1616.
Joshi M.C, Dorababu M, Parabha T. 2004. Effect of pterocarpusmarsupium on NIDDM- induced rat gastric ulceration and mucosal offensive and defensive factors. Indian J pharmacol, 36: 296-302.
Kipnis J, Cohen H, Cardon M, Ziv Y, Schwartz M. 2004. T cell deficiency leads to cognitive dysfunction: implications for therapeutic vaccination for schizophrenia and other psychiatric conditions. Proc Natl Acad Sci U S A, 101: 8180-8185.
Klein AD, Penneys NS. 1988. Aloe vera. J Am Acad Dermatol, 18: 714-720.
Labenz J, Börsch G.1994. Role of Helicobacter pylori eradication in the prevention of peptic ulcer bleeding relapse. Digestion, 55: 19-23.
Lindgren S, Stewenius J, Sjölund K, Lilja B, Sundkvist G. 1993. Autonomic vagal nerve dysfunction in patients with ulcerative colitis. Scand J Gastroenterol, 28: 638-642.
Lindgren S, Lilja B, Rosën I, Sundkvist G. 1991. Disturbed autonomic nerve function in patients with Crohn’s disease. Scand J Gastroenterol, 26: 361-366.
Lushbaugh CC, Hale DB. 1953. Experimental acute radioder-matitis following beta irradiation. V. Histopath-ological study of the mode of action of therapy with Aloe vera. Cancer, 6: 690-698.
Maunder RG, Levenstein S. 2008. The role of stress in the development and clinical course of inflammatory bowel disease: epidemiological evidence. Curr Mol Med, 8: 247-252.
Moon EJ, Lee YM, Lee OH, Lee MJ, Lee SK, Chung MH, Park YI, Sung CK, Choi JS, Kim KW. 1999. A novelangiogenic factor derived from Aloe vera gel: beta-sitosterol, a plant sterol. Angiogenesis, 3: 117-123.
Nabavizadeh F, Shahrani M, Vahedian Z, Vahedian M. 2007. Marjoram increases basal gastric acid and pepsinsecretions in rat. Phytother Res, 21: 1036-1038.
Nusrat A, Turner JR, Madara JL. 2000. Molecular physiology and pathophysiology of tight junctions. IV. Regulation of tight junctions by extracellular stimuli: nutrients, cytokines, and immune cells. Am J Physiol Gastrointest Liver Physiol, 279: G851-857.
O’Connor CA, Cernak I, Vink R. 2005. Bothestrogen and progesterone attenuate edema formationfollowing diffuse traumatic brain injury in rats. Brain Res, 1062: 171-174.
Okabe S, Amagase K. 2005. An overview of acetic acid ulcer models the history and state of the art of peptic ulcer research. Biol Pharm Bull, 28: 1321-1341.
Parish LC, Witkoski JA, Millikan LE. 1991. Aloe vera: its chemical and therapeutic properties. Int J Dermatol, 30: 679.
Rates SMK. 2001. Plants as source of drugs. Toxicon, 39: 603-613.
Surjushe A, Vasani R, Saple DG. 2008. Aloe vera: A short review. Indian J Dermatol, 53: 163-166.
Somboonwong J, Thanamittramanee S, Jariryapongskul A, Patumraj S. 2000. Therapeutic effects of Aloe vera on cutaneous microcirculation and wound healing in second degree burn model in rats. J Med Assoc Thai, 83: 417-425.
Visuthikosol V, Chowchuen B, Sukwanarat Y, Sriurairatana S, Boonpucknavig V. 1995. Effect of Aloe vera gel to healing of burn wound a clinical and histologic study. J Med Assoc Thai, 78: 403-409.
Vogler BK. 1999. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract, 49: 823-828.