TY - JOUR ID - 8853 TI - Effect of the methanolic extracts of different parts of Ferula assa-foetida on naloxone-induced withdrawal behavior in morphine-dependent mice JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Khanavi, Mahnaz AU - Maadani, Sajad AU - Farahanikia, Behnaz AU - Eftekhari, Mahdieh AU - Sharifzadeh, Mohammad AD - Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran. AD - Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran AD - Department of Toxicology and Pharmacology and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran. Y1 - 2017 PY - 2017 VL - 7 IS - 5 SP - 426 EP - 435 KW - Ferula assa-foetida KW - Extract KW - Gamma-aminobutyric acid (GABA) KW - Morphine dependence KW - Withdrawal syndrome DO - 10.22038/ajp.2017.17885.1696 N2 - Objective: Ferula assa-foetida, a native species in Iran, is used for treatment of several diseases particularly for neurological disorders in Iranian Traditional Medicine. The aim of this study is to investigate the effect of methanolic roots, fruits, and aerial parts extracts of Ferula assa-foetida on withdrawal syndrome in morphine-dependent mice. Materials and Methods: Aerial parts, roots, and fruits of the plant were separately extracted with 80% MeOH. For induction of dependence, morphine (50, 50 and 75 mg/kg) was injected subcutaneously three times daily (10 am, 1 pm and 4 pm) for three days and a last dose of morphine (50 mg/kg) was administrated on the fourth day. Withdrawal syndrome was induced by injection of naloxone (5 mg/kg, intraperitoneal) 2 hr after the final dose of morphine. Different doses of the extracts were administered i.p. 60 minutes before naloxone injection and withdrawal sign was recorded 2 minutes after naloxone injection for a period of 60 minutes.   Results: Pre-treatment of animals with different doses (2.5, 5, 10, 20 mg/kg) of methanolic extract of the aerial parts of F. assa-foetida caused a significant decrease in naloxone-induced behavior. Intraperitoneal administration of different doses (10, 15, 20, 25 mg/kg) of methanolic extract of the fruit significantly reduced the naloxone-induced withdrawal behavior (p<0.001). Conclusion: It might be concluded that the extracts of Ferula assa-foetida affect morphine withdrawal syndrome possibly via interference with the neurotransmitters in nervous system. UR - https://ajp.mums.ac.ir/article_8853.html L1 - https://ajp.mums.ac.ir/article_8853_336ec608546c5deadb4bc57b3a44dceb.pdf ER -