TY - JOUR ID - 7882 TI - Evaluation of fibrinolytic and antioxidant effects of Allium elburzense bulb extracts JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Safaeian, Leila AU - Zolfaghari, Behzad AU - Aghaye-Ghazvini, Mohammadreza AU - Behnampour, Mahya AD - Department of Pharmacology and Toxicology, Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran AD - Department of Pharmacognosy, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran AD - Isfahan Center of Public Health Training and Research, Institute of Public Health Research, Tehran University of Medical Science, Iran Y1 - 2017 PY - 2017 VL - 7 IS - 3 SP - 223 EP - 231 KW - Allium elburzense Wendelbo KW - Antioxidant KW - Fibrinolytic agents DO - 10.22038/ajp.2016.7882 N2 - Objective: Allium elburzense is an endemic plant of the family Amaryllidaceae that grows wild in northern Iran with some nutritional and medicinal applications. The present study was aimed to investigate the fibrinolytic and antioxidant effects of A. elburzense bulb extracts. Materials and Methods: Hydroalcoholic, aqueous, chloroformic and butanolic extracts were evaluated in this research. In vitro antioxidant assays were performed using total phenolic, DPPH, and FRAP methods. In the in vivo analysis, animals receivedi.p. injection of A. elburzense hydroalcoholic extract for 21 days and hydroperoxides level, FRAP value, PT and aPTT were determined in serum samples. The fibrinolytic activity of different extracts was quantitatively evaluated by measurement of clot weight. Results: In vitro antioxidant assay showed that A. elburzense aqueous extract had the highest DPPH scavenging and the highest total antioxidant capacity. In the in vivo assay, A. elburzense hydroalcoholic extract reduced serum hydroperoxides level and increased serum total antioxidant capacity in rats.In vitro fibrinolytic assay revealed remarkable thrombolytic activity for this plant with the highest effect for the aqueous extract. However, coagulation parameters including PT and aPTT were not affected by administration of A. elburzense hydroalcoholic extract in rats. Conclusion: In conclusion, the results of this study revealed the potential antioxidant and fibrinolytic effects of A. elburzense bulbextracts. For developing novel thrombolytic agents, further investigations for isolation of bioactive constituents and finding the underlying mechanisms are suggested.   UR - https://ajp.mums.ac.ir/article_7882.html L1 - https://ajp.mums.ac.ir/article_7882_2f3addb334315a6f8c04431c9a1df234.pdf ER -