TY - JOUR ID - 7757 TI - Preventive effect of Coriandrum sativum on neuronal damages in pentylentetrazole-induced seizure in rats JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Pourzaki, Mojtaba AU - Homayoun, Mansour AU - Sadeghi, Saeed AU - seghatoleslam, Masoumeh AU - Hosseini, Mahmoud AU - Ebrahimzadeh Bideskan, Alireza AD - Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Microanatomy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Department of Anatomy and Cell Biology, Microanatomy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2017 PY - 2017 VL - 7 IS - 2 SP - 116 EP - 128 KW - Coriandrum sativum KW - Seizure KW - Apoptosis KW - Neuronal damage KW - Hippocampus DO - 10.22038/ajp.2016.7757 N2 - Objective:Coriandrum sativum (C. sativum) as a medicinal plant has been pointed to have analgesic, hypnotic and anti-oxidant effects. In the current study, a possible preventive effect of the hydro-alcoholic extract of the plant on neuronal damages was examined in pentylenetetrazole (PTZ) rat model of seizure.Materials and Methods: Forty male rats were divided into five main groups and treated by (1) saline, (2) PTZ: 100 mg/kg PTZ (i.p) and (3-5) 50, 100 and 200 mg/kg of hydro-alcoholic extract of C. sativum during seven consecutive days before PTZ injection. After electrocorticography (ECoG), the brains were removed to use for histological examination.Results:  All doses of the extract reduced duration, frequency and amplitude of the burst discharges while prolonged the latency of the seizure attacks (p<0.05, p<0.01, and p<0.001). Administration of all 3 doses of the extract significantly prevented from production of dark neurons (p<0.01, and p<0.001) and apoptotic cells (p<0.05, p<0.01, and p<0.001) in different areas of the hippocampus compared to PTZ group.Conclusion: The results of this study allow us to conclude that C. sativum,because of its antioxidant properties, prevents from neuronal damages in PTZ rat model of seizure. UR - https://ajp.mums.ac.ir/article_7757.html L1 - https://ajp.mums.ac.ir/article_7757_06062e445614ed2f7d8ad7a3d39cf88c.pdf ER -