TY - JOUR ID - 6187 TI - Novel delivery system for natural products: Nano-curcumin formulations JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Rahimi, Hamid Reza AU - Nedaeinia, Reza AU - Sepehri Shamloo, Alireza AU - Nikdoust, Shima AU - Kazemi Oskuee, Reza AD - Students Research Committee, Mashhad University of Medical Sciences, Iran AD - Department of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AD - Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Y1 - 2016 PY - 2016 VL - 6 IS - 4 SP - 383 EP - 398 KW - Curcumin KW - Curcumin Nano formulations KW - Nano micelle DO - 10.22038/ajp.2016.6187 N2 - Objective: Curcumin is extracted from Curcuma longa and regulates the intracellular signal pathways which control the growth of cancerous cell, inflammation, invasion and apoptosis. Curcumin molecules have special intrinsic features that can target the intracellular enzymes, genome (DNA) and messengers (RNA). A wide range of studies have been conducted on the physicochemical traits and pharmacological effects of curcumin on different diseases like cardiovascular diseases, diabetes, cancer, rheumatoid arthritis, Alzheimer’s, inflammatory bowel disease (IBD), and even it has wound healing. Oral bioavailability of curcumin is rather poor, which would certainly put some boundaries in the employment of this drug. Materials and Methods: Bibliographical searches were performed using MEDLINE/ScienceDirect/OVID up to February 2015 using the following keywords (all fields): (“Curcumin” OR “Curcuma longa”) AND [(nanoparticles) OR (Nanomicelles) OR (micro emulsions) OR (liposome) OR (phospholipid). Results: Consequently, for any developments of curcumin in the future, analogues of curcumin that have better bioavailability or substitute formulations are needed crucially. Conclusion: These studies indicated that nanotechnology can formulate curcumin effectively, and this nano-formulated curcumin with a potent ability against various cancer cells, were represented to have better efficacy and bioavailability under in vivo conditions. UR - https://ajp.mums.ac.ir/article_6187.html L1 - https://ajp.mums.ac.ir/article_6187_fa00aef51aa9891d1f1325eaef72a8a9.pdf ER -