TY - JOUR ID - 5485 TI - Anti-inflammatory and antinociceptive activities of Solenostemon monostachyus aerial part extract in mice JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Okokon, Jude Fiom AU - Davis, Koofreh AU - Nwidu, Lucky Legbosi AD - Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria AD - Department of Physiology, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria AD - Department of Pharmacology and Toxicology, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State Y1 - 2016 PY - 2016 VL - 6 IS - 3 SP - 284 EP - 294 KW - Solenostemon monostachyus KW - Antiinflammatory KW - Analgesic DO - 10.22038/ajp.2016.5485 N2 - Objective: Solenostemon monostachyus is used in traditional medicine for the treatment of various ailments such as ulcer, hypertension, pains and inflammatory diseases. Evaluation of anti-inflammatory and analgesic activities of S. monostachyus aerial parts was carried out to ascertain its uses in traditional medicine. Materials and Methods: The aerial parts of S. monostachyus was cold extracted by soaking the dried powdered material in ethanol. The aerial parts crude extract (75 –225 mg/kg) of  S. monostachyus was investigated for analgesic and anti-inflammatory activities using various experimental models; acetic acid, formalin and thermal- induced pains models for analgesic study and carrageenin, egg albumin and xylene – induced edema models for anti-inflammatory investigation. Results: The extract caused a significant (pConclusion: The anti-inflammatory and analgesic effects of this plant may in part be mediated through the chemical constituents of the plant and the results of the analgesic action suggest central and peripheral mechanisms. The findings of this work confirm the ethno medical use of this plant to treat inflammatory conditions. UR - https://ajp.mums.ac.ir/article_5485.html L1 - https://ajp.mums.ac.ir/article_5485_e8fc1ac326bc75d4ee2443dc4b3db959.pdf ER -