TY - JOUR ID - 4046 TI - The protective effect of Nigella sativa against cisplatin-induced nephrotoxicity in rats JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Hosseinian, Sara AU - Khajavi rad, Abolfazl AU - Hadjzadeh, Mousa-Al-Reza AU - Mohamadian Roshan, Nema AU - Havakhah, Shahrzad AU - Shafiee, Somayeh AD - Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Neurocognitive Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Departmant of Pathology, Qaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. Y1 - 2016 PY - 2016 VL - 6 IS - 1 SP - 44 EP - 54 KW - Cisplatin KW - Nigella Sativa KW - Vitamin E KW - Renal failure DO - 10.22038/ajp.2016.4046 N2 - Objective: The clinical use of cisplatin is highly restricted, because of its nephrotoxicity.In this study the protective effect of Nigella sativa (N. sativa) against cisplatin-induced nephrotoxicity was investigated in rats. Materials and Methods: In the current study, the effects of the administration of aqueous-ethanolic extract of N. sativa (100 and 200 mg/kg, BW) and vitamin E (100 mg/kg, BW) against blood and urine biochemical alterations and kidney function in rats treated with cisplatin were investigated. Cisplatin was injected at a dose of 6 mg/kg, BW, on the sixth day of the experiment. Results: The results indicated significant changes in serum urea and creatinine concentration, urine glucose concentration, and urine output in cisplatin group compared with control group. Serum urea and creatinine concentration in preventive and preventive+treatment vitamin E and preventive+treatment N. sativa (200 mg/kg, BW) groups and also serum creatinine concentration in preventive+treatment N. sativa (100 mg/kg, BW) group significantly decreased compared with cisplatin group. Urine glucose concentration in preventive and preventive+treatment N. sativa groups and urine output in preventive and preventive+treatment N. sativa (200 mg/kg, BW) groups significantly decreased compared with cisplatin group.Osmolarity excretion rate in preventive and preventive+treatment vitamin E and preventive N. sativa groups was significantly higher than control group. Conclusions: The current study suggests that N. sativa extract and vitamin E in a dose- and time-dependent manner improved the serum and urine biochemical parameters and kidney function in cisplatin-induced nephrotoxicity in rats. However, it needs more investigations to determine the mechanism of N. sativa action on cisplatin-induced kidney toxicity. UR - https://ajp.mums.ac.ir/article_4046.html L1 - https://ajp.mums.ac.ir/article_4046_42345665e53c01afde657052133f46a3.pdf ER -