TY - JOUR ID - 33 TI - Evaluation of the anti–depressant activity of Myristica fragrans (Nutmeg) in male rats JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Moinuddin, Ghulam AU - Devi, Kshama AU - Kumar Khajuria, Deepak AD - Department of Pharmacology, Al-Ameen College of Pharmacy, Near Lalbagh Main Gate, Bangalore-560027. India Y1 - 2012 PY - 2012 VL - 2 IS - 2 SP - 72 EP - 78 KW - Antidepressant activity KW - Imipramine KW - Myristica fragrans DO - 10.22038/ajp.2012.33 N2 - Objective: The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans(MS). Materials and Methods: Male Wistar rats were subjected to imipramine and herbal extract ofMS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST). Results: Administration of MS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to the control group. However, there was no significant potentiation of PST. Conclusion: Our study demonstrated the potential antidepressant activity of MS. UR - https://ajp.mums.ac.ir/article_33.html L1 - https://ajp.mums.ac.ir/article_33_2b1e89476c706346ee7f1fe81c7408ef.pdf ER -