TY - JOUR ID - 1974 TI - Evaluation of anti-urolithiatic effect of aqueous extract of Bryophyllum pinnatum (Lam.) leaves using ethylene glycol-induced renal calculi JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Shukla, Apexa Bhanuprasad AU - Mandavia, Divyesh Rasikbhai AU - Barvaliya, Manish Jasmatbhai AU - Baxi, Seema Natvarlal AU - Tripathi, Chandrabhanu Rajkishore AD - Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001 (Gujarat), IndiaHospital, Bhavnagar-364001 (Gujarat), India AD - Department of Pharmacology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001 (Gujarat), India AD - Department of Pathology, Government Medical College and Sir Takhtsinhji General Hospital, Bhavnagar-364001 (Gujarat), India Y1 - 2014 PY - 2014 VL - 4 IS - 3 SP - 151 EP - 159 KW - Bryophyllum pinnatum (Lam.) KW - Calcium oxalate KW - Ethylene glycol KW - Renal calculi DO - 10.22038/ajp.2014.1974 N2 - Objective: To investigate the anti-urolithiatic effect of aqueous extract of leaves of Bryophyllum pinnatum (B. pinnatum) on ethylene glycol-induced renal calculi. Materials and Methods: Thirty-six Wistar male rats were randomly divided into six equal groups. group A animals received distilled water for 28 days. Group B to group F animals received 1% v/v ethylene glycol in distilled water for 28 days and group B served as ethylene glycol control. Groups C and D (preventive groups) received aqueous extract of leaves of B. pinnatum 50 and 100 mg/kg intraperitoneally, respectively for 28 days. Groups E and F (treatment groups) received aqueous extract of leaves of B. pinnatum 50 and 100 mg/kg intraperitoneally, respectively from 15th to 28th day. On days 0 and 28, 24 hrs urine samples were collected for urinary volume and urinary oxalate measurement. On day 28, blood was collected for serum creatinine and blood urea level monitoring. All animals were sacrificed and kidneys were removed, weighed, and histopathologically evaluated for calcium oxalate crystals deposition. Results: Administration of aqueous extract of leaves of B. pinnatum reduced urine oxalate level significantly, as compared with Group B (p<0.001). Serum creatinine and blood urea level were improved significantly in all aqueous extract of leaves of B. pinnatum-treated groups. Relative kidney weight and calcium oxalate depositions were found significantly reduced in animals received ABP as compared with Group B (p<0.001). Conclusion: B. pinnatum is effective in prevention and treatment of ethylene glycol-induced urolithiasis. UR - https://ajp.mums.ac.ir/article_1974.html L1 - https://ajp.mums.ac.ir/article_1974_03acceb6c5531b7c503e4cef11f1ef58.pdf ER -