TY - JOUR ID - 1914 TI - Effect of hydroalcoholic extract of ginger on the liver of epileptic female rats treated with lamotrigine JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Poorrostami, Ameneh AU - Farokhi, Farah Farokhi AU - Heidari, Reza AD - Department of Biology, Faculty of Science, Urmia University, Urmia, I. R. Iran Y1 - 2014 PY - 2014 VL - 4 IS - 4 SP - 276 EP - 286 KW - Epilepsy KW - Lamotrigine KW - Liver KW - Zingiber officinale KW - Rat DO - 10.22038/ajp.2014.1914 N2 - Objective: Lamotrigine is an antiepileptic drug, widely used in the treatment of epilepsy; long-term use of this drug can cause hepatotoxicity. Zingiber officinale Roscoe (ginger) possesses antioxidant properties. In present research, the effect ofhydroalcoholic extract of ginger (HEG) on the liver of lamotrigine-treated epileptic rats was investigated Material and Methods: Forty-eight female Wistar rats were selected and allocated to 8 groups of 6 each.  Group 1: Negative controls were treated with normal saline. Group 2: Positive controls were treated with lamotrigine (LTG) (10 mg/kg) daily by gavages for 4 consecutive weeks. Epilepsy was induced in treatment groups by i.p. injection of pentylenetetrazol (PTZ) (40 mg/kg). Group 3: Epileptic group received normal saline (10 ml/kg). Group 4: Epileptic group was treated with LTG (10 mg/kg). Groups 5 and 6: Epileptic groups received HEG (50 and 100 mg/kg). Groups 7 and 8: Epileptic groups received LTG and HEG (50 and 100 mg/kg). At the end of 28 days, blood samples were drawn and their livers were processed for light microscopy. Results: The mean values of TG, CHOL, AST, and ALT activity significantly rose (p<0.01) in groups 2, 3, and 4, while in rats treated with HEG (groups 5, 6, 7, and 8), the levels of liver enzymes significantly decreased (p<0.05) compared with epileptic group treated with lamotrigine (group 4). Histopathological changes of liver samples were comparable with respective control. Conclusion: These results suggest that hydroalcoholic extract of ginger improves liver function in lamotrigine-induced hepatotoxicity. UR - https://ajp.mums.ac.ir/article_1914.html L1 - https://ajp.mums.ac.ir/article_1914_c0eff9c5e7119f860b52376331c5ef9e.pdf ER -