TY - JOUR ID - 109 TI - Effect of curcumin, the active constituent of turmeric, on penicillin-induced epileptiform activity in rats JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Tamaddonfard, Esmaeal AU - Erfanparast, Amir AU - Hamzeh-Gooshchi, Nasrin AU - Yousofizadeh, Shahnaz AD - Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia 57153-1177, I.R. Iran Y1 - 2012 PY - 2012 VL - 2 IS - 4 SP - 196 EP - 205 KW - Curcumin KW - Diazepam KW - Penicillin-Induced Seizures KW - Rats DO - 10.22038/ajp.2012.109 N2 - Objective: Curcumin is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. The present study was conducted to investigate the effects of curcumin and diazepam in separate and combined treatments on penicillin-induced seizures in rats. Materials and Methods: In urethane-anesthetized rats, epileptiform activity was induced by intracortical (i.c.) administration of penicillin (200 IU, 1 µl), and frequency and amplitude of spike waves were analyzed using electrocorticographic recordings. Results: Intraperitoneal (i.p.) injections ofcurcumin at doses of 100 and 200 mg/kg, and intracerebroventricular (i.c.v.) injection of diazepam at a dose of 5 µg significantly (p<0.05) reduced both frequency and amplitude of spike waves. Co-administrations of curcumin (50 mg/kg, i.p.) with diazepam (5 µg, i.c.v.) enhanced the antiepileptic effect of diazepam (5 µg, i.c.v.).  Conclusion: The results suggested that both curcumin and diazepam suppressed penicillin-induced epileptiform activity. A potentiation effect was observed between curcumin and diazepam in reducing penicillin-induced seizures.  UR - https://ajp.mums.ac.ir/article_109.html L1 - https://ajp.mums.ac.ir/article_109_557710a0af18c607818d4df91928bf85.pdf ER -