TY - JOUR ID - 104 TI - Neuro-pharmacological effects of Crinum zeylanicum in mice JO - Avicenna Journal of Phytomedicine JA - AJP LA - en SN - 2228-7930 AU - Tijani, Adeniyi Yahaya AU - Salawu, Oluwakanyinsola Adeola AU - Jaiyeoba, Good-luck AU - Akponso Anuka, Joseph AU - Hussaini, Isah Marte AD - Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development Idu industrial Area, Abuja, Nigeria AD - Department of Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria Y1 - 2012 PY - 2012 VL - 2 IS - 3 SP - 162 EP - 168 KW - Crinum Zeylanicum KW - Pentobarbitone KW - Psychosis KW - Sleep KW - Stereotype Behaviour DO - 10.22038/ajp.2012.104 N2 - Objectives: The aim of present study was to evaluate some effects of Crinum zeylanicum (C. zeylanicum) on central nervous system. Materials and Methods: C. zeylanicum methanolic bulb extract (250-1000 mg/kg orally), 2 mg chlorpromazine and 4 mg diazepam /kg body weight intraperitoneally respectively were tested in mice using Irwin test, pentobarbitone-induced sleep test, spontaneous motor activity, apomorphine-induced stereotype behaviour, and rota-rod performance. Results: The C. zeylanicum bulb extract significantly and dose-dependently decreased apomorphine-induced hyperactivity in mice (p<0.001). The Irwin test revealed dose-dependent central depressant effect of the extract, shortened (p<0.05-0.01) the onset of sleep and prolonged the duration of sleep. The extract produced significant (p<0.05-0.001) and dose- dependent reduction in spontaneous motor activity and apomorphine-induced stereotype behaviours in mice. The extract had no effect on performance of mice on rotarod.   Conclusion: The results suggest that the extract may possess sedative principles with potential neuroleptic properties. UR - https://ajp.mums.ac.ir/article_104.html L1 - https://ajp.mums.ac.ir/article_104_8831c98b733c5858c85a34ddd60cb1e7.pdf ER -