Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
4
4
2014
07
01
Omega-3 and omega-6 content of medicinal foods for depressed patients: implications from the Iranian Traditional Medicine
225
230
EN
Mandana
Tavakkoli-Kakhki
Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, I. R. Iran
Malihe
Motavasselian
Department of Traditional Medicine, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, I. R. Iran
m_motevasselian@yahoo.com
Mahmoud
Mosaddegh
0000-0001-7737-1158
Department of Pharmacognosy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, I. R. Iran
mahmoudmosaddegh@yahoo.com
Mohammad Mahdi
Esfahani
Department of Traditional Medicine, Faculty of Traditional Medicine, Tehran University of Medical Sciences, Tehran, I. R. Iran
markazqt@yahoo.com
Mohammad
Kamalinejad
0009-0006-6373-1320
Department of Pharmacognosy, Faculty of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, I. R. Iran
mkamalinejad@yahoo.com
Mohsen
Nematy
0000-0001-9907-5317
Department of Nutrition, School of Medicine, Biochemistry and Nutrition, Endoscopic and Minimally Invasive Surgery and Cancer Research Centers, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
nematym@mums.ac.ir
Saeid
Eslami
School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Medical Informatics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands
eslamis@mums.ac.ir
10.22038/ajp.2014.2163
Objectives: Considering the increasing prevalence of depression in modern societies and the positive effects of omega-3 polyunsaturated fatty acids on depression, this study aims to investigate the omega-3 and omega-6 content of various foodstuffs, prescribed or prohibited by Iranian Traditional Medicine (ITM). <br/>Materials and Methods: Firstly, reliable sources of Iranian Traditional Medicine were reviewed in order to identify the prescribed and prohibited foodstuffs for depressed patients. Afterwards, according to the online database of United States Department of Agriculture (URL: http://ndb.nal.usda.gov/ndb/search/list), the ratio of linoleic acid to alpha linolenic acid (as representatives of omega-6 and omega-3, respectively) was identified in each foodstuff. Finally, the ratios of omega-6 to omega-3 were compared between seven food groups of vegetables, fruits, dry goods, high protein products, dairies, breads, and spices. <br/>Results: Based on the resources of Iranian Traditional Medicine, the following foods are prescribed for depressed patients: basil, coriander, spinach, lettuce, squash, peppermint, dill, chicory, celery, beet, quince, cucumber, watermelon, grape, peach, pomegranate, banana, apple, currant, pistachio, dried fig, almond, egg, chicken, lamb, trout, milk, bread without bran,saffron, oregano, and coriander seeds. On the other hand, cabbage, eggplant, onion, garlic, broad beans, lentils, beef, whole wheat bread, and mustard are prohibited. It should be noted that omega-3 content in some prescribed foods is more than that of the prohibited ones. <br/>Conclusion: The present study showed that mint, basil, spinach, lettuce, squash, lamb, saffron, oregano, cucumber, pistachio, milk, and also wild trout can be considered as medicinal foods for depressed patients.
Depression,Fatty Acids,Functional food,medicine,Omega-3,Traditional
https://ajp.mums.ac.ir/article_2163.html
https://ajp.mums.ac.ir/article_2163_7370ed8fdf84a84b81ca7365ed7d0892.pdf
Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
4
4
2014
07
01
Phenolic and flavonoid content of Elaeagnus angustifolia L. (leaf and flower)
231
238
EN
Fereshte
Saboonchian
Department of Biology, Faculty of Science, Urmia University, Urmia, I. R. Iran
frsaboonchian@yahoo.com
Rashid
Jamei
Department of Biology, Faculty of Science, Urmia University, Urmia, I. R. Iran
r.jamei@urmia.ac.ir
Siavash
Hosseini Sarghein
Department of Biology, Faculty of Science, Urmia University, Urmia, I. R. Iran
10.22038/ajp.2014.1975
Objectives: Leaves and flowers of<em>Elaeagnus angustifolia</em> contain phenolic and flavonoid compounds. These compounds have antioxidant properties that protect cells from oxidative damage. The aim of this study was to determine and analyze total phenolic and flavonoid content of leaves and flowers in two <em>E. angustifolia</em> variants using different solvents (ethanol and methanol). <br/>Materials and Methods: Ethanolic and methanolic extracts of the plant leaves and flowers were prepared. Experiments were carried out to measure their phenolic and flavonoid content using two solvents. Data were analyzed using Instat-N software. <br/>Results:Results showed that the amount of phenolic and flavonoid compounds in both ethanolic and methanolic extracts was higher in Fariman variant compared with Mashhad variant. Ethanolic and methanolic extracts of Fariman variant had the highest amount of phenolic compound (10.91±0.18, 10.28± 0.36 mgGAE/100gFW, respectively) and also the highest amounts of flavonoids (5.80±0.10, 3.36±0.05 mgQE/100gFW, respectively). Phenolic and flavonoids compounds were better extracted using methanol and ethanol solvent. <br/>Conclusion: In both varieties and solvents, the amount of phenolic and flavonoids compounds in leaves were higher than flowers. In addition, the phenolic and flavonoids compounds were higher in Fariman compared to Mashhad variants.
Elaeagnus angustifolia,Flavonoid,Phenolic compounds
https://ajp.mums.ac.ir/article_1975.html
https://ajp.mums.ac.ir/article_1975_1debf2fed2f70544afb017bbead64a62.pdf
Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
4
4
2014
07
01
Cosmetic ethnobotany practiced by tribal women of Kashmir Himalayas
239
250
EN
Hamayun
Shaheen
Department of Botany, University of Azad Jammu & Kashmir Muzaffarabad, Pakistan
hamayunmaldial@yahoo.com
Jaweria
Nazir
Department of Botany, University of Azad Jammu & Kashmir Muzaffarabad, Pakistan
Syeda Sadiqa
Firdous
Department of Botany, University of Azad Jammu & Kashmir Muzaffarabad, Pakistan
Abd-Ur-Rehman
Khalid
Department of Plant Pathology, the University of Poonch Rawalakot, Azad Jammu & Kashmir, Pakistan
10.22038/ajp.2014.2680
<br/>Objective: Himalayan mountain populations have been dependent upon indigenous plant resources for their health care for many years. Tribal women are interested in use of local herbs for cosmetic purposes. The present work is based on the results of research conducted on cosmetic uses of some important plants by the tribal women in District Poonch, Azad Kashmir Pakistan. <br/>Materials and Methods: An ethno botanical survey was carried out during summer 2012. The data were collected from 310 female informants from 16 villages using questionnaire method and semi structured interviews. <br/>Results: A total of 39 plants species belonging to 20 families, being used for various cosmetic purposes were recorded. Indigenous species are traditionally used by the locals for problems including acne (16%), hair growth (11%), bad breath (12%), facial spots (9%), allergy, (9%), fairness (8%), wrinkles (8%), eye and lip care (9%). Seventy different recipes were recorded to be practiced by locals using herbal parts. The major plant parts utilized in herbal recipes included fruit (32.8%), Leaves (25.2%), seeds (13.4%) and roots (8.9%). Women of older (>30 years) age group showed greater (67%) response regarding knowledge and practice of cosmetic herbs. <br/>Conclusion: This study was the 1<sup>st</sup> ever project focusing on cosmetic perspectives of ethno-botany in the area. Our study contributes to an improved understanding of ignored aspect of cosmetic ethnobotany among the local women. Further detailed investigations are recommended to record and preserve precious ethno-botanical knowledge of the area.
Cosmetic herbs,Himalayas,Skin treatment,Tribal women
https://ajp.mums.ac.ir/article_2680.html
https://ajp.mums.ac.ir/article_2680_3a954a6d4297c28f9882c09fc1afee2a.pdf
Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
4
4
2014
07
01
The role for nitric oxide on the effects of hydroalcoholic extract of Achillea wilhelmsii on seizure
251
259
EN
Mahmoud
Hosseini
0000-0001-6425-5123
Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, I. R. Iran
hosseinim@mums.ac.ir
Fatemeh
Harandizadeh
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences Mashhad, I. R. Iran
f.harandizadeh@yahoo.com
Saeed
Niazmand
0000-0001-6595-8170
Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, I. R. Iran
niazmands@mums.ac.ir
Mohammad
Soukhtanloo
0000-0003-2145-125X
Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, I. R. Iran
soukhtanloom@mums.ac.ir
Azadeh
Faizpour
Neurogenic Inflammation Research Center, School of Medicine, Mashhad University of Medical Sciences, I. R. Iran
feizpoura891@mums.ac.ir
Marzieh
Ghasemabady
Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, I. R. Iran
ghasemabadym@yahoo.com
10.22038/ajp.2014.2217
Objective: Nitric oxide (NO) plays an important role both as a consequence and as a cause of epileptic seizures.Regarding the central nervous system depressant effects of <em>Achillea wilhelmsii</em> <em>(A. wilhelmsii)</em>, as well the effects of the plant on NO, this study was aimed to elucidatethe possible role for nitric oxide on the effects of hydroalcoholic extract of <em>A. wilhelmsii</em> on pentylenetetrazole (PTZ)-induced seizures. <br/>Materials and Methods: Fifty-six male Wistar rats were divided into 7 groups (n=8 in each group) and treated with (1) normal saline, (2) normal saline before pentylenetetrazole (PTZ, 90 mg/kg), (3-7) <em>A. wilhelmsii</em> extract (100, 200, 400, 800, and 1200 mg/kg) before PTZ. Latency to first minimal colonic seizure (MCS) and the first generalized tonic-clonic seizures (GTCS) as well as the mortality rate were recorded. The brain tissues were then removed for biochemical measurements. Fisher’s exact probability test as well as analysis of variance (ANOVA), followed by Tukey’s test were used for statistical evaluation. <br/>Results: Treatment with 100- 1200 mg/kg of the extract did not affect MCS latencies. 400 mg/kg of the extract prolonged GTCS latency (p<0.001), however, the lower and higher doses were not effective. Nitric oxide metabolites concentrations in the hippocampal tissues of the animals treated with 100, 200, and 400 mg/kg of the extract were increased compared with saline (pConclusion: The present study showed that hydroalcoholic extract of <em>A. wilhelmsii</em> affects NO metabolites in brain tissues as well the severity of seizures in PTZ-induced seizure model.
Achillea wilhelmsii,Hippocampus,Nitric oxide,Pentylenetetrazole,Rat,Seizures
https://ajp.mums.ac.ir/article_2217.html
https://ajp.mums.ac.ir/article_2217_c3a2abc065a77847c6ffba3c486a2fe8.pdf
Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
4
4
2014
07
01
Identification, determination, and study of antioxidative activities of hesperetin and gallic acid in hydro-alcoholic extract from flowers of Eriobotrya japonica (Lindl.)
260
266
EN
Amir Hossein
Esmaeili
Department of Laboratory Science, Babol-Branch, Islamic Azad University, Babol, I. R. Iran
amir5762002@yahoo.com
Akbar
Hajizadeh Moghaddam
Faculty of Basic Science, University of Mazandaran, Babolsar, I. R. Iran
a.hajizadeh@umz.ac.ir
Mohammad
Chaichi
Faculty of Chemistry, University of Mazandaran, Babolsar, I. R. Iran
jchaichi@yahoo.com
10.22038/ajp.2014.2332
Objectives: <em>Eriobotrya japonica</em> belongs to the Rosaceae. Studies have shown that the flowers of this plant are rich in phenolic and flavonoid compounds. Accorrdingly, the evaluation of antioxidative effects of <em>Eriobotrya japonica </em>Flower Extract (EJFE) have been performed <em>in vitro</em>. <br/>Material and Methods: In this study, to investigate the influences of components of EJFE on its antioxidative activity, extract was prepared using hydro-alcoholic (25:75 V/V) solvent and the antioxidative activity of the extract was evaluated based on the scavenging of various radicals (DPPH and H<sub>2</sub>O<sub>2</sub>) by spectrophotometric method and chelating of ferrous ions by ferrozine reagent. <br/>Results: HPLC analysis of the <em>Eriobotrya</em> <em>japonica </em>Flower Extract (EJFE) revealed hesperetin and gallic acid as the major antioxidants. When the content of total flavonoid and polyphenolic compounds in the flower extract of this plant was examined, a significantly higher level of total polyphenols was found in <em>Eriobotrya japonica </em>flower extract. <br/>Conclusion: Results demonstrate that the high ability to scavenge free radicals, reducing power, and Fe<sup>+2</sup>chelating activity exerted by the EJFE were due to the high content of hesperetin and gallic acid in the flowers.
Antioxidant,Eriobotrya japonica Lindl,Flavonoids,Free radicals,Phenolic compounds
https://ajp.mums.ac.ir/article_2332.html
https://ajp.mums.ac.ir/article_2332_e95b3569f560f3add77897b32a919911.pdf
Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
4
4
2014
07
01
Moderate dose of watercress and red radish does not reduce oxygen consumption during graded exhaustive exercise
267
275
EN
Abbas
Meamarbashi
Department of Physical Education and Sports Sciences, University of Mohaghegh Ardabili, Ardabil, I. R. Iran
a_meamarbashi@yahoo.com
Meysam
Alipour
Department of Physical Education and Sports Sciences, University of Mohaghegh Ardabili, Ardabil, I. R. Iran
pooyacaliper@yahoo.com
10.22038/ajp.2014.2874
Objective: Very recent studies have reported positive effects of dietary nitrate on the oxygen consumption during exercise. This research aimed to study the effect of moderate dose of high-nitrate vegetables, watercress (<em>Nasturtium officinale</em>) and red radish (<em>Raphanus sativus</em>) compared with a control group on the incremental treadmill exercise test following a standard Bruce protocol controlled by computer. <br/>Materials and Methods: Group 1 consumed 100 g watercress (n=11, 109.5 mg nitrate/day), and group 2 consumed 100 g red radish (n=11, mg 173.2 mg nitrate/day) for seven days, and control group (n=14) was prohibited from high nitrate intake. <br/>Results: During exercise, watercress group showed significant changes in the maximum values of Respiratory Exchange Ratio (RER) (p<0.05), End-Tidal O<sub>2</sub> Fraction (FETO<sub>2</sub>) (p<0.05), and energy consumption from carbohydrate (p<0.01). Red radish group had a significant increase in the VCO<sub>2</sub> (p<0.01), RER (p<0.01), VT (p<0.05), VCO<sub>2</sub>/kg (p<0.05), and energy consumption from carbohydrates (p<0.01). When all groups in the same workload were normalized by the subject’s body mass, watercress had a significant increase in the total expired CO<sub>2 </sub>(p<0.05), RER (p<0.05), FETO<sub>2</sub> (p<0.05), and energy consumption from carbohydrates (p<0.05) compared with the control group. Similar comparison between red radish and control group revealed a significant increase during pre-test in the total CO<sub>2</sub> production (p<0.05), VCO<sub>2</sub> (p<0.05), RER (p<0.01), VT (p<0.05), and VCO<sub>2</sub>/kg (p<0.05). <br/>Conclusion: Current results indicate higher carbon dioxide production in the experimental groups in the same workload. This might have a negative impact on the exercise performance. Further investigations with controlled exercise program will be necessary.
Exercise,Nitrate,Red radish,Watercress
https://ajp.mums.ac.ir/article_2874.html
https://ajp.mums.ac.ir/article_2874_fea4a331ed28cf542baf3dc5ea762a7a.pdf
Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
4
4
2014
07
01
Effect of hydroalcoholic extract of ginger on the liver of epileptic female rats treated with lamotrigine
276
286
EN
Ameneh
Poorrostami
Department of Biology, Faculty of Science, Urmia University, Urmia, I. R. Iran
a.poorrostam@yahoo.com
Farah Farokhi
Farokhi
Department of Biology, Faculty of Science, Urmia University, Urmia, I. R. Iran
Reza
Heidari
Department of Biology, Faculty of Science, Urmia University, Urmia, I. R. Iran
10.22038/ajp.2014.1914
Objective: Lamotrigine is an antiepileptic drug, widely used in the treatment of epilepsy; long-term use of this drug can cause hepatotoxicity. <em>Zingiber officinale</em> Roscoe <em>(ginger</em>) possesses antioxidant properties. In present research, the effect ofhydroalcoholic extract of <em>ginger</em> (HEG) on the liver of lamotrigine-treated epileptic rats was investigated <br/>Material and Methods: Forty-eight female Wistar rats were selected and allocated to 8 groups of 6 each. Group 1: Negative controls were treated with normal saline. Group 2: Positive controls were treated with lamotrigine (LTG) (10 mg/kg) daily by gavages for 4 consecutive weeks. Epilepsy was induced in treatment groups by i.p. injection of pentylenetetrazol (PTZ) (40 mg/kg). Group 3: Epileptic group received normal saline (10 ml/kg). Group 4: Epileptic group was treated with LTG (10 mg/kg). Groups 5 and 6: Epileptic groups received HEG (50 and 100 mg/kg). Groups 7 and 8: Epileptic groups received LTG and HEG (50 and 100 mg/kg). At the end of 28 days, blood samples were drawn and their livers were processed for light microscopy. <br/>Results: The mean values of TG, CHOL, AST, and ALT activity significantly rose (p<0.01) in groups 2, 3, and 4, while in rats treated with HEG (groups 5, 6, 7, and 8), the levels of liver enzymes significantly decreased (p<0.05) compared with epileptic group treated with lamotrigine (group 4). Histopathological changes of liver samples were comparable with respective control. <br/>Conclusion: These results suggest that hydroalcoholic extract of <em>ginger</em> improves liver function in lamotrigine-induced hepatotoxicity.
Epilepsy,Lamotrigine,Liver,Zingiber officinale,Rat
https://ajp.mums.ac.ir/article_1914.html
https://ajp.mums.ac.ir/article_1914_c0eff9c5e7119f860b52376331c5ef9e.pdf
Mashhad University of Medical Sciences
Avicenna Journal of Phytomedicine
2228-7930
2228-7949
4
4
2014
07
01
Evaluation of analgesic, anti-inflammatory and CNS depressant activities of methanolic extract of Lawsonia inermis barks in mice
287
296
EN
Luthfun
Nesa
Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh
luthfunnesa_ph@yahoo.com
Shirajum
Munira
Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh
Shabnam
Mollika
Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh
Md. Monirul
Islam
Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh
Habibullah
choin
Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh
Aktar
Uzzaman Chouduri
Department of Pharmacy, University of Rajshahi, Bangladesh
Nazmun
Naher
Radiant Pharmaceutical Ltd, Tongi, Bangladesh
10.22038/ajp.2014.2347
Objectives: The study was carried out to assess the analgesic, anti-inflammatory, and CNS depressant activity of the methanolic extract of the <em>Lawsonia inermis </em>barks(MELIB). <br/>Materials and Methods: Anti-inflammatory effects of MEBLI were studied using carrageenan-induced inflammatory method at the dose of 300 and 500 mg/kg b.wt., p.o. Analgesic activity was measured using acetic acid-induced writhing model and formalin-induced licking and biting in mice. The CNS depressant activity was evaluated by observing the reduction of locomotor and exploratory activities in the open field and hole cross tests at a dose of 300 and 500 mg/kg body weight. <br/>Results: Statistical analysis showed that dose of 500 mg/kg exhibited higher analgesic activity against acetic acid-induced pain in mice than the standard drug diclofenac sodium. Furthermore, doses of 300 and 500 mg/kg caused higher percent of protection (91.16% and 95.03%, respectively) of licking and biting of formalin-induced mice than diclophenac sodium (70.72%). The Lawsonia inemis methanolic extract (300 and 500 mg/kg) alsoexhibited sustained inhibition (54.97% and 65.56%) of paw edema at the 4<sup>th</sup> hour compared with standard indomethacin (74.17%). Besides, the plant extract also had significant (p<0.05) dose-dependent CNS depressant activity. <br/>Conclusion: this study recommends that the methanolic extract of <em>Lawsonia inermis </em>barks has significant analgesic, anti-inflammatory, and CNS depressant properties.
Analgesic,Anti-inflammatory,Carrageenan,CNS depressant,Formalin induced pain Methanolic,extract of Lawsonia inermis barks,Writhing
https://ajp.mums.ac.ir/article_2347.html
https://ajp.mums.ac.ir/article_2347_a033f38b6bd2e1a3c89c725079726a43.pdf