ORIGINAL_ARTICLE
Antioxidant activity and total phenolic content of Boerhavia elegans (choisy) grown in Baluchestan, Iran
Objective: Boerhaavia elegans L. (Nyctaginaceae) is a medicinal plant used for the treatment of kidney disorders, urinary tract disorders and blood purification in Baluch tribe. The aim of present study is to evaluate the antioxidant propertyof B. elegans species for the first time. Materials and Methods: Different parts (leaf, stem and fruit) of the plant were extracted by using various solvents (water, methanol, chloroform and ethyl acetate) and evaluated for their antioxidant activity using DPPH (2, 2-diphenyl-1 picryl hydrazyl) and FRAP (ferric reducing antioxidant power) methods. In addition, total phenolic content was determined by Folin–Ciocalteu reagent. Results: Antioxidant results were expressed as IC50. The antioxidant power in DPPH and FRAP assay were evaluated as shown in decreasing order: Methanolic extract > Aqueous extract > Ethyl acetate extract > Chloroform extract, for all parts of the plant. In both methods of antioxidant assay and Folin-Ciocalteu method, methanolic extract of leaf exhibited the highest activity and the most phenolic content IC50= 6.85ppm and 16.41 mg GA/g d w respectively. Total phenolic content had a positive relationship with antioxidant capacity in extracts and there was a high correlation (r=1.00, p<0.01) between antioxidant activities as determined by both antioxidant assays for various parts. Conclusion: The results of the experiments showed that B. elegans extract had significant antioxidant effects. This high antioxidant activity may be linked to phenolic contents of the plant but complementary investigations are suggested in order to determine active elements.
https://ajp.mums.ac.ir/article_3415_e95031305e0dea8a724fa6ac9a245f81.pdf
2015-01-01
1
9
10.22038/ajp.2014.3415
Boerrhavia elegans
Antioxidants
DPPH
FRAP
Total phenolic content
Zahra
Sadeghi
z.sad224@gmail.com
1
Department of Production and Utilization of Medicinal Plants, Faculty of Agricultural and Natural Resources, Higher Educational Complex of Saravan, Saravan, I. R. Iran
LEAD_AUTHOR
Jafar
Valizadeh
walisade@hamoon.usb.ac.ir
2
Department of Biology, University of Sistan & Baluchestan, Zahedan, I. R. Iran
AUTHOR
Omid
Azyzian Shermeh
omid_azizyan@yahoo.com
3
Department of Biology, University of Sistan & Baluchestan, Zahedan, I. R. Iran
AUTHOR
Maryam
Akaberi
akaberim911@mums.ac.ir
4
Biotechnology Research Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I. R. Iran
AUTHOR
Aksoy L, Kolay E, Agılonu Y, Aslan Z, Kargıoglu M. 2013. Free radical scavenging activity, total phenolic content, total antioxidant status, and total oxidant status of endemic Thermopsis. Turcica, 20: 235–239.
1
Bhatt P, Negi PS. 2012. Antioxidant and antibacterial activities in the leaf extracts of Indian Borage (Plectranthusamboinicus).Food Nutr Sci, 3: 146-152.
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3
Chen SH, Wu MJ. 2007. A taxonomical study of the genus Boerhavia (Nyctaginaceae) in Taiwan. Taiwania, 52: 332-342
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Clarke G, Ting KN, Wiart Ch, Fry J. 2013. High correlation of 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, ferric reducing activity potential and total phenolics content indicates redundancy in use of all three assays to screen for antioxidant activity of extracts of plants from the malaysian rainforest. Antioxidants, 2: 1-10.
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Ebrahimzadeh MA, Pourmorad F, Hafezi S. 2008. Antioxidant activities of Iranian corn silk. Turk J Biol, 32:43-49.
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Huang WY, Cai YZ, Zhang Y.2009. Natural phenolic compounds from medicinal herbs and dietary plants: Potential use for cancer prevention. Nutr Cancer, 62: 1-20.
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Jayavelu A, Natarajan A, Sundaresan S, Devi K, Senthilkumar B. 2013. Hepatoprotective activity of Boerhavia Diffusa L. (Nyctaginaceae) against Ibuprofen Induced Hepatotoxicity in Wistar Albino Rats. Int J Pharm Res Rev, 2: 1-8.
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Khoddami A, Wilkes MA, Roberts TH. 2013. Techniques for analysis of plant phenolic compounds. Molecules, 18: 2328-2375
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Najam A, Singh AK, Verma HN. 2008. Ancient and modern medicinal potential of Boerhaavia diffusa and Clerodendrum aculeatum. Res Environ Life Sci, 1: 1-4.
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Parsa, A. 1980. Flora of Iran, vol. 4, pp. 1175, Tehran, Tehran university press.
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Ramazani A, Zakeri S, Sardari S, Khodakarim N, Dinparas Djadidt N. 2010. In vitro and in vivo anti-malarial activity of Boerhavia elegans and Solanum surattense. Malaria J, 9:124.
22
Sadeghi Z, Kuhestani K, Abdollahi V, Mahmood A. 2014. Ethnopharmacological studies of indigenous medicinal plants of Saravan region, Baluchistan, Iran. J Ethnopharmacol, 153: 111–118.
23
Sadeghi Z, Kuhestani K, Abdollahi V. Indigenous knowledge of medicinal plants: An approach to sustainable development of Baluchistan region, 10 March. 2013, 1th national conference on solutions to access sustainable development in agriculture, natural resources and the environment. Tehran. Iran.
24
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25
Sonboli A, Mojarrad M, Nejad Ebrahimi S, Enayat S. 2010. Free radical scavenging activity and total phenolic content of methanolic extracts from male inflorescence of Salix aegyptiacagrown in Iran. Iranian J Pharmaceut Res, 9: 293-296.
26
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31
ORIGINAL_ARTICLE
Neuroprotective, antimicrobial, antioxidant, chemotherapeutic, and antidiabetic properties of Salvia Reuterana: A mini review
Objectives: Herbal medicine is known as a valid alternative treatment. Salvia Reuterana, which has been used in the Iranian traditional medicine, is mostly distributed in the central highlands of Iran. Salvia Reuterana is a medicinal herb with various therapeutic usages. The aim of the present review is to take account of pharmacological properties of Salvia Reuterana. Materials and Methods: The present review summarizes the literature with respect to various pharmacological properties of Salvia Reuterana. Results: Salvia Reuterana possesses neurological, antimicrobial, antioxidant, chemotherapeutic, and antidiabetic properties. Conclusions: Salvia Reuterana can be used as an alternative for treatment of several disorders.
https://ajp.mums.ac.ir/article_3695_16c073c4ceea17a2a0710c578f30c240.pdf
2015-01-01
10
16
10.22038/ajp.2014.3695
Salvia Reuterana
Neurological property
Antimicrobial property
Antioxidant property
Chemotherapeutic property
Antidiabetic property
Elham
Jafari
jafarie@gmail.com
1
Isfahann Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, I. R. Iran
AUTHOR
Sasan
Andalib
andalibsa@tbzmed.ac.ir
2
Neurosciences Research Center, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, I. R. Iran
LEAD_AUTHOR
Alireza
Abed
abed@gmail.com
3
Isfahann Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical Science, Isfahan University of Medical Sciences, Isfahan, I. R. Iran
AUTHOR
Mahmoud
Rafieian-Kopaei
rafieiamm@yahoo.com
4
Medicinal Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, I. R. Iran
AUTHOR
Golnaz
Vaseghi
golnazvaseghi@yahoo.com
5
Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, I. R. Iran
AUTHOR
Amirghofran Z, Zand F, Javidnia K, & Miri R. 2010. The Cytotoxic Activity of Various Herbals against Different Tumor Cells: An in Vitro Study. Ir Red Cres Med J, 12(3): 260-265.
1
Amiri H. 2007. Quantative and qualative changes of essential oil of Salvia bracteata Bank et Sol. in different growth stages. DARU J Pharm Sci, 15(2): 79-82.
2
Andalib S, Naeini A M, Vaseghi A, & Vaseghi G. 2011. Sedative and hypnotic effects of Iranian traditional medicinal herbs used for treatment of insomnia. EXCLI, 10: 192-197.
3
Batooli H, Safaei-Ghomi J, Haghir-Ebrahim-Abadi A, & Masoomi R. 2013. Evaluating the chemical composition of the essential oil obtained from the vegetative and reproductive organs and an antimicrobial activity of essential oil and extract of two Salvia species in Kashan region. Feyz J Kashan Uni Med Sci, 16(6): 536-545.
4
Eidi A, Eidi M, Mozaffarian V, & Rustaiyan A. 2012. Effect of Salvia Reuterana aerial parts on serum parameters in normal and streptozotocin-induced diabetic rats. Health Med: 1199.
5
Esmaeili M A, Kanani M R, & Sonboli A. 2010. Salvia Reuterana extract prevents formation of advanced glycation end products: an in vitro study. Iran J Pharm Sci, 6(1): 33-50.
6
Ghomi J S, Masoomi R, Kashi F J, & Batooli H. 2012. In vitro bioactivity of essential oils and methanol extracts of Salvia Reuterana from Iran. Nat Prod Com, 7(5): 651-654.
7
Gilhotra N, & Dhingra D. 2008. A review on antianxiety plants. Nat Prod Rad, 7( 5): 476-483.
8
Javidnia K, Miri R, Assadollahi M, Gholami M, & Ghaderi M. 2009. Screening of Selected Plants Growing in Iran for Antimicrobial Activity. Ir J Sci Tech, 33(A4): 229-333.
9
Kalia B, Kainth A, Kalia A, Kumar S, & Bhanot A. 2012. A Comprehensive Study on Anxiety: A Review. Int J Pharm Chem Sci, 1(4): 1298-1310.
10
Kamal M, & Jawaid T. 2011. Herbal Drugs in mirror of Anxiety Disorder-A Review. Int J Biomed Res, 2(1): 62-72.
11
Karamian R, Asadbegy M, & Pakzad R. 2013. Essential oil compositions and in vitro antioxidant and antibacterial activities of the methanol extracts of two Salvia species (Lamiaceae) from Iran. Intl J Agri Crop Sci, 5(11): 1171-1182.
12
Masoud S, Alijanpoo B, & Khayyami M. 2011. Contribution to cytology of genus Salvia L.(Lamiaceae) in Iran. Caryologia, 64(4): 405.
13
Mirza M, & Sefidkon F. 1999. Essential oil composition of two Salvia species from Iran, Salvia nemorosa L. and Salvia Reuterana Boiss. Flav and Frag J, 14(4): 230-232.
14
Nadaf M, Nasrabadi M, & Halimi M. 2012. GC-MS Analysis of n-Hexane Extract from Aerial Parts of Salvia nemorosa. Middle-East J Sci Res, 11(8): 1127-1130.
15
Naser Moadeli N, Rowshan S, & A A. 2013. Comparison of the essential oil components in wild and cultivate population of Salvia virgata. J Appl Bas Sci, 4(2): 237-340.
16
Nickavar B. 2012. Free radical scavenging activities of four Salvia species. Res Pharm Sci, 7(5): S795.
17
Nickavar B, Abolhasani L, & Izadpanah H. 2010. α-Amylase Inhibitory Activities of Six Salvia Species. Iranian Journal of Pharmaceutical Research: 297-303.
18
Nickavar B, Kamalinejad M, & Izadpanah H. 2007. In vitro free radical scavenging activity of five Salvia species. Pak J Pharm Sci, 20(4): 291-294.
19
Perry N S, Bollen C, Perry E K, & Ballard C. 2003. Salvia for dementia therapy: review of pharmacological activity and pilot tolerability clinical trial. Pharm Bioch Behav, 75(3): 651-659.
20
Rabbani M, Sajjadi S, Jafarian A, & Vaseghi G. 2005. Anxiolytic effects of Salvia Reuterana Boiss. on the elevated plus-maze model of anxiety in mice. J Ethenopharm, 101(1): 100-103.
21
Rabbani M, Vaseghi G, Sajjadi S, & Amin B. 2011. Persian herbal medicines with anxiolytic properties. J Med Plants, 10(39): 7-11.
22
Sajjadi S E, & Shahpiri Z. 2004. Chemical composition of the essential oil of Salvia limbata CA Mey. DARU J Pharm Sci, 12(3): 94-97.
23
Salimpour F, Mazooji A, & Darzikolaei S A. 2011. Chemotaxonomy of six Salvia species using essential oil composition markers. J Med Plants Res, 5: 1795-1805.
24
Sonboli A, Babakhani B, & Mehrabian A R. 2006. Antimicrobial activity of six constituents of essential oil from Salvia. Zeitschrift fur Naturforschung C-J Biosci, 61(3-4): 160-164.
25
Vaseghi G, Andalib S, Rabani M, Sajjadi S, & Jafarian A. 2013. Hypnotic Effect of Salvia Reuterana Boiss for Treatment of Insomnia. J Med Plants, 12(45): 7-13.
26
Verma H, Verma N, Singh A, Singh M, & Singh A. 2010. Anxiolytic potential of volatile oil obtained from Ocimum Gratissimum. Deccan J Pharm, 1(2): 34-39.
27
ORIGINAL_ARTICLE
Renal Effects of Anchomanes difformis Crude Extract in Wistar Rats
Objective: Anchomanes difformis is a member of the plant family Araceae which is used as a diuretic but also has other medicinal applications. This study investigates the dietary effects of A. difformis on the kidneys of adult wistar rats. Materials and Methods: Sixteen rats were used and were weighed, before and after the experiment. All rats were randomly divided into four groups. All groups were treated with the following regimen for two weeks. The control group (A) was fed on feed mash and water ad libitum throughout the period. The treatment groups B, C, and D received feed mash mixed with crude extract of A. difformis in the following proportions: 25:75(g), 50:50(g), and 75:25(g), respectively. The kidneys of the experimental animals were histologically examined for morphologic changes. Results: Results showed a significant difference (p<0.05) in the kidney weight of the treatment groups compared with the control. Histological examination of the renal tissues also showed considerable lesions such as inflammation, focal cortical and interstitial hemorrhage, and fibrosis in the treated rats compared with the control. Conclusion: The current study results suggest renal toxicity with excessive consumption of A.difformis.
https://ajp.mums.ac.ir/article_3433_c2cfb561e591b8935e53a5eb3959b505.pdf
2015-01-01
17
25
10.22038/ajp.2014.3433
Anchomanes difformis
Crude extract
Kidney FRAP
Wistar rats
Jacob
Ataman E
atamanje@yahoo.com
1
Department of Anatomy, University of Benin, PMB 1154, Benin City, Nigeria
AUTHOR
MacDonald
Idu
mcdonald.idu@gmail.com
2
Department of Plant Biology and Biotechnology, University of Benin, Benin City, Nigeria
LEAD_AUTHOR
Gilani AH, Rahman AU. 2005. Trends in Ethnopharmacology. J. Ethnopharmacol, 100:43-49
1
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Dalziel JM.1937. The Useful Plants of West Tropical Africa, pp 18-22, Crown Agents for the Colonies, London.
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21
ORIGINAL_ARTICLE
Effect of five year storage on total phenolic content and antioxidant capacity of almond (Amygdalus communisL.) hull and shell from different genotypes
Objectives: Almond (Prunus amygdalus) hull and shell are agricultural by-products that are a source of phenolic compounds.The processing of almond produce shell and hull, accounts for more than 50% by dry weight of the almond fruits. Recently, more studies have focused on the influence of storage conditions and postharvest handling on the nutritional quality of fruits, especially the antioxidant phenolics. In this study, influence of long-term storage (five years) on the total phenolic and antioxidant capacity of almond hull and shell from different genotypes was evaluated. Materials and Methods: The fruits of subjected genotypes were collected and their hull and shell were separated. They were dried and reduced to fine powder. This powder stored at room temperature for five years. The total phenolic content (TPC) and bioactivities (antioxidant potential: DPPH and ABTS radical scavenging and reducing power) of extracts were evaluated using spectrophotometric methods. Results: It was found that TPC content and bioactivity levels in the stored almond hull and shell were different, compared to the hulls and shells which were evaluated in 2007. S1-4 genotype had the highest TPC and reducing power in its hull and shell.Low correlation coefficient was observed between phenolic content and the DPPH radical scavenging percentage in hull and shell extract. Conclusions: For the first time, results of this investigation showed that storage can influence the antioxidant and antiradical potential of almond hull and shell.
https://ajp.mums.ac.ir/article_3512_5c4fadf735edcb15d0c83458b408641c.pdf
2015-01-01
26
33
10.22038/ajp.2014.3512
Almond
Hull
Shell
Genotype
Radical scavenging
Storage
Khadijeh Sadat
Moosavi Dolatabadi
1
Department of Biology, Faculty of Science, Urmia University, Urmia, Iran, I. R. Iran
AUTHOR
Gholamreza
Dehghan
dehghan2001d@yahoo.com
2
Department of Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran, I. R. Iran
AUTHOR
Siavash
Hosseini
gdehghan@tabrizu.ac.ir
3
Department of Biology, Faculty of Science, Urmia University, Urmia, Iran, I. R. Iran
AUTHOR
Ali
Jahanban Esfahlan
ali.jahanban@gmail.com
4
Biotechnology Research Centre, Tabriz University of Medical Sciences, Tabriz 51664-14766, Iran
AUTHOR
Awad MA, de Jager A. 2003. Influences of air and controlled atmosphere storage on the concentration of potentially healthful phenolics in apples and other fruits. Postharvest Biol Tec, 27: 53–58.
1
Barreira JCM, Ferreira ICFR, Oliveira MBPP, Pereira JA. 2008. Antioxidant activity and bioactive compounds of ten Portuguese regional and commercial almond cultivars. Food ChemToxicol, 46: 2230–2235.
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Jahanban AS, Mahmoodzadeh A, Hasanzadeh A, Heidari R,Jamei R. 2009. Antioxidants and antiradicals in almond hull and shell (Amygdaluscommunis L.) as a function of genotype. Food Chem, 115: 529–533.
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Pellegrini N, Serafini M, Salvatore S, Del Rio D, Bianchi M, Brighenti F, 2006. Total antioxidant capacity of spices, dried fruits, nuts, pulses, cereals and sweets consumed in Italy assessed by three different in vitro assays. MolNutr Food Res. 50: 1030–1038.
26
Pennycooke JC, Cox S,Stushnoff JC. 2005. Relationship of cold acclimation, total phenolic content and antioxidant capacity with chilling tolerance in petunia (Petunia hybrida). Environ Exp Bot, 53: 225–232.
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32
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33
ORIGINAL_ARTICLE
Efficacy of Cuminum cyminum essential oil on FUM1 gene expression of fumonisin-producing Fusarium verticillioides strains
Objectives: The purpose of this study was to evaluate the effect of Cuminum cyminum (C. cyminum) essential oil on the growth and FUM1 gene expression of fumonisin-producing Fusarium verticillioides (F. verticillioides) strains isolated from maize. Materials and Methods: All fungal strains were cultured on potato dextrose agar (PDA) slopes at 30°C for 7 days. The antifungal activity was evaluated by broth microdilution assay. One set of primers was F. verticillioides species specific, which selectively amplified the intergenic space region of rDNA. The other set of primers was specific to FUM1 gene region of fumonisin-producing F. verticillioides. FUM1 transcript levels were quantified using a reverse transcription-polymerase chain reaction (RT-PCR) protocol. Results: Minimum inhibitory concentration (MIC) values of C. cyminum oil against F. verticillioides strains varied from 0.195 to 0.781 µl.ml-1 (mean MIC value: 0.461 µl.ml-1) indicating 54.5% of the fungal strains inhibited at 0.390 µl.ml-1. PCR analysis of FUM1 gene expression revealed that DNA fragment of 183 bp was amplified in all the isolates of F. verticillioides before treatment with C. cyminum essential oil. Based on RT-PCR analyses, reduction in the expression of fumonisin biosynthetic genes was significant only for FUM1 gene (p<0.05), while no effect was observed on ITS gene. Conclusions: This study showed that all F. verticillioides isolates were susceptible to C. cyminum essential oil, indicating a significant reduction in the growth of fungal isolates. In addition, this oil completely inhibited the expression of FUM1 gene in concentrations dose-dependently.
https://ajp.mums.ac.ir/article_3434_9a063163bd476bed4f8db5c5ff79adb5.pdf
2015-01-01
34
42
10.22038/ajp.2014.3434
Fusarium verticillioides
Fumonisin
Cuminum cyminum
RT-PCR
FUM1 gene
Ali Reza
Khosravi
khosravi@ut.ac.ir
1
Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, I. R. Iran
LEAD_AUTHOR
Hojjatollah
shokri
hshokri@ut.ac.ir
2
Faculty of Veterinary Medicine, Amol University of Special Modern Technologies, Amol, I. R. Iran
AUTHOR
Ali Reza
Mokhtari
amokhtari@yahoo.com
3
Mycology Research Center, Faculty of Veterinary Medicine, University of Tehran, Tehran, I. R. Iran
AUTHOR
Abd-Elsalam KA, Aly NI, Abdel-Satar AM, Khalil SM, Verreet AJ. 2013. PCR identification of Fusarium genus based on nuclear ribosomal-DNA sequence data. African J Biotech, 2: 82-85.
1
Bluhm BM, Cousin MA, Woloshuk CP. 2004. Multiplex real-time PCR detection of fumonisin-producing and trichotheceneproducing groups of Fusarium species. J Food Prot, 3: 536-543.
2
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3
Desjardins AE, Munkvold GP, PlattnerRD, Proctor RH. 2002. Fum1: a gene required for fumonisin biosynthesis but not for maize ear rot and ear infection by Gibberella moniliforme in field tests. Mol Plant Microbe Inter, 15: 1157-1164.
4
FarmacopeiaBrasileira. 2000. 4th ed. Atheneu, Sa˜o Paulo, Brazil.
5
Gonzalez-Jaen MT, Mirete S, Patino B, Lopez-Errasquın E, Vazquez C. 2004. Genetic markers for the analysis of variability and for production of specific diagnostic sequences in fumonisin-producing strains of Fusarium verticillioides. Eur J Plant Pathol,110: 525-532.
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7
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8
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9
Jurado M. 2006. “Ana´lisis y diagno´stico de especies de Fusarium productoras de toxinas, y supresencia en cerealesespan˜oles.”Ph.D. thesis.Universidad Complutense de Madrid, Madrid, Spain.
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22
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Proctor RH, Brown DW, Plattner RD, Desjardins AE. 2003. Co-expression of 15 contiguous genes delineates a fumonisin biosynthetic gene cluster in Gibberella moniliformis. Fungal Genet Biol, 38: 237-249.
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29
ORIGINAL_ARTICLE
Pomegranate seed hydroalcoholic extract improves memory deficits in ovariectomized rats with permanent cerebral hypoperfusion /ischemia
Objective: Estrogen deficit following menopause results in cognitive behaviors impairment. Severity of these impairments in menopause women suffer with cerebral hypo perfusion/ischemia (HI) cause the brain damage and neuronal death. This study aimed to evaluate the effects of pomegranate seed extract (PGSE) on avoidance memories after permanent bilateral common carotid arteries occlusion (2CCAO) in ovariectomized (OVX) rats. Materials and Methods: Adult female Wistar rats were divided randomly into eight groups with 8 rats in each group: 1) Sham-operated for ovaries and 2CCAO (ShO); 2) OVX and sham operated for ischemia (OShI); 3-7) OVX with 2CCAO (OI) received PGSE (100, 200, 400 and 800 mg/2ml/kg or normal saline, orally) for 14 days (OI+E100, 200, 400, 800 or OI+Veh); 8) OShI received most effective dose of PGSE (200 and 400 mg/kg for passive and active avoidance memories respectively). Active and passive avoidance tasks were measured in Y-maze and two-way shuttle box respectively. Data were analyzed with one-way and RM-ANOVA followed by HSD post-hoc test. Results: Sensorimotor impaired in OShI+Veh and OI+Veh (P
https://ajp.mums.ac.ir/article_3754_da919a52688371fc0e239458847b04bb.pdf
2015-01-01
43
55
10.22038/ajp.2014.3754
Ovariectomy
Cerebral ischemia
Pomegranate
Memory
Rat
Alireza
Sarkaki
sarkaki_a@ajums.ac.ir
1
Physiology Research Center, Dept. of Physiology, Ahvaz Jundishpur University of Medical Sciences, 61357-15794, P.O.Box: 45, Ahvaz-Iran. Telefax: +98-611-3738248
AUTHOR
Yaghoob
Farbood
y_farbood@yahoo.com
2
Dept. of Physiology, Medicine Faculty, Ahvaz Jundishpur University of Medical Sciences, Ahvaz-Iran
LEAD_AUTHOR
Shieda
Hashemi
sheidahashemi_2010@yahoo.com
3
Dept. of Physiology, Medicine Faculty, Ahvaz Jundishpur University of Medical Sciences, Ahvaz-Iran
AUTHOR
Maryam
Rafiei Rad
rafieirad.m@gmail.com
4
Dept. of Biology, faculty of Sciences, Islamic Azad University, Izeh branch, Izeh-Iran.
AUTHOR
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48
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49
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50
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60
ORIGINAL_ARTICLE
Antibacterial and antifungal activities of the endemic species Glaucium vitellinum Boiss. and Buhse
Objectives: Belonging to Papaveraceae family, Glaucium vitellinum is one of the Persian endemic plants which has not been investigated biologically. The present paper focused on the assessment of the antibacterial and antifungal activities of the total methanol extract and alkaloid sub-fraction of the flowering aerial parts of G. vitellinum. Materials and Methods: The antibacterial and antifungal activities were investigated using cup plate method and disc diffusion assay, respectively. The MIC values of the active samples were determined using micro plate dilution method. Results: The crude extract and alkaloid sub-fraction of G. vitellinum had significant inhibition activity on the growth of S. aureus and S. typhi. From antifungal assay, it is concluded that only the yeast C. albicans, showed a high sensitivity to the extract and especially to the related alkaloid sub-fraction. Conclusions: Regarding the results, G. vitellinum could be employed as a natural antibacterial and antifungal agent against S. aureus, S. typhi, and C. albicans, respectively. Moreover, based on the results of this study, further in vivo and ex vivo confirmatory tests for total methanol extract and alkaloid sub-fraction are recommended.
https://ajp.mums.ac.ir/article_3558_e1fb77a567ad215699bf8e3cfa0ac8ee.pdf
2015-01-01
56
61
10.22038/ajp.2014.3558
Glaucium vitellinum
Papaveraceae
Antibacterial
Antifungal
Mina
Mehrara
1
Department of Pharmacognosy, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran – Iran (IAUPS)
AUTHOR
Mehri
Halakoo
2
Department of Pharmacognosy, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran – Iran (IAUPS)
AUTHOR
Mojdeh
Hakemi-Vala
3
Microbiology Department, Medical School, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
AUTHOR
Seyyde Jamal
Hashemi
4
Department of Medical Mycology and Parasitology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Jinous
Asgarpanah
asgarpanah@iaups.ac.ir
5
Department of Pharmacognosy, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran – Iran (IAUPS)
LEAD_AUTHOR
Al-Khalil S, Afifi FU, Aqel M. 1991. The Relaxing Effect of an Aqueous Extract of Glaucium arabicum on Uterine Smooth Muscle of Rat and Guinea Pig. Pharm Biol, 29: 241-244.
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ORIGINAL_ARTICLE
Immunomudulatory effects of hydroalcoholic extract of Hypericum perforatum
Objective: Hypericum perforatum (St. John's Wort) has long been used in traditional medicine to treat a variety of internal and external ailments. The present study was done to evaluate the immumodulatory potentials of the hydroalcoholic extract of H. perforatum. Materials and Methods: Twenty male BALB/c-mice were randomly allocated in two equal groups and immunized with sheep red blood cells (SRBCs) and complete Freund’s adjuvant. Mice in the treatment group orally received hydroalcoholic extract of H. perforatum (110 mg/Kg daily) from the beginning of the study which continued for 2 weeks. Results: The data indicated a significant increase in the level of anti-SRBC antibody and simultaneously a significant decrease in the level of cellular immunity, an enhancement in foot pad thickness, in treatment group compared to control group. The level of the respiratory burst in phagocytic cells and the level of lymphocyte proliferation in splenocytes were significantly decreased in the treatment group compared to control group. Moreover, extract caused a significant reduction in the production of pro-inflammatory IL-17 as well as IFN-γ, parallel to increasing the level of IL-6. Conclusions: The hydroalcoholicextract of H. perforatum may be used as a natural source for treatment of immunopathologic conditions.
https://ajp.mums.ac.ir/article_3476_a86284e93d6bb8232f42b6c020a8301d.pdf
2015-01-01
62
68
10.22038/ajp.2014.3476
Hypericum perforatum
Humoral immunity
Cellular immunity
Lymphocyte response
Seyyed Meysam
Abtahi Froushani
meysamabtahi@hotmail.com
1
Assistant professor of Immunology, Department of Microbiology Veterinary Medicine Faculty, Urmia University, Urmia, Iran
LEAD_AUTHOR
Hadi
Esmaili gouvarchin Galee
h.smaili69@yahoo.com
2
MSc Student of Immunology, Department of Microbiology, Veterinary Faculty, Urmia University, Urmia, Iran
AUTHOR
Mahsa
Khamisabadi
m.khamisabadi@yahoo.com
3
Student of Veterinary Medicine, Veterinary Faculty, Urmia University, Urmia, Iran.
AUTHOR
Bita
Lotfallahzade
b.lotfallahzade@yahoo.com
4
Student of Veterinary Medicine, Veterinary Faculty, Urmia University, Urmia, Iran.
AUTHOR
Aranami T,Yamamura T . 2008. Th17 cells and autoimmune encephalomyelitis (eae/ms). Allergol Int, 57: 115-120.
1
Asgary S, Solhpour A, Parkhideh S, Madani H, Mahzouni P, Kabiri N . 2012. Effect of hydroalcoholic extract of hypericum perforatum on selected traditional and novel biochemical factors of cardiovascular diseases and atherosclerotic lesions in hypercholesterolemic rabbits: A comparison between the extract and lovastatin. J Pharm Bioallied Sci, 4: 212-218.
2
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3
Birt DF, Widrlechner MP, Hammer KD, Hillwig ML, Wei J, Kraus GA, Murphy PA, Mccoy J, Wurtele ES, Neighbors JD, Wiemer DF, Maury WJ, Price JP . 2009. Hypericum in infection: Identification of anti-viral and anti-inflammatory constituents. Pharm Biol, 47: 774-782.
4
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29
ORIGINAL_ARTICLE
Anti-inflammatory, Analgesic and Antiulcer properties of Porphyra vietnamensis
Objectives: Aim of the present work was to investigate the anti-inflammatory, analgesic and antiulcer effects of red seaweed Porphyra vietnamensis (P. vietnamenis). Materials and Methods: Aqueous (POR) and alcoholic (PE) fractions were successfully isolated from P. vietnamenis. Further biological investigations were performed using a classic test of paw edema induced by carrageenan, writhing induced by acetic acid, hot plate method and naproxen induced gastro-duodenal ulcer. Results: Among the fractions POR showed better activity. POR and PE significantly (p < 0.05) reduced carrageenan induced paw edema in a dose dependent manner. In the writhing test POR significantly (p < 0.05) reduced abdominal writhes than PE. In hot plate method POR showed better analgesic activity than PE. POR showed comparable ulcers reducing potential (p<0.01) to that of omeprazole, and has more ulcer reducing potential then PE. Conclusions: The results of this study demonstrated that P. vietnamenis aqueous fraction possesses biological activity that is close to the standards taken for the treatment of peripheral painful or/and inflammatory and ulcer conditions.
https://ajp.mums.ac.ir/article_3758_5dd45b899ba3d030482a8d526d7371a2.pdf
2015-01-01
69
77
10.22038/ajp.2014.3758
Porphyra
Porphyran
Carrageenan
Analgesia
Ulcer
Saurabh
Bhatia
sbsaurabhbhatia@gmail.com
1
DM College of Pharmacy, Bahadurgah, Haryana, India.
LEAD_AUTHOR
Kiran
Sharma
kiransharmapharma@gmail.com
2
Deptt. of Pharmaceutical Sciences, Jamia Hamdard, New Delhi, India.
AUTHOR
Ajay
Sharma
ajaysharmapharma1979@gmail.com
3
Seoul National University, Republic of Korea, Korea.
AUTHOR
Kalpana
Nagpal
kalpananagpal@gmail.com
4
Division of Pharmaceutics, Faculty of Medical Sciences, Lovely Professional University, Phagwara, Punjab India.
AUTHOR
Tanmoy
Bers
proftanmoybera@gmail.com
5
Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India.
AUTHOR
Bandyopadhyay U, Biswas K, Chatterjee R, Bandyopadhyay D, Chattopadhyay I, Ganguly CK, Chakraborty T, Bhattacharya K, Banerjee RK. 2002. Gastroprotective effect of Neem (Azadirachta indica) bark extract: Possible involvement of H+-K+-ATPase inhibition and scavenging of hydroxyl radical. Life Sciences, 71: 2845–2865.
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4
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5
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