ORIGINAL_ARTICLE
Effects of aqueous extract of Hyssopus officinalis on seizures induced by pentylenetetrazole and hippocampus mRNA level of iNOS in rats
Objective: We examined the effectiveness of Hyssopus officinalis (hyssop) aqueous extract on pentylenetetrazole (PTZ)-induced acute seizures and the hippocampus iNOS (induciblenitric oxide synthases) gene expression as a potential mediator of the effects. Materials and Methods: Adult male Wistar rats were used. Tonic-clonic seizures were induced by intraperitoneal (i.p.) injection of PTZ (80 mg/kg) then behavioral profile during 30 min was characterized by stages defined as seizure scores. Hyssop extract were prepared and injected (i.p.) 15 minutes before the seizure induction at three doses 50, 100 and 200 mg/kg. Experimental groups were as below: (1) saline+PTZ (n=5); (2) Hyssop 50mg/kg+PTZ (n=10); (3) Hyssop 100mg/kg+PTZ (n=10); (4) Hyssop 200 mg/kg+PTZ (n=8). Two hours after the experimental procedure, all animals were decapitated, brain was removed and right hippocampus was quickly dissected. After total RNA extraction and cDNA synthesis quantitative PCR were used for gene expression of iNOS. Results: Our results showed significant increase (p<0.05) in latency to reach stages 5 and 6 of tonic-clonic seizure at dose 100 mg/kg hyssop extract. In addition, this dose caused significant increase in the gene expression of iNOS in the hippocampus. Conclusion: It seems a 100 mg/kg dose of hyssop extract might have anticonvulsant effects. However, these anticonvulsant effects might not occur through the iNOS gene expression.
https://ajp.mums.ac.ir/article_13556_a4795f86e3af2285b30bf306c3d8fa4b.pdf
2020-05-01
213
221
10.22038/ajp.2019.13556
Anticonvulsive
Epilepsy
Aqueous extract
Nitric oxide
Hyssopus officinalis
Masoumeh
Gholami
masoumeh.gholami1983@gmail.com
1
Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
AUTHOR
Faranak
Jafari
fjafari32@gmail.com
2
Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
AUTHOR
Zahra
Baradaran
zahrabaradaran@gmail.com
3
Student Research Committee, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
AUTHOR
Jamal
Amri
jamalamri@gmail.com
4
Traditional and Complementary Medicine Research Center, Arak University of Medical Sciences, Arak, Iran
AUTHOR
Hassan
Azhdari-zarmehri
hassanazhdari@gmail.com
5
Neuroscience Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran.
AUTHOR
Mehdi
Sadegh
m.sadegh@arakmu.ac.ir
6
Traditional and Complementary Medicine Research Center, Arak University of Medical Sciences, Arak, Iran.
LEAD_AUTHOR
Ahmadi A, Sayyah M, Khoshkholgh-Sima B, Choopani S, Kazemi J, Sadegh M, Moradpour F, Nahrevanian H. 2013. Intra-hippocampal injection of lipopolysaccharide inhibits kindled seizures and retards kindling rate in adult rats. Exp Brain Res, 226: 107-120.
1
Auditeau E, Moyano L, Bourdy G, Nizard M, Jost J, Ratsimbazafy V, Preux P, Boumediene F. 2018. Herbal medicine uses to treat people with epilepsy: A survey in rural communities of northern Peru. J Ethnopharmacol, 215: 184-190.
2
Banach M, Piskorska B, Czuczwar S, Borowicz K. 2011. Nitric oxide, epileptic seizures, and action of antiepileptic drugs. CNS Neurol Disord Drug Targets, 10: 808-819.
3
Byun J, Lee S, Jeon S, Kwon Y, Lee H, Kim S, Kim Y, Kim M, Chun W. 2009. Kainic acid-induced neuronal death is attenuated by aminoguanidine but aggravated by L-NAME in mouse hippocampus. Korean J Physio Pharma, 13: 265-271.
4
De Almeida ER, Rafael KR, Couto GB, Ishigami AB. 2009. Anxiolytic and anticonvulsant effects on mice of flavonoids, linalool, and alpha-tocopherol presents in the extract of leaves of Cissus sicyoides L. (Vitaceae). J Biomed Biotechnol, 2009: 274740.
5
Elisabetsky E, Brum L, Souza D. 1999. Anticonvulsant properties of linalool in glutamate-related seizure models. Phytomedicine, 6: 107-113.
6
Frazer CJ, Christensen H, Griffiths KM. 2005. Effectiveness of treatments for depression in older people. Med J Aust, 182: 627-632.
7
Gonzalez-Hernandez T, Garcia-Marin V, Perez-Delgado M, Gonzalez-Gonzalez M, Rancel-Torres N, Gonzalez-Feria L. 2000. Nitric oxide synthase expression in the cerebral cortex of patients with epilepsy. Epilepsia, 41: 1259-1268.
8
Hold KM, Sirisoma NS, Sparks SE, Casida JE. 2002. Metabolism and mode of action of cis- and trans-3-pinanones (the active ingredients of hyssop oil). Xenobiotica, 32: 251-265.
9
Javadi B, Sahebkar A, Emami S. 2017. Medicinal plants for the treatment of asthma: A traditional Persian medicine perspective. Curr Pharm Des, 23: 1623-1632.
10
Li J, O W, Li W, Jiang ZG, Ghanbari HA. 2013. Oxidative stress and neurodegenerative disorders. Int J Mol Sci, 14: 24438-24475.
11
Löscher W. 2011. Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs. Seizure, 20: 359-368.
12
Luttjohann A, Fabene PF, Van Luijtelaar G. 2009. A revised Racine's scale for PTZ-induced seizures in rats. Physiol Behav, 98: 579-586.
13
Ma X, Ma X, Ma Z, Sun Z, Yu W, Wang J, Li F, Ding J. 2014. The effects of uygur herb Hyssopus officinalis L. on the process of airway remodeling in asthmatic mice. Evid Based Comple Alter Med, 2014.
14
Mazzio E, Deiab S, Park K, Soliman KF. 2013. High throughput screening to identify natural human monoamine oxidase B inhibitors. Phytother Res, 27: 818-28.
15
Millet Y, Jouglard J, Steinmetz Md, Tognetti P, Joanny P, Arditti J. 1981. Toxicity of some essential plant oils. Clinical and experimental study. Clin Toxicol, 18: 1485-1498.
16
Millet Y, Tognetti P, Lavaire-Perlovisi M, Steinmetz Md, Arditti J, Jouglard J. 1979. [Experimental study of the toxic convulsant properties of commercial preparations of essences of sage and hyssop (author's transl)]. Rev Electroencephalogr Neurophysiol Clin, 9: 8-12.
17
Miyazaki H, Matsuura H, Yanagiya C, Mizutani J, Tsuji M, Ishihara C. 2003. Inhibitory effects of Hyssop (Hyssopus of ficinalis) extracts on intestinal α-glncosidase activity and postprandial hyperglycemia. J Nutr Sci Vitamin, 49: 346-349.
18
Murashima Y, Yoshii M, Suzuki J. 2000. Role of nitric oxide in the epileptogenesis of EL mice. Epilepsia, 41 Suppl 6: S195-S199.
19
Ngugi A, Bottomley C, Kleinschmidt I, Sander J, Newton C. 2010. Estimation of the burden of active and life-time epilepsy: a meta-analytic approach. Epilepsia, 51: 883-890.
20
Özer H, Şahin F, Kılıç H, Güllüce M. 2005. Essential oil composition of Hyssopus officinalis L. subsp. angustifolius (Bieb.) Arcangeli from Turkey. Flavo Frag J, 20: 42-44.
21
Park K, Reuben J, Soliman K. 2001. The role of inducible-nitric oxide in cocaine-induced kindling. Exper Bio Med, 226: 185-190.
22
Peana A, Marzocco S, Popolo A, Pinto A. 2006. (-)-Linalool inhibits in vitro NO formation: probable involvement in the antinociceptive activity of this monoterpene compound. Life Sci, 78: 719-723.
23
Rutkowski R, Pancewicz S, Rutkowski K, Rutkowska J. 2007. [Reactive oxygen and nitrogen species in inflammatory process]. Pol Merkur Lekarski, 23: 131-136.
24
Sadegh M, Sakhaie M. 2018. Carvacrol mitigates proconvulsive effects of lipopolysaccharide, possibly through the hippocampal cyclooxygenase-2 inhibition. Metab Brain Dis, 33: 2045-2050.
25
Schmidt D, Schachter S. 2014. Drug treatment of epilepsy in adults. BMJ, 348: 354.
26
Shin E, Jeong J, Chung Y, Kim W, Ko K, Bach J, Hong J, Yoneda Y, Kim H. 2011. Role of oxidative stress in epileptic seizures. Neurochem Inter, 59: 122-137.
27
Sucher N, Carles M. 2015. A pharmacological basis of herbal medicines for epilepsy. Epilepsy Behav, 52: 308-318.
28
Theodore W & Fisher R. 2004. Brain stimulation for epilepsy. Lancet Neurol, 3: 111-118.
29
Tolou-Ghamari Z, Zare M, Habibabadi J, Najafi M. 2013. Antiepileptic drugs: a consideration of clinical and biochemical outcome in patients with epilepsy. Inter J Preven Med, 4: S330-S337.
30
Vezzani A, French J, Bartfai T, Baram T. 2011. The role of inflammation in epilepsy. Nature reviews. Neurol, 7: 31-40.
31
Wasowski C, Marder M. 2012. Flavonoids as GABAA receptor ligands: the whole story? J Exp Pharmacol, 4: 9-24.
32
Wlodarczyk B, Palacios A, George T, Finnell R. 2012. Antiepileptic drugs and pregnancy outcomes. Ameri J Med Gen. Part A, 158A: 2071-2090.
33
Zareie P, Sadegh M, Palizvan M, Moradi-Chameh H. 2018. Anticonvulsive effects of endocannabinoids; an investigation to determine the role of regulatory components of endocannabinoid metabolism in the pentylenetetrazol induced tonic- clonic seizures. Metab Brain Dis, 33: 939-948.
34
ORIGINAL_ARTICLE
Complications of leech therapy
Objective: The principle of the use of leeches is associated with traditional medicine of many countries and its application has different philosophies for use in different areas of the body. Leeches, with all the benefits, can have dangers. Materials and Methods: A review of complications of leech therapy was done based on English articles indexed in the databases up to July 1, 2018. A strategic search has done independently by members of the research team and then all of the articles were +categorized by subject. Results: Related articles were mostly case-reports. Complications were divided into five categories including infection, allergy, prolonged bleeding, migration, and others. Infection is the most-reported complication related to leech therapy and Aeromonas spp. has the most participation in infections. Conclusion: Leech therapy can be a therapeutic complementary method if the possible complications are managed properly.
https://ajp.mums.ac.ir/article_14181_dd0343a51004750b841da9932b5374c4.pdf
2020-05-01
222
234
10.22038/ajp.2019.14181
Leech
Leech therapy
complication
Complementary Medicine
Matineh
Pourrahimi
matinehpourrahimi@gmail.com
1
Student Research Committee, Faculty of allied medicine Branch, Iran University of medical sciences, Tehran, Iran
AUTHOR
Mojtaba
Abdi
prof.m.abdi@gamil.com
2
Student Research Committee, School of nursing and midwifery Branch, Iran University of medical sciences, Tehran, Iran
AUTHOR
Roshanak
Ghods
ghods.r@iums.ac.ir
3
Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Therapeutic effects of HESA-A (a herbal-marine compound) in acute organophosphorus pesticide poisoning
Objective: Organophosphorus compounds (OPs) are common causes of poisonings. Atropine and oximes are pharmacological antidotes of OPs. However, because of their adverse effects and insufficient performance, several other compounds have been evaluated as adjuvant therapy. HESA-A is a herbal-marine drug that contains material from Carum carvi (Persian cumin), Penaeus latisculatus (king prawn), and Apium graveolens (celery) with anti-inflammatory and antioxidants properties, which has shown useful effects as adjuvant therapy on some diseases. We have evaluated the effect of HESA-A on 69 moderate to severe acute OPs poisoned patients (44 HESA-A treated and 25 controls) as an adjuvant drug. Materials and Methods: Two randomized age and sex matched groups of OPs poisoned patients were treated in Medical Toxicology Center of Imam Reza hospital, Mashhad, by conventional therapy with or without HESA-A (50 mg/kg/day orally). The evaluation criteria were total administrated doses of atropine and pralidoxime, intensive care unit (ICU) admission rate, mechanical respiration need, number of hospitalization days and mortality. Results: There were no significant differences between the morbidity and mortality rate criteria of the two groups; moreover, we did not observe significant adverse effects for HESA-A. Conclusion: HESA-A did not reduce morbidity and mortality of OPs poisoning and did not induce any major side effect in the patients.
https://ajp.mums.ac.ir/article_13882_a1bc5625f7b687a72c161212e5ae2b42.pdf
2020-05-01
235
242
10.22038/ajp.2019.13882
Organophosphorus pesticides
Poisoning
Clinical trial
HESA-A
Seyed Reza
Mousavi
mousavir@mums.ac.ir
1
Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Mohammad
Moshiri
moshiri.mo@gmail.com
2
Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Emadodin
Darchini-Maragheh
darchinime971@mums.ac.ir
3
Cutaneous Leishmaniasis Research Center, Emam Reza Hospital, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Seyed Khosro
Ghasempouri
ghasemporikkh@sums.ac.ir
4
Department of Forensic Medicine and Toxicology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.
AUTHOR
Bita
Dadpour
dadpourb@mums.ac.ir
5
Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Faezeh
Sardar Antighechi
sardaraf1@mums.ac.ir
6
Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Mahdi
Balali-Mood
mbalalimood@hotmail.com
7
Medical Toxicology and Drug Abuse Research Center, Birjand University of Medical Sciences, Birjand, Iran.
LEAD_AUTHOR
Abbasi MM, Helli S, Monfaredan A, Jahanban-Esfahlan R. 2015a. Hesa-A improves clinical outcome of oral carcinoma by affecting p53 gene expression in vivo. Asian Pac J Cancer Prev, 16: 4169-4172.
1
Abbasi MM, Mehdipour M, Monfaredan A, Jahanban-Esfahlan R. 2015b. Hesa-A down-regulates erb/b2 oncogene expression and improves outcome of oral carcinoma in a rat model. Asian Pac J Cancer Prev, 16: 6947-6951.
2
Abdollahi M, Jalali N, Sabzevari O, Hoseini R, Ghanea T. 1997. A retrospective study of poisoning in Tehran. J Toxicol Clin Toxicol, 35: 387-393.
3
Afshari R, Majdzadeh R, Balali-Mood M. 2004. Pattern of acute poisonings in Mashhad, Iran 1993-2000. J Toxicol Clin Toxicol, 42: 965-975.
4
Ahmadi A, Mohagheghi M, Karimi M, Seyed Ali G, Naseri M. 2009. Anticancer effects of HESA-A in patients with metastatic colon cancer. Integr Cancer Ther, 8: 71-74.
5
Ahmadi A, Mohagheghi M, Karimi M, Golestanha SA, Naseri M, Faghihzadeh S, Habibi G. 2010. Therapeutic effects of HESA-A in patients with end-stage metastatic cancers. Integr Cancer Ther, 9: 32-35.
6
Ahmadi A, Barikbin B, Naseri M, Mohagheghi M. The effect of HESA-A on psoriasis vulgaris. 2008. J Drugs Dermatol, 7: 559-561.
7
Ahmadi A, Naderi G, Asgary S. 2005a. Evaluation of hepatoprotective potential of HESA-A (a marine compound) pretreatment against thioacetamide-induced hepatic damage in rabbits. Drugs Exp Clin Res, 31: 1-6.
8
Ahmadi A, Mohagheghi MA, Fazeli MS, Nahavandian B, Bashardoost N, Musavi Jarahi A, Gharipoor M. 2005b. HESA-A: new treatment for breast cancer and choroidal metastasis. Med Sci Monit, 11: CR300-303.
9
Alizadeh AM, Ahmadi A, Paknejad M, Mohammadzadeh M, Mohagheghi M. 2009. The effect of HESA-A, an Herbal-marine compound, on wound healing process: An experimental study. Res J Biol Sc, 4: 298-302.
10
Amitai G, Adani R, Fishbein E, Meshulam H, Laish I, Dachir S. 2006. Bifunctional compounds eliciting anti-inflammatory and anti-cholinesterase activity as potential treatment of nerve and blister chemical agents poisoning. J Appl Toxicol, 26: 81-87.
11
Balali-Mood M, Saber H. 2012. Recent advances in the treatment of organophosphorous poisonings. Iran J Med Sci, 37: 74-91.
12
Balali-Mood M, Ayati MH, Ali-Akbarian H. 2005. Effect of high doses of sodium bicarbonate in acute organophosphorous pesticide poisoning. Clin Toxicol (Phila), 43: 571-574.
13
Banks CN, Lein PJ. 2012. A review of experimental evidence linking neurotoxic organophosphorus compounds and inflammation. Neurotoxicology, 33: 575-584.
14
Barikbin B, Qeisari M, Saeedi M, Esmailiazad M, Moravvej H, Yousefi M, Ahmadi A. 2010. Efficacy of HESA-A in the treatment of chronic plaque type psoriasis. Iran J Dermatol, 13: 16-19.
15
Basher A, Rahman SH, Ghose A, Arif SM, Faiz MA, Dawson AH. 2013. Phase II study of magnesium sulfate in acute organophosphate pesticide poisoning. Clin Toxicol (Phila), 51: 35-40.
16
Bertolote JM, Fleischmann A, Eddleston M, Gunnell D. 2006. Deaths from pesticide poisoning: Are we lacking a global response? Br J Psychiatry, 189: 201-203.
17
El-Shenawya NS, El-Salmyb F, Al-Eisab RA, El-Ahmaryb B. 2010. Amelioratory effect of vitamin E on organophosphorus insecticide diazinon-induced oxidative stress in mice liver. Pestic Biochem Phys, 96: 101-107.
18
Etemad L, Moshiri M, Balali-mood M. 2015. Chronic toxicity of OP compounds, in basic and clinical toxicology of organophosphorous compounds. London Springer: p. 79-119.
19
Fattahi S, Vosough Hosseini S, Aghbali AA, Mehdipour M, Helli S, Damghani H. 2017. Effects of systemic administration of HESA-A on the expression of cyclin D1 and EGFR and E-cadherin in the induced tongue dysplasia in rats. J Dent Res Dent Clin Dent Prospects, 11:201-207.
20
Mehrbod P, Ideris A, Rahman Omar A, Hair-Bejo M. 2014. Prophylactic effect of herbal-marine compound (HESA-A) on influenza A virus infectivity. BMC Complement Altern Med, 14: 131.
21
Moallem SA, Ahmadi A, Moshafi M, Taghavi MM. 2010. Teratogenic effects of HESA-A, a natural anticancer product from Iran, in mice. Hum Exp Toxicol, 30: 851-859.
22
Moallem SA, Ahmadi A, Moshafi M, Taghavi MM. 2011. Teratogenic effects of HESA-A, a natural anticancer product from Iran, in mice. Hum Exp Toxicol, 30:851-859.
23
Moshiri M, Darchini-Maragheh E, Balali-Mood M. 2012. Advances in toxicology and medical treatment of chemical warfare nerve agents. Daru, 20: 81.
24
Moshiri M, Alizadeh A, Balali-mood M, 2015. Clinical management of organophosphorus nerve agents’ poisonings, in basic and clinical toxicology of organophosphorous compounds. London Springer; p. 177-213.
25
Moshiri M, Vahabzadeh M, Etemad L, Hosseinzadeh H. 2013. Failure of intravenous lipid emulsion to reduce diazinon-induced acute toxicity: a pilot study in rats. Iran J Pharm Res, 12: 897-902.
26
Muhammadnejad S, Zendehdel K, Mazaheri Z, Muhammadnejad A, Haddadi M, Mohagheghi MA, Amanpou S. 2014. Assessment of selective growth inhibitory effects of HESA-A on some human neoplastic cell lines. Basic Clin Cancer Res, 6: 10-15.
27
Roudkenar MH, Bahmani P, Halabian R, Mohammadi Oushandeh A, Jahanian Najafabadi A, Shokrgozar MA. 2012. HESA-A Exerts its cytoprotective effects through scavenging of free radicals: An in vitro study. Iran J Med Sci, 37: 47-53.
28
Sadeghi-Aliabadi H, Ahmadi A. 2003. Cytotoxicity and antitumor properties of a marine compound, HESA-A, on cancer cells. Daru, 11: 82-87.
29
Sadeghi Aliabadi H, Ahmadi A. 2001. Cytotoxicity and antitumor properties of a marine compound on cancer cells (HESA-A). Med J Islamic Acad Sci, 13: 55–61
30
Schumacher M, Kelkel M, Dicato M, Diederich M. 2011. A survey of marine natural compounds and their derivatives with anti-cancer activity reported in 2010. Molecules, 16: 5629–5646.
31
Vahabpour R, Sadat SM, Zabihollahi R, Ahmadi A, Keivani H, Amini S, Siadat SD, Aghasadeghi MR. 2012. In vitro inhibitory effects of the herbal-marine compound HESA-A against replication of human immunodeficiency virus-1. Jundishapur J Microbiol, 5: 315-319.
32
ORIGINAL_ARTICLE
Cinnamon extract supplementation improves inflammation and oxidative stress induced by acrylamide: An experimental animal study
Objective: Toxic effects of acrylamide on body organs incline researches to prevent or decrease these effects. The objective of the present study was to evaluate the effects of cinnamon extract (CE) supplementation on inflammation and oxidative stress induced by acrylamide in rats. Materials and Methods: Thirty two rats were divided into four groups as follow 1) The control group received distilled water, 2) Acrylamide- intoxicated group was administrated with 35 ml/kg/day acrylamide for two weeks, 3) Acrylamide- intoxicated rats treated with CE 250 mg/kg/day for 28 days, and 4) Acrylamide- intoxicated rats treated with CE 500 mg/kg day for 28 days. Fasting blood sample was obtained for subsequent analysis. Results: The results showed that acrylamide- intoxicated group had significantly higher levels of malondialdehyde, tumor necrosis factor alpha, high sensitive C reactive protein, leptin and alanine transaminase (p0.05). Conclusion: This study suggests that cinnamon extract may potentially be effective as a dietary source of bioactive compounds for managing acrylamide intoxication.
https://ajp.mums.ac.ir/article_13899_880e554cd07e44bc660d92f12a6da180.pdf
2020-05-01
243
252
10.22038/ajp.2019.13899
Cinnamon extract
Acrylamide
Oxidative stress
Liver Enzyme
Inflammation
Fatemeh
Haidari
haidari58@yahoo.com
1
Nutrition and Metabolic Diseases Research Center, Department of Nutrition, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
AUTHOR
Majid
Mohammadshahi
shahi334@yahoo.com
2
Hyperlipidemia Research Center, Department of Nutrition, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
AUTHOR
Behnaz
Abiri
behnaz.abiri@yahoo.com
3
Department of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
AUTHOR
Mehdi
Zarei
m.zarei@yahoo.com
4
Department of Food Hygiene, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
AUTHOR
Mojdeh
Fathi
behnaz.abiri@gmail.com
5
Department of Nutrition, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
LEAD_AUTHOR
Ansar S, Siddiqi NJ, Zargar S, Ganaie MA, Abudawood M. 2016. Hepatoprotective effect of Quercetin supplementation against Acrylamide-induced DNA damage in wistar rats. BMC Complement Altern Med,16:327-332.
1
Alturfan AA, Tozan-Beceren A, Şehirli AÖ, Demiralp E, Şener G, Omurtag GZ. 2012. Resveratrol ameliorates oxidative DNA damage and protects against acrylamide-induced oxidative stress in rats. Mol Biol Rep, 39:4589-4596.
2
Askari F, Rashidkhani B, Hekmatdoost A. 2014. Cinnamon may have therapeutic benefits on lipid profile, liver enzymes, insulin resistance, and high-sensitivity C-reactive protein in nonalcoholic fatty liver disease patients. Nutr Res, 34:143-148.
3
Amin KA, El-Twab A. 2009. Oxidative markers, nitric oxide and homocysteine alteration in hypercholesterolimic rats: role of atorvastatine and cinnamon. Int J Clin Exp Med, 2 :254-265.
4
Braithwaite I, Stewart AW, Hancox RJ, Beasley R, Murphy R, Mitchell EA, ISAAC Phase Three Study Group; ISAAC Phase Three Study Group. 2014. Fast-food consumption and body mass index in children and adolescents: an international cross-sectional study. BMJ Open, 4:e005813.
5
Cao H, Polansky MM, Anderson RA. 2007. Cinnamon extract and polyphenols affect the expression of tristetraprolin, insulin receptor, and glucose transporter 4 in mouse 3T3-L1 adipocytes. Arch Biochem Biophys, 459: 214-222.
6
Dehghan G, Shaghaghi M, Jafari A, Mohammadi M, Badalzadeh R. 2014. Effect of endurance training and cinnamon supplementation on post-exercise oxidative responses in rats. Mol Biol Res Commun, 3:269-281.
7
Einstein A, Podolsky B, Rosen N. 1935. Can quantum-mechanical description of physical reality be considered complete? Phys Rev, 47: 777-780.
8
El-Baroty GS, El-Baky HA, Farag R, Saleh MA. 2010. Characterization of antioxidant and antimicrobial compounds of cinnamon and ginger essential oils. AJBR, 4: 167-174.
9
Eidi A, Mortazavi P, Bazargan M, Zaringhalam J. 2012. Hepatoprotective activity of cinnamon ethanolic extract against CCL 4-induced liver injury in rats. EXCLI J, 11:495-507.
10
El-Mehi AE, El-Sherif NM. 2015. Influence of acrylamide on the gastric mucosa of adult albino rats and the possible protective role of rosemary. Tissue Cell, 47: 273-283.
11
El‐Raouf A, Ola M, El‐Sayed ESM, Manie MF. 2015. Cinnamic acid and cinnamaldehyde ameliorate cisplatin‐induced splenotoxicity in rats. J Biochem Mol Toxicol, 29: 426-431.
12
Ejaz A, Wu D, Kwan P, Meydani M. 2009. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. J Nutr, 2009;139: 919-925.
13
Goffeng LO, Kjuus H, Heier MS, Alvestrand M, Ulvestad B, Skaug V. 2008. Colour vision and light sensitivity in tunnel workers previously exposed to acrylamide and N-methylolacrylamide containing grouting agents. Neurotoxicology, 29: 31-39.
14
Ghobadi Pour M, Mirazi N, Seif A. 2019. Treatment of liver and spleen illnesses by herbs: Recommendations of Avicenna’s heritage "Canon of Medicine". Avicenna J Phytomed, 9:101-116.
15
Ghorbel I, Chaabane M, Elwej A, Kallel C, Grati Kamoun N, Najiba Z. 2017. Extra Virgin olive oil mitigates hematotoxicity induced by acrylamide and oxidative damage in adult rats. Mazums-pbr, 3 :34-40.
16
Gaique TG, Lopes BP, Souza LL, Paula GS, Pazos‐Moura CC, Oliveira KJ. 2016. Cinnamon intake reduces serum T3 level and modulates tissue‐specific expression of thyroid hormone receptor and target genes in rats. J Sci Food Agric, 96: 2889-2895.
17
Gunawardena D, Karunaweera N, Lee S, van Der Kooy F, Harman DG, Raju R, Bennett L, Gyengesi E, Sucher NJ, Münch G. 2015. Anti-inflammatory activity of cinnamon (C. zeylanicum and C. cassia) extracts–identification of E-cinnamaldehyde and o-methoxy cinnamaldehyde as the most potent bioactive compounds. Food Funct, 6: 910-919.
18
Hansen SH, Olsen AK, Søderlund EJ, Brunborg G. 2010. In vitro investigations of glycidamide-induced DNA lesions in mouse male germ cells and in mouse and human lymphocytes. Mutat Res, 696: 55-61.
19
Hagenlocher Y, Hösel A, Bischoff SC, Lorentz A. 2016. Cinnamon extract reduces symptoms, inflammatory mediators and mast cell markers in murine IL-10−/− colitis. J Nutr Biochem, 30:85-92.
20
Haidari F, Omidian K, Rafiei H, Zarei M, Mohamad Shahi M. 2013. Green tea (Camellia sinensis) supplementation to diabetic rats improves serum and hepatic oxidative stress markers. Iran J Pharm Res, 12: 109-114.
21
Hong J-W, Yang G-E, Kim YB, Eom SH, Lew J-H, Kang H. 2012. Anti-inflammatory activity of cinnamon water extract in vivo and in vitro LPS-induced models. BMC Complement Altern Med, 12: 1-8.
22
Heber D, Zhang Y, Yang J, Ma JE, Henning SM, Li Z. 2014. Green tea, black tea, and oolong tea polyphenols reduce visceral fat and inflammation in mice fed high-fat, high-sucrose obesogenic diets. J Nutr, 144: 1385-1393.
23
Ismail NS. 2014. Protective effects of aqueous extracts of cinnamon and ginger herbs against obesity and diabetes in obese diabetic rat. WJDFS, 9: 145-153.
24
Jiang L, Cao J, An Y, Geng C, Qu S, Jiang L, Zhong L. 2007. Genotoxicity of acrylamide in human hepatoma G2 (HepG2) cells. Toxicol In Vitro, 21: 1486-1492.
25
Kokanova-Nedialkova Z, Nedialkov P, Kondeva-Burdina M, Simenova R, Tsankova V, Nikolov S. 2016. Good king-henry (Chenopodium bonus-henricus L.)–a source of hepatoprotective flavonoids. Planta Med, 81: 840-841.
26
Koochaksaraie R, Irani M, Gharavysi S. 2011. The effects of cinnamon powder feeding on some blood metabolites in broiler chicks. Rev Bras Cienc Avic, 13: 197-202.
27
Lasekan O, Abbas K. 2010. Analysis of volatile flavour compounds and acrylamide in roasted Malaysian tropical almond (Terminalia catappa) nuts using supercritical fluid extraction. Food Chem Toxicol, 48: 2212-2216.
28
Liu S, Jiang L, Zhong T, Kong S, Zheng R,Kong F, Zhang C, Zhang L, An L. 2015. Effect of Acrylamide on Oocyte Nuclear Maturation and Cumulus Cells Apoptosis in Mouse In Vitro. PloS One, 10:e0135818.
29
Li RW, Theriault AG, Au K, Douglas TD, Casaschi A, Kurowska EM, Mukherjee R. 2006. Citrus polymethoxylated flavones improve lipid and glucose homeostasis and modulate adipocytokines in fructose-induced insulin resistant hamsters. Life Sci, 79: 365-373.
30
Lu T, Sheng H, Wu J, Cheng Y, Zhu J, Chen Y. 2012. Cinnamon extract improves fasting blood glucose and glycosylated hemoglobin level in Chinese patients with type 2 diabetes. Nutr Res, 32: 408-412.
31
Mroueh M, Saab Y, Rizkallah R. 2004. Hepatoprotective activity of Centaurium erythraea on acetaminophen‐induced hepatotoxicity in rats. Phytother Res, 18: 431-433.
32
Moselhy SS, Ali HK. 2009. Hepatoprotective effect of cinnamon extracts against carbon tetrachloride induced oxidative stress and liver injury in rats. Biol Res, 42: 93-98.
33
Machado MV, Coutinho J, Carepa F, Costa A, Proença H, Cortez-Pinto H. 2012. How adiponectin, leptin, and ghrelin orchestrate together and correlate with the severity of nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol, 24: 1166-1172.
34
Matsunami T, Sato Y, Ariga S, Sato T, Kashimura H, Hasegawa Y, Yukawa M. 2010. Regulation of oxidative stress and inflammation by hepatic adiponectin receptor 2 in an animal model of nonalcoholic steatohepatitis. Int J Clin Exp Pathol, 3: 472-481.
35
Mahmoud AM. 2013. Hematological alterations in diabetic rats—role of adipocytokines and effect of citrus flavonoids. EXCLI J, 12:647-657.
36
Ohashi K, Parker JL, Ouchi N, Higuchi A, Vita JA, Gokce N, Pedersen AA, Kalthoff C, Tullin S, Sams A, Summer R, Walsh K. 2010. Adiponectin promotes macrophage polarization toward an anti-inflammatory phenotype. J Biol Chem, 285: 6153-6160.
37
Papoušek R, Pataj Z, Nováková P, Lemr K, Barták P. 2014. Determination of acrylamide and acrolein in smoke from tobacco and E-cigarettes. Chromatographia, 77: 1145-1151.
38
Roussel A-M, Hininger I, Benaraba R, Ziegenfuss TN, Anderson RA. 2009. Antioxidant effects of a cinnamon extract in people with impaired fasting glucose that are overweight or obese. J Am Coll Nutr, 28: 16-21.
39
Raj VP, Chandrasekhar RH, Vijayan P, Dhanaraj S, Rao MC, Rao VJ, Nitesh K. . 2010. In vitro and in vivo hepatoprotective effects of the total alkaloid fraction of Hygrophila auriculata leaves. Indian J Pharmacol, 42: 99-104.
40
Septembre‐Malaterre A, Le Sage F, Hatia S, Catan A, Janci L, Gonthier MP. 2016. Curcuma longa polyphenols improve insulin‐mediated lipid accumulation and attenuate proinflammatory response of 3T3‐L1 adipose cells during oxidative stress through regulation of key adipokines and antioxidant enzymes. Biofactors, 8: 418-430.
41
Shen Y, Wang Q, Zhao Q, Zhou J. 2009. Leptin promotes the immune escape of lung cancer by inducing proinflammatory cytokines and resistance to apoptosis. Mol Med Rep, 2: 295-299.
42
Shatwan IA, Ahmed LA, Badkook MM. 2013. Effect of barley flour, crude cinnamon, and their combination on glycemia, dyslipidemia, and adipose tissue hormones in type 2 diabetic rats. J Med Food, 16: 656-662.
43
Shihabudeen HMS, Priscilla DH, Thirumurugan K. 2011. Cinnamon extract inhibits α-glucosidase activity and dampens postprandial glucose excursion in diabetic rats. Nutr Metab (Lond), 8: 46-57.
44
Taubert D, Glöckner R, Müller D, Schömig E. 2006. The garlic ingredient diallyl sulfide inhibits cytochrome P450 2E1 dependent bioactivation of acrylamide to glycidamide. Toxicol Lett, 164: 1-5.
45
Tang H, Sebastian BM, Axhemi A, Chen X, Hillian AD, Jacobsen DW, Nagy LE. 2012. Ethanol‐induced oxidative stress via the CYP2E1 pathway disrupts adiponectin secretion from adipocytes. Alcohol Clin Exp Res, 36: 214-22.
46
Watzek N, Scherbl D, Schug M, Hengstler JG, Baum M, Habermeyer M, Richling E, Eisenbrand G. 2013. Toxicokinetics of acrylamide in primary rat hepatocytes: coupling to glutathione is faster than conversion to glycidamide. Arch Toxicol, 87: 1545-1556.
47
Williams CD, Stengel J, Asike MI, Torres DM, Shaw J, Contreras M, et al. 2011. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology, 140: 124-131.
48
Wang F, Pu C, Zhou P, Wang P, Liang D, Wang Q, Hu Y, Li B, Hao X. 2015. Cinnamaldehyde prevents endothelial dysfunction induced by high glucose by activating nrf2. Cell Physiol Biochem, 36: 315-324.
49
Wang G-W, Deng L-Q, Luo Y-P, Liao Z-H, Chen M. 2016. Hepatoprotective triterpenoids and lignans from the stems of Schisandra pubescens. Nat Prod Res, 16:1855-1860.
50
Wickenberg J, Lindstedt S, Nilsson J, Hlebowicz J. 2014. Cassia cinnamon does not change the insulin sensitivity or the liver enzymes in subjects with impaired glucose tolerance. Nutr J, 13: 1-6.
51
Zhao M, Wang P, Zhu Y, Liu X, Hu X, Chen F. 2015. Blueberry anthocyanins extract inhibits acrylamide-induced diverse toxicity in mice by preventing oxidative stress and cytochrome P450 2E1 activation. J Funct Foods, 14: 95-101.
52
Zhang K, Han ES, Dellinger TH, Lu J, Nam S, Anderson RA, Hu Y, Li B, Hao X. 2016. Cinnamon extract reduces VEGF expression via suppressing HIF‐1α gene expression and inhibits tumor growth in mice. Mol Carcinog, 56: 436-446.
53
Zheng Y-F, Wei J-H, Fang S-Q, Tang Y-P, Cheng H-B, Wang T-L, Li CY, Peng GP. 2015. Hepatoprotective triterpene saponins from the roots of Glycyrrhiza inflata. Molecules, 20: 6273-6283.
54
ORIGINAL_ARTICLE
Cardiovascular effects of standardized hydroalcoholic extract of Ribes khorasanicum fruit in acute hypertensive rats
Objective: Ribes khorasanicum (R. khorasanicum)traditionally has been used for the treatment of higher blood pressure. In this study, the effect of hydroalcoholic extract of R. khorasanicum fruit in normotensive and hypertensive rats was evaluated. Materials and Methods: Animals were assigned into the following groups: 1) Control, 2) AngII (50 ng/kg), 3) AngII + losartan (Los, 10 mg/kg) and 4-6) Doses 4, 12 and 24 mg/kg of extract +AngII groups. AngII and Los were injected intravenously and the extract was injected intraperitoneal. In R. khorasanicum groups, AngII injected 30 after injection of the extract. The femoral artery was cannulated and mean arterial pressure (MAP), systolic blood pressure (SBP), and heart rate (HR) were recorded by Power Lab software. Maximal changes (∆) of cardiovascular responses were determined and compared with those of control and AngII groups. Finally, oxidative stress parameters in the heart and aorta were also determined. Results: In normotensive rats, 12 mg/kg of the extract showed significant hypotensive effects while 24 mg/kg produced significant tachycardia. Increased ∆SBP and ∆MAP in AngII group were significantly blunted by Los. Doses 4 and 12 mg/kg of the plant also significantly attenuate the effect of AngII on ∆SBP and ∆MAP. Tachycardia induced by 24 mg/kg of the extract didn't affect by AngII. Extract also significantly improved the effect of AngII on MDA, total thiol content, CAT and SOD in both heart and aorta tissues. Conclusion: R. khorasanicum at lower doses showed hypotensive effects and attenuated cardiovascular parameters in hypertensive rats via its antioxidant effects.
https://ajp.mums.ac.ir/article_13930_0966c1d779a724569c7b9a495e3205f0.pdf
2020-05-01
253
262
10.22038/ajp.2019.13930
Ribes khorasanicum
Angiotensin II
blood pressure
Herat rate
Hypertension
Ismael
Hamounpeima
hamounpimae931@mums.ac.ir
1
Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Reza
Mohebbati
mohebbatir931@mums.ac.ir
2
Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Mahmoud
Hosseini
hosseinim@mums.ac.ir
3
Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Abolfazl
Khajavi Rad
khajavirada@mums.ac.ir
4
Department of Physiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Hasan
Rakhshandeh
rakhshandehh@mums.ac.ir
5
Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Abbas
Safarnejad
sebre14@yahoo.com
6
Faculty of Khorasan Razavi Agricultural and Natural Resources Research Center, Education and Extension Organization (AREEO), Mashhad, Iran.
AUTHOR
Mohammad Naser
Shafei
shafeimn@mums.ac.ir
7
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
Adibi F, Ejtehadi H, Abrishamchi P. 2007. Phytochemicals and antibacterial effects of Ribes khorassanicum Saghafi & Assadi, an Endemic Plant Species to North-East of Khorasan. J Med Plants, 4: 64-73.
1
Ainsworth EA, Gillespie KM. 2007. Estimation of total phenolic content and other oxidation substrates in plant tissues using Folin–Ciocalteu reagent. Nat Protoc, 2: 875-877 .
2
Apostolidis E, Kwon Y-I, Shetty K. 2006. Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pac J Clin Nutr, 15: 433-341.
3
Beheshti F, Hashemzehi M, Sabeti N, Sadr SH, Hosseini M. 2019. The effects of aminoguanidine on hippocampal cytokines, amyloid beta, brain-derived neurotrophic factor, memory and oxidative stress status in chronically lipopolysaccharide-treated rats. Cytokine, 113: 347-355.
4
Beheshti F, Norouzi F, Abareshi A, Khazaei M, Alikhani V, Moussavi S, Biglari G, Soukhtanloo M, Hosseini M. 2018. Nigella sativa prevented liver and renal tissue damage in lipopolysaccharide-treated rats. Saudi J Kidney Dis Transpl, 29: 554-566.
5
Botelho AFM, Santos-Miranda A, Joca HC, Mattoso CRS, de Oliveira MS, Pierezan F, Cruz JS, Soto-Blanco B, Melo MM. 2017. Hydroalcoholic extract from Nerium oleander L. (Apocynaceae) elicits arrhythmogenic activity. J Ethnopharmacol, 206: 170-177.
6
Brunner HR, Chang P, Wallach R, Sealey JE, Laragh JH. 1972. Angiotensin II vascular receptors: their avidity in relationship to sodium balance, the autonomic nervous system, and hypertension. J Clin Invest, 51: 58-67.
7
Calderone V, Chericoni S, Martinelli C, Testai L, Nardi A, Morelli I, Breschi MC, Martinotti E. 2004. Vasorelaxing effects of flavonoids: investigation on the possible involvement of potassium channels. Naunyn Schmiedebergs Arch Pharmacol, 370: 290-298.
8
Croquet V, Moal F, Veal N, Wang J, Oberti F, Roux J, Vuillemin E, Gallois Y, Douay O, Chappard D. 2002. Hemodynamic and antifibrotic effects of losartan in rats with liver fibrosis and/or portal hypertension. J Hepatol, 37: 773-780.
9
Enayatfard L, Mohebbati R, Niazmand S, Hosseini M, Shafei MN.2018. The standardized extract of Nigella sativa and its major ingredient, thymoquinone, ameliorates angiotensin II-induced hypertension in rats. J Basic Clin Physiol Pharmacol, 30: 51-58.
10
Ferrario CM.2006. Role of angiotensin II in cardiovascular disease—therapeutic implications of more than a century of research. J Renin Angiotensin Aldosterone Syst, 7: 3-14.
11
Jeon BH, Kim CS, Park KS, Lee JW, Park JB, Kim K-J, Kim SH, Chang SJ, Nam KY. 2000. Effect of Korea red ginseng on the blood pressure in conscious hypertensive rats. Gen Pharmacol, 35: 135-141.
12
Jouad H, Lacaille-Dubois M, Lyoussi B, Eddouks M. 2001. Effects of the flavonoids extracted from Spergularia purpurea Pers. on arterial blood pressure and renal function in normal and hypertensive rats. J Ethnopharmacol, 76: 159-163.
13
Mahmoudabady M, Shafei MN, Niazmand S, Khodaee E. 2014. The effects of hydroalchoholic extract of Teucrium polium L. on hypertension induced by angiotensin II in rats. Int J Prev Med, 5: 1255-1260.
14
Moradi MT, Asadi-Samani M, Bahmani M. 2016. Hypotensive medicinal plants according to Ethnobotanical evidence of Iran: A Systematic Review. Int J Pharmtech Res, 9: 416-426.
15
Oliveira AC, Sena-Filho JG, Mendes-Júnior LG, Anjos RM, Ribeiro TP, Barbosa-Filho JM, Braga VA, Medeiros IA. 2012. Erythroxylum pungens elicits vasorelaxation by reducing intracellular calcium concentration in vascular smooth muscle cells of rats. Rev Bras Farmacogn, 22: 436-442.
16
Perez YY, Jimenez-Ferrer E, Alonso D, Botello-Amaro CA, Zamilpa A. 2010. Citrus limetta leaves extract antagonizes the hypertensive effect of angiotensin II. J Ethnopharmacol, 128: 611-614.
17
Polizio AH, Balestrasse KB, Yannarelli GG, Noriega GO, Gorzalczany S, Taira C, Tomaro ML. 2008. Angiotensin II regulates cardiac hypertrophy via oxidative stress but not antioxidant enzyme activities in experimental renovascular hypertension. Hypertens Res, 31: 325-334.
18
Polizio AH, Peña C. 2005. Effects of angiotensin II type 1 receptor blockade on the oxidative stress in spontaneously hypertensive rat tissues. Regul Pept, 128: 1-5.
19
Rodrigues H, Diniz Y, Faine L, Galhardi C, Burneiko R, Almeida J, Ribas B, Novelli E. 2005. Antioxidant effect of saponin: potential action of a soybean flavonoid on glucose tolerance and risk factors for atherosclerosis. Int J Food Sci Nutr, 56: 79-85.
20
Romero JC, Reckelhoff JF. 1999. Role of angiotensin and oxidative stress in essential hypertension. Hypertension, 34: 943-949.
21
Saghafi F, Assadi M. 1996. Ribes Khorasanica (Grossulariaceae), a new species from NE. IRAN. Iran J Bot, 7: 7-10.
22
Sata M, Fukuda D. 2010. Crucial role of renin-angiotensin system in the pathogenesis of atherosclerosis. J Med Invest, 57: 12-25.
23
Schmieder RE, Hilgers KF, Schlaich MP, Schmidt BM. 2007. Renin-angiotensin system and cardiovascular risk. Lancet, 369: 1208-1219.
24
Shafei MN, Faramarzi A, Rad AK, Anaeigoudari A. 2017. Crocin prevents acute angiotensin II-induced hypertension in anesthetized rats. Avicenna J Phytomed, 7: 345- 352.
25
Shafei MN, Nasimi A, Alaei H, Pourshanazari AA, Hosseini M. 2012. Role of cuneiform nucleus in regulation of sympathetic vasomotor tone in rats. Pathophysiology, 19: 151-155.
26
Shafei MN, Niazmand S, Hosseini M, Daloee MH. 2013. Pharmacological study of cholinergic system on cardiovascular regulation in the cuneiform nucleus of rat. Neurosci Lett, 549: 12-17.
27
Usui M, Egashira K, Kitamoto S, Koyanagi M, Katoh M, Kataoka C, Shimokawa H, Takeshita A. 1999. Pathogenic role of oxidative stress in vascular angiotensin-converting enzyme activation in long-term blockade of nitric oxide synthesis in rats. Hypertension, 34: 546-551.
28
Xue B, Li J, Chai Q, Liu Z, Chen L. 2008. Effect of total flavonoid fraction of Astragalus complanatus R. Brown on angiotensin II-induced portal-vein contraction in hypertensive rats. Phytomedicine, 15: 759-762.
29
Yazdi MET, Khara J, Housaindokht MR, Sadeghnia HR, Bahabadi SE, Amiri MS, Mosawee H, Taherzadeh D, Darroudi M. 2018a. Role of Ribes khorassanicum in the biosynthesis of AgNPs and their antibacterial properties. IET nanobiotechnol, 13: 189-192.
30
Yazdi MET, Khara J, Husaindokht MR, Reza H, Sadeghnia SEB, Amiri MS, Darroudi M. 2018b. Biocomponents and antioxidant activity of Ribes khorasanicum. Int J Basic Sci Med, 3: 99-103
31
Yuan C-S, Wang C-Z, Wicks SM, Qi L-W. 2010. Chemical and pharmacological studies of saponins with a focus on American ginseng. J Ginseng Res, 34: 160-167.
32
Ziberna L, Lunder M, Moze S, Vanzo A, Tramer F, Passamonti S, Drevensek G. 2010. Acute cardioprotective and cardiotoxic effects of bilberry anthocyanins in ischemia–reperfusion injury: Beyond concentration-dependent antioxidant activity. Cardiovasc Toxicol, 10: 283-294.
33
ORIGINAL_ARTICLE
Effects of Salvia officinalis L. (common sage) leaves tea on insulin resistance, lipid profile, and oxidative stress in rats with polycystic ovary: An experimental study
Objective: Oxidative stress conditions and metabolic complications are common among polycystic ovary syndrome (PCOS) patients. There are various reports about hypoglycemic and antioxidant effects of Salvia officinalis L. (common sage). This study evaluated the possible medicinal effects of sage tea drinking on oxidative status, lipid profile, and insulin resistance in rats with testosterone-induced PCOS. Materials and Methods: Eighteen immature female Wistar rats (21-day old) were divided into 3 groups: 1) The Control group (n=6) that received no treatment. 2) The PCOS group (n=6) that received testosterone enanthate 10 mg/kg BW for 35 days subcutaneously. (3) The PCOS -sage tea group (n=6) to which after induction of PCOS by injection of testosterone enanthate, the sage tea was administered as a replacement of water for 14 days. The beverages were refreshed every day. The serum levels of total antioxidant capacity (TAC), malondialdehyde (MDA), glucose, insulin, HDL-C, total cholesterol, LDL-C, VLDL-C, total triglycerides, and atherogenic index were measured. Results: Sage tea consumption increased serum TAC and decreased serum HDL-C, glucose, total cholesterol, LDL-C, and atherogenic index levels but it did not change the levels of MDA, insulin, total triglycerides, and VLDL-C. Conclusion: Results suggested that sage tea consumption may influence the oxidative status and reduce the blood glucose and atherogenic index and may have cardiovascular protective effects in PCOS women.
https://ajp.mums.ac.ir/article_14005_99937ec4a1be92eb90eebc88b07fad75.pdf
2020-05-01
263
272
10.22038/ajp.2019.14005
Salvia officinalis L
Polycystic ovary syndrome
lipid profile
insulin resistance
Oxidative stress
Mahnaz
Ghowsi
ghowsi.mahnaz@gmail.com
1
Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran
LEAD_AUTHOR
Namdar
Yousofvand
yousofnam@yahoo.com
2
Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran
AUTHOR
Saman
Moradi
moradi.saman62@gmail.com
3
Department of Biology, Faculty of Sciences, Razi University, Kermanshah, Iran
AUTHOR
ORIGINAL_ARTICLE
Ameliorative effect of cotreatment with the methanolic leaf extract of Urtica dioica on acute kidney injury induced by gentamicin in rats
Objective: Effects of cotreatment with Urtica dioica (UD) methanolic leaf extract on gentamicin (GM)-induced acute kidney injury were evaluated in rats. Materials and Methods: Male Wistar rats (n=32) were separated into four groups. Gentamicin (100 mg/kg/day, IP) was injected for eight days with or without UD methanolic extract (200 mg/kg/day, gavage). The renal blood flow (RBF) and systolic blood pressure of rats were recorded. Concentration of creatinine, blood urea nitrogen (BUN), sodium, and potassium and osmolarity were measured in the urine and plasma samples. Oxidative stress level was determined by assessment of the levels of antioxidant power (FRAP) and lipid peroxidation (MDA) in the renal tissue. The renal injury and histopathological changes in the kidney were determined by microscopic evaluations. Results: Administration of UD extract along with GM, compared to GM group, significantly decreased the amounts of plasma creatinine and BUN, urinary sodium excretion, fractional excretion of sodium and potassium, and MDA levels but significantly increased creatinine clearance, urine osmolarity, renal blood flow and FRAP levels. Conclusion: The cotreatment of UD extract can attenuate renal injury of GM by reduction of oxidative stress, lipid peroxidation, and oxygen free radicals. The potential nephroprotective effects of UD extract are probably mediated via its antioxidant and anti-inflammatory activity.
https://ajp.mums.ac.ir/article_14048_dbb409dde13c5db5b6fb1b3fcd936260.pdf
2020-05-01
273
286
10.22038/ajp.2019.14048
Gentamicin
Cotreatment
Nephrotoxicity
Urtica dioica
Nephroprotective
Rat
Saeed
Hajihashemi
s.hajihashemi@gmail.com
1
Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
LEAD_AUTHOR
Mahboubeh
Ahmadi
mahboobeh_ahmadi7@yahoo.com
2
Department of Physiology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
AUTHOR
Ali
Chehrei
alichehrei@yahoo.com
3
Department of Pathology, Faculty of Medicine, Arak University of Medical Sciences, Arak, Iran.
AUTHOR
Fatemeh
Ghanbari
f.ghanbari@gmail.com
4
Department of Pharmacology, Islamic Azad University, Arak Branch, Arak, Iran.
AUTHOR
ORIGINAL_ARTICLE
Jujube and green tea extracts protect human fibroblast cells against UVB-mediated photo damage and MMP-2 and MMP-9 production
Objective: Oxidative stress and ultraviolet B (UVB) irradiation are known as principal inducers of DNA damage and modulators of gene expression in aging process and skin photoaging, which are associated with upregulation of matrix metalloproteinases (MMPs). Because of the antioxidant capacity of jujube and green tea, we decided to determine their protective effects of human fibroblast cells against UVB-induced photo-damage and reduction of MMP-2 and MMP-9 expression. Materials and Methods: We exposed human fibroblast cells to different doses of UVB (0-20mJ/cm2) with or without different concentrations of jujube and green tea extracts. Cell viability was assessed using MTT assay. Total antioxidant capacity and free radical scavenging activity of cell supernatant were assessed using FRAP and DPPH methods, respectively. The concentrations of MMP-2 and MMP-9 in the samples were determined by ELISA kits. Results: Fibroblast cells viability, 24 hr after UVB irradiation, reduced about 70% compared to the controls. Pre-treatment of the cells with jujube extract (8mg/ml) increased the cell viability by almost 85% while green tea (0.5mg/ml) protected the irradiated cells by 71%. Also, MMP-2 and MMP-9 content decreased in a concentration-dependent manner in the cells pre-treated with jujube and green tea extracts. Conclusion: These data suggest that jujube and green tea could be useful to attenuate solar UVB light-induced oxidative stress and skin photoaging and can be suggested as a potential candidate for the development of new anti-UVB medicines and cosmetic products.
https://ajp.mums.ac.ir/article_14078_cb2341f30e4598d951810b7835866c8a.pdf
2020-05-01
287
296
10.22038/ajp.2019.14078
UVB
Jujube
green tea
Oxidative stress
MMPs
Zahra
Abotorabi
abotorabi.zahra@yahoo.com
1
Clinical Biochemistry Department, Faculty of Medicine,Birjand University of Medical Sciences, Birjand, Iran
AUTHOR
Mohsen
Khorashadizadeh
mohsen.khorashadi@gmail.com
2
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran
AUTHOR
Mina
Arab
arab.mina70@gmail.com
3
Clinical Biochemistry Department, Faculty of Medicine,Birjand University of Medical Sciences, Birjand, Iran
AUTHOR
Mohammad
Hassanpour Fard
mhassanpour61@yahoo.com
4
Pharmacology Department, Faculty of Medicine, Birjand University of Medical Sciences, Birjand, Iran
AUTHOR
Asghar
Zarban
azarban@yahoo.com
5
Clinical Biochemistry Department, Faculty of Medicine,Birjand University of Medical Sciences, Birjand, Iran
LEAD_AUTHOR
Al- Reza SM, Bajpai VK, Kang SC. 2009. Antioxidant and anti listerial effect of seed essential oil and organic extracts from Zizyphus jujuba. Food Chem Toxicol, 47: 2374-2380.
1
Anggakusuma, Yanti A, Hwang JK. 2010. Effects of macelignan isolated from Myristica fragrans Houtt. on UVB-induce matrix metalloproteinase-9 and cyclooxygenase-2 in HaCaT cells. J Dermatol Sci, 57:114-122.
2
Azuha Y, Shi-ping C, Kazoko K, Xia J, Qian R, Tetseuo S. 2013. The involvement of Annexin II in resistance to UVB-induced cell death and in the increased nucleotide excision repair capacity of UV-damaged DNA in human cells. Biosci Biotechnol Biochem, 77: 307-311.
3
Benelli R, Vene R, Bissachi D, Garbisa S, Albini A. 2002. Anti-invasive effects of green tea polyphenol epigallocatechin-3-gallate (EGCG), a natural inhibitor of metallo and serine proteases. Biol Chem, 383: 101-105.
4
Benzie I, Strain J. 1996. The ferric reducing ability of plasma (FRAP) as a measure of ‘‘Antioxidant power’’: The FRAP assay. Anal Biochem, 39: 70-76.
5
Brown MD. 1999. Green tea (Camellia sinensis) extract and its possible role in the prevention of cancer. Altern Med Rev, 4: 360-370.
6
Duan X, Wo T, Liu T, Yang H, Ding X, Chen Y, Mu Y. 2019. Vicenin-2 ameliorates oxidative damage and photoaging via modulation of MAPKs and MMPs signaling in UVB radiation exposed human skin cells. J Photochem Photobiol B, 190: 76-85.
7
Farajdokht F, Amani M, Mirzaei F, Hemmati A, Mohaddes G, Babri S. 2017. Troxerutin protects hippocampal neurons against amyloidbeta-induced oxidative stress and apoptosis. EXCLI J, 16: 1081-1089.
8
Hemmati M, Zohoori E, Mehrpour O, Karamian M, Asghari S, Zarban A, Nasouti R. 2015. Anti-atherogenic potential of jujube, saffron and barberry: Anti-diabetic and antioxidant actions. EXCLI J, 14: 908-915.
9
Hibbert S, Watson R, Griffiths C, Gibbs N, Sherratt M. 2019. Selective proteolysis by matrix metalloproteinases of photo-oxidised dermal extracellular matrix proteins. Cell Signal, 54:191-199
10
Hoshyar R, Jamali S, Fereidouni M, Abedini MA. 2015. The cytotoxic activity of Ziziphus Jujube on cervical cancer cells: In Vitro study. Cell Mol Biol (Noisy-le-grand), 61: 128-130.
11
Kim M, Lee H, Choi H. 2014. Protective effects of ginseng leaf extract using enzymatic extraction against oxidative damage of UVA-irradiated human keratinocytes. Appl Biochem Biotechnol, 173: 933-945.
12
Li J, Fang L, Ding S, Ding X. 2007. Nutritional composition of five cultivars of Chinese jujube. Food Chem, 103:454-460.
13
Magalhaes A, Silva BM, Pereira JA, Andrade PB, Valentao P, Carvalho M. 2009. Protective effect of quince fruit against oxidative hemolysis of human erythrocytes. Food Chem Toxicol, 47: 1372-1377.
14
Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods, 65: 55-63.
15
Naponelli V, Ramazzina L, Lenzi C. 2017. Green tea catechins for prostate cancer prevention: Present achievements and future challenges. Antioxidants (Basel), 5:6.
16
Nichols JA, Katiyar SK. 2010. Skin photoprotection by natural polyphenols: Anti-inflammatory, anti-oxidant and DNA repair mechanisms. Arch Dermatol Res, 302:71-83.
17
Plastina P, Bonofiglio D, Vizza D, Fazio A, Rovito D, Giordano C, Barone I, Catalano S, Gabriele B. 2012. Identification of bioactive constituents of Ziziphus jujube fruit extracts exerting antiproliferative and apoptotic effects in human breast cancer cells. J Ethnopharmacol, 140: 325-332.
18
Salucci S, Burattini S, Buontempo F, Martelli AM, Falcieri E, Battistelli M. 2017. Protective effect of different antioxidant agents in UVB-irradiated keratinocytes. Eur J Histochem, 18: 215-221.
19
San B, Yildirim A. 2010. Phenolic, alpha-tocopherol, beta-carotene and fatty acid composition of four promising jujube (Ziziphus jujube Miller) selections. J Food Compos Anal, 23: 706-710.
20
Synowiec E, Hoser G, Wojcik K. 2015. UV differentially induces oxidative stress, DNA damage and apoptosis in BCR-ABL1-positive cells sensitive and resistant to imatinib. Int J Mol Sci, 16:18111-18128.
21
Vahedi F, Fathi M, Bozar K. 2008. Evaluation of inhibitory effect and apoptosis induction of Zyzyphus Jujube on tumor cell lines, an in vitro preliminary study. Cytotechnology, 56: 105-111.
22
Vayalil P, Mittal A, Hara Y. 2004. Green tea polyphenols prevent ultraviolet light-induced oxidative damage and matrix metalloproteinases expression in mouse skin. Invest Dermatol, 122: 1480-1487.
23
Williamson G, Coppens B, Serra-Majem L, Dew T. 2011. Review of the efficacy of green tea, isoflavones and aloe vera supplements based on randomised controlled trials. Food Funct, 2: 753-759.
24
Yamagishi S, Matsui T, Nakamura k. 2008. Blockade of the advanced glycation end products (AGEs) and their receptor (RAGE) system is a possible mechanism for sustained beneficial effects of multifactorial intervention on mortality in type 2 diabetes. Med Hypotheses, 71: 749-751.
25
Zaid MA, Afaq F, Syed DN, Dreher M. 2007. Inhibition of UVB-mediated oxidative stress and markers of photoaging in immortalized HaCaT keratinocytes by pomegranate polyphenol extract POMx. Photochem Photobiol, 83: 882-888.
26
Zegarska B, Pietkun K, Zigareski W. 2016. Air pollution, UV irradiation and skin carcinogenesis: what we know, where we stand and what is likely to happen in the future? Adv Dermatol Allergol, 1: 6-14.
27
ORIGINAL_ARTICLE
Effects of Valeriana officinalis (Valerian) on tension-type headache: A randomized, placebo-controlled, double-blind clinical trial
Objective: Tension-type headache is the most frequent type of headache. Considering the effectiveness of Valeriana officinalis (Valerian) in treatment of some types of headache, the effect of valerian root was studied in patients with tension-type headache. Materials and Methods: The current study is a double-blind randomized clinical trial that was conducted in Shams Hospital of Mashhad University of Medical Sciences, Mashhad, Iran, from January to June 2018. We included 88 participants with tension-type headache and randomly assigned them to intervention and control group by block randomization in a 1:1 ratio. The intervention group received Sedamin® capsule (530 mg of valerian root extraction) while the placebo group received 500 mg of breadcrumbs both given as two capsules daily for a month -after dinner. The headache impact on activity of daily livings performance, headache disability, and headache severity were measured using questionnaires in baseline and one month after intervention in both groups. Results: The average age (±SD) of the participants was 34.9 (±8.7) years old. After one month, the impact of headache on daily livings performance, significantly reduced in intervention group (mean=51.2) versus the placebo (mean=57.0), (p<0.001). There was a significant reduction in disability in intervention group (mean=22.9) compared to the placebo (mean=27.4) (p<0.001) and the severity score showed significant reductions in intervention group (mean=3.5) versus the placebo group (mean=5.1) (p<0.001). Conclusion: The present trial showed that valerian capsule could reduce the headache impact on daily livings performance, disability and severity of tension-type headache.
https://ajp.mums.ac.ir/article_14211_735c60fd2028170d8368abd16f8ca37c.pdf
2020-05-01
297
304
10.22038/ajp.2019.14211
Tension-type headache
Valeriana Officinalis
Persian Medicine
Clinical trial
Hossein
Azizi
azizitarin@gmail.com
1
Research Institute for Islamic and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
AUTHOR
Asie
Shojaii
pasban.s@gmu.ac.ir
2
Research Institute for Islamic and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
AUTHOR
Fataneh
Hashem-Dabaghian
asa_ys1990@yahoo.com
3
Research Institute for Islamic and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
AUTHOR
Mohammadreza
Noras
s_yas190@yahoo.com
4
Faculty of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Amirreza
Boroumand
s_yas@yahoo.com
5
Department of Neurology, Shams Hospital, Mashhad, Iran
AUTHOR
Bita
Ebadolahzadeh Haghani
asa_yas1990@yahoo.com
6
Faculty of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Roshanak
Ghods
pasban_saeid@yahoo.com
7
Research Institute for Islamic and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
Carlini EA. 2003. Plants and the central nervous system. Pharmacol Biochem Behav, 75: 501-512.
1
Cheshti MA. 2007. Exir-e Azam,Soda. pp.58-62, Tehran, Iran Univ of Med Sci, Institute for Islamic and Complement Med.
2
Eskandari Z, Mirzaei B, Arazi H. 2017. The effect of eight weeks of aerobic training and complementary plant supplements (Indian Valerian and Melissa Officinalis) on migraine. Armaghane Danesh, 22: 442-458.
3
Hazelhoff B, Malingré TM, Meijer DK. 1982. Antispasmodic effects of valeriana compounds: An in-vivo and in-vitro study on the guinea-pig ileum. Arch Int Pharmacodyn Ther, 257: 274-287.
4
Houghton PJ. 1999. The scientific basis for the reputed activity of Valerian. J Pharm Pharmacol, 51: 505-512.
5
Jacobs BP, Bent S, Tice JA, Blackwell T, Cummings SR. 2005. An internet-based randomized, placebo-controlled trial of kava and valerian for anxiety and insomnia. Medicine, 84: 197-207.
6
Miguel H, Feistel B, Hartwig S, Romanus L, Mirjam H, Hilke W. 2008. Extracts of Valeriana officinalis L. S.L. show anxiolytic and antidepressant effects but neither sedative nor myorelaxant properties. Phytomedicine, 15: 2-15.
7
Mirabi P, Dolatian M, Mojab F, Majd HA. 2011. Effects of valerian on the severity and systemic manifestations of dysmenorrhea. Int J Gynaecol Obstet, 115 : 285-288.
8
Mirzaee MG, Kheiri S, Bahrami M. 2015. Effect of valerian capsules in patients with migraine attacks treated with sodium valproate: a randomized clinical trial. J Shahrekord Univ of Med Sci, 16: 119-126.
9
Morazzoni P, Bombardelli E. 1995. Valeriana officinalis: Traditional use and recent evaluation of activity. Fitoterapia, 66: 99-112.
10
Murakami N, Ye Y, Kawanishi M, Aoki S, Kudo N, Yoshida M, Nakayama EE, Shioda T, Kobayashi M. 2002. New rev-transport inhibitor with anti-HIV activity from Valerianae Radix. Bioorg Med Chem Lett, 12: 2807-2810.
11
Nunes A, Sousa M. 2011. Use of valerian in anxiety and sleep disorders: what is the best evidence? Acta medica portuguesa, 24: 961-966.
12
Pilerood SA, Prakash J. 2013. Nutritional and medicinal properties of valerian (Valeriana officinalis) herb: A review. Int J Food Sci Nutr Diet, 1: 25-33.
13
Sarris J, Panossian A, Schweitzer I, Stough C, Scholey A. 2011. Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. Eur Neuropsychopharmacol, 21: 841-860.
14
Taavoni S, Ekbatani N, Haghani H. 2012. Effect of Sedamin capsule on sleep disorder among menopausal women. J Gorgan Univ of Med Sci, 14: 39-45.
15
Taavoni S, Ekbatani N, Kashaniyan M, Haghani H. 2011. Effect of valerian on sleep quality in postmenopausal women: a randomized placebo-controlled clinical trial. Menopause, 18: 951-955.
16
McCabe S. 2002. Complementary herbal and alternative drugs in clinical practice. Perspect Psychiatr Care, 38: 98-107.
17
Balaban H, Senturk IA, Kavakci O, Cinar Z, Dikici A, et al. 2012. Migraine prevalence, alexithymia, and post-traumatic stress disorder among medical students in Turkey. J Headache Pain, 13: 459-467.
18
Becker H, Chavadej S. 1985. Valepotriate production of normal and colchicine-treated cell suspension cultures of Valeriana wallichii. J Nat Prod, 48: 17-21.
19
Bjorner JB, Kosinski M, Ware JE Jr. 2003. Calibration of an item pool for assessing the burden of headaches: An application of item response theory to the Headache Impact Test (HIT™). Qual Life Res, 12: 913-933.
20
Carlsson AM. 1983. Assessment of chronic pain. I. Aspects of the reliability and validity of the visual analogue scale. Pain, 16: 87-101.
21
Evans RW EJ, MN. 2000. Rosenthal RC Handbook of Headache. Philadelphia: Lipphncott Willams and Wilkins, 80-81.
22
Ghorbanifar Z, Delavar Kasmaei H, Minaei B, Rezaeizadeh H, Zayeri F. 2014. Types of nasal delivery drugs and medications in Iranian traditional medicine to treatment of headache. Iran Red Crescent Med J, 16: e15935.
23
Isetts BJ. 2007. Valerian. Herbal Products, Springer: pp. 55-70.
24
Jacobson GP, Ramadan NM, Aggarwal SK, Newman CW. 1994. The Henry Ford hospital headache disability inventory (HDI). Neurology, 44: 837-843.
25
Jacobson GP, Ramadan NM, Norris L, Newman CW. 1995. Headache disability inventory (HDI): Short‐term test‐retest reliability and spouse perceptions. Headache. J of Head and Face Pain, 35: 534-539.
26
Jia JN, Zhang BH. 1999. Effect of valerian extract (V3d) on cardiovascular system [J]. J Guangxi Coll Tradit Chin Med, 16: 40-42.
27
Kasper DL FA, HS, Lango DL, Jameson JL, Lascalzo J. 2016. Harrisons principles of internal medicine. migrain and other Primary Headache disorders, Ebook convertion by CodeMantra.Version 1. 19th Edition. 17: 2593-2594.
28
Kosinski M, Bayliss MS, Bjorner JB, Ware JE Jr, Garber WH, Batenhorst A, Cady R, Dahlöf CG, Dowson A, Tepper S. 2003. A six-item short-form survey for measuring headache impact: The HIT-6. Qual Life Res, 12: 963-974.
29
Nachit-Ouinekh F, Dartigues JF, Henry P, Becg JP, Chastan G, Lemaire N, El Hasnaoui A. 2005. Use of the headache impact test (HIT‐6) in general practice: relationship with quality of life and severity. Eur J Neurol, 12: 189-193.
30
Jugran AK, Rawat S, Bhatt ID, Rawal RS. 2018. Valeriana Officinalis: a review of its traditional uses, phytochemistry and pharmacology. Asian J Pharma Clin Res, 11: 36-41.
31
Nazari F, Safavi M, Mahmudi M. 2010. Migraine and its relation with lifestyle in women. Pain Pract. 10: 228-234.
32
Olesen J. 2018. International classification of headache disorders. Lancet Neurol, 17: 396-397.
33
Organization WH. 2000. General guidelines for methodologies on research and evaluation of traditional medicine, Geneva: World Health Organization.
34
Oshima Y, Matsuoka S, Ohizumi Y. 1995. Antidepressant principles of Valeriana fauriei roots. Chem Pharm Bull (Tokyo), 43: 169-174.
35
Sajadinezhad M, Mohammadi N, Ashjazadeh N. 2007. The evaluation of psychometric properties of headache disability inventory in the headache patients. J Shahrekord Univ of Med Sci, 9: 55-62.
36
Zandifar A, Banihashemi M, Haghdoost F, Masjedi SS, Manouchehri N, Asgari F, Najafi MR, Ghorbani A, Zandifar S, Saadatnia M, White MK. 2014. Reliability and validity of the Persian HIT‐6 questionnaire in migraine and tension‐type headache. Pain Pract, 14: 625-631.
37
ORIGINAL_ARTICLE
Effects of conjugated linoleic acid supplementation on serum levels of interleukin-6 and sirtuin 1 in COPD patients
Objective: Chronic obstructive pulmonary disease (COPD) is characterized by systemic inflammation and accelerated inflammaging of the lungs. Some studies showed that conjugated linoleic acid (CLA) has anti-inflammatory effects. The aim of the present study was to evaluate the effect of CLA supplementationon serum levels of interleukin (IL)-6 and sirtuin1 (SIRT1) in patients with COPD. Materials and Methods: 82 patients with stable COPD were enrolled in a double blind clinical trial. Subjects were randomly assigned to two groups: placebo (n=42) and 3.2 g CLA daily supplementation (n=40). Forced expiratory volume in one second (FEV1%), BODE index, and serum levels of IL-6, and SIRT1 were measured at the baseline and six weeks after the intervention. In addition, the study parameters in the two groups were compared based on the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria. Results: After supplementation with CLA, serum levels of IL-6 and BODE index significantly decreased (p Conclusion: Supplementation with CLA can modify the inflammatory markers and improve the health status of COPD patients. The results suggest that CLA supplementation in COPD patients can be useful in the management of the disease.
https://ajp.mums.ac.ir/article_14385_3d2ec186b65dc0561d1c74bf9783875b.pdf
2020-05-01
305
315
10.22038/ajp.2019.42689.2426
Conjugated linoleic acid
COPD
Sirtuin 1
IL-6
BODE index
Mohammad Reza
Aslani
mraslani105@yahoo.com
1
Lung Inflammatory Diseases Research Center, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
AUTHOR
Somaieh
Matin
smh.matin@yahoo.com
2
Internal Medicine Department, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
AUTHOR
Ali
Nemati
ali.nemati@arums.ac.ir
3
Biochemistry and Nutrition Department, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
AUTHOR
Mehran
Mesgari Abbasi
mesgarim@tbzmed.ac.ir
4
Drug Applied Research Center, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
AUTHOR
Saeid
Ghorbani
saeidghorbany1993@gmail.com
5
Medical student, Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
AUTHOR
Hassan
Ghobadi
h.ghobadi@arums.ac.ir
6
Internal Medicine Department (Pulmonary Division), Faculty of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
LEAD_AUTHOR
ORIGINAL_ARTICLE
Nephroprotective activity of virgin coconut oil on diclofenac-induced oxidative nephrotoxicity is associated with antioxidant and anti-inflammatory effects in rats
Objective: Diclofenac is a non-steroidal anti-inflammatory drug linked with considerable organ toxicity caused via increased generation of reactive oxygen species. We evaluated whether the antioxidant effect of virgin coconut oil (VCO) could prevent diclofenac-induced oxidative nephrotoxicity in rats. Materials and Methods: Randomized rats were pre-supplemented orally with VCO (5 or 10 ml/kg body weight) from day 1 to 24, and injected with normal saline or diclofenac (100 mg/kg) from day 22 to day 24 intraperitoneally. Results: Diclofenac significantly (p<0.05) increased serum urea and creatinine levels. Renal tumor necrosis factor-α (TNF-α) and malondialdehyde (MDA) levels markedly (p<0.05) increased, whereas renal glutathione peroxidase (GPx), catalase (CAT), and superoxide dismutase (SOD) activities considerably (p<0.05) decreased compared to normal control. Histopathological alterations were caused by diclofenac. However, treatment with oral VCO for 21 days prior to diclofenac administration, attenuated histological renal damage, and restored antioxidant enzyme activities and TNF-α levels in kidney. Conclusion: These findings revealed that VCO has potential benefits to prevent diclofenac-induced nephrotoxic damage.
https://ajp.mums.ac.ir/article_14263_847fc6c2a86bfcfdf9f68edb63483f5b.pdf
2020-05-01
316
324
10.22038/ajp.2019.14263
Diclofenac
virgin coconut oil
Nephrotoxicity
Antioxidants
Oxidative stress
Ademola
Famurewa
ademola.famurewa@funai.edu.ng
1
Department of Medical Biochemistry, Faculty of Basic Medical Sciences, Alex-Ekwueme Federal University, Ndufu-Alike, Ikwo, Ebonyi State.
LEAD_AUTHOR
Gabriel
Akunna
ggakunna@gmail.com
2
Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, Afe Babalola University, Ado-Ekiti, Ekiti State, Nigeria
AUTHOR
Joseph
Nwafor
jnwafor@gmail.com
3
Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, Alex-Ekwueme Federal University, Ndufu-Alike, Ikwo, Ebonyi State, Nigeria.
AUTHOR
Onyebuchi
Chukwu
ochukwu@gmail.com
4
Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, Alex-Ekwueme Federal University, Ndufu-Alike, Ikwo, Ebonyi State, Nigeria.
AUTHOR
Chima
Ekeleme-Egedigwe
chimaeges@gmail.com
5
Department of Biochemistry, Faculty of Science, Alex-Ekwueme Federal University, Ndufu-Alike, Ikwo, Ebonyi State, Nigeria.
AUTHOR
Janet
Oluniran
janetodogwu@yahoo.com
6
Ministry of Agriculture and Rural Development, Ebonyi State Agricultural Development Programme, Abakaliki, Nigeria
AUTHOR