ORIGINAL_ARTICLE
The effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina: A randomized clinical trial
Objective: Inflammation along with oxidative stress has an important role in the pathophysiology of unstable angina which leads to acute myocardial infarction, arrhythmias and eventually heart failure. Curcumin has anti-inflammatory and anti-oxidant effects and thereby, it may reduce cardiovascular complications. This randomized controlled trial aimed to investigate the effects of curcumin on the prevention of atrial and ventricular arrhythmias and heart failure in patients with unstable angina. Materials and Methods: Forty patients with unstable angina who met the trial inclusion and exclusion criteria, participated in this double-blind randomized clinical trial. The patients were randomized into two groups: curcumin (80 mg/day for 5days) and placebo (80 mg/day for 5days). Cardiac function was evaluated by two-dimensional echocardiography devices at baseline (immediately after hospitalization) and 5 days after the onset of the trial. Atrial and ventricular arrhythmias were recorded by Holter monitors in cardiology ward, Ghaem academic hospital, Mashhad, Iran. Progression to heart failure, myocardial infarction, and pulmonary and cardiopulmonary resuscitation events as well as mortality were recorded daily throughout the study. Results: There were no significant differences between the two groups in atrial and ventricular arrhythmias (p=0.2), and other echocardiographic parameters (Ejection fraction, E, A, E/A ratio, Em, and pulmonary artery pressure) at baseline and five days after the start of the trial. Conclusion: Nanocurcumin administered at the dose of 80 mg/day for five days had no effect in the incidence of cardiovascular complications in patients with unstable angina.
https://ajp.mums.ac.ir/article_11294_dda1933a184a00daf6e141311110625f.pdf
2019-01-01
1
9
10.22038/ajp.2018.11294
Angina
Unstable
Arrhythmias
Cardiac
Curcumin
heart failure
Acute coronary syndrome
Mostafa
Dastani
dastanim@mums.ac.ir
1
Department of cardiology, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
leila
Bigdelu
bigdelul@mums.ac.ir
2
Cardiovascular Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
mahsa
hoseinzadeh
hoseinzadehm@mums.ac.ir
3
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Hamid Reza
Rahimi
rahimihr@mums.ac.ir
4
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Asieh
Karimani
karimania921@mums.ac.ir
5
Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Amir Houshang
Mohammadpour
mohamadpoorah@mums.ac.ir
6
Department of Clinical Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Masoumeh
Salari
salarim@mums.ac.ir
7
Department of Internal Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Abe Y, Hashimoto S, Horie T. 1999. Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacol Res, 39:41-47
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Shishodia S, Singh T, Chaturvedi MM. 2007. Modulation of transcription factors by curcumin the molecular targets and therapeutic uses of curcumin in health and disease. Springer, p 127-148
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35
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36
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37
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38
ORIGINAL_ARTICLE
Effects of L-citrulline supplementation on blood pressure: A systematic review and meta-analysis
Objective: We aimed to conduct a systematic review and meta-analysis of clinical trials that examined the effects of L-citrulline supplementation on blood pressure (BP). Materials and Methods: We searched MEDLINE, SCOPUS, PUBMED and Google scholar databases from inception to November 16, 2017 and 811 papers were identified, of which 8 trials with 10 data sets met the inclusion criteria. Inclusion criteria were: (1) application of randomized clinical trial with either crossover or parallel designs; (2) studies conducted in adults (≥18 y); (3) oral supplementation with L-citrulline compared to control group; (4) expression of sufficient data about systolic and diastolic BP at baseline and at the end of the study in each group. BP effects were pooled by random-effects models, with trials weighted by inverse variance. Results: The included studies’ sample size ranged between 12 and 34 subjects. The mean age of the participants in these trials ranged between 22 and 71 years. Dosage of L-citrulline supplementation varied from 3 to 9 g/day. Duration of the intervention ranged between 1 and 17 weeks. The pooled changes in systolic and diastolic BP were (MD, −4.10 mm Hg; 95% CI [−7.94, -0.26]; p=0.037) and (MD −2.08 mm Hg; 95% CI [−4.32, 0.16]; P=0.069), respectively. The subgroup analysis showed a significant diastolic BP reduction in studies that used doses of ≥6 g/day (MD −2.75 mm Hg; 95% CI [−5.37, -0.12]; p=0.04). Conclusion: Our results suggest that L-citrulline supplementation may reduce systolic BP. A significant reduction in diastolic BP was observed only in the studies that used doses ≥ 6 g/day.
https://ajp.mums.ac.ir/article_11590_723fa90bf77f15de567149bdfcf1fa3b.pdf
2019-01-01
10
20
10.22038/ajp.2018.11590
L-citrulline
blood pressure
Supplementation
Bahareh
Barkhidarian
bahar.darian@gmail.com
1
Department of Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Masoud
Khorshidi
bakhshandehhoo@gmail.com
2
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
AUTHOR
Sakineh
Shab-bidar
s.shabbidar@yahoo.com
3
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran
LEAD_AUTHOR
Baran
Hashemi
baran.hashemi@gmail.com
4
Rajaie Cardiovascular Medical and Research Center, Iran University of Medical Sciences, Tehran, Iran.
AUTHOR
Bailey SJ, Blackwell JR, Lord T, Vanhatalo A, Winyard PG, Jones AM. 2015. L-citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans. J Appl Physiol, 119: 385-395.
1
Balderas-Munoz K, Castillo-Martínez L, Orea-Tejeda A, Infante-Vázquez O, Utrera-Lagunas M, Martínez-Memije R, Keirns-Davis C, Becerra-Luna B, Sánchez-Vidal G. 2012. Improvement of ventricular function in systolic heart failure patients with oral L-citrulline supplementation. Cardiol J, 19: 612-617.
2
Breuillard C, Cynober L, Moinard C. 2015. Citrulline and nitrogen homeostasis: an overview. Amino Acids, 47: 685-691.
3
Chowdhary S, Nuttall SL, Coote JH, Townend JN. 2002. L-arginine augments cardiac vagal control in healthy human subjects. Hypertension, 39: 51-56.
4
Curis E, Nicolis I, Moinard C, Osowska S, Zerrouk N, Bénazeth S, Cynober L. 2005. Almost all about citrulline in mammals. Amino Acids, 29: 177.
5
Figueroa A, Alvarez-Alvarado S, Jaime SJ, Kalfon R. 2016. L-Citrulline supplementation attenuates blood pressure, wave reflection and arterial stiffness responses to metaboreflex and cold stress in overweight men. Br J Nutr, 116: 279-285.
6
Figueroa A, Alvarez-Alvarado S, Ormsbee MJ, Madzima TA, Campbell JC, Wong A. 2015. Impact of L-citrulline supplementation and whole-body vibration training on arterial stiffness and leg muscle function in obese postmenopausal women with high blood pressure. Exp Gerontol, 63: 35-40.
7
Figueroa A, Sanchez-Gonzalez MA, Wong A, Arjmandi BH. 2012. Watermelon extract supplementation reduces ankle blood pressure and carotid augmentation index in obese adults with prehypertension or hypertension. Am J Hypertens, 25: 640-643.
8
Figueroa A, Trivino JA, Sanchez-Gonzalez MA, Vicil F. 2010. Oral L-citrulline supplementation attenuates blood pressure response to cold pressor test in young men. Am J Hypertens, 23: 12-16.
9
Gamboa A, Figueroa R, Paranjape SY, Farley G, Diedrich A, Biaggioni I. 2016. Autonomic blockade reverses endothelial dysfunction in obesity-associated hypertension. Hypertension, 116: 07681.
10
Gonzales JU, Raymond A, Ashley J, Kim Y. 2017. Does l‐citrulline supplementation improve exercise blood flow in older adults? Exp Physiol, 102: 1661-1671.
11
Hart EC, Joyner MJ, Wallin BG, Johnson CP, Curry TB, Eisenach JH, Charkoudian N. 2009. Age-related differences in the sympathetic-hemodynamic balance in men. Hypertension, 54: 127-133.
12
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13
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Moinard C, Maccario J, Walrand S, Lasserre V, Marc J, Boirie Y, Cynober L. 2016. Arginine behaviour after arginine or citrulline administration in older subjects. Br J Nutr, 115: 399-404.
15
Mori A, Morita M, Morishita K, Sakamoto K, Nakahara T, Ishii K. 2015. L-Citrulline dilates rat retinal arterioles via nitric oxide-and prostaglandin-dependent pathways in vivo. J Pharmacol Sci, 127: 419-423.
16
Morita M, Hayashi T, Ochiai M, Maeda M, Yamaguchi T, Ina K, Kuzuya M. 2014. Oral supplementation with a combination of L-citrulline and L-arginine rapidly increases plasma L-arginine concentration and enhances NO bioavailability. Biochem Biophys Res Commun, 454: 53-57.
17
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18
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19
Organization W. H. 2008. Causes Of Death. 2008 [Online Database]. Geneva: World Health Organization.
20
Organization W. H. 2013. A global brief on hypertension: silent killer, global public health crisis: World Health Day 2013.
21
Orozco-Gutiérrez JJ, Castillo-Martínez L, Orea-Tejeda A, Vázquez-Díaz O, Valdespino-Trejo A, Narváez-David R, Keirns-Davis C, Carrasco-Ortiz O, Navarro-Navarro A, Sánchez-Santillán R. 2010. Effect of L-arginine or L-citrulline oral supplementation on blood pressure and right ventricular function in heart failure patients with preserved ejection fraction.Cardiol J, 17: 612-618.
22
Raghavan, SA, Dikshit M. 2001. L-citrulline mediated relaxation in the control and lipopolysaccharide-treated rat aortic rings.
23
Eur J Pharmacol, 431: 61-69.
24
Sanchez-Gonzalez MA, Koutnik AP, Ramirez K, Wong A, Figueroa A. 2012. The effects of short term L-citrulline supplementation on wave reflection responses to cold exposure with concurrent isometric exercise. Am J Hypertens, 26:518-526.
25
Schwedhelm E, Maas R, Freese R, Jung D, Lukacs Z, Jambrecina A, Spickler W, Schulze F, Böger RH. 2008. Pharmacokinetic and pharmacodynamic properties of oral L‐citrulline and L‐arginine: impact on nitric oxide metabolism. Br J Clin Pharmacol, 65: 51-59.
26
TainYL, Hsieh CS, Lin IC, Chen CC, Sheen JM, Huang, LT. 2010. Effects of maternal L-citrulline supplementation on renal function and blood pressure in offspring exposed to maternal caloric restriction: the impact of nitric oxide pathway. Nitric Oxide, 23: 34-41.
27
Tipton M. 1989. The initial responses to cold-water immersion in man. Clin Sci, 77:581-588.
28
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29
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30
Wong A, Alvarez-Alvarado S, Jaime SJ, Kinsey AW, Spicer MT, Madzima TA, Figueroa A. 2015. Combined whole-body vibration training and L-citrulline supplementation improves pressure wave reflection in obese postmenopausal women. Appl Physiol Nutr Metab, 41: 292-297.
31
Wong A, Chernykh O, Figueroa A. 2016. Chronic l-citrulline supplementation improves cardiac sympathovagal balance in obese postmenopausal women: A preliminary report. Auton Neurosci, 198: 50-53.
32
Wu Y, Zhang Q, Ren Y, Ruan Z. 2017. Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials. PloS one, 12: e0178868.
33
ORIGINAL_ARTICLE
Histomorphological effects of the oil extract of Sphenocentrum jollyanum seed on benign prostatic hyperplasia induced by exogenous testosterone and estradiol in adult Wistar rats
benefits due to its very potent anti-inflammatory and antioxidant properties. Despite its widespread use, it has not been validated for use in the treatment of benign prostatic hyperplasia (BPH). This study was conducted to examine histomorphological effects of SJ seed on BPH that usually causes bladder outlet obstruction.
Materials and Methods: There were a total of six groups of animals each comprising 5 adult male rats. Apart from group 1 (normal control), in the remaining five groups, BPH was induced. Group 2 (negative control) was sacrificed immediately after BPH induction; groups 3 and 4 received the extract at 300 and 600 mg/kg respectively by gavages for thirty days; group 5 received finasteride (0.1 mg/kg) for thirty days and group 6 received the extract (600 mg/kg) simultaneously with the steroid administration for thirty days. The animals’ were weighed before the experiment and subsequently every three days until the end of the study.
Results: The extract caused marked decrease in prostate weight of rats with BPH with histo-morphology of the tissue showing degenerated stromal and epithelial cells with few epithelial involutions of glandular tissue. Prostate specific antigen (PSA) level as well as testosterone level significantly (p<0.05) decreased in the treated groups compared to negative control. BPH animals treated with extract/finasteride exhibited remarkable increases in anti-oxidant enzymes level with concurrent decreases in peroxidative activity.
Conclusion: SJ effectively ameliorated prostatic hyperplasia in BPH animals causing marked degenerative changes in prostate stromal and epithelial cells and also exhibited marked anti-oxidant effect.
https://ajp.mums.ac.ir/article_11100_9561e8c3eec6e68e853d822ebfddba46.pdf
2019-01-01
21
33
10.22038/ajp.2018.24039.1882
Histomorphology
Sphenocentrum jollyanum seed
Phytotherapy
Benign prostatic hyperplasia
male rats
Godwin
Mbaka
mbaakagm@yahoo.com
1
Department of Anatomy, Faculty of Basic Medical Sciences, Lagos State University College of Medicine, Ikeja, Lagos, Nigeria
LEAD_AUTHOR
Steve
Ogbonnia
steve_ogbonnia@yahoo.com
2
Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, Idi-Araba, Lagos, Nigeria
AUTHOR
Adeola
Sulaiman
caringadeola@yahoo.co.uk
3
Department of Anatomy, Olabisi Onabanjo University, Remo Campus, Ogun State, Nigeria
AUTHOR
Daniel
Osiagwu
dosiagwu@unilag.edu.ng
4
Department of Anatomic and Molecular Pathology, College of Medicine of the University of Lagos, Nigeria
AUTHOR
Afriyie DK, Asare GA, Bugyei K, Adjei S, Lin J, Peng J, Hong Z. 2014. Treatment of benign prostatic hyperplasia with Croton membranaceus in an experimental animal model. J Ethnopharmacol, 157: 90–98. http://dx.org/10.1016/j.jep.2014.09.007.
1
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2
Aryal M, Pandeya A, Gautam N, Baral N, Lamsal M. 2007. Stress in benign prostatic hyperplasia. NapalColl J, 9: 222-224.
3
Aydin A, Arsova-Sarafinovska Z, Sayal A, Eken A, Erdem O, Erten K, Ozök Y, Dimovski A. 2006. Oxidative stress and antioxidant status in non-metastatic prostate cancer and benign prostatic hyperplasia. ClinBiochem, 39: 176-179.
4
Bhargava S, Canda AE, Chapple CR. 2004. A rational approach to benign prostate hyperplasia evaluation: recent advance. CurrOpinUrol, 14: 1–6.
5
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7
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12
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17
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18
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19
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42
ORIGINAL_ARTICLE
Modulation of in vitro proliferation and cytokine secretion of human lymphocytes by Mentha longifolia extracts
Objective: Mentha longifolia L. Hudson has been used in folk medicine for various purposes especially for its anti-inflammatory effects. Lymphocytes play a central role in development of inflammation. In the present study, we investigated the immunomodulatory effects of different extracts of M. longifolia on human peripheral blood lymphocytes (PBLs), as main players in development of inflammation. Materials and Methods: PBLs stimulated with phytohemagglutinin (PHA) were cultured in the presence of the plant extracts. The effects of the extracts on activation of cells were determined by BrdU assay. The viability of cells was examined by flow cytometry using propidium iodide staining. Also, IFN-γ (T helper 1, TH1) and IL-4 (TH2) secretion was measured by ELISA. Results: Except for the water extract which had a weak inhibitory effect, treatment of cells with more than 1μg/ml of butanol, hexane, ethyl acetate and dichloromethane extracts resulted in strong inhibition of cells proliferation (IC50 4.6-9.9 µg/ml). Flow cytometry analysis showed that these extracts at ≤10μg/ml were non-cytotoxic. Dichloromethane and ethyl acetate extracts at 10 μg/ml decreased IFN-γ production in a dose-dependent manner from 919±91.1 pg/ml in PHA-only-treated cells to 568±22.6 pg/ml (in dichloromethane-treated cells) and 329±12.3 pg/ml (in ethyl acetate-treated cells) (p<0.001). At 10 μg/ml, the ethyl acetate extract increased IL-4 secretion compared to PHA-only-treated cells (p<0.05). The hexane extract decreased IFN-γ level but did not affectIL-4 production. Conclusion: Reduction of IFN-γ and augmentation of IL-4 secretion induced by the extracts suggested the potential of M. longifolia to inhibit TH1 inflammatory responses toward a TH2 dominant response.
https://ajp.mums.ac.ir/article_11541_e8d512d1abfb559a31a2f99aa5c961e6.pdf
2019-01-01
34
43
10.22038/ajp.2018.11541
Mentha longifolia
Lymphocytes
Immunomodulation
Yahya
Asemani
yaahyaa.assemani@yahoo.com
1
Immunology Department, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Maryam
Bayat
maryambayat2@yahoo.com
2
Department of Immunology, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Saeed
Malek-Hosseini
immunolog2@sums.ac.ir
3
Immunology Department, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Zahra
Amirghofran
amirghz@sums.ac.ir
4
Autoimmune Diseases Research Center, and Medicinal and Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Amirghofran Z, Ahmadi H, Karimi MH, Kalantar F, Gholijani N, Malek-Hosseini Z. 2016.In vitro inhibitory effects of thymol and carvacrol on dendritic cell activation and function. Pharm Biol, 54:1125-1132.
1
Amirghofran Z, Bahmani M, Azadmehr A, Javidnia K, Miri R. 2009. Immunomodulatory activities of various medicinal plant extracts: effects on human lymphocytes apoptosis. Immunol Invest, 38:181-192.
2
Amirghofran Z, Bahmani M, Azadmehr A, Javidnia K, Ramazani M, Ziaei A. 2010. Effect of Salvia mirzayanii on the immune system and induction of apoptosis in peripheral blood lymphocytes. Nat Prod Res, 24:500-508.
3
Amirghofran Z, Hashemzadeh R, Javidnia K, Golmoghaddam H, Esmaeilbeig A. 2011a. In vitro immunomodulatory effects of extracts from three plants of the Labiatae family and isolation of the active compound(s). J Immunotoxicol, 8:265–273.
4
Amirghofran Z, Malek-Hosseini S, Gholmoghaddam H, Kalalinia F. 2011b. Inhibition of tumor cells growth and stimulation of lymphocytes by Euphorbia species. Immunopharmacol Immunotoxicol, 33:34-42
5
Amirghofran Z. 2010. Medicinal plants as immunosuppressive agents in traditional Iranian medicine. Iran J Immunol, 7:65-73.
6
Amirghofran Z. 2012. Herbal medicines for immunosuppression. Iran J Allergy Asthma
7
Bakht J, Shaheen S, Shafi M. 2014. Antimicrobial potentials of Mentha longifolia by disc diffusion method. Pak J Pharm Sci, 27:939-945.
8
Ebadi P, Karimi MH, Amirghofran Z. 2014. Plant components for immune modulation targeting dendritic cells: implication for therapy. Immunotherapy, 6:1037-1053.
9
Eissa TF, González-Burgos E, Carretero ME, Gómez-Serranillos MP. 2014. Phenolic content, antioxidant and astroprotective response to oxidative stress of ethanolic extracts of Mentha longifolia from Sinai. Nat Prod Commun, 9:1479-1482.
10
Gao X, Kuo J, Jiang H, Deeb D, Liu Y, Divine G, Chapman RA, Dulchavsky SA, Gautam SC. 2004. Immunomodulatory activity of curcumin: suppression of lymphocyte proliferation, development of cell-mediated cytotoxicity, and cytokine production in vitro. Biochem Pharmacol, 1;68:51-61.
11
Ghafourian Boroujerdnia M, Khosravi N, Malek-Hosseini S, Amirghofran Z. 2014. Augmentation of lymphocytes activation and T cell modulation by the extracts from some Euphorbia species. Pharm Biol, 52:1471-1477.
12
Gharagozloo M, Amirghofran Z. 2007, Effects of silymarin on the spontaneous proliferation and cell cycle of human peripheral blood leukemia T cells. J Cancer Res Clin Oncol, 133: 525-532.
13
Gholijani N, Amirghofran Z. 2016. Effects of thymol and carvacrol on T-helper cell subset cytokines and their main transcription factors in ovalbumin-immunized mice. J Immunotoxicol, 13:729-737.
14
Gholijani N, Gharagozloo M, Farjadian S, Amirghofran Z. 2016. Modulatory effects of thymol and carvacrol on inflammatory transcription factors in lipopolysaccharide-treated macrophages. J Immunotoxicol, 13:157-164.
15
Gholijani N, Gharagozloo M, Kalantar F, Ramezani A, Amirghofran Z. 2015. Modulation of cytokine production and transcription factors activities in human Jurkat T cells by thymol and carvacrol. Adv Pharm Bull, 5(Suppl 1):653-660.
16
Gulluce M, Orhan F, Yanmis D, Arasoglu T, Guvenalp Z, Demirezer LO. 2015. Isolation of a flavonoid, apigenin 7-O-glucoside, from Mentha longifolia (L.) Hudson subspecies longifolia and its genotoxic potency. ToxicolInd Health, 31:831-840.
17
Hirahara K, Nakayama T. 2016, CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm. Int Immunol, 28:163-171.
18
Immunol. 11:111-119.
19
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20
Karimian P, Kavoosi G, Amirghofran Z. 2013. Anti-inflammatory effect of Mentha longifolia in lipopolysaccharide-stimulated macrophages: reduction of nitric oxide production through inhibition of inducible nitric oxide synthase. J Immunotoxicol, 10:393-400.
21
Karimian P, Kavoosi G, Amirghofran Z. 2014. Anti-oxidative and anti-inflammatory effects of Tagetesminuta essential oil in activated macrophages. Asian Pac J Trop Biomed, 4:219-227.
22
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23
Mkaddem M, Bouajila J, Ennajar M, Lebrihi A, Mathieu F, Romdhane M. 2009. Chemical composition and antimicrobial and antioxidant activities of Mentha (longifolia L. and viridis) essential oils. J Food Sci,74:M358-363.
24
Mokaberinejad R, Zafarghandi N, Bioos S, Dabaghian FH, Naseri M, Kamalinejad M, Amin G, Ghobadi A, Tansaz M, Akhbari A, Hamiditabar M. 2012. Mentha longifolia syrupin secondary amenorrhea: a double-blind, placebo-controlled, randomized trials. Daru, 21: 20:97.
25
Morgan BP, Harris CL. 2003. Complement therapeutics; history and current progress. Mol Immunol, 40:159-170.
26
Murad HA, Abdallah HM, Ali SS. 2016. Mentha longifolia protects against acetic-acid induced colitis in rats. J Ethnopharmacol, 190:354-361.
27
Naghibi F, Mosaddegh M, Motamed SM, Ghorbani A. 2005. Labiatae family in folk medicine in Iran: From ethnobotany to pharmacology. Iran J Pharm Res, 4:63–79
28
Tahvili S, Zandieh B, Amirghofran Z. 2015. The effect of dimethyl fumarate on gene expression and the level of cytokines related to different T helper cell subsets in peripheral blood mononuclear cells of patients with psoriasis. Int J Dermatol, 54:e254-260.
29
Yoshioka Y, Li X, Zhang T, Mitani T, Yasuda M, Nanba F, Toda T, Yamashita Y, Ashida H. 2017. Black soybean seed coat polyphenols prevent AAPH-induced oxidative DNA-damage in HepG2 cells. J Clin Biochem Nutr, 60:108-114.
30
Zhang S, Liu X, Sun C, Yang J, Wang L, Liu J, Gong L, Jing Y. 2016. Apigenin Attenuates Experimental Autoimmune Myocarditis by Modulating Th1/Th2 Cytokine Balance in Mice. Inflammation, 39:678-686.
31
Zhou W, Cheng X, Zhang Y. 2016. Effect of LiuweiDihuang decoction, a traditional Chinese medicinal prescription, on the neuroendocrine immunomodulation network. Pharmacol Ther, 162:170-178
32
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33
ORIGINAL_ARTICLE
Effects of standardized hydro-alcoholic extract of Vaccinium arctostaphylos leaf on hypertension and biochemical parameters in hypertensive hyperlipidemic type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial
Objective: To study the blood pressure, lipid and glycemic effects and safety of Vaccinium arctostaphylos leaf in the hypertensive hyperlipidemic type 2 diabetic patients. Materials and Methods: The patients took 350 mg standardized plant leaf hydro-alcoholic extract capsule (n=50) or placebo capsule (n=50) three times daily alongside conventional drugs for 2 months. At the baseline and endpoint, systolic and diastolic blood pressures and blood levels of fasting glucose (FG), 2-hr postprandial glucose (2hPPG), glycosylated hemoglobin (HbA1c), total cholesterol (TC), LDL-C, triglyceride, HDL-C, SGOT, SGPT and creatinine were determined in both groups. To evaluate the extract safety, serum SGOT, SGPT and creatinine levels were tested; also, the patients were requested to report any adverse effects. Results: FG, 2hPPG, HbA1c, TC, LDL-C, triglyceride and systolic and diastolic blood pressures were decreased, whereas HDL-C was increased significantly in the extract group compared to those of the placebo group at the endpoint (for all cases, p<0.05). The extract did not significantly influence other parameters and no adverse effects were reported. Conclusion: V. arctostaphylosleaf hydro-alcoholic extract as an adjunct to the conventional drugs has additional antihypertensive as well as anti-dyslipidemic and anti-hyperglycemic effects in hypertensive hyperlipidemic type 2 diabetic patients. Besides, the extract lacks hepatic, renal and patient-reported adverse effects.
https://ajp.mums.ac.ir/article_11588_6fedfe9284a8f018f3379eb17ded2e1e.pdf
2019-01-01
44
53
10.22038/ajp.2018.11588
Vaccinium arctostaphylos
Hypertension
Diabetes Mellitus
Dyslipidemia
Reza
Mohtashami
reza_mohtashami1979@yahoo.com
1
Medicine, Quran and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
AUTHOR
Hasan
Fallah huseini
huseini_fallah@yahoo.com
2
Medicinal Plants Research Center, Institute of Medicinal Plants,ACECR, Karaj, Iran.
AUTHOR
Farzaneh
Nabati
nabati_f3@yahoo.com
3
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.
AUTHOR
Reza
Hajiaghaee
rhajiaghaee@yahoo.com
4
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran.
AUTHOR
Saeed
Kianbakht
skianbakht@yahoo.com
5
Institute of Medicinal Plants (ACECR)
LEAD_AUTHOR
Abidov M, Ramazanov A, Jimenez Del Rio M, Chkhikvishvili I. 2006. Effect of Blueberin on fasting glucose, C-reactive protein and plasma aminotransferases, in female volunteers with diabetes type 2: double-blind, placebo-controlled clinical study. Georgian Med News, 141: 66-72.
1
Chrysant SG, Chrysant GS. 2017. Herbs used for the treatment of hypertension and their mechanism of action. Curr Hypertens Rep, 19: 77-86.
2
Feshani AM, Kouhsari SM, Mohammadi S. 2011. Vaccinium arctostaphylos,a common herbal medicine in Iran: molecular and biochemical study of its anti-diabetic effects on alloxan-diabetic Wistar rats. J Ethnopharmacol, 133: 67-74.
3
GBD 2015 Mortality and Causes of Death Collaborators. 2016. Global, regional, and national life expectancy, all-cause mortality and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet, 388: 1459-1544.
4
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5
Haddad PS, Eid HM. 2017. The anti-diabetic potential of quercetin: underlying mechanisms. Curr Med Chem, 24: 355-364.
6
Iranian Herbal Pharmacopoeia Commission. 2002. Iranian Herbal Pharmacopoeia. Ministry of Health, Treatment and Medical Education: Tehran; 575.
7
Katsiki N, Kolovou G, Perez-Martinez P, Mikhailidis DP. 2018. Dyslipidemia in the elderly: to treat or not to treat? Expert Rev Clin Pharmacol, 11: 259-278.
8
Khalili A, Khosravi MB, Nekooeian AA. 2011. The effects of aqueous extract of Vaccinium arctostaphylos leaves on blood pressure in renal hypertensive rats. Iran Red Crescent Med J, 13: 123-127.
9
Khonche A, Fallah Huseini H, Abdi H, Mohtashami R, Nabati F, Kianbakht S. 2017.Efficacy of Mentha pulegium extract in the treatment of functional dyspepsia: a randomized double-blind placebo-controlled clinical trial. J Ethnopharmacol, 206: 267-273.
10
Kianbakht S, Abasi B, Hashem Dabaghian F. 2013. Anti-hyperglycemic effect of Vaccinium arctostaphylos in type 2 diabetic patients. Forsch Komplementmed, 20: 17-22.
11
Kianbakht S, Abasi B, Hashem Dabaghian F. 2014. Improve lipid profile in hyperlipidemic patients taking Vaccinium arctostaphylos fruit hydro-alcoholic extract: A randomized double-blind placebo-controlled clinical trial. Phytother Res, 28: 432-436.
12
Larsen JR, Dima L, Correll CU. 2018. The pharmacological management of metabolic syndrome. Expert Rev Clin Pharmacol, 11: 397-410.
13
Lupsa BC, Inzucchi SE. 2018. Diabetes medications and cardiovascular disease: at long last progress. Curr Opin Endocrinol Diabetes Obes, 25: 87-93.
14
Mozaffarian V. 2013. Identification of medicinal and aromatic plants of Iran. Farhang Moaser: Tehran; 391-392.
15
Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, Das SR, de Ferranti S, Després JP, Fullerton HJ, Howard VJ, Huffman MD, Isasi CR, Jiménez MC, Judd SE, Kissela BM, Lichtman JH, Lisabeth LD, Liu S, Mackey RH, Magid DJ, McGuire DK, Mohler ER 3rd, Moy CS, Muntner P, Mussolino ME, Nasir K, Neumar RW, Nichol G, Palaniappan L, Pandey DK, Reeves MJ, Rodriguez CJ, Rosamond W, Sorlie PD, Stein J, Towfighi A, Turan TN, Virani SS, Woo D, Yeh RW, Turner MB. 2016. Heart disease and stroke statistics-2016 update: a report from the American Heart Association. Circulation, 133: e38-360.
16
Naveed M, Hejazi V, Abbas M, Kamboh AA, Khan GJ, Shumzaid M, Ahmad F, Babazadeh D, FangFang X, Modarresi-Ghazani F, WenHua L, XiaoHui Z. 2018. Chlorogenic acid (CGA): a pharmacological review and call for further research. Biomed Pharmacother, 97: 67-74.
17
Nickavar B, Amin G. 2011. Enzyme assay guided isolation of an α-amylase inhibitor flavonoid from Vaccinium arctostaphylos leaves. Iran J Pharm Res, 10: 849-853.
18
Soltani R, Hakimi M, Asgary S, Ghanadian SM, Keshvari M, Sarrafzadegan N. 2014. Evaluation of the effects of Vaccinium arctostaphylos L. fruit extract on serum lipids and hs-CRP levels and oxidative stress in adult patients with hyperlipidemia: a randomized, double-blind, placebo-controlled clinical trial. Evid Based Complement Alternat Med, 2014: 217451-217456.
19
Verma N, Trehan N. 2013. HPLC analysis of methanolic extracts of herbs for quercetin content. J Pharmacognosy Phytochem, 2: 159-162.
20
Wen J, Kang L, Liu H, Xiao Y, Zhang X, Chen Y. 2012. A validated UV-HPLC method for determination of chlorogenic acid in Lepidogrammitis drymoglossoides (Baker) Ching, Polypodiaceae. Pharmacognosy Res, 4: 148-153.
21
Williamson G. 2017. The role of polyphenols in modern nutrition. Nutr Bull, 42: 226-235.
22
Yandrapalli S, Aronow WS. 2017. Cardiovascular benefits of the newer medications for treating type 2 diabetes mellitus. J Thorac Dis, 9: 2124-2134.
23
ORIGINAL_ARTICLE
Skin inflammatory reactions to capsaicin in rheumatoid arthritis patients compared to healthy controls
Objective: Previous studies have examined the role of sensory nerves and neural mediators in symmetrical joint inflammation and autoimmunity in rheumatoid arthritis (RA). In this study, we sought to examine the association between capsaicin skin test and disease activity in RA patients. Materials and Methods: Eighty RA patients (case group) and 20 healthy volunteers were enrolled in this experiment. The subjects in case group were calcified to newly diagnosed patients and those previously diagnosed with RA. A topical solution of capsaicin (0.075%) was applied on the volar forearm during the skin test, and evaluations were done after 5, 10, and 20 min. The parameters recorded in capsaicin skin test were time to tingling, area of induration (cm2), and area of redness (cm2). Results: A faster capsaicin skin reaction was observed in healthy controls compared to the case group (p=0.02). Newly diagnosed and previously diagnosed RA patients were not significantly different in terms of reaction latency (p=0.06). The redness area after 15 (p=0.04) and 20 (p=0.001) min was significantly larger in previously diagnosed RA patients than in newly diagnosed ones. The area of redness and time to tingling did not show any difference between active and inactive RA patients, but after 15 and 20 min, the area of redness was significantly greater in inactive RA patients compared to active RA patients (p=0.01 and p=0.03, respectively). Conclusion: This study suggested that capsaicin skin test is not an efficient tool for the examination of synovial inflammation and disease activity in RA.
https://ajp.mums.ac.ir/article_11589_7113efe904006c9835cf2055dc2b3140.pdf
2019-01-01
54
61
10.22038/ajp.2018.11589
Rheumatoid arthritis
Capsaicin
Inflammation
Masoumeh
Salari
salarim@mums.ac.ir
1
Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Roshanak
Salari
salarir@mums.ac.ir
2
Department of Traditional Persian Pharmacy, School of Persian and Complementary Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Hoshang
RafatPanah
rafatpanahh@mums.ac.ir
3
Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
yalda
Ravanshad
ravanshady@mums.ac.ir
4
Clinical Research Unit, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Danial
Zirachi
rdrc@mums.ac.ir
5
Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Maryam
Sahebari
sahebarim@mums.ac.ir
6
Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Arendt-Nielsen L, Skou ST, Nielsen TA, Petersen KK. 2015. Altered central sensitization and pain modulation in the CNS in chronic joint pain. Curr Osteoporos Rep, 13:225-234.
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27
ORIGINAL_ARTICLE
Antimutagenic, antitumor and estrogen receptor binding activity of the rare plant Shortia galacifolia: An ethnobotanical and chemosystematic approach
Objective: Shortia and other members of the Diapensiaceae family have ethnomedicinal history in both Eastern and Western hemispheres. Based on ethnopharmacological and chemosystematic evidence, pharmacological and toxicological bioassays were conducted on the rare plant Oconee Bell, Shortia galacifolia. Materials and Methods: Extracts were examined in assays for antimutagenicity, antitumor and estrogen receptor (ER)-binding activity. Antitumor activity was assessed by the tumor induction assay (TiA), using Agrobacterium tumefaciens based on its ability to transform plant tissue. Antimutagenicity was examined using the Ames bacterial reverse mutation test. Recombinant human ERα and ERβ proteins were utilized to screen extracts for receptor selectivity. Results: All concentrations of extracts inhibited A. tumefaciens-induced tumor formation on potato discs, with the mature rhizome extracts having the most marked inhibition. All three plant extracts significantly inhibited the formation of histidine-independent revertant colonies after exposure to the mutagen 2-aminoanthracene (2-AA) in the Ames Salmonella mutagenicity assay. In the ER binding assays, ERβ, but not ERα, displayed affinity for Shortia extracts. Conclusion: Antitumor, ER binding and antimutagenic activities of S. galacifolia extracts were identified using rapid bench-top assays and warrant further investigations.
https://ajp.mums.ac.ir/article_11593_a502eda9f4e4a9a01ac8c066713c2301.pdf
2019-01-01
62
71
10.22038/ajp.2018.11593
Antimutagenic
Antitumor
Bioassay
Estrogen receptor
Ethnopharmacology
Sandra
Gray
sngry@clemson.edu
1
Endocrine Physiology Lab, AVS Department, Clemson University, Clemson, SC 29634
LEAD_AUTHOR
Brett
Lackey
brlacke@clemson.edu
2
Endocrine Physiology Lab, AVS Department, Clemson University, Clemson, SC, 29634, USA
AUTHOR
Patricia
Tate
ptate@clemson.edu
3
School of Nursing, Clemson University, Clemson, SC, 29634, USA
AUTHOR
Atanasov AG, Waltenberger B, Pferschy-Wenzig E-M, Linder T, Wawrosch C, Uhrin P, Temml V, Wang L, Schwaiger S, Heiss EH, Rollinger JM, Schuster D, Breuss JM, Bochkov V, Mihovilovic MD, Kopp B, Bauer R, Dirsch VM, Stuppner H. 2015. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol Adv, 33:1582–1614.
1
Averater. 2017. https://commons.wikimedia.org/wiki/File:Berneuxia_thibetica_02.jpg, “Berneuxia thibetica 02”, https://creativecommons.org/licenses/by-sa/3.0/legalcode.
2
Badal S, Byfield G, Brown MC, Lawrence Y, Hartley S-A, Daley DK, Smith KN. 2017. Areas of Science Embraced by Pharmacognosy: Constituent Sciences of Pharmacognosy. In Badal S, Delgoda R (eds) Pharmacognosy Fundamentals, Applications and Strategies pp. 31-44. London, United Kingdom: Academic Press.
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Bodner T. 2017. Southern Weed Science Society, Bugwood.org. https://commons.wikimedia.org/wiki/File:Galax_urceolata.jpg, “Galax urceolata”, size, https://creativecommons.org/licenses/by-sa/3.0/legalcode.
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Jenkins CF. 1946. Asa Gray and his quest for Shortia galacifolia. Arnoldia 2:18–28.
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Jeon G-C, Park M-S, Yoon D-Y, Shin C-H, Sin H-S, Um S-J. 2005. Antitumor activity of spinasterol isolated from Pueraria roots. Exp Mol Med, 37:111–120.
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Ronblom K, Anderberg AA. 2002. Phylogeny of Diapensiaceae based on molecular data and morphology. Syst Bot, 2:383–395.
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Silva ID, Rodrigues AS, Gaspar J, Maia R, Laires A, Rueff J. 1997. Involvement of rat cytochrome 1A1 in the biotransformation of kaempferol to quercetin: relevance to the genotoxicity of kaempferol. Mutagenesis, 12:383–390.
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Soltis DE, Bohm BA, Nesom GL. 1983. Flavonoid chemistry of cytotypes in Galax (Diapensiaceae). Syst Bot, 8:15–23.
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Song H-P, Wu S-Q, Hao H, Chen J, Lu J, Xu X. 2016. A chemical family-based strategy for uncovering hidden bioactive molecules and multicomponent interactions in herbal medicines. Sci Rep, 6:23840.
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Vivian VE. 1967. Shortia galacifolia: Its life history and microclimatic requirements. Bull Torrey Bot Club, 94:369.
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Wang MK, Cai H, Peng SL, Ding LS, Wu FE, Chen YZ. 1998. Triterpenoid saponins from Berneuxia thebetica. Phytochemistry, 48:1411–1414.
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Zoechling A, Reiter E, Eder R, Wendelin S, Liebner F, Jungbauer A. 2009. The flavonoid kaempferol is responsible for the majority of estrogenic activity in red wine. Am J Enol Vitic, 60:223–232.
32
ORIGINAL_ARTICLE
The protective effect of Zataria multiflora Boiss. hydroalcoholic extract on TNF-α production, oxidative stress, and insulin level in streptozotocin-induced diabetic rats
Objective: Oxidative stress leads to reactive oxygen species (ROS) overproduction, which causes tissue injury in diabetic patients. The aim of this study was to evaluate the effects of Zataria multiflora extract on TNF-α, oxidative stress products, and insulin levels as well as lipid profile in diabetic rats. Materials and Methods: Rats were randomly divided into 6 groups of 10 animals. Diabetes was induced by a single injection of streptozotocin (STZ). Control and diabetic control rats orally received 1 mL/day of normal saline, whereas the other three groups received 250, 500 and 1000 mg/kg/day of Z. multiflora extract, and one non-diabetic group orally received 1000 mg/kg/day Z. multiflora extract, for 28 days. At the end of the treatment course, rats were anesthetized and their serum samples were analyzed for TNF-α, malondialdehyde (MDA), super oxide dismutase (SOD), total antioxidant capacity (TAC), lipid profile, total plasma protein, blood glucose, insulin, and liver enzymes levels. Results: Our results showed that cholesterol, LDL, TG, MDA and TNF-α levels decreased, but HDL, SOD, TAC, and total protein increased significantly in the diabetic group receiving 1000 mg/kg Z. multiflora compared to the diabetic control group (P<0.05). Moreover, blood glucose level was significantly reduced following administration of different concentrations of Z. multiflora. Liver sections of diabetic rats treated with Z. multiflora 1000 mg/kg showed normal hepatocytes and restoration of liver architecture. Conclusion: Z. multiflora extract ameliorated oxidative stress, TNF-α serum level, lipid abnormality, blood glucose, and liver damage in rats with diabetes mellitus.
https://ajp.mums.ac.ir/article_11614_82512585e0b80060b20efbde12ba3959.pdf
2019-01-01
72
83
10.22038/ajp.2018.11614
Zataria multiflora
TNF-α
Insulin
Liver
Diabetes
STZ
marzieh
mahmoodi
marzieh.mahmoodi123@gmail.com
1
Student Research Committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Farhad
koohpeyma
koohpeyma.f@sums.ac.ir
2
Department of Endocrinology, Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Forough
saki
sakeif@sums.ac.ir
3
Shiraz Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
AUTHOR
Amir
Maleksabet
maleksabet.amir@yahoo.com
4
Department of Medical Biotechnology, Faculty of Advanced Medical Sciences and Technology, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
mohammad Ali
zare
m.zare_f@yahoo.com
5
Department of Endocrinology, Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Aboonabi A, Rahmat A, Othman F. 2014. Antioxidant effect of pomegranate against streptozotocin-nicotinamide generated oxidative stress induced diabetic rats. Toxicol Rep, 1:915-922.
1
Akan Z, Dikilidal M, Ozdemir H, Oto G, Yilmaz A. 2014. Effects of Thymus Vulgaris L. And Thymbra Spicata L. On diabetes mellitus associated cognitive impairment and neuropathy: Thymus Vulgaris and Cognitive Function Improvements. Med Sci Discov, 1:16-21.
2
Alavinezhad A, Hedayati M, Boskabady MH. 2017. The effect of Zataria multiflora and carvacrol on wheezing, FEV1 and plasma levels of nitrite in asthmatic patients. Avicenna J Phytomed, 7: 531-541.
3
Arabbi PR, Genovese MI, Lajolo FM. 2004. Flavonoids in vegetable foods commonly consumed in Brazil and estimated ingestion by the Brazilian population. J Agric Food Chem, 52:1124-1131.
4
Boskabady MH, Gholami Mhtaj L. 2014. Effect of the Zataria multiflora on systemic inflammation of experimental animal’s model of COPD. Biomed Res Int, 2014: 1-9.
5
Dadashi M, Hashemi A, Eslami G, Fallah F, Goudarzi H, Erfanimanesh S, Taherpour A. 2016. Evaluation of antibacterial effects of Zataria multiflora Boiss extracts against ESBL-producing Klebsiella pneumoniae strains. Avicenna J Phytomed, 6: 336-343.
6
Dauqan EM, Abdullah A. 2017. Medicinal and functional values of thyme (Thymus vulgaris L.) Herb. J appl biol biotechnol, 5: 017-022.
7
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Fazeli MR, Amin G, Attari MMA, Ashtiani H, Jamalifar H, Samadi N. 2007. Antimicrobial activities of Iranian sumac and avishan-e shirazi (Zataria multiflora) against some food-borne bacteria. Food control, 18: 646-649.
9
Ghafarzadegan R, Masror D, Parvizy S, Khamseh ME, Haghani H. 2013. Quality of life in patients with type II diabetes, Payesh, 12: 489-495.
10
Gholamhoseinian Najar A, Fallah H, Sharififar F. 2015. Anti-hyperglycemic activity of four plants extracts effective against alpha glucosidase in normal and diabetic rats. J Kerman Univ Med Sci. 16:35-44
11
Ghorbani A. 2017. Mechanisms of antidiabetic effects of flavonoid rutin. Biomed Pharmacother, 96, 305-312.
12
Hosseini SE, Tavakoli F, Karami M. 2014. Medicinal Plants in the treatment of Diabetes mellitus. Clinical Excellence, 2: 64-89.
13
Hosseinzadeh H, Ramezani M, Salmani G.-a. 2000. Antinociceptive, anti-inflammatory and acute toxicity effects of Zataria multiflora Boiss extracts in mice and rats. J Ethnopharmacol, 73: 379-385.
14
Kahn R. 2003. Follow-up report on the diagnosis of diabetes mellitus: the expert committee on the diagnosis and classifications of diabetes mellitus. Diabetes care, 26: 3160-3167.
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Kalaivanam K, Dharmalingam M, Marcus SR. 2006. Lipid peroxidation in type 2 diabetes mellitus. Int J Diabetes Dev Ctries, 26:30-32.
16
Kavoosi G. 2011. Zataria multiflora essential oil reduces diabetic damages in streptozotocin-induced diabetic rats. Afr J Biotechnol, 10:17632-17639.
17
Khoshvaghti A, Nazifi S, Derakhshaniyan S, Akbarpour B. 2012. The Effects of Zataria multiflora hydroalcoholic extract on some liver enzymes, cholesterol, triglyceride, HDL-Cholesterol, LDL Cholesterol, Albumin and Total Protein in Rat. J Basic & Appl Sci, 8: 217-222.
18
Lee K.-g, Shibamoto T. 2002. Determination of antioxidant potential of volatile extracts isolated from various herbs and spices. J Agric Food Chem, 50: 4947-4952.
19
Masiello P, Broca C, Gross R, Roye M, Manteghetti M, Hillaire-Buys D, Ribes G. 1998. Experimental NIDDM: development of a new model in adult rats administered streptozotocin and nicotinamide. J Diabetes, 47: 224-229.
20
Matough FA, Budin SB, Hamid ZA, Alwahaibi N, Mohamed J. 2012. The role of oxidative stress and antioxidants in diabetic complications. Sultan Qaboos Univ Med J, 12: 5-18.
21
Meites S. 1986. Biochemical Values in Clinical Medicine, RD Eastham, John Wright & Sons Ltd., Techno House, Redcliffe Way, Bristol BS1 6NX, UK, distributed in the US by PSG Publishing Co., Inc., Littleton, MA 01460, August, 1985, ix+ 473 pp. Paperback, $15.00. ISBN 0-7236-0820-2. Clin Chem, 32: 409-410.
22
Noh MK, Jung M, Kim SH, Lee SR, Park KH, Kim DH, Park YG. 2013. Assessment of IL‑6, IL‑8 and TNF‑α levels in the gingival tissue of patients with periodontitis. Exp Ther Med, 6: 847-851.
23
Ois Moreau F, Pinget M, Maillard E, verine Sigrist S. 2015. Oxidative stress status and liver tissue defenses in diabetic rats during intensive subcutaneous insulin therapy, Exp Biol Med, 1-9.
24
Patche J, Girard D, Catan A, Boyer F, Dobi A, Planesse C, Bravo SB. 2017. Diabetes-induced hepatic oxidative stress: a new pathogenic role for glycated albumin. Free Radic Biol Med, 102:133-148.
25
Sabu M, Smitha K, Kuttan R. 2002. Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes. J Ethnopharmacol, 83: 109-116.
26
Sajed H, Sahebkar A, Iranshahi M. 2013. (Zataria multiflora Boiss. (Shirazi thyme)-An ancient condiment with modern pharmaceutical uses). J Ethnopharmacol, 145:686-698.
27
Sakai I, Izumi S.-i, Murano T, Okuwaki S, Makino T, Suzuki T. 2001. Presence of aldose reductase inhibitors in tea leaves. Jpn J Pharmacol, 85: 322-326.
28
Samarghandian S, Azimini-Nezhad M, Farkhondeh T. 2016. The effects of Zataria multiflora on blood glucose, lipid profile and oxidative stress parameters in adult mice during exposure to bisphenol A. Cardiovascular & Haematological Disorders-Drug Targets (Formerly Current Drug Targets-Cardiovascular & Hematological Disorders), 16: 41-46.
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Sharififar F, Moshafi M, Mansouri S, Khodashenas M, Khoshnoodi M. 2007. In vitro evaluation of antibacterial and antioxidant activities of the essential oil and methanol extract of endemic Zataria multiflora Boiss. Food control, 18: 800-805.
30
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31
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32
Swaroop JJ, Rajarajeswari D, Naidu J. 2012. Association of TNF-α with insulin resistance in type 2 diabetes mellitus. Indian J Med Res, 135: 127-130.
33
Verma S, Chandra H, Banerjee M. 2016. Cyclooxygenase 1 (COX1) expression in Type 2 diabetes mellitus: A preliminary study from north India. Egypt J Med Hum Genet, 17:41-45.
34
ORIGINAL_ARTICLE
Effect of acupressure on constipation in patients undergoing hemodialysis: A randomized double-blind controlled clinical trial
Objective: Constipation is one of the most common digestive problems in patients undergoing hemodialysis. It has a negative effect on quality of life in these patients. As routine treatments are not effective in this regard, complementary therapies may help to overcome this condition. This study aimed to investigate the effect of acupressure on constipation in patients undergoing hemodialysis. Materials and Methods: This was a randomized double- blind placebo- controlled clinical trial conducted in 2014.A convenience sample of 70 patients undergoing hemodialysis was selected from hemodialysis units of three hospitals affiliated to Mazandaran University of Medical Sciences, Mazandaran, Iran. Patients were randomly assigned to intervention or control group. Intervention group received acupressure in acupressure points three times a week for four weeks during hemodialysis. In control group, acupressure was delivered in false points. We assessed the frequency of defecation in the two groups before and after the study. The study instruments consisted of a demographic questionnaire, and a data sheet for documenting constipation frequency. Results: The results indicated a significant difference between intervention group (13.73±3.63) and control group (10.06±3.77) in frequency of defecation during the fourth week of intervention (p<0.001). Regarding quality of stool, there was a meaningful difference between the groups in the fourth week in a way that the stool in the intervention group was more natural and in the control group, it was thicker and more adhesive. Conclusion: Acupressure seems to be an effective complementary treatment for constipation in patients undergoing hemodialysis.
https://ajp.mums.ac.ir/article_11626_45100deac7c5cfa72d9a01a7202008ab.pdf
2019-01-01
84
91
10.22038/ajp.2018.11626
Acupressure
hemodialysis
Constipation
Parivash
Abbasi
parivashabasi@yahoo.com
1
Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran
AUTHOR
Mohammad
Mojalli
mmojali@yahoo.com
2
Social Development and Health Promotion Research Center & Department of Nursing, Faculty of Nursing and Midwifery, Gonabad University of Medical Sciences, Gonabad, Iran
LEAD_AUTHOR
Mojtaba
Kianmehr
kianmehr.m@gmu.ac.ir
3
Department of Medical Physics, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad, IR Iran.
AUTHOR
Somayeh
Zamani
somayehzamani55@yahoo.com
4
Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran
AUTHOR
Andrews CN, Storr M. 2011. The pathophysiology of chronic constipation. Can J Gastroenterol Hepatol, 25(Suppl B): 16B-21B.
1
Atashpeikar S, Jalilazar T, Heidarzade M. 2012. Self-care ability in hemodialysis patients. J Caring Sci, 1: 31-35.
2
Chao H.-L, Miao SJ, Liu PF, Lee HH, Chen YM, Yao CT, Chou HL. 2013. The beneficial effect of ST-36 (Zusanli) acupressure on postoperative gastrointestinal function in patients with colorectal cancer. Oncol Nurs Forum, 40: E61-68.
3
Chen M.-L, Lin LC, Wu SC, Lin JG. 1999. "The effectiveness of acupressure in improving the quality of sleep of institutionalized residents. J Gerontol A Biol Sci Med Sci, 54: M389-M394.
4
Cho YC, Tsay SL. 2004. "The effect of acupressure with massage on fatigue and depression in patients with end-stage renal disease. J Nurs Res, 12: 51-54.
5
Fang Y-Y, Wang P-L, Tsai C-M, Hsieh M-H. 2012. Application of acupressure as a constipation intervention method in patients with acute coronary artery diseases: a systematic review. Sigma theta tau internationals 23rd international nursing research congress, Brisbane.
6
Hammer J, Osterreicher C, Hammer K, Koch U, Traiendi O, Kovarik J. 1998. Chronic gastrointestinal symptoms in hemodialysis patients. Wien Klin Wochenschr, 110: 287-291.
7
Lehnhardt A, Kemper MJ. 2011. Pathogenesis, diagnosis and management of hyperkalemia. Pediatric nephrology, 26: 377-384.
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Lew S. 2001. The digestive tract. Handbook of Dialysis: 601-610.
9
Maa S. 2005. Application of acupressure in nursing practice. Hu Li Za Zhi, 52: 5-10.
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Murtagh FE, Addington-Hall J, Higginson IJ. 2007. The prevalence of symptoms in end-stage renal disease: a systematic review. Adv Chronic Kidney Dis, 14: 82-99.
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Rogers J. 2011. How to manage chronic constipation in adults. Nursing times, 108: 12- 16.
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Sorouri M, Pourhoseingholi MA, Vahedi M, Safaee A, Moghimi-Dehkordi B, Pourhoseingholi A, Habibi M, Zali MR. 2010. Functional bowel disorders in Iranian population using Rome III criteria. Saudi J Gastroenterol, 16: 154-160.
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Stark ME. 1999. Challenging problems presenting as constipation. Am J Gastroenterol, 94: 567-574.
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Stein A. 2005. Acupressure guide: alleviate headaches, neck and joint pain, anxiety attacks and other ailments, author house. available at:https://scholar.google.com in: 10/1/ 2018.
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Sun JL, Sung MS, Huang MY, Cheng GC, Lin CC. 2010. Effectiveness of acupressure for residents of long-term care facilities with insomnia: a randomized controlled trial. Int J Nurs Stud, 47: 798-805.
16
Tsai H. 2011. The Effectiveness of acupressure on improving bowel movement in long-term care patient (Thesis).
17
Tsay SL, Chen ML. 2003. Acupressure and quality of sleep in patients with end-stage renal disease—a randomized controlled trial. Int J Nurs Stud, 40: 1-7.
18
Tsay SL, Cho YC, Chen ML. 2004. Acupressure and transcutaneous electrical acupoint stimulation in improving fatigue, sleep quality and depression in hemodialysis patients. Am J Chin Med, 32: 407-416.
19
Tsay S. L,Rong JR, Lin PF. 2003. Acupoints massage in improving the quality of sleep and quality of life in patients with end‐stage renal disease. J Adv Nurs, 42: 134-142.
20
Vatarii, I. 2011. The effect of acupressure on quality of sleep in hemodialysis patients. J Med Sci 11: 236-240.
21
Wang X and Yin J. 2015. Complementary and Alternative Therapies for Chronic Constipation. Evid Based Complement Alternat Med. 2015:1-11.
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Xing JH, Soffer EE. 2001. Adverse effects of laxatives. Diseases of the colon & rectum, 44: 1201-1209.
23
Yang LY, Yates P, Chinn CC, Kaot K. 2010. Effect of acupressure on thirst in hemodialysis patients. Kidney Blood Press Res, 33: 260-265.
24