ORIGINAL_ARTICLE
The effect of Ficus carica latex on 7, 12-dimethylbenz (a) anthracene-induced breast cancer in rats
Objective: In traditional medicine, Ficus carica (also known as fig) latex is recognized as a remedy with various therapeutic effects. Recently, in vitro studies have reported the anticancer effect of this latex on cancer cell lines. This study evaluated the effect of this latex on breast cancer growth, hematological parameters, and histopathology in rats. Materials and Methods: Twenty-four female rats were randomly divided into 3 groups. In cancerous group, 0.5 ml 7, 12-dimethylbenz (a) anthracene was injected to nipple for breast cancer induction. The control group received sesame oil at the same volume through similar route. In fig latex treated group (Fle), breast cancer was induced and then 0.5 ml of fig latex was intratumorally injected on a daily basis for 4 weeks. Tumor size was measured at the 2nd, 4th and 6th weeks of the experiment. Blood samples were used for investigation of the hematological parameters and livers, kidneys and tumor tissues were removed for histopathological analysis. Results: The tumor size in Fle group was significantly decreased compared to the cancerous group. Haematocrit, hemoglobin, RBC and their indices were significantly decreased, whereas platelet, leukocyte and white blood cell numbers were significantly increased in cancerous group compared to the control group. There were no changes in these parameters in the Fle group compared to the control group. There were severe pathological changes in the livers and kidneys of cancerous group, but not in Fle group. Conclusion: These results suggest that fig latex could decrease tumor growth without having any adverse effect on hematological and histological factors. However, further investigation is required in this field.
https://ajp.mums.ac.ir/article_10014_34cdd5cce770f8dafdcca2954484fec6.pdf
2018-07-01
286
295
10.22038/ajp.2017.10014
Breast Cancer
Ficus carica latex
hematological parameters
Histopathology
Rat
Mahnoosh
Fatemi
mehr.fatemi7@gmail.com
1
Department of Biology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
LEAD_AUTHOR
Fereshte
Ghandehari
fe_gh_2010@yahoo.com
2
Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
AUTHOR
Abdelhalim MAK, Jarrar BM.2012. Histological alterations in the liver of rats induced by different gold nanoparticle sizes, doses and exposure duration. J Nanobiotechnology, 10: 1-9.
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41
ORIGINAL_ARTICLE
Cytotoxic activity of the genus Ferula (Apiaceae) and its bioactive constituents
Objective: The genus Ferula L. includes perennial flowering plants belonging to the Apiaceae family. This genus is a rich source of biologically active phytochemicals such as sulfur-containing derivatives, coumarins, sesquiterpenes, sesquiterpene lactones, sesquiterpene coumarins, glucuronic acid, galactose, arabinose, rhamnose, and daucane esters. Over the last decade, considerable attention has been paid to biological activities of these compounds; it is assumed that the most prominent biological features of the genus Ferula are their cytotoxic effects. This article discusses cytotoxic activity of the genus Ferula and their important compounds. Methods: In this mini-review article, papers published from 1990 to April 2016 were included and the following information was discussed; cytotoxic activity of the genus Ferula and their important compounds, the type of cell line used in vitro, concentrations of the extracts/active compound that were used, and the underlying mechanisms of action through which Ferula-related chemicals induced cytotoxicity. In addition, we explained different mechanisms of action through which the active constituents isolated from Ferula, could decrease cellular growth. Conclusion: It is highly recommended that potent and effective compounds that were isolated from Ferula plants and found to be appropriate as adjuvant therapy for certain diseases, should be identified. Also, the versatile biological activities of sesquiterpene coumarins suggest them as promising agents with a broad range of biological applications to be used in the future.
https://ajp.mums.ac.ir/article_10379_5ae213e4b921cac81dfc6ad98bc9b1f7.pdf
2018-07-01
296
312
10.22038/ajp.2018.26953.1963
Ferula
Biological activity
Cytotoxicity
Umbelliprenin
Sesquiterpene coumarin
Farnesiferol C
Mehrdad
Iranshahi
iranshahim@mums.ac.ir
1
Biotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Ramin
Rezaee
raminrezaee1983@gmail.com
2
Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mona
Najaf Najafi
najafnm@mums.ac.ir
3
Clinical Research Unit, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Ali
Haghbin
4
Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
AUTHOR
Jamal
Kasaian
kasaianj1@gmail.com
5
Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
LEAD_AUTHOR
Aas Z, Babaei E, Feizi MAH, Dehghan G. 2015. Anti-proliferative and apoptotic effects of dendrosomal farnesiferol c on gastric cancer cells. Asian Pac J Cancer Prev, 16:5325-5329.
1
Alam M, Khan A, Wadood A, Khan A, Bashir S, Aman A, Jan AK, Rauf A, Ahmad B, Khan AR. 2016. Bioassay-guided isolation of sesquiterpene coumarins from Ferula narthex Bioss: A new anticancer agent. Front pharmacol, 7: 26-40.
2
Aldaghi L, Rad A, Arab A, Kasaian J, Iranshahi M, Sadr A, Soltani F. 2016. In silico and in vitro evaluation of cytotoxic activities of farnesiferol c and microlobin on MCF-7, HeLa and KYSE Cell Lines. Drug Res, 66: 532–538.
3
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5
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6
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7
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8
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11
Barthomeuf C, Lim S, Iranshahi M, Chollet P. 2008. Umbelliprenin from Ferula szowitsiana inhibits the growth of human M4Beu metastatic pigmented malignant melanoma cells through cell-cycle arrest in G1 and induction of caspase-dependent apoptosis. Phytomedicine, 15:103-111.
12
Behnam Rassouli F, Matin MM, Iranshahi M, Bahrami AR, Neshati V, Mollazadeh S, Neshati Z. 2009. Mogoltacin enhances vincristine cytotoxicity in human transitional cell carcinoma (TCC) cell line. Phytomedicine,16:181-187.
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15
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16
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17
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19
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26
Gholami O, Jeddi-Tehrani M, Iranshahi M, Zarnani AH, Ziai SA. 2013. Umbelliprenin from Ferula szowitsiana activates both intrinsic and extrinsic pathways of apoptosis in jurkat T-CLL cell line. Iran J Pharm Res, 12:371-376.
27
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28
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29
Gudarzi H, Salimi M, Irian S, Amanzadeh A, Mostafapour Kandelous H, Azadmanesh K, Salimi M. 2015. Ethanolic extract of Ferula gummosa is cytotoxic against cancer cells by inducing apoptosis and cell cycle arrest. Nat Prod Res, 29:546-550.
30
Haghighitalab A, Matin MM, Bahrami AR, Iranshahi M, Saeinasab M, Haghighi F. 2014. In vitro investigation of anticancer, cell-cycle-inhibitory, and apoptosis-inducing effects of diversin, a natural prenylated coumarin, on bladder carcinoma cells. Z Naturforsch Bio Sci C, 69:99-109.
31
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32
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33
Hanafi-Bojd MY, Iranshahi M, Mosaffa F, Tehrani SO, Kalalinia F, Behravan J. 2011. Farnesiferol A from Ferula persica and galbanic acid from Ferula szowitsiana inhibit P-glycoprotein-mediated rhodamine efflux in breast cancer cell lines. Planta Med, 77:1590-1593.
34
Huang J, Han H-Y, Li G-Y, Wang H-Y, Zhang C, Zhang K, Tan Y, Li P-Y, Wang J-H. 2013. Two new terpenoid benzoates with antitumor activity from the roots of Ferula dissecta. J Asian Nat Prod Res, 15:1100-1106.
35
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36
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37
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38
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39
Karimi G, Iranshahi M, Hosseinalizadeh F, Riahi B, Sahebkar A. 2010. Screening of acetylcholinesterase inhibitory activity of terpenoid and coumarin derivatives from the genus Ferula. Pharmacol Online, 1:566-574.
40
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41
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42
Kasaian J, Mosaffa F, Behravan J, Masullo M, Piacente S, Ghandadi M, Iranshahi M. 2015. Reversal of P-glycoprotein-mediated multidrug resistance in MCF-7/Adr cancer cells by sesquiterpene coumarins. Fitoterapia, 103:149-154.
43
Kasaian J, Mosaffa F, Behravan J, Masullo M, Piacente S, Iranshahi M. 2016. Modulation of Multidrug Resistance Protein 2 Efflux in the Cisplatin Resistance Human Ovarian Carcinoma Cells A2780/RCIS by Sesquiterpene Coumarins. Phytother Res, 30:84-89.
44
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46
Kim KH, Lee HJ, Jeong SJ, Lee EO, Kim HS, Zhang Y, Ryu SY, Lee MH, Lü J, Kim SH. 2011. Galbanic acid isolated from Ferula assafoetida exerts in vivo anti-tumor activity in association with anti-angiogenesis and anti-proliferation. Pharm Res, 28:597-609.
47
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48
Li G, Li X, Cao L, Zhang L, Shen L, Zhu J, Wang J, Si J. 2015. Sesquiterpene coumarins from seeds of Ferula sinkiangensis. Fitoterapia, 103:222-226.
49
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50
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51
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53
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54
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55
Miski M. 2013. Biologically Active Sesquiterpenes from the Indigenous Ferula species (Apiaceae) of Turkey. Planta Med, 79:PN32.
56
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57
Mollazadeh S, Matin MM, Bahrami AR, Iranshahi M, Behnam-Rassouli M, Rassouli FB, Neshati V. 2011. Feselol enhances the cytotoxicity and DNA damage induced by cisplatin in 5637 cells. Z Naturforsch C, 66: 555-561.
58
Mollazadeh S, Matin MM, Iranshahi M, Bahrami AR, Neshati V, Behnam-Rassouli F. 2010. The enhancement of vincristine cytotoxicity by combination with feselol. J Asian Nat Prod Res, 12:569-575.
59
Mousavi SH, Davari A-S, Iranshahi M, Sabouri-Rad S, Najaran ZT. 2015. Comparative analysis of the cytotoxic effect of 7-prenyloxycoumarin compounds and herniarin on MCF-7 cell line. Avicenna J Phytomed, 5:520-530.
60
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61
Neshati V, Matin MM, Bahrami AR, Iranshahi M, Rassouli FB, Saeinasab M. 2012. Increasing the cisplatin cytotoxicity and cisplatin-induced DNA damage by conferone in 5637 cells. Nat Prod Res. 26:1724-1727.
62
Neshatia V, Matin MM, Iranshahi M, Bahrami AR, Behravan J, Mollazadeh S, Rassouli FB. 2009. Cytotoxicity of vincristine on the 5637 cell line is enhanced by combination with conferone. Z Naturforsch C, 64:317-322.
63
Oh BS, Shin EA, Jung JH, Jung DB, Kim B, Shim BS, Yazdi MC, Iranshahi M, Kim SH. 2015. Apoptotic effect of galbanic acid via activation of caspases and inhibition of Mcl-1 in H460 non-small lung carcinoma cells. Phytother Res, 29:844-849.
64
Paydar M, Wong YL, Abdulkarim Moharam B, Movahed E, Fen Wong W, Yeng Looi C. 2013. Pharmacological activities and chemical constituents of Ferula szowitsiana DC. J Med Sci (Faisalabad), 13:236-243.
65
Ramezani A, Iranshahi M, Hanafi-Bojd MY, Malaekeh-Nikouei B. 2014. Preparation, characterization and cytotoxic effects of nanoliposomes containing umbelliprenin. Intern J Pharm Res. 6:79-84.
66
Rassouli FB, Matin MM, Iranshahi M, Bahrami AR. 2011. Investigating the cytotoxic and apoptosis inducing effects of monoterpenoid stylosin in vitro. Fitoterapia, 82:742-749.
67
Rassouli FB, Matin MM, Iranshahi M, Bahrami AR, Behravan J, Mollazadeh S, Neshati V, Kalalinia F. 2011. Investigating the enhancement of cisplatin cytotoxicity on 5637 cells by combination with mogoltacin. Toxicol in Vitro, 25:469-474.
68
Razavi SM, Janani M. 2015. A new ester coumarin from Ferula Persica wild, indigenous to Iran. Nat Prod Res, 29:717-721.
69
Razavi SM, Nahar L, Talischi H, Sarker SD. 2016. Ferulone A and ferulone B: two new coumarin esters from Ferula orientalis L. roots. Nat Prod Res, 30:2183-2189.
70
Ryu S-Y, Lee C-O, Choi S-U, Park S-h, Kim Y-S, Kim S-K, Kim S-K, Kang S-K. 2001. Anticancer composition comprising sesquiterpenes isolated from Resina ferulae. In: Google Patents. Publication number : US 20040043083 A1.
71
Sadeghizadeh M, Ranjbar B, Damaghi M, Khaki L, Sarbolouki MN, Najafi F, Parsaee S, Ziaee AA, Massumi M, Lubitz W. 2008. Dendrosomes as novel gene porters‐III. J Chem Technol Biotech, 83:912-920.
72
Sadooghi SD, Nezhad Shahrokh Abadi K, Zafar Balanzhad S. 2013. Investigating the cytotoxic effects of ethanolic extract of Ferula assa-foetida resin on HepG2 cell line. KAUMS J (FEYZ), 17:323-330.
73
Safi R, Rodriguez F, Hilal G, Diab-Assaf M, Diab Y, El-Sabban M, Najjar F, Delfourne E. 2015. Hemisynthesis, Antitumoral Effect, and Molecular Docking Studies of Ferutinin and Its Analogues. Chem Biol Drug Des, 87:382-397.
74
Sahranavard S, Naghibi F, Mosaddegh M, Esmaeili S, Sarkhail P, Taghvaei M, Ghafari S. 2009. Cytotoxic activities of selected medicinal plants from Iran and phytochemical evaluation of the most potent extract. Res Pharm Sci, 4:133-137.
75
Shafri MAM, Yusof FA, Zain AZM. 2015. In vitro cytotoxic activity of Ferula assafoetida on osteosarcoma cell line (HOS CRL). J Teknol, 77:7-11.
76
Shakeri A, Iranshahy M, Iranshahi M. 2014. Biological properties and molecular targets of umbelliprenin-a mini-review. J Asian Nat Prod Res, 16:884-889.
77
Soltani F, Mosaffa F, Iranshahi M, Karimi G, Malekaneh M, Haghighi F, Behravan J. 2009. Evaluation of antigenotoxicity effects of umbelliprenin on human peripheral lymphocytes exposed to oxidative stress. Cell Biol Toxicol, 25:291-296.
78
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79
Tayeboon GS, Tavakoli F, Hassani S, Khanavi M, Sabzevari O, Ostad SN. 2013. Effects of Cymbopogon citratus and Ferula assa-foetida extracts on glutamate-induced neurotoxicity. In Vitro Cell Dev Biol Anim, 49:706-715.
80
Vahabi L, Shahanipour K, Monajemi R, Mortazavifar F. 2014. Study of Cytotoxic Effect of Methanolic Extract of Ferula assa-foetida Resin of Mashhad and Yazd on MDA-MB-231 Cell Line. Bulletin Environ Pharmacol Life Sci, 3:231-236.
81
Valiahdi SM, Iranshahi M, Sahebkar A. 2013. Cytotoxic activities of phytochemicals from Ferula species. DARU J Pharm Sci,. 21(39).
82
Yaqoob U, Nawchoo IA, Ahmad M. 2016. Phytochemical screening of the root tuber extracts of Ferula jaeschkeana vatke. J Essent Oil Bear Pl, 19:208-211.
83
Yu SM, Hu DH, Zhang JJ. 2015. Umbelliferone exhibits anticancer activity via the induction of apoptosis and cell cycle arrest in HepG2 hepatocellular carcinoma cells. Mol Med Rep, 12:3869-3873.
84
Zhang H, Lu J, Zhou L, Jiang L, Zhou M. 2015. Antioxidant and antitumor effects of Ferula sinkiangensis KM Shen. Int J Clin Exp Med, 8:20845-20852.
85
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86
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87
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88
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89
ORIGINAL_ARTICLE
Quantitative ethnobotanical appraisal of medicinal plants used by inhabitants of lower Kurram, Kurram agency, Pakistan
Objective: Medicinal plants are used for treatment of ailments throughout rural and urban areas of the world. Such use of plants varies from one region to another and is measured using quantitative techniques. The current research which was conducted from March to October 2015, is the first explorative study of medicinal plants used by inhabitants of lower Kurram, Kurram agency, Pakistan. Materials and Methods: Field trips were done to 20 location of lower Kurram and information regarding medicinal use of plants was collected from the locals through semi-structured interviews. Results: A total of 52 plant species that were reported by the people from the region, to have medicinal value, fall within 48 genera and 35 families. The family Asteraceae comprised most of these herbs (6 species) followed by the family Lamiaceae (4 species) and Solanaceae (3 species). Leaves (24.3%) and fruits (21.6%) were the frequently used parts in preparation of remedies. The reported plants were used for treatment of 50 ailments with most of these plants (35 species; 30.97%) being used for treatment of digestive problems. Seriphidium kurramensis had the highest relative frequency of citation (66.18) and use value (1.10). Fidelity level of Caralluma tuberculata and Artemisia scoparia for diabetes was (61.22) and (55.56), respectively. The highest fidelity level for malaria was reported for Artemisia absinthium (43.66) and S. kurramensis (40.00). Conclusion: The inhabitants of lower Kurram still practice medicinal plants and few of the plants were used for treatment of fatal diseases like malaria, hepatitis and blood cancer. Haphazard cutting of plants and overgrazing are major threats that can affect plants biodiversity.
https://ajp.mums.ac.ir/article_10738_a4c2f260daad3e0ce51c08702979e1fb.pdf
2018-07-01
313
329
10.22038/ajp.2018.20910.1792
Artemisia absinthium
Nannorrhops ritchiana
Seriphidium kurramense
Traditional knowledge
Pakistan
Wahid
Hussain
wahidhussaiwahid@gmail.com
1
Department of Botany, GPGC Parachinar Kurram agency Pakistan
AUTHOR
Manzoor
Ullah
manzoorkhan536@yahoo.com
2
Department of Botany, University of Science and Technology Bannu KP, Pakistan
LEAD_AUTHOR
Ghulam
Dastagir
dastagirbotany@yahoo.com
3
Department of Botany, University of Peshawar, KP, Pakistan
AUTHOR
LAL
Badshah
badshahmasood1@gmail.com
4
Department of Botany, University of Peshawar, KP, Pakistan
AUTHOR
J, Moreira F Guimaraes F. 2006. Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug. Braz J Med Biol Res, 39: 421-429.
1
ORIGINAL_ARTICLE
The effects of curcumin and a modified curcumin formulation on serum Cholesteryl Ester Transfer Protein concentrations in patients with metabolic syndrome: A randomized, placebo-controlled clinical trial
Objective: Cholesteryl Ester Transfer Protein (CETP) mediates the transfer of cholesteryl ester from HDL-C to LDL-C and VLDL-C. The aim of the present trial was to evaluate the effect of curcumin and its modified formulation on serum CETP concentrations in patients with metabolic syndrome. Materials and Methods: Participants were randomly allocated to one of three groups of 40 subjects receiving either unmodified curcumin or its phospholipid complex or placebo. Lipid profile and plasma CETP were measured at the start and sixweeksafter initiation of the treatment.The normality of data distribution was assessed by Kolmogorov-Smirnov test. Wilcoxon test was used for comparing the data before and after the intervention. The percent changes of CETP and biochemical factors among the three groups were compared using Kruskal-Wallis test. Results: Serum CETP levels were not significantly altered among patients receiving curcumin. Conclusion: Curcumin and its complex had no significant effect on serum CETP concentrations.
https://ajp.mums.ac.ir/article_10348_d684ca3ae29a031ecd31f954bbdc3e68.pdf
2018-07-01
330
337
10.22038/ajp.2018.10348
metabolic syndrome
HDL-C
CETP
Curcumin
Atherogenesis
Ali
Javandoost
javandoosta1@mums.ac.ir
1
Metabolic Syndrome Research Center, Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Asma
Afshari
afsharia3@mums.ac.ir
2
Department of Nutrition, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Maryam
Saberi Karimian
saberikm911@mums.ac.ir
3
Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Amirhosein
Sahebkar
sahebkara@mums.ac.ir
4
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Hamideh
Safarian Bana
safarianh921@mums.ac.ir
5
Metabolic Syndrome Research Center, Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Maliheh
Moammeri
moammerism921@mums.ac.ir
6
Metabolic Syndrome Research Center, Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Behdokht
Fathi Dizaji
fathib921@mums.ac.ir
7
Department of Genetic, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Shima
Tavalaei
tavalaiesh1@mums.ac.ir
8
Metabolic Syndrome Research Center, Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Gordon
A. A. Ferns
g.ferns@bsms.ac.uk
9
Institute for Science and Technology in Medicine, University of Keele, Thornburrow Drive, Stoke-on-Trent, Staffordshire ST4 7QB, UK
AUTHOR
Alireza
Pasdar
pasdara@mums.ac.ir
10
Department of Modern Sciences and Technologies, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
AUTHOR
Seyed Mohammad Reza
Parizadeh
parizadehmr@mums.ac.ir
11
Metabolic Syndrome Research Center, Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Majid
Ghayour Mobarhan
ghayourm@mums.ac.ir
12
Biochemistry and Nutrition Research Center, Department of Biochemistry, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
Aggarwal BB. 2010. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr, 30: 173-199.
1
Aggarwal BB, Kumar A, Aggarwal MS, Shishodia S. 2005. Curcumin derived from turmeric (Curcuma longa): a spice for all seasons. Phytopharmaceutic Cancer Chemoprev, 23: 351-387.
2
Anand P, Sundaram C, Jhurani S, Kunnumakkara AB, Aggarwal BB. 2008. Curcumin and cancer: an “old-age” disease with an “age-old” solution. Cancer lett, 267: 133-164.
3
Chapman MJ, Ginsberg HN, Amarenco P, Andreotti F, Borén J, Catapano AL, Descamps OS, Fisher E, Kovanen PT, Kuivenhoven JA, Lesnik P. 2011. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J, 32(11):1345-1361.
4
Curb JD, Abbott RD, Rodriguez BL, Masaki K, Chen R, Sharp DS, Tall AR. 2004. A prospective study of HDL-C and cholesteryl ester transfer protein gene mutations and the risk of coronary heart disease in the elderly. J Lipid Res, 45: 948-953.
5
Davidson MH. 2012. HDL and CETP inhibition: will this DEFINE the future?.Curr Treat Options Cardiovasc Med, 14: 384-390.
6
Elseweidy MM, Younis NN, Elswefy SE, Abdallah FR, El-Dahmy SI, Elnagar G, Kassem HM. 2015. Atheroprotective potentials of curcuminoids against ginger extract in hypercholesterolaemic rabbits. Nat Prod Res, 29: 961-965.
7
Epstein J, Sanderson IR, MacDonald TT. 2010. Curcumin as a therapeutic agent: the evidence from in vitro, animal and human studies. Br J nutr 103:1545-1557.
8
Fisher EA, Feig JE, Hewing B, Hazen SL, Smith JD. 2012. High-density lipoprotein function, dysfunction, and reverse cholesterol transport. Arterioscler Thromb Vasc Biol, 32: 2813-2820.
9
Ghatreh-Samani K, Farrokhi E, Hashemzadeh-Chaleshtori M, Nikookar M, Noormohammadian Z. 2012. Study of I405V polymorphism of cholesterol ester transfer protein gene in efficacy of statins on plasma level of high density lipoprotein cholesterol. J Shahrekord Univ Med Sci, 14: 1-10.
10
Julie S, Jurenka M. 2009. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa. A preclinical and clinical research. Altern Med Rev, 14: 277.
11
Kidd PM. 2009. Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea, and grape seed extracts. Altern Med Rev, 14: 226-46.
12
Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. 2006. Multiple biological activities of curcumin: a short review. Life Sci,78: 2081-2087.
13
Marczylo TH, Verschoyle RD, Cooke DN, Morazzoni P, Steward WP, Gescher AJ. 2007. Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother Pharmacol, 601: 71-7.
14
Rahimi HR, Mohammadpour AH, Dastani M, Jaafari MR, Abnous K, Mobarhan MG and Oskuee RK. 2016. The effect of nano-curcumin on HbA1c, fasting blood glucose, and lipid profile in diabetic subjects: a randomized clinical trial. Avicenna J Phytomed, 6: 567.
15
Ritchie S, Connell JM. 2007. The link between abdominal obesity, metabolic syndrome and cardiovascular disease. Nutr Metab Cardiovasc Dis, 17: 319-326.
16
Saberi-Karimian M, Parizadeh SMR, Ghayour-Mobarhan M, Moammeri SM, Fathi DB, Safarian H, Javandoost A, Ferns GA, Sahebkar A, Ahmadinejad M. 2018. Evaluation of the effects of curcumin in patients with metabolic syndrome. Comp Clin Pathol, 2018: 1-9.
17
Sahebkar A. 2014. Curcuminoids for the management of hypertriglyceridaemi. Nat Rev Cardiol, 11: 123-123.
18
Sandhofer A, Kaser S, Ritsch A, Laimer M, Engl J, Paulweber B, Patsch JR, Ebenbichler CF. 2006. Cholesteryl ester transfer protein in metabolic syndrome. Obesity, 14: 812-818.
19
Shehzad A, Lee Y. 2010. Curcumin: Multiple molecular targets mediate multiple pharmacological actions: A review. Drugs Fut, 35: 113.
20
Shin SK, Ha TY, McGregor RA, Choi MS. 2011. Long‐term curcumin administration protects against atherosclerosis via hepatic regulation of lipoprotein cholesterol metabolism. MolNutr Food Res, 55:1829- 1840.
21
Tavil Y, Sen N, Yazıc HU, Hızal F, Abacı A, Cengel A. 2007. Cengel, Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease. Thromb Res, 120: 245-250.
22
Upadhyay S, Dixit M. 2015. Role of polyphenols and other phytochemicals on molecular signaling. Oxid Med Cell Longev, 2015.
23
ORIGINAL_ARTICLE
The effect of asafoetida essential oil on myocardial ischemic-reperfusion injury in isolated rat hearts
Objective: Previous studies reported that asafetida from Ferula assa-foetida Linn. species and its essential oil (AEO) have antioxidant effects. In the present study, the effect of AEO was evaluated on ischemic-reperfusion injury in isolated rat hearts. Materials and Methods: Forty-eight male Wistar rats were divided into 6 groups: 1) control group, 2) vehicle group, 3-5) AEO groups and, 6) carvedilol group. In the control group, hearts were only subjected to 30-min global ischemia followed by 120-min reperfusion. Hearts in other groups were perfused with vehicle (Tween 0.1%), AEO (0.125, 0.25 or 0.50 µL/g heart) or carvedilol (10 µM) for 5 min immediately before the induction of ischemia. Results: Compared to the control group, myocardial dysfunction was significantly more severe only in group 5 in which a significant increase in left ventricular end diastolic pressure and a significant decrease in left ventricular developed pressure and ±dp/dt. Also, the activities of lactate dehydrogenase and creatine kinase as the markers of myocardial injury were significantly higher only in group 5 compared to control group. The size of infarct and the incidence of irreversible fibrillation did not show any significant differences between the control group and groups 3-5. Conclusion: These results showed that perfusion of isolated rat hearts with AEO 0.5 µL/g heart, but not at lower concentrations, might worsen myocardial ischemic-reperfusion injury.
https://ajp.mums.ac.ir/article_10315_0fc7bfdac51091eb2019d7e2c02f28bf.pdf
2018-07-01
338
349
10.22038/ajp.2018.10315
Asafoetida
Heart
Essential oil
Ischemic-reperfusion injury
Hassan
Esmaeili
he_md1972@yahoo.com
1
Department of heart, School of Medicine, Gorgan University of Medical Sciences, Gorgan, Iran
AUTHOR
Zahra
Hafezimoghadam
hafezi.zahra_2310@yahoo.com
2
Department of Pharmacology, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
AUTHOR
Mansour
Esmailidehaj
ned1382@gmail.com
3
Department of Physiology, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
LEAD_AUTHOR
Mohammad Ebrahim
Rezvani
erezvani@yahoo.com
4
Department of physiology, school of medicine, Yazd university of medical sciences
AUTHOR
Zeynab
Hafizibarjin
mopbgmm3@yahoo.co.uk
5
Department of Pharmacology, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
AUTHOR
Abu-Zaiton AS. 2010. Anti-diabetic activity of Ferula assafoetida extract in normal and alloxan-induced diabetic rats. Pak J Biol Sci, 13: 97-100.
1
Ahmadvand H, Amiri H, Dehghani Elmi Z, Bagheri S. 2013. Chemical composition and antioxidant properties of Ferula-assa-foetida leaves essential oil. Iranian. J Pharmacol Ther, 12: 52-57.
2
Alves-Santos TR, de Siqueira RJ, Duarte GP, Lahlou S. 2016. Cardiovascular Effects of the Essential Oil of Croton argyrophylloides in Normotensive Rats: Role of the Autonomic Nervous System. Evid Based Complement Alternat Med, 2016: 4106502.
3
Amalraj, Augustine, and Sreeraj Gopi. 2016. Biological activities and medicinal properties of Asafoetida: A review. J Tradit Complement Med, 7:347-359
4
Anaya-Prado R, Toledo-Pereyra LH, Lentsch AB, Ward PA. 2002. Ischemia/reperfusion injury. J Surg Res, 105: 248-58.
5
Arora S, Das N, Srivastava K. 2009. Nitric oxide and eNOS gene in essential hypertension. International. Int J Collab Res Intern Med Public Health , 1: 56-71.
6
Bagheri SM, Yadegari M, Porentezari M, Mirjalili A, Hasanpor A, Dashti RM, Anvari M. 2015. Effect of Ferula assa-foetida oleo gum resin on spermatic parameters and testicular histopathology in male wistar rats. J Ayurveda Integr Med, 6: 175-80.
7
Bahrami, G, Soltani R, Sajjadi, Kanani MR, Naderi R, Ghiasvand N, Shokoohinia Y. 2013. Essential oil composition of Ferula assa-foetida L. fruits from Western Iran. J Rep Pharm Sci, 2: 90-97.
8
Bamoniri A, Mazoochi A. 2009. Determination of bioactive and fragrant molecules from leaves and fruits of Ferula assa-foetida L. growing in central Iran by nanoscal injection. Digest J Nanomater Biostruct, 4: 323-28.
9
Bayrami G, Boskabady MH, Iranshahi M, Gholamnezhad Z. 2013. Relaxant effects of asafoetida extract and its constituent umbelliprenin on guinea-pig tracheal smooth muscle. Chin J Integr Med, 12:1-6
10
Becker LB, 2004. New concepts in reactive oxygen species and cardiovascular reperfusion physiology. Cardiovasc Res, 61: 461-70.
11
Bellows SD, Hale SL, Simkhovich BZ, Kay GL, Kloner RA. 1995. Do antioxidant vitamins reduce infarct size following acute myocardial ischemia/reperfusion? Cardiovasc Drugs Ther, 9: 117-23.
12
Brunvand H, Frlyland L, Hexeberg E, Rynning SE, Berge RK, Grong K. 1996. Carvedilol improves function and reduces infarct size in the feline myocardium by protecting against lethal reperfusion injury. Eur J Pharmacol, 314:99-107.
13
Cherkaoui-Tangi K, Israili ZH, Lyoussi B. 2016. Vasorelaxant effect of essential oil isolated from Nigella sativa L. seeds in rat aorta: Proposed mechanism. Pak J Pharm Sci, 29: 1-8.
14
Dandagi PM, Patil MB, Mastiholimath VS, Gadad AP, Dhumansure RH. 2008. Development and evaluation of hepatoprotective polyherbal formulation containing some indigenous medicinal plants. Indian J Pharm Sci, 70: 265.
15
Dehpour AA, Ebrahimzadeh MA, Nabavi SF, Nabavi SM. 2009. Antioxidant activity of the methanol extract of Ferula assafoetida and its essential oil composition. Grasas y Aceites, 60: 405-12.
16
DiNicolantonio JJ, Lavie CJ, Fares H, Menezes AR, O'Keefe JH. 2013. Meta-analysis of carvedilol versus beta 1 selective beta-blockers (atenolol, bisoprolol, metoprolol, and nebivolol). Am J Cardiol, 111(5):765-9.
17
Donsi F, Ferrari G. 2016. Essential oil nanoemulsions as antimicrobial agents in food. J Biotechnol, 233: 106-20.
18
Edris AE. 2007. Pharmaceutical and therapeutic potentials of essential oils and their individual volatile constituents: a review.Phytother Res, 21: 308-23.
19
El Deeb HK, Al Khadrawy FM, Abd El-Hameid AK. 2012. Inhibitory effect of Ferula asafoetida L. (Umbelliferae) on Blastocystis sp. subtype 3 growth in vitro. Parasitol res, 111: 1213-21.
20
Esmailidehaj M, Kakoo M, Rezvani ME, Mosaddeghmehrjardi MH. 2014. Pretreatment with Assafoetida exerts dose-dependent dual effects on rat hearts. Pharmacogn Mag, 10: 147-53.
21
Esmaeili H, Sharifi M, Esmailidehaj M, Rezvani ME, Hafizibarjin Z. 2017. Vasodilatory effect of Asafoetida essential oil on rat aorta rings: The role of nitric oxide, prostacyclin, and calcium channels. Phytomedicine, 36: 88-94
22
Fatehi M, Farifteh F, Fatehi-Hassanabad Z. 2004. Antispasmodic and hypotensive effects of Ferula asafoetida gum extract. J Ethnopharmacol, 91: 321-24.
23
Hadavand Mirzaei H, Hasanloo T. 2014. Assessment of chemical composition of essential oil of Ferula assa-foetida oleo-gum-resin from two different sites of Yazd province in center of Iran. Res J Pharmacogn, 1: 51-54.
24
Iranshahi M, Alizadeh M. 2012. Antihyperglycemic Effect of Asafoetida (Ferula assafoetida Oleo-Gum-Resin) in Streptozotocin-induced Diabetic Rats. World Appl Sci J, 17: 157-62.
25
Iranshahy M, Iranshahi M. 2011. Traditional uses, phytochemistry and pharmacology of asafoetida (Ferula assa-foetida oleo-gum-resin)-a review. J Ethnopharmacol,134: 1-10.
26
Jemai H, Bouaziz M, Fki I, El Feki A, Sayadi S. 2008. Hypolipidimic and antioxidant activities of oleuropein and its hydrolysis derivative-rich extracts from Chemlali olive leaves. Chem Biol Interact, 176: 88-98.
27
Kavoosi G, Rowshan V. 2013. Chemical composition, antioxidant and antimicrobial activities of essential oil obtained from Ferula assa-foetida oleo-gum-resin: effect of collection time. Food Chem, 138: 2180-87.
28
Kavoosi G, TafsiryA, Ebdam AA, Rowshan V. 2013. Evaluation of antioxidant and antimicrobial activities of essential oils from Carum copticum seed and Ferula assafoetida latex. J Food Sci, 78: T356-T61.
29
Kavoosi G, Mahammadi Purfard A. 2013. Scolicidal effectiveness of essential oil from Zataria multiflora and Ferula assafoetida: disparity between phenolic monoterpenes and disulphide compounds. Comp Clin Path, 22: 999-1005.
30
Keshri G, Bajpai M, Lakshmi V, Setty BS, Gupta G. 2004. Role of energy metabolism in the pregnancy interceptive action of Ferula assafoetida and Melia azedarach extracts in rat. Contraception, 70: 429-32.
31
Kharadi GB, Patel KJ, Purohit BM, Baxi SN, Tripathi CB. 2016. Evaluation of cardioprotective effect of aqueous extract of Allium cepa Linn. Bulb on isoprenaline-induced myocardial injury in Wistar albino rats. Res Pharm Sci, 11:419-27.
32
Kiyanmehr M, Boskabady MH, Khazdair MR, Hashemzehi M. 2016. Possible Mechanisms for Functional Antagonistic Effect of Ferula assafoetida on Muscarinic Receptors in Tracheal Smooth Muscle. Malays J Med Sci, 23: 35-43.
33
Korashy HM, Al-Jenoobi FI, Raish M, Ahad A, Al-Mohizea AM, Alam MA, Alkharfy KM, Al-Suwayeh SA. 2015. Impact of Herbal Medicines like Nigella sativa, Trigonella foenum-graecum, and Ferula asafoetida, on Cytochrome P450 2C11 Gene Expression in Rat Liver. Drug Res (Stuttg), 65: 366-72.
34
Li J, Chen Z, Gao X, Zhang H, Xiong W, Ju J, et al. 2017. Meta-Analysis Comparing Metoprolol and Carvedilol on Mortality Benefits in Patients with Acute Myocardial Infarction. Am J Cardiol 120:1479-86.
35
Mahendra P, Bisht S. 2012. Ferula asafoetida: Traditional uses and pharmacological activity. Pharmacog rev, 6: 141-46.
36
Mallikarjuna GU, Dhanalakshmi S, Raisuddin S, Rao AR. 2003. Chemomodulatory influence of Ferula asafoetida on mammary epithelial differentiation, hepatic drug metabolizing enzymes, antioxidant profiles and N-methyl-N-nitrosourea-induced mammary carcinogenesis in rats. Breast Cancer Res Treat, 81: 1-10.
37
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46
ORIGINAL_ARTICLE
Evaluation of hematopoietic stem cell expansion in the presence of garcinol
Objective: The application of human cord blood (hCB) is limited to children by using relatively small volume of cord blood that does not contain enough hematopoietic stem cells (HSCs). So, efforts for applying cord blood stem cells in transplantation have led to establishment of some approaches for ex vivo expansion of HSCs such as garcinol. Materials and Methods: CD133+ HSCs were separated by a magnetic-activated cell sorting (MACS) system. Isolated cells were cultured with different doses of garcinol, SCF, TPO and FLT-3L. The optimal dose of garcinol for ex vivo expansion of HSCs was determined by direct counting. Flow cytometry was used to evaluate the expression of CD133 marker to check the ability of garcinol in maintenance of HSCs. Colony forming cell (CFC) assay was performed to evaluate clonogenic capability of treated cells. The level of expression of CXCR4 gene was evaluated by RT-PCR. Data were analyzed using Student’s t test. Results: Our results showed that CD133+ HSCs in the presence of garcinol (5-10 µM) had high expansion activity and cell counting showed that the number of cells in treated group was higher than control group (1.9 –fold) and CFC assay showed that the number of colonies following treatment with garcinol had 1.3-fold increase. Treatment of HSCs with garcinol resulted in 9.6-fold increase in terms of CXCR4 expression in comparison to control group. Conclusion: The present study showed that garcinol can improve ex vivo expansion of HSCs and enhance their potential for homing to bone marrow.
https://ajp.mums.ac.ir/article_10786_5a9e5dc4a4968277399b04f9c8a0df85.pdf
2018-07-01
350
357
10.22038/ajp.2018.18903.1729
Hematopoietic stem cells
expansion
Garcinol
Small-molecule compounds
Azam
Habibi
a.habibi@modares.ac.ir
1
Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
AUTHOR
Masoud
Soleimani
soleim_m@modares.ac.ir
2
Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
LEAD_AUTHOR
Amir
Atashi
atashia@shmu.ac.ir
3
Stem Cell and Tissue Engineering Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
AUTHOR
Mahshid
AkhavanRahnama
mahshidakhavan69@yahoo.com
4
Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Azadeh
Anbarlou
anbarlou1990@gmail.com
5
Department of Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Mansoureh
Ajami
minoo.ajami@gmail.com
6
Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
AUTHOR
Monireh
Ajami
mina.ajami@gmail.com
7
Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
AUTHOR
Anbarlou A, Atashi A, Soleimani M, AkhavanRahnama M, Bohloli M, Mossahebi-Mohammadi M. 2015. Differential characteristics of CD133+ and CD133− Jurkat cells. In Vitro Cell Dev Biol Anim, 51: 556–561.
1
Boitano A, Wang J, Romeo R, Bouchez L, Parker A, Sutton S, Denison M. 2010. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science, 329: 1345–1348.
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Nishino T, Osawa M, Iwama A. 2012. New approaches to expand hematopoietic stem and progenitor cells. Expert Opin Biol Ther, 12: 743–756.
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30
ORIGINAL_ARTICLE
Aqueous extract of saffron administration along with amygdala deep brain stimulation promoted alleviation of symptoms in post-traumatic stress disorder (PTSD) in rats
Objective: Post-traumatic stress disorder (PTSD) as one of the most devastating kinds of anxiety disorders, is the consequence of a traumatic event. Crocus sativus L., commonly known as saffron have been traditionally used for treatment of stress and anxiety. In this study, we evaluated the effects of peripheral administration of saffron, along with deep brain stimulation (DBS) in a post-traumatic stress disorder (PTSD) model caused by contextual fear conditioning (electrical foot shock chamber) in male Wistar rats. Materials and Methods: rats (220-250 g) were divided into 7 groups (n=8) and underwent stereotactic surgery for implantation of the electrodes in the right-baso lateral of the amygdala (BLA). After 7 days, some animals received the foot shock, followed by another 7-day treatment (DBS treatment or combination treatment by saffron 5 mg/kg (i.p)) then freezing behavior as a predicted response in the absence of the foot shock (re-exposure time) and general anxiety were measured using elevated plus maze test. Serum corticosterone level and amygdala c-Fos protein expression were assessed using ELISA and Western blot analysis, respectively. Results: DBS treatment and the combination therapy of saffron (5 mg/kg (I.P)) with DBS significantly (p<0.001) increased serum corticosterone levels. Also both treatments could significantly (p<0.001) reduce c-Fos protein expression and freezing behaviors time. However, DBS treatment had no effect on the general anxiety in rats with PTSD. On the other hand, combination therapy significantly (p<0.001) reduced anxiety behavior in rats with PTSD. Conclusion: These results might show the potential of this combination therapy for treatment of treatment-resistant PTSD patients.
https://ajp.mums.ac.ir/article_10361_f0fd14a74633a9da8a611f78810d2ae3.pdf
2018-07-01
358
369
10.22038/ajp.2018.10361
Deep brain stimulation
Saffron
Post-traumatic stress disorder
Contextual fear conditioning
Corticosterone
C-Fos protein
Mina
Mokhtari Hashtjini
mina_hashtjin65@yahoo.com
1
Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran
AUTHOR
Gila
Pirzad Jahromi
dbspaper1395@gmail.com
2
Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
Gholam Hossein
Meftahi
shamemahtab.mokhtary@gmail.com
3
Neuroscience Research Centre, Baqiyatallah University of Medical Sciences, Tehran, Iran
AUTHOR
Davoud
Esmaeili
esm114@gmail.com
4
Applied Microbiology Research Center, and Microbiology Department, Baqiyatallah University of Medical Sciences, Tehran, Iran
AUTHOR
Danial
Javidnazar
dan_javid@yahoo.com
5
Electrophysiology Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Calleja-Castillo JM, De La Cruz-Aguilera DL, Manjarrez J, Velasco-Velázquez MA, Morales-Espinoza G, Moreno-Aguilar J, et al. 2013.Chronic deep brain stimulation of the hypothalamic nucleus in Wistar rats alters circulatory levels of corticosterone and proinflammatory cytokines. Clin Dev Immunol, 2013.
1
Cordero MI, Venero C, Kruyt ND, Sandi C .2003. Prior exposure to a single stress session facilitates subsequent contextual fear conditioning in rats: Evidence for a role of corticosterone. Horm Behav, 44: 338-345.
2
De Kloet C, Vermetten E, Geuze E, Kavelaars A, Heijnen C, Westenberg H. 2006. Assessment of HPA-axis function in posttraumatic stress disorder: pharmacological and non-pharmacological challenge tests, a review. J Psychiatr Res, 40:550-567.
3
De Koning PP, Figee M, Endert E, Storosum JG, Fliers E, Denys D. 2013. Deep brain stimulation for obsessive–compulsive disorder is associated with cortisol changes. Psychoneuroendocrinology, 38:1455-1459.
4
Delgado MR, Olsson A, Phelps EA. 2006. Extending animal models of fear conditioning to humans. Biol Psychol, 73:39-48.
5
Frances Davies M, Tsui J, Flannery JA, Li X, DeLorey TM, Hoffman BB. 2003. Activation of [alpha]2 adrenergic receptors suppresses fear conditioning: expression of c-Fos and phosphorylated CREB in mouse amygdala. Neuropsychopharmacology, 29:229-239
6
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Georgiadou G, Tarantilis P, Pitsikas N. 2012. Effects of the active constituents of Crocus Sativus L., crocins, in an animal model of obsessive–compulsive disorder. Neurosci. Lett , 528 : 27-30.
8
Halataei B, Khosravi SM, Arbabian S, Sahraei H, Golmanesh L, Zardooz H, Jalili C, Ghoshooni H. 2011. Saffron (Crocus sativus) Aqueous Extract and its Constituent Crocin Reduces Stress‐induced Anorexia in Mice. Phytother Res , 25: 1833-1838.
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Hosseinzadeh H, Jahanian Z. 2010. Effect of Crocus sativus L.(saffron) stigma and its constituents, crocin and safranal, on morphine withdrawal syndrome in mice. Phytother Res, 24 : 726-730.
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Hosseinzadeh H, Noraei NB. 2009. Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice. Phytother Res, 23: 768-774.
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Khazdair MR, Boskabady MH, Hosseini M, Rezaee R, Tsatsakis AM. 2015. The effects of Crocus sativus (saffron) and its constituents on nervous system: A review. AJP, 5 :376.
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Langevin J P, De Salles AAF, Kosoyan HP, Krahl SE. 2010. Deep brain stimulation of the amygdala alleviates post-traumatic stress disorder symptoms in a rat model. J Psychiatr Res, 44 : 1241-1245.
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18
Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C, Schwalb JM , Kennedy SH. 2005. Deep brain stimulation for treatment-resistant depression. Neuron , 45: 651-660.
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McIntyre CC, Savasta M, Kerkerian-Le Goff L, Vitek JL. 2004. Uncovering the mechanism (s) of action of deep brain stimulation: activation, inhibition, or both. Clin Neurophysiol, 115: 1239-1248.
20
Mokhtari-Zaer A, Khazdair MR, Boskabady MH. 2015. Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms. AJP, 5 :365.
21
Milad MR, Rauch SL, Pitman RK, Quirk GJ. 2006 . Fear extinction in rats: implications for human brain imaging and anxiety disorders. Biol Psychol, 73: 61-71.
22
Noorbala A, Akhondzadeh S, Tahmacebi-Pour N, Jamshidi A. 2005. Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial. J Ethnopharmacol, 97: 281-284.
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Petrov T, Jhamandas JH, Krukoff TL. 1994. Electrical stimulation of the central nucleus of the amygdala induces fos-like immunoreactivity in the hypothalamus of the rat: a quantitative study. Mol Brain Res, 22: 333-340.
24
Pitsikas N, Boultadakis A, Georgiadou G, Tarantilis P, Sakellaridis N. 2008. Effects of the active constituents of Crocus sativus L., crocins, in an animal model of anxiety. Phytomedicine, 15: 1135-1139.
25
Putman P, Hermans EJ, Koppeschaar H, Van Schijndel A, Van Honk J. 2007. A single administration of cortisol acutely reduces preconscious attention for fear in anxious young men. Psychoneuroendocrinology, 32: 793-802.
26
Rosa M, Giannicola G, Marceglia S, Fumagalli M, Barbieri S, Priori A. 2012. Neurophysiology of deep brain stimulation. Int Rev Neurobiol , 107: 23-55.
27
Sahraei H, Fatahi Z, Eidi A, Haeri-Rohani A, Hooshmandi Z, Shekarforoush S, Tavalaei SA. 2012. Inhibiting Post Traumatic Stress Disorder (PTSD) induced by electric shock using ethanol extract of saffron in rats. J. Biol. Res. Thessalon, 18: 320-327.
28
Schiller D, Monfils MH, Raio CM, Johnson DC, LeDoux JE, Phelps EA. 2010. Preventing the return of fear in humans using reconsolidation update mechanisms. Nature, 463: 49-53.
29
Stidd DA, Vogelsang K, Krahl SE, Langevin JP, Fellous JM. 2013. Amygdala deep brain stimulation is superior to paroxetine treatment in a rat model of posttraumatic stress disorder. Brain Stimul, 6: 837-844.
30
Yehuda R. 2009. Status of Glucocorticoid Alterations in Post‐traumatic Stress Disorder. Ann N Y Acad Sci, 1179 : 56-69.
31
Yehuda R, LeDoux J. 2007. Response variation following trauma: a translational neuroscience approach to understanding PTSD. Neuron, 56: 19-32.
32
Yu H, Neimat JS. 2008. The treatment of movement disorders by deep brain stimulation. Neurotherapeutics, 5 : 26-36.
33
ORIGINAL_ARTICLE
Renoprotective effects of the methanolic extract of Tanacetum parthenium against carbon tetrachloride-induced renal injury in rats
Objective: Studies have demonstrated that carbon tetrachloride (CCl4) increases the generation of reactive oxygen species (ROS) in many tissues including the kidney, heart, lung, brain, and liver. The major aim of the present study was to evaluate the protective activity of Tanacetum parthenium extract (TPE) in renal tissues of CCl4-intoxicated rats. Materials and Methods: Animals were divided into seven groups of six rats. Group 1 was the control group that was not treated with CCl4. The rats in the other groups were intraperitoneally injected with CCl4 (1.5 ml/kg, 1:1 in olive oil) on day 14. Rats in the groups bTPE40, bTPE80, and bTPE120 were gavaged with 40, 80, and 120 mg/kg of TPE, respectively for 14 constitutive days on a daily basis, before CCl4 administration. Rats in groups aTPE80 and aTPE120 were gavaged with 80 and 120 mg/kg of TPE, respectively, 2, 6, 24 and 48 hr after receiving CCl4. Blood samples were collected at the end of the 16th day through an intracardiac puncture and then serums were separated. Results: CCl4 increased urea, creatinine, uric acid and creatinine: albumin (C/A) ratio level in serum and decreased total antioxidant and antioxidant enzymes (SOD and GPx) when compared to the control group (p<0.001). But administration of TPE to rats either before or after exposure to CCl4, attenuated these changes when compared with CCl4 control group (p Conclusion: TPE had potent nephroprotective effects against oxygen free radicals produced through CCl4 metabolism.
https://ajp.mums.ac.ir/article_10397_2f4313f762205b7bc52821012088ec3b.pdf
2018-07-01
370
379
10.22038/ajp.2018.10397
Tanacetum parthenium
Carbon tetrachloride
Antioxidant
Oxidative stress
Kidney
Mohammad
Mazani
m.mazani@arums.ac.ir
1
Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
AUTHOR
Yavar
Mahmoodzadeh
ymahmoudzade@gmail.com
2
Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
AUTHOR
Mir Mehdi
Chinifroush-Asl
m.chinifroush@arums.ac.ir
3
Department of Pathology, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
AUTHOR
Shokofeh
Banaei
s.banaei@arums.ac.ir
4
Department of Physiology, Ardabil University of Medical Sciences, Ardabil, Iran
AUTHOR
Lotfollah
Rezagholizadeh
reza34055@gmail.com
5
Department of Biochemistry, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
LEAD_AUTHOR
Alireza
Mohammadnia
alireza.mohammadnia@gmail.com
6
Department of Health Information Technology Management, School of Medicine, Ardabil University of Medical Sciences, Ardabil, Iran
AUTHOR
Aksoy L, Sözbilir NB. 2012. Effects of Matricaria chamomilla L. on lipid peroxidation, antioxidant enzyme systems, and key liver enzymes in CCl4-treated rats. Toxicol Environ Chem, 94: 1780-1788.
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ORIGINAL_ARTICLE
Enhancing effect of Tiliacora triandra leaves extract on spatial learning, memory and learning flexibility as well as hippocampal choline acetyltransferase activity in mice
Objective: The present study investigates the effect of Tiliacora triandra leaf extract on spatial learning, memory, and learning flexibility as well as hippocampal choline acetyltransferase (ChAT) activity in mice. Materials and Methods: Thirty male ICR mice were randomly divided into three groups including 10% Tween 80, T. triandra 300 mg/kg and T. triandra 600 mg/kg. All administrations were done orally for 18 consecutive days. Spatial learning, memory and learning flexibility were assessed using the Morris water maze. ChAT activity and hippocampal neuronal cell number were assessed by immunohistochemistry and histological methods, respectively. Results: The results demonstrated that T. triandra leaf extract (300 and 600 mg/kg) significantly enhances spatial learning and learning flexibility. Only 300 mg/kg of T. triandra significantly improved the spatial memory. The hippocampal ChAT activity and total hippocampal cell number were significantly increased in T. triandra-treated groups. Conclusion: The present study indicated that T. triandra leaf extract improves the spatial learning, memory and learning flexibility, exerts neuroprotective effects on hippocampal neurons and maintains ChAT activity in this brain area.
https://ajp.mums.ac.ir/article_10678_dd094f2b50ffc415f8fe63a2ff14fd5c.pdf
2018-07-01
380
388
10.22038/ajp.2018.10678
Choline acetyltransferase
Spatial learning
Learning flexibility
Hippocampus
Tiliacora triandra
Morris Water Maze
Wachiryah
Thong-asa
fsciwyth@ku.ac.th
1
Animal Toxicology and Physiology Specialty Research Unit (ATPSRU), Physiology Division, Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, Thailand
LEAD_AUTHOR
Hathaipat
Laisangunngam
ktant212@hotmail.com
2
Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, Thailand
AUTHOR
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