ORIGINAL_ARTICLE
The effect of Saqez (Pistacia atlantica) ointment on nipple fissure improvement in breastfeeding women during one-month follow-up
Objective: Painful nipple fissure is a troublesome problem for breastfeeding mothers. This study was conducted to evaluate the effect of saqez (Pistacia atlantica) ointment on the improvement of nipple fissure in breastfeeding women during one-month follow-up. Materials and Methods: This randomized controlled clinical trial was conducted on 100 eligible women who visited the selected health centers affiliated to Shahid Beheshti University of Medical Sciences, Tehran, Iran, from July 2015 to December 2015 during their postpartum period. A total of 100 subjects were randomly divided into two equal groups of 50 women grouped as saqez ointment group and breast milk group, and followed-up for one month. Both groups received face-to-face instructions on breastfeeding techniques. For severity of nipple fissure, Storr scale and to measure the intensity of pain, visual analog scale (VAS) were used. Results: The results showed that the two groups were matched in terms of demographic and obstetric characteristics. Mean of nipple fissure severity in ointment group (42.62) was lower than that of the control group (48.02), that was significantly different between the two groups (p=0.047). In addition, Mean nipple pain intensity in ointment group (40.57) was lower than that of the control group (49.81), but there was no significant difference between the two groups (p=0.056). Conclusion: The present study showed that saqez ointment was more effective than breast milk in healing and controlling nipple fissures during one-month follow-up, without resulting in any side effects.
https://ajp.mums.ac.ir/article_9336_28aea4a7ec0c1a91ebedf2935d687b58.pdf
2017-11-01
477
485
10.22038/ajp.2017.22182.1827
Nipple fissure
Pain
sagez ointment
Pistacia atlantica
Breast milk
Nayereh
Asadi
nayereh.asadi62@gmail.com
1
Student Research Committee, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Nourossadat
Kariman
n_kariman@yahoo.com
2
Research Center for Midwifery and Reproductive Health, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
Faraz
Mojab
sfmojab@sbmu.ac.ir
3
Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Mohammad Amin
Pourhoseingholi
amin_phg@yahoo.com
4
Liver Department, Research Center for Gastroenterology and Liver Disease, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Abou-Dakn M, Fluhr J, Gensch M, Wöckel A. 2011. Positive effect of HPA lanolin versus expressed breastmilk on painful and damaged nipples during lactation. Skin Pharmacol physiol, 24:27-35.
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Aeenechi Y A. 1999. Materia Medica and Medicinal Plants of Iran.pp.267,Tehran University publishing.
2
Ahmed EMS, El fattah Mohamed HA, Abu-talib YM. 2015. Evidence Based Guideline Using to Alleviate Traumatic Nipple among Nursing Mothers. World J Nursing Sci, 1:35-44.
3
Amir Ali Akbari S, Alamolhoda SH, Baghban AA, Mirabi P. 2014. Effects of menthol essence and breast milk on the improvement of nipple fissures in breastfeeding women. J Res Med Sci, 19:629-33.
4
Alamolhoda SH, Amir Ali Akbari S, Akbarzadeh Baghban A, Esmaili S. 2014. The effect of aloe vera gel on the breast fissures in lactating women. J Pajoohandeh (research journal of Shahid Beheshti University of Sciences, 19:13-17.
5
Amin Gh. 2008. Popular Medicinal Plants of Iran, pp. 178, Tehran University of Medical Sciences.
6
As'adi N, Kariman N, Mojab F, Pourhoseingholi MA. 2017. The effect of Saqez (Pistacia atlantica) ointment on the treatment of nipple fissure and nipple pain in breastfeeding women. Electron Physician. 9:4952-4960.
7
As'adi N, Kariman N, Shahrahmai H, Ghalandari S, Khodakarami N. 2016. A systematic review of clinical trials in the treatment of sore nipples and nipple pain in breastfeeding women. Iran J Obstet Gyneco Infert, 19: 22-33.
8
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Buck ML, Amir LH, Donath SM. 2015. Topical Treatments Used by Breastfeeding Women to Treat Sore and Damaged Nipples. Clin Lact, 6:16-23.
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Dennis C-L, Schottle N, Hodnett E, McQueen K. 2012. An all-purpose nipple ointment versus lanolin in treating painful damaged nipples in breastfeeding women: A randomized controlled trial. Breastfeeding Med, 7:473-9.
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Essa RM, Ebrahim EM. 2013. Effect of Breast Milk versus Therapeutic Honey (Apicare) on Cracked Nipples' healing. Life Sci J, 10: 2137-2147.
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Gourine N, Yousfi M, Bombarda I, Nadjemi B, Stocker P, Gaydou EM. 2010. Antioxidant activities and chemical composition of essential oil of Pistacia atlantica from Algeria. Ind Crops Prod, 31:203-8.
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Guyton AS HJ. 2011. Textbook of medical physiology, pp. 697-1335, Tehran, Andishe Rafi.
19
Haghdoost F, Baradaran Mahdavi MM, Zandifar A, Sanei MH, Zolfaghari B, Javanmard SH. 2013. Pistacia atlantica resin has a dose-dependent effect on angiogenesis and skin burn wound healing in rat. Evid -Based Complementary Alternat Med, 2013: 1-8.
20
Heller MM, Fullerton‐Stone H, Murase JE. 2012. Caring for new mothers: diagnosis, management and treatment of nipple dermatitis in breastfeeding mothers. Int J Dermatol, 51:1149-61.
21
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22
Khodavvaisy S, Rezaie S, Noorbakhsh F, Baghdadi E, Sharifynia S, Aala F. Effects of Pistacia atlantica subsp. Kurdica on growth and Aflatoxin production by Aspergillus parasiticus.2016. Jundishapur J Microbiol, 9: 1-4.
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Marrazzu A, Sanna MG, Dessole F, Capobianco G, Piga MD, Dessole S. 2015. Evaluation of the Effectiveness of a Silver-Impregnated Medical Cap for Topical Treatment of Nipple Fissure of Breastfeeding Mothers. Breastfeed Med, 10:232-8.
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27
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Pourreza M, Shaw JD, Zangeneh H. 2008. Sustainability of wild pistachio (Pistacia atlantica Desf.) in Zagros forests, Iran. For Ecol Manage, 255:3667-71.
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30
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34
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37
ORIGINAL_ARTICLE
A review on botanicals with wound healing activity for pemphigus vulgaris: perspective of traditional Persian medicine and conventional medicine
Objective: As a rare autoimmune disease, pemphigus vulgaris has a poor prognosis especially in lack of proper medical support. This blistering disease involves both the skin and mucus membranes. The challenge is improving the healing process of skin lesions of which, superimposed infections are among the main causes of the disease mortality. Accordingly, we aimed to assess the treatment options suggested by traditional Persian medicine (TPM) and compare them with current findings. Materials and Methods: We studied the main clinical and pharmaceutical textbooks of TPM (Kitāb al-hāwīfī al-tibb, the Canon of Medicine, Eksir-e-Aazam, Tuhfat al-mu'minīn, Makhzan al-adviyah (focusing on the skin chapter and respective herbal remedies for the inflamed skin and ulcers. Additionally, scientific databases such as PubMed, Science direct, Scopus, and Google Scholar were searched for the current pharmacological evidence. In the studied books, the term “hot ulcers” was found close to what is known as “Pemphigus vulgaris”. Results: Reported medicinal herbs possess anti-inflammatory, antioxidant, wound healing, and antibacterial activities reported by recent studies. Therefore, they could be introduced as novel natural remedies for pemphigoid wounds. Conclusion: Taken as a whole, the review of traditional remedies for hot ulcers in Persian medical and pharmaceutical literature may open a new window toward developing new topical treatments for this disease.
https://ajp.mums.ac.ir/article_8261_d29eea9e3b30e5040af2ef15d3b55269.pdf
2017-11-01
486
494
10.22038/ajp.2017.17889.1695
Pemphigus vulgaris
Traditional Persian Medicine
Herbal remedies
Fatemeh
Atarzadeh
dr.atarzadeh@gmail.com
1
Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Amir Mohammad
Jaladat
drjaladat@gmail.com
2
Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
LEAD_AUTHOR
Babak
Daneshfard
babakdaneshfard@gmail.com
3
Essence of Parsiyan Wisdom Institute, Phytopharmaceutical Technology and Traditional Medicine Incubator, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Ladan
Dastgheib
dastgheibl@sums.ac.ir
4
Shiraz Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Mohammad
Kamalinejad
mkamalinejad@yahoo.com
5
Department of Pharmacognosy, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Gholamreza
Amin
amin@sina.tums.ac.ir
6
Department of Traditional Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Abida O, Mansour RB, Gargouri B, Ayed MB, Masmoudi A, Turki H, Masmoudi H, Lassoued S. 2012. Catalase and lipid peroxidation values in serum of Tunisian patients with pemphigus vulgaris and foliaceus. Biol Trace Elem Res, 150:74-80.
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64
ORIGINAL_ARTICLE
Effects of Musa sapientum stem extract on experimental models of anxiety
Objective: The Musa sapientum (banana) plant extract has shown antioxidant activity in previous studies. Oxidative stress is one of the important factors implicated in the pathogenesis of anxiety disorders. The present study aimed to evaluate the anxiolytic activity of aqueous extract of M. sapientum stem (MSSE) in experimental models in mice. Material and Methods: Elevated Plus Maze method and locomotor monitoring by photoactometer were used. Animals were divided into five different groups (n=6/group). The vehicle, standard and the experimental groups were given distilled water (10 ml/kg), diazepam (1 mg /kg intraperitoneally) and incremental doses of 25, 50 and 100 mg/kg of MSSE, respectively, prior to the experiment. The standard group received diazepam. Results: The number of open arm entries and the duration of time spent in the open arms in the MSSE-treated groups increased significantly in a dose-dependent manner as compared to that of control group. The duration of time spent in closed arms in the MSSE-treated groups decreased significantly in a dose-dependent manner as compared to that of the control group. MSSE also decreased the locomotor activity significantly at all three test doses. Conclusion: The results of this study suggest an anxiolytic activity for MSSE, which make it a potential natural compound for treatment of anxiety disorders.
https://ajp.mums.ac.ir/article_8822_0c9114227428ef9aac2a0bd6ec53fa63.pdf
2017-11-01
495
501
10.22038/ajp.2017.8822
Musa sapientum
Anxiety
Oxidative stress
Elevated plus maze
Mice
Aditya
Jielella Reddy
adityareddy.jilella@gmail.com
1
Department of Pharmacology, SMS&R, Sharda University, Gr. Noida, NCR, India
AUTHOR
Ashok
Kumar Dubey
ak.dubey@sharda.ac.in
2
Department of Pharmacology, SMS&R, Sharda University, Gr. Noida, NCR, India
LEAD_AUTHOR
Shailendra
Handu
shailendra.handu@sharda.ac.in
3
Department of Pharmacology, SMS&R, Sharda University, Gr. Noida, NCR, India
AUTHOR
Sachin
Manocha
sachin.manocha@sharda.ac.in
4
Department of Pharmacology, SMS&R, Sharda University, Gr. Noida, NCR, India
AUTHOR
Pramod
Kumari Mediratta
pramod.kumari@shrada.ac.in
5
Department of Pharmacology, SMS&R, Sharda University, Gr. Noida, NCR, India
AUTHOR
Qazi
Ahmed Mushtaq
qm.ahmed@sharda.ac.in
6
Department of Pharmacology, SMS&R, Sharda University, Gr. Noida, NCR, India
AUTHOR
Adewoye EO, Taiwo VO, Olayioye FA. 2009. Anti-oxidant and anti-hyperglycemic activities of musa sapientum root extracts in alloxan-induced diabetic rats. Afr J Med Med Sci, 38:109-117.
1
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Cryan JF, Sweeney FF. 2011.The age of anxiety: role of animal models of anxiolytic action in drug discovery. Br J Pharmacol, 164:1129-1161.
3
Dikshit P, Tyagi MK, Shukla K, Sharma S, Gambhir JK, Shukla R. 2011. Hepatoprotective effect of stem of Musa sapientum Linn in rats intoxicated with carbon tetrachloride. Ann Hepatol, 10:333-339.
4
Emhan A, Selek S, Bayazıt H, Fatih Kİ, Katı M, Aksoy N. 2015. Evaluation of oxidative and antioxidative parameters in generalized anxiety disorder. Psychiatry Res, 230:806-810.
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Goel RK, Sairam K, Rao CV. 2001. Role of gastric antioxidant and anti-Helicobactor pylori activities in antiulcerogenic activity of plantain banana (Musa sapientum var. paradisiaca). Indian J Exp Biol, 39:719-722.
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Grases G, Colom MA, Fernandez RA, Costa-Bauzá A, Grases F. 2014. Evidence of higher oxidative status in depression and anxiety. Oxid Med Cell Longev, doi: 10.1155/2014/430216.
7
Hajhashemi V, Rabbani M, Ghanadi A, Davari E. 2010. Evaluation of antianxiety and sedative effects of essential oil of Ducrosia anethifolia in mice. Clinics, 65:1037-1042.
8
Kessler RC. 2007. The global burden of anxiety and mood disorders: putting the European Study of the Epidemiology of Mental Disorders (ESEMeD) findings into perspective. J Clin Psychiatry,68:10-19.
9
Krolow R, Arcego DM, Noschang C, Weis SN, Dalmaz C. 2014. Oxidative imbalance and anxiety disorders. Curr Neuropharmacol, 12:193-204.
10
Kumar GP, Khanum F. 2012. Neuroprotective potential of phytochemicals. Pharmacogn Rev, 6:81-90.
11
Michel Bourin. 2015. Animal models for screening anxiolytic-like drugs: a perspective. Dialogues Clin Neurosci, 17:295-303.
12
Pellow S, File S. 1986. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav, 24:525- 529
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Pereira A, Maraschin M. 2015. Banana (Musa spp) from peel to pulp: ethnopharmacology, source of bioactive compounds and its relevance for human health. J Ethnopharmacol, 160:149-163.
14
Reddy AJ, Handu SS, Dubey AK, Mediratta PK, Shukla R, Ahmed QM. 2016. Effect of Musa sapientum Stem Extract on Animal Models of Depression. Pharmacogn Res, 8:249-252.
15
Roy-Byrne PP, Davidson KW, Kessler RC, Asmundson GJ, Goodwin RD, Kubzansky L, Lydiard RB, Massie MJ, Katon W, Laden SK, Stein MB. 2008. Anxiety disorders and comorbid medical illness. Gen Hosp Psychiatry, 30:208-225.
16
Sajja VS, Hubbard WB, VandeVord PJ. 2015. Subacute Oxidative Stress and Glial Reactivity in the Amygdala are Associated with Increased Anxiety Following Blast Neurotrauma. Shock, Suppl 1:71-78.
17
Smaga I, Niedzielska E, Gawlik M, Moniczewski A, Krzek J, Przegaliński E, Pera J, Filip M. 2015. Oxidative stress as an etiological factor and a potential treatment target of psychiatric disorders. Part 2. Depression, anxiety, schizophrenia and autism. Pharmacol Rep, 67:569-580.
18
Tsai MC, Huang TL. 2016. Increased activities of both superoxide dismutase and catalase were indicators of acute depressive episodes in patients with major depressive disorder. Psychiatry Res, 235:38-42.
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Turner R. 1965. Screening Methods in Pharmacology. Vol. 1. New York: Academic Press, p. 26.
20
Trebaticka J, Durackova Z. 2015. Psychiatric Disorders and Polyphenols: Can They Be Helpful in Therapy? Oxid Med Cell Longev, doi:10.1155/2015/248529
21
ORIGINAL_ARTICLE
Thymoquinone restores liver fibrosis and improves oxidative stress status in a lipopolysaccharide-induced inflammation model in rats
Objective: Liver fibrosis is the primary sign of chronic liver injury induced by various causes. Thymoquinone (TQ) is the major ingredient of Nigella sativa with several beneficial effects on the body. In the present study, we aimed to investigate the effect of TQ on liver fibrosis in a lipopolysaccharide (LPS)-induced inflammation in male rats. Materials and methods: Fifty male Wistar rats were randomly divided into five groups (n=10 in each group) as follow: (1) control; (2) LPS (1 mg/kg/day; i.p); (3) LPS+TQ 2 mg/kg/day (i.p) (LPs+TQ2); (4) LPS+TQ 5 mg/kg/day (LPS+TQ5); (5) LPS+ TQ 10 mg/kg/day (LPS+ TQ10). After three weeks, blood samples were taken for evaluation of liver function tests. Then, the livers were harvested for histological evaluation of fibrosis and collagen content and measurement of oxidative stress markers including malondialdehyde (MDA), total thiol groups, superoxide dismutase (SOD) and catalase activity in tissue homogenates. Results: LPS group showed higher levels of fibrosis and collagen content stained by Masson’s trichrome in liver tissue with impaired liver function test and increased oxidative stress markers (p<0.05). Treatment by TQ restored liver fibrosis, improved liver function tests and increased the levels of anti-oxidative enzymes (SOD and catalase), while reduced MDA concentration (p<0.05). Conclusion: Treatment by TQ restores inflammation-induced liver fibrosis possibly through affecting oxidative stress status. It seems that administration of TQ can be considered as a part of liver fibrosis management.
https://ajp.mums.ac.ir/article_8932_d99f0126132ab630157206dbbc8e15db.pdf
2017-11-01
502
510
10.22038/ajp.2017.21744.1815
Inflammation
Thymoquinone
Liver
Fibrosis
Fereshteh
Asgharzadeh
asgharzadehf931@mums.ac.ir
1
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Rahimeh
Bargi
bargir931@mums.ac.ir
2
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Farimah
Beheshti
beheshtif1@thums.ac.ir
3
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Seyed Mahmoud
Hosseini
hosseinim@mums.ac.ir
4
Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mehdi
Farzadnia
farzadniam@mums.ac.ir
5
Departments of Pathology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Majid
Khazaei
khazaeim@mums.ac.ir
6
Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Alsaif MA. 2007. Effect of thymoquinone on ethanol-induced hepatotoxicity in Wistar rats. J Med Sci, 7:1164-1170.
1
Amin B, Hosseinzadeh H. 2016. Black cumin (Nigella sativa) and its active constituent, thymoquinone: an overview on the analgesic and anti-inflammatory effects. Planta Medica, 82:8-16.
2
Awad AS, Al Haleem ENA, El-Bakly WM, Sherief MA. 2016. Thymoquinone alleviates nonalcoholic fatty liver disease in rats via suppression of oxidative stress, inflammation, apoptosis. Naunyn Schmiedebergs Arch Pharmacol, 389:381-391.
3
Bai T, Lian L-H, Wu Y-L, Wan Y, Nan J-X. 2013. Thymoquinone attenuates liver fibrosis via PI3K and TLR4 signaling pathways in activated hepatic stellate cells. Int immunopharmacol, 15:275-281.
4
Bataller R, Brenner DA. 2005. Liver fibrosis. J Clin Invest, 115:209-218.
5
Beheshti F, Hosseini M, Shafei MN, Soukhtanloo M, Ghasemi S, Vafaee F, Zarepoor L. 2016. The effects of Nigella sativa extract on hypothyroidism-associated learning and memory impairment during neonatal and juvenile growth in rats. Nutritional neuroscience:1-11.
6
Ceccarelli S, Panera N, Mina M, Gnani D, De Stefanis C, Crudele A, Rychlicki C, Petrini S, Bruscalupi G, Agostinelli L. 2015. LPS-induced TNF-factor mediates pro-inflammatory and pro-fibrogenic pattern in non-alcoholic fatty liver disease. Oncotarget, 6:41434-41452.
7
Darakhshan S, Pour AB, Colagar AH, Sisakhtnezhad S. 2015. Thymoquinone and its therapeutic potentials. Pharmacol Res, 95:138-158.
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9
Friedman SL. 2000. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem, 275:2247-2250.
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Friedman SL. 2008. Mechanisms of hepatic fibrogenesis. Gastroenterology, 134:1655-1669.
11
Gholamnezhad Z, Havakhah S, Boskabady MH. 2016. Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review. J Ethnopharmacol, 190:372-386.
12
Harry D, Anand R, Holt S, Davies S, Marley R, Fernando B, Goodier D, Moore K. 1999. Increased sensitivity to endotoxemia in the bile duct–ligated cirrhotic rat. Hepatology, 30:1198-1205.
13
Hassanein KM, Al-Emam A, Radad K. 2016. Prophylactic effects of thymoquinone against carbon tetrachloride-induced hepatic damage in Sprague-Dawley rats. J Appl Pharm Sci, 6:167-171.
14
Karaa A, Thompson KJ, McKillop IH, Clemens MG, Schrum LW. 2008. S-adenosyl-L-methionine attenuates oxidative stress and hepatic stellate cell activation in an ethanol-LPS-induced fibrotic rat model. Shock, 30:197-205.
15
Koyama I, Matsunaga T, Harada T, Hokari S, Komoda T. 2002. Alkaline phosphatases reduce toxicity of lipopolysaccharides in vivo and in vitro through dephosphorylation. Clin Biochem, 35:455-461.
16
Liver EAFTSOT. 2012. EASL–EORTC clinical practice guidelines: management of hepatocellular carcinoma. J Hepatol, 56:908-943.
17
Nagi MN, Al-Shabanah OA, Hafez MM, Sayed-Ahmed MM. 2011. Thymoquinone supplementation attenuates cyclophosphamide-induced cardiotoxicity in rats. J Biochem Mol Toxicol, 25:135-142.
18
Oguz S, Kanter M, Erboga M, Erenoglu C. 2012. Protective effects of thymoquinone against cholestatic oxidative stress and hepatic damage after biliary obstruction in rats. J Mol Histol, 43:151-159.
19
Paik YH, Schwabe RF, Bataller R, Russo MP, Jobin C, Brenner DA. 2003. Toll‐like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Hepatology, 37:1043-1055.
20
Poynard T1, Lebray P, Ingiliz P, Varaut A, Varsat B, Ngo Y, Norha P, Munteanu M, Drane F, Messous D, Bismut FI, Carrau JP, Massard J, Ratziu V, Giordanella JP. 2010. Prevalence of liver fibrosis and risk factors in a general population using non-invasive biomarkers (FibroTest). BMC Gastroenterol, 22;10:40.
21
Rockey DC, Friedman SL. 2012. Hepatic fibrosis and cirrhosis. Zakim and Boyer’s hepatology, 6th edn Elsevier Saunders, Philadelphia:64-85.
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Sánchez-Valle V, C Chavez-Tapia N, Uribe M, Méndez-Sánchez N. 2012. Role of oxidative stress and molecular changes in liver fibrosis: a review. Curr Med Chem, 19:4850-4860.
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24
Tsochatzis EA, Bosch J, Burroughs AK. 2014. Liver cirrhosis. Lancet, 383:1749-1761.
25
Woo CC, Kumar AP, Sethi G, Tan KH. 2012. Thymoquinone: potential cure for inflammatory disorders and cancer. Biochem Pharmacol, 83:443-451.
26
ORIGINAL_ARTICLE
The effect of hydro-alcoholic of Phoenix Dactylifera extract on sleep and EEG in rat
Objective: Hard envelope of date palm pollen is used as a sedative and calmative compounds in Iranian traditional medicine. We tried to study the effects of Phoenix dactylifera (Tarooneh) extract on sleep time and Brian waves. Materials and Methods: Rats were divided into control and test groups in sleep experiment. Control groups included intact group (without any injection), negative control group (saline) and positive control group (midazolam 0.1 mg/kg). Test groups received three doses of Tarooneh extract (62.5, 125 and 250 mg/kg). Rat were placed in sleep physiograph system and recording started 20 min after 2-hr calming down. Four parameters including sleep time, awakening, most activity period and main sleep time interval were measured. In EEG experiment electrodes were placed under the cranium for EEG recording and waves were compared with their baselines. Results: All doses of the extract increased sleeping time (p< 0.05) but just the dose of 250 mg/kg (p<0.05) and midazolam (p< 0.001) decreased the awakening time. EEG results showed that the dose of 125 mg/kg increased the low frequency waves (p< 0.05) and the dose of 250 mg/kg decreased high frequency waves of alpha and beta (p< 0.05). Conclusion: Due to these effect on sleeping time and EEG, Tarooneh extract consumption can be useful as a sedative agent in Iranian traditional medicine. According to this study, the doses of 125 and 250 mg/kg of the extract would be the appropriate doses to be further studied.
https://ajp.mums.ac.ir/article_9055_66f204dae6ccbe0b147a1b54662a15a2.pdf
2017-11-01
511
518
10.22038/ajp.2017.12730.1522
insomnia
Sleep
EEG
Tarooneh
Sahar
Rahimi
rahimi.8844@yahoo.com
1
Department of Physiology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
AUTHOR
Hojjatollah
Alaie
alaei@med.mui.ac.ir
2
Department of Physiology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
AUTHOR
Parham
Reisi
p_reisi@med.mui.ac.ir
3
Department of Physiology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
AUTHOR
Zahra
Siahmard
pagrom_qeshm@yahoo.com
4
Department of Physiology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
AUTHOR
Behzad
Zolfaghari
behzadz@gmail.com
5
Department of Pharmacognosy, School of Pharmacy, Isfahan University of Medical Science, Isfahan, Iran
AUTHOR
Aliasghar
Pourshanazari
dagh_sabz@yahoo.com
6
Department of Physiology, School of Medicine, Isfahan University of Medical Science, Isfahan, Iran
LEAD_AUTHOR
Abram RM. 2015. Sleep deprivation. Obst and gyn hospital and lab, 42:493-506.
1
Alaei H. 2001. Effects of serotonergic system on the sleeping time and EEG in rats. Tehran Univ Med J, 59:8-17
2
Al –Taher AY. 2008. Possible anti-diarrhoeal effect of the date palm (Phoenix Dactylifera L) spathe aqueous extract in rats. Sci J Faisal Uni, 9:131-138.
3
Bastien CH, LeBlanc M, Carrier J, Morin CM. 2003. Sleep EEG power spectra, insomnia, and chronic use of benzodiazepines. Sleep, 26:313–7.
4
Budhiraja R, Roth T, Hudgel D.W, Budhiraja P, and Drake C.L. 2014. Prevalence and polysomnographic correlates of insomnia comorbid with medical disorders. Sleep, 34: 859-867.
5
Budhiraja R, Roth T, Hudgel DW, Budhiraja P and Drake CL. 2011. Prevalence and polysomnographic correlates of insomnia comorbid with medical disorders. Sleep, 34: 859–867.
6
Cipriani G, Lucetti C, Danti S, Nuti A. 2015. Sleep disturbances and dementia. Psychogeriatrics, 15: 65–74.
7
Crunelli V and Hughes SW. 2010. The slow (1 Hz) rhythm of non-REM sleep: a dialogue between three cardinal oscillators. Nat Neurosci, 13: 9 – 17.
8
Dashti M, Vahidi A, panjalizadeh A. 2012. Effect of phoenix dactylifera spathe hydroalcoholic extract on chronic pain in mice. J Med Plant, 11:136-44.
9
David F, Schmiedt JT, Taylor HL, Orban G, Di Giovanni G, Uebele VN, Renger JJ, Lambert RC, Leresche N, Crunelli V. 2013. Essential thalamic contribution to slow waves of natural sleep. J Neurosci, 33:19599 – 19610.
10
Demirci B, Tsikolia M, Bernier R, Agramonte M, Alqasoumi S, Al-Yahya M, Al-Rehaily AJ, Yusufoglu HS, Demirci F, Başer KH, Khan IA, Tabanca N. 2013. Phoenix dactylifera L. spathe essential oil: Chemical composition and repellent activity against the yellow fever mosquito. Actatropica, 128:557-560.
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Freedom T. 2011. Pharmacologic Treatment Of Insomnia. Disease a Month, 57: 345-352.
12
Hamedi A, Mohagheghzadeh A, Rivaz S. 2013. Preliminary pharmacognostic evaluation and volatile constituent analysis of spathe of Phoenix dactylifera L. (Tarooneh). pharmacognosy j, 5:83-86.
13
Koch S, Fitzgerald M, Hathway G. 2008. Midazolam Potentiates Nociceptive Behavior, Sensitizes Cutaneous Reflexes, and Is Devoid of Sedative Action in Neonatal Rats. Anesthesiology, 108: 122–129.
14
Lee BG, Lee BL and ChungWY. 2014. Mobile Healthcare for Automatic Driving Sleep-Onset Detection Using Wavelet-Based EEG and Respiration Signals. Sensors, 14: 17915-17936.
15
Luan B, Jia W, Thirumala PD, Balzer J, Gao D and Sun M. 2014. A Feasibility Study on a Single-Unit Wireless EEG Sensor. Signal proc, 2014: 2282–2285.
16
Michal M, Wiltink J, Kirschner Y, Schneider A, Wild P S, Munzel T , Blentetner M, Schulz A, Lackner K, Pfeiffer N, Blankenberg S, Tschan R, Tunia I, Buetel ME. 2014. Complaints of sleep disturbances are associated with cardiovascular disease: results from the gutenberg health study. PLoS ONE, 9: 1-8.
17
Mokhtari M, Sharifi E. 2007. Effect of alcoholic extract of phoenix dactylifera spathe on histological change in testis and concentrations of LH, FSH and testosterone in male rat. Iran J Basic Med Sci, 4:265-271.
18
Neuendorf R, Wahbeh H, Chamine I, Yu J, Hutchison K, Oken BS. 2015. The Effects of Mind-Body Interventions on Sleep Quality: A Systematic Review. Evid Base Compl Alter Med, 2015: 1-7.
19
Shivani Gh, Manish G, Vinod J, and Raj G. 2014. Analgesic and hypnotic activities of Laghupanchamula: A preclinical study. Ayurveda, 35: 79–84.
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24
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25
ORIGINAL_ARTICLE
In vitro and in vivo effects of Peganum harmala L. seeds extract against influenza A virus
Objective: Influenza A virus infections are still a major health problem and the choices available for the control and treatment of the disease are limited. This research evaluated in vitro and in vivo antiviral effects of Peganum harmala L. seeds (PHS) extract against influenza A virus. Materials and Methods: In this research, in vitro anti-influenza A virus activity of the extract was assessed in Madin-Darby canine kidney (MDCK) cells. In order to evaluate anti-influenza activity of PHS extract in vivo, BALB/c mice were infected with 5LD50 of mouse-adapted influenza virus (H1N1; PR8) and received 200 mg/kg/day of PHS extract or 20 mg/kg/day oseltamivir. Lungs of seven mice per group were removed on day 3 post-infection and lung virus titers were determined by qRT-PCR. Mice survival, body weights and general conditions were observed for up to 14 days post-infection. Results: The results demonstrated that, the ethanolic extract of PHS possesses high activity against influenza virus with IC50 value of 15.7 (CI95%:11.7-21) μg/ml in MDCK cells. Our results also showed that, oral administration of PHS extract (200 mg/kg/day) or oseltamivir (20 mg/kg/day) to infected mice, increased the survival rate, reduced body weight loss, and decreased lung virus titer. Conclusion: Based on our findings, P. harmala seeds extract can inhibit influenza A virus replication in vitro and in vivo. Therefore, isolation and characterization of the plant’s active compounds and investigation of the underlying mechanisms of its antiviral action are highly suggested.
https://ajp.mums.ac.ir/article_9060_8c85287ee87c018b0e0d0c74f53ba5c0.pdf
2017-11-01
519
530
10.22038/ajp.2017.22265.1830
Influenza A virus
Antiviral activity
Peganum harmala L
Mohammad-Taghi
Moradi
mtmoradi65@gmail.com
1
Students Research Committee, Medical Plants Research Center, Shahrekord University of Medical Science, Shahrekord, Iran
AUTHOR
Ali
Karimi
kakarimi42@gmail.com
2
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
LEAD_AUTHOR
Fatemeh
Fotouhi
fotouhi@pasteur.ac.ir
3
Department of Influenza and other Respiratory Viruses, Pasteur Institute of Iran, Tehran, Iran
AUTHOR
Soleiman
Kheiri
mtmoradi51@gmail.com
4
Department of Epidemiology and Biostatistics, Shahrekord University of Medical Sciences, Shahrekord, Iran
AUTHOR
Ali
Torabi
alitorabi@pasteur.ac.ir
5
Department of Influenza and other Respiratory Viruses, Pasteur Institute of Iran, Tehran, Iran
AUTHOR
Aarons DH, Rossi GV , Orzechowski RF. 1977. Cardiovascular actions of three harmala alkaloids: harmine, harmaline, and harmalol. J Pharm Sci, 66:1244-1248.
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Akbari F, Ansari-Samani R, Karimi A, Mortazaei S, Shahinfard N ,Rafieian-Kopaei M. 2013. Effect of turnip on glucose and lipid profiles of alloxan-induced diabetic rats. Iran J Endocrin Metabol, 14: 492-497
2
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Astulla A, Zaima K, Matsuno Y, Hirasawa Y, Ekasari W, Widyawaruyanti A, Zaini NC ,Morita H. 2008. Alkaloids from the seeds of Peganum harmala showing antiplasmodial and vasorelaxant activities. J Nat Med, 62:470-472.
5
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6
Bukhari N, Choi J, Jeon C, Park H, Kim W, Khan MA ,Leet S. 2008. Phytochemical studies of the alkaloids from Peganum harmala. Applied Cham, 12:101-104.
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Cannell JJ, Zasloff M, Garland CF, Scragg R ,Giovannucci E. 2008. On the epidemiology of influenza. Virol J, 5:422X-425.
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65
ORIGINAL_ARTICLE
The effect of Zataria multiflora and carvacrol on wheezing, FEV1 and plasma levels of nitrite in asthmatic patients
Objective: The preventive effect of Zataria multiflora in animal models of asthma has been reported. In the present study, its effect on wheezing, forced expiratory volume in 1 second, and plasma nitrite (NO2-) in asthmatic patients was studied. Materials and Methods: In this study, forty asthmatic patients including 15 males and 25 females (aged 45.8±6.21 years) were randomly allocated in four groups including placebo group (P), and three treatment groups which received two doses of Z. multiflora (groups Z low and Z high that received 5 and 10 mg/kg/day, respectively) and carvacrol (group C treated with 1.2 mg/kg/day). All patients were treated for two months in a double-blind manner. At three time points (before starting the treatment (pretreatment), and one and two month after treatment), wheezing during day and exercise, forced expiratory volume in 1 second and NO2- were measured. Results: Day wheeze and exercise wheeze were significantly reduced in treated groups with carvacrol and both doses of Z. multiflora compared to pretreatment (p1% was significantly increased in treated groups with carvacrol and both doses of Z. multiflora (p2- was also significantly decreased in Z high and carvacrol groups after two months of treatment (p Conclusion: Z. multiflora and its constituent, carvacrol, improved FEV1% while reduced wheezing and plasma level of NO2- in asthmatic patients. Therefore, a possible therapeutic potential for this plant and its constituent, carvacrol could be suggested to be used against asthma.
https://ajp.mums.ac.ir/article_9099_6448cf37376be1b5a6ab620772e25943.pdf
2017-11-01
531
541
10.22038/ajp.2017.24102.1883
Asthma
Zataria multiflora
Carvacrol
Forced expiratory volume in one second
Wheezing
Nitrite
Azam
Alavinezhad
alavina901@mums.ac.ir
1
Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mahdiyeh
Hedayati
hedayatim912@mums.ac.ir
2
Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mohammad Hossein
Boskabady
boskabadymh@mums.ac.ir
3
Neurogenic Inflammation Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Aristatile B, Al-Assaf AH, Pugalendi KV. 2013. Carvacrol suppresses the expression of inflammatory marker genes in D-galactosamine-hepatotoxic rats. Asian Pac J Trop Med, 6:205-211.
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51
ORIGINAL_ARTICLE
The protective effect of hydroalcoholic extract of Ginger (Zingiber officinale Rosc.) against iron-induced functional and histological damages in rat liver and kidney
Objective: Iron overload in the body is related with toxic effects and threatens the health. The aim of this study was to evaluate the protective role of hydroalcoholic extract of ginger (Zingiber officinale) against ferrous sulfate-induced hepatic and renal functional disorders and histological damages in rats. Materials and Methods: The rats were divided into four groups (n=7): Sham, Sham + G.E (ginger extract, 400 mg/kg/day for 14 days), FS (ferrous sulfate, 30 mg/kg/day for 14 days), FS+G.E (ferrous sulfate, 30 mg/kg/day for 14 days; ginger extract, 400 mg/kg/day for 11 days from the fourth day of ferrous sulfate injection). After 24 hr, blood, urine and tissue samples were collected. Results: Compared with Sham and Sham + G.E groups, administration of ferrous sulfate resulted in liver and kidney dysfunction as evidenced by significantly higher levels of serum hepatic markers and bilirubin, and lower levels of serum albumin, total protein, triglyceride, cholesterol and glucose, as well as lower creatinine clearance and higher fractional excretion of sodium (p<0.001). This was accompanied by increased malondialdehyde levels and histological damages (p<0.001). In the FS + G.E, ginger extract significantly (p<0.01) reversed the levels of serum hepatic markers, renal functional markers and lipid peroxidation marker. Furthermore, it restored the levels of serum total protein, albumin, glucose, triglycerides and cholesterol and decreased bilirubin concentration in the blood. All these changes were corroborated by histological observations of liver and kidney. Conclusion: In conclusion, ginger extract appears to exert protective effects against ferrous sulfate-induced hepatic and renal toxicity by reducing lipid peroxidation and chelating iron.
https://ajp.mums.ac.ir/article_9113_aa5b6d082c2ea61eda154515969892d7.pdf
2017-11-01
542
553
10.22038/ajp.2017.22297.1831
Albumin
Ferrous sulfate
Kidney
Lipid Peroxidation
Liver
Zingiber officinale
Firouzeh
Gholampour
gholampour@shirazu.ac.ir
1
Department of Biology, School of Sciences, Shiraz University, Shiraz, Iran
LEAD_AUTHOR
Fatemeh
Behzadi Ghiasabadi
frzhgholampour@yahoo.com
2
Department of Biology, School of Sciences, Shiraz University, Shiraz, Iran
AUTHOR
Seyed Mohammad
Owji
smowji@yahoo.com
3
Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Jaafar
Vatanparast
jafarvatanparast@gmai.com
4
Department of Biology, School of Sciences, Shiraz University, Shiraz, Iran
AUTHOR
Ajith TA, Nivitha V, Usha S. 2007. Zingiber officinale Roscoe alone and in combination with alpha-tocopherol protect the kidney against cisplatin-induced acute renal failure. Food Chem Toxicol, 45: 921-927.
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Bhandari U, Kanojia R, Pillai KK. 2005. Effect of ethanolic extract of Zingiber officinale on dyslipidaemia in diabetic rats. J Ethnopharmacol, 97:227-230
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ORIGINAL_ARTICLE
Effect of Apium graveolens and Trachyspermum copticom on clinical symptoms of patients with functional dyspepsia
Objectives:This study aimed at investigating the effect of Iranian traditional remedy prepared from Apium graveolens and Trachyspermum copticom (AT) on the severity and frequency of symptoms in patients with functional dyspepsia (FD). Material and Methods:In total, 150 FD patients were included in this randomized double-blind trial, based on the ROME III diagnostic criteria, and they were divided into three intervention groups namely, AT, Placebo and omeprazole. Then, severity and frequency of symptoms during this eight-week trial were measured. Obtained information was analyzed using Chi-square test and repeated measures test. Result:In general, the severity and frequency of symptoms after the 4th week significantly decreased in the AT group as compared to the omeprazole and placebo groups, and continued to reduce by the end of the eighth week. General reduction of symptom severity and frequency in the omeprazole group was significantly different from the placebo group by the end of the 4th and 8th weeks. With respect to each individual symptom, AT markedly improved symptoms, such as burning, pain, early satiation, fullness, bloating, belching and nausea, as compared to placebo-treated group. Moreover, AT significantly improved symptoms, like vomiting, and nausea, except for pain, as compared to omeprazole-treated subjects. Conclusion:According to the results, AT, as Iranian traditional remedy, was more effective than omeprazole and placebo in reducing the symptoms in FD patients.
https://ajp.mums.ac.ir/article_9131_e201cea3de0f63f9d6899c46fda920d1.pdf
2017-11-01
554
564
10.22038/ajp.2017.20630.1786
IranianTraditional medicine
Apium Graveolens
Trachyspermum Copticom
Functional Dyspepsia
Maryam
Azimi
dr.azim@gmail.com
1
Department of Traditional Medicine, School of Traditional Medicine, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Mohammad Javad
Zahedi
zahedimj@yahoo.com
2
Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran
LEAD_AUTHOR
Mitra
Mehrabani
mmehrabani@hotmail.com
3
Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Haleh
Tajadini
dr_haleh@yahoo.com
4
Department of Traditional Medicine, School of Traditional Medicine, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Farzaneh
Zolala
zolalafarzaneh@gmail.com
5
Associate Professor of Biostatistics Modeling in Health Research Center Institute for Futures Studies in Health Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Mohammad
Baneshi
rbaneshi@gmail.com
6
Biostatistics and Epidemiology Department, Modeling in Health Research Center, Institute for Futures Studies in Health Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Rasool
Choopani
rchoopani@hotmail.com
7
Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran
AUTHOR
Fariba
Sharififar
fsharififar@kmu.ac.ir
8
Herbal and Traditional Medicines Center, Kerman University of Medical Science, Kerman, Iran
AUTHOR
Ali
Asadipour
aliasadipour@yahoo.com
9
Herbal and Traditional Medicines Center, Kerman University of Medical Science, Kerman, Iran
AUTHOR
Mohammad
Hayatbakhsh
m24672@yahoo.com
10
Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Bijan
Ahmadi
ay-bijan@yahoo.com
11
Gastroenterology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
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