ORIGINAL_ARTICLE
Tiliacora triandra (Colebr.) Diels leaf extract enhances spatial learning and learning flexibility, and prevents dentate gyrus neuronal damage induced by cerebral ischemia/reperfusion injury in mice
Objective: The present study investigated the effects of a local Thai vegetable, Tiliacora triandra (Colebr.) Diels, also known as Yanang, against cerebral ischemia/reperfusion injury in mice. Materials and Methods: Thirty male ICR mice were divided into three experimental groups of BLCCAO + 10% Tween 80, BLCCAO + T. triandra 300 mg/kg, and BLCCAO + T. triandra 600 mg/kg. Cerebral ischemia/reperfusion was induced by three minutes of bilateral common carotid artery occlusion (BLCCAO) followed by 18 days of reperfusion. Leaf extract was administered orally 24 hours after arterial occlusion and continued for 18 consecutive days. Cognitive abilities were evaluated using the Morris water maze. Histological analysis was conducted in the dorsal hippocampus subregions CA1, CA3, and DG and white matter regions (the corpus callosum, internal capsule, and optic tract) using 0.1 % cresyl violet and 0.1% Luxol fast blue staining. Results: Results showed that T. triandra leaf extract at the doses of 300 and 600 mg/kg significantly enhanced spatial learning, and learning flexibility, and prevented neuronal death in the DG of mice following ischemia/reperfusion. Conclusion: T. triandra leaf extract enhanced spatial learning, and learning flexibility, and prevented DG neuronal death in a mice model of cerebral ischemia/reperfusion.
https://ajp.mums.ac.ir/article_8398_e6ebcf95a2a55fa1f01bcdc551388dfa.pdf
2017-09-01
389
400
10.22038/ajp.2017.19681.1756
Spatial learning
Learning flexibility
Morris Water Maze
Cerebral ischemia/reperfusion injury
Tiliacora triandra
Dorsal hippocampus
Wachiryah
Thong-asa
fsciwyth@ku.ac.th
1
Physiology Division, Animal Toxicology and Physiology Specialty Research Unit (ATPRU), Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, Thailand
LEAD_AUTHOR
Panas
Tumkiratiwong
fscipnt@ku.ac.th
2
Physiology Division, Animal Toxicology and Physiology Specialty Research Unit (ATPRU), Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, Thailand
AUTHOR
Vasakorn
Bullangpoti
fscivkb@ku.ac.th
3
Animal Toxicology and Physiology Specialty Research Unit (ATPRU), Department of Zoology, Faculty of Science, Kasetsart University, Bangkok, Thailand
AUTHOR
Kasem
Kongnirundonsuk
fsciksk@ku.ac.th
4
Faculty of Science and Technology, Bansomdejchaopraya Rajabhat University, Hiranruchi, Dhonburi Bangkok, Thailand
AUTHOR
Kanokwan
Tilokskulchai
kanokwan.til@mahidol.ac.th
5
Neuroscience Unit, Department of Physiology, Faculty of Medicine Siriraj, Siriraj Hospital, Mahidol University, Bangkok, Thailand
AUTHOR
Boonsong P, Laohakunjit N, Kerdchoechuen O. 2009. Identification of polyphenolic compounds and colorants from Tiliacora triandra (Diels) Leaves. Agr Sci J, 40: 13-16.
1
Broadbent NJ, Squire LR, Clark RE. 2004. Spatial memory, recognition memory, and the hippocampus. Proc Natl Acad Sci U S A, 101: 14515-14520.
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24
ORIGINAL_ARTICLE
Effects of ethanolic extract of Jasminum grandiflorum Linn. flowers on wound healing in diabetic Wistar albino rats
Objective: To evaluate wound healing activity of ethanolic extract of Jasminum grandiflorum Linn. (J. grandiflorum) flowers in diabetic rats. Materials and Methods: Streptozotocin-induced diabetic Wistar albino rats were divided into six groups (n=6).Three groups – diabetic control, positive control (that received Glibenclamide) and treatment (that received J. grandiflorum Linn. Flower extract) were operated for excision wounds (EW). These groups were evaluated for wound contraction and re-epithelization. The other three groups were operated for incision wounds (IW) and dead space wounds (DW). Incision and dead space wounds were produced in the same rats. IWs were analyzed for wound breaking strength and the granulation tissues from DWs were analyzed for dry weight, hydroxyproline content, and histology. Results: IWs and DWs showed significant improvement in wound breaking strength (265.8±10.4 vs 332.5±8.2; p<0.05), granulation tissue dry weight (26.1±0.6vs 40.4±0.3; p<0.01) and hydroxyproline content (19.3±0.5 vs 32.6±0.8; p<0.01) in treatment group as compared to control group. Neo-angiogenesis was also high in treatment group. Wound contraction was earlier (day 14) in treatment group compared to diabetic control (day 20). No significant improvement was seen in re-epithelization in treatment group. Conclusion: Ethanolic extract of J. grandiflorum Linn. flowers increases granulation tissue formation as well as neo-angiogenesis. It also enhances wound contraction; however, re-epithelization was not significantly affected. J. grandiflorum Linn. flowers could be potentially effective in promotion of diabetic wounds healing by increasing granulation tissue formation and enhancing wound contraction; however, further studies are required for its clinical application. .
https://ajp.mums.ac.ir/article_8699_b995ea83ae2cc62557f48f8d0f8b2281.pdf
2017-09-01
401
408
10.22038/ajp.2017.14406.1580
Jasminum grandiflorum Linn. flowers
Streptozotocin induced diabetes
Granulation tissue
Hiren
Hirapara
dr.hirenhirpara@gmail.com
1
GMERS Medical College, Junagadh, Gujarat, India
AUTHOR
Vishal
Ghori
drvishalghori@gmail.com
2
Billev Pharma East , Ljubljana, Slovenia
AUTHOR
Ashish
Anovadiya
dr.ashishanovadiya@gmail.com
3
Government Medical College, Bhavnagar, Gujarat, India
AUTHOR
Seema
Baxi
seemabaxi@gmail.com
4
Government Medical College, Bhavnagar, Gujarat, India
AUTHOR
Chandrabhanu
Tripathi
cbrtripathi@yahoo.co.in
5
Government Medical College, Bhavnagar, Gujarat, India
LEAD_AUTHOR
Abramov Y, Golden B, Sullivan M, Botros SM, Miller J, Alshahrour A, Goldberg R and Sand P.2007. Histologic characterization of vaginal vs. abdominal surgical wound healing in a rabbit model. Wound Repair Regen, 15: 80-86.
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32
ORIGINAL_ARTICLE
Modulation of lung inflammation and immune markers in asthmatic rats treated by Portulaca oleracea
Objective: Previous studies indicated anti-inflammatory effects for Portulaca oleracea in various inflammatory disorders. In this study, the effects of P. oleracea on bronchoalveolar lavage fluid (BALF) levels of total protein (TP), Phospholipase A2(PLA2) and IgE in sensitized rats were examined. Materials and Methods: Male rats were randomly divided into six groups namely, control (group C), sensitized rats (group S), sensitized animal treated with three concentrations of the extract of P. oleracea and dexamethasone (n = 8 for each group). The levels of TP, PLA2 and IgE in BALF were measured. Results:The levels of TP, PLA2and IgE were significantly increased in the BALF of group S compared to group C (pand IgE compared to group S (pand IgE (p Conclusion: The results indicated anti-inflammatory and immunomodulatory effects of P. oleracea in sensitized rats (as an animal model of asthma) which was equal or more marked than dexamethasone at studied concentrations.
https://ajp.mums.ac.ir/article_8824_47134a23f403dce749a6e2c494e1cc88.pdf
2017-09-01
409
416
10.22038/ajp.2017.8824
Portulaca oleracea
Total protein
Phospholipase A2 (PLA2)
Immunoglobulin E
Rat model of asthma
Mahsa
Kaveh
kaveh_mahsa@yahoo.com
1
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
AUTHOR
Akram
Eidi
akram_eidi@yahoo.com
2
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.
AUTHOR
Ali
Neamati
neamati_ali@yahoo.com
3
Department of Biochemistry and Biophysics, Faculty of Science, Mashhad Branch, Islamic Azad University, Mashhad, I.R. Iran
AUTHOR
Mohammad Hossein
Boskabady
boskabadymh@mums.ac.ir
4
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Abdel Moneim AE, Dkhil MA, Al-Quraishy S. 2013. The potential role of Portulaca oleracea as a neuroprotective agent in rotenone-induced neurotoxicity and apoptosis in the brain of rats. Pestic Biochem Physiol, 105: 203-212.
1
Ahmad Al Obaidi AH, Mohamed Al Samarai AG, Yahya Al Samarai AK, Al Janabi JM. 2008. The predictive value of IgE as biomarker in asthma. J Asthma, 45: 654-663.
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Arruda SF, Siqueira EM, Souza EM. 2004. Malanga (Xanthosoma sagittifolium) and purslane (Portulaca oleracea) leaves reduce oxidative stress in vitamin A-deficient rats. Ann Nutr Metab, 48: 288-295.
3
Askari VR, Rezaei SA, Abnus K, Iranshahi M, Boskabady MH. 2016. The Influence of Hydro-Ethanolic Extract of Portulaca oleracea on Th1/Th2 balance in Isolated Human Lymphocytes. J Ethnopharmacol, 194: 1112-1121.
4
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Boroushaki MT, Boskabady MH, Malek F. 2010. Antitussive effect of Portulaca oleracea L. in guinea pigs. Iran J Pharm Res, 3: 187-190.
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Boskabady MH, Boroushaki M and Aslani MR. 2004. Relaxant effect of Portulaca oleraceae on guinea pig tracheal chainsand its possible mechanism (s) of action. Med Hypotheses Res, 1: 139-147.
8
Boskabady MH, Hashemzehi M, Khazdair MR, Askari VR. 2016. Hydro-ethanolic Extract of Portulaca oleracea Affects Beta-adrenoceptors of Guinea Pig Tracheal Smooth Muscle. Iran J Pharm Res, 15: 867–874.
9
Boskabady MH, Tabatabaee A, Jalali S. 2014. Potential effect of the extract of Zataria multiflora and its constituent, carvacrol, on lung pathology, total and differential WBC, IgE and eosinophil peroxidase levels in sensitized guinea pigs. J Funct Foods, 11: 49–61.
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Chan K, Islam MW, Kamil M, Radhakrishnan R, Zakaria MNM, Habibullah M, et al. 2000. The analgesic and anti-inflammatory effects of Portulaca oleracea L. subs. sativa (Haw.) Celak. J Ethnopharmacol, 73: 445-451.
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Hashemzehi M, Khazdair MR, Kiyanmehr M, Askari VR, Boskabady MH. 2016. Portulaca oleracea Affects Muscarinic Receptors of Guinea Pig Tracheal Smooth Muscle. Indian J Pharm Sci, 78: 388-394.
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Islam MW, Zakaria MNM, Radhakrishnan R, Habibullah M, Chan K. 1998. Evaluation of analgesic activity of the aerial parts of Portulaca oleracea v. sativa and its comparison with two related spices. J Pharm Pharmacol, 50: 226-230.
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Keyhanmanesh R, Boskabady MH, Khamneh S, Ebrahimi MA. 2009. The effect of thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and WBC count in lung lavage of sensitized guinea-pigs. Planta Med, 75: 1–5.
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Keyhanmanesh R, Boskabady MH, Khamneh S, Ebrahimi MA. 2010. The effect of thymoquinone, the main constituent of Nigella sativa on tracheal responsiveness and WBC count in lung lavage of sensitized guinea-pigs. Planta Med, 76: 218–222.
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Kianmehr M, Haghmorad D, Nosratabadi R, Rezaei A, Alavinezhad A, Boskabady MH. 2017. The effect of Zataria multiflora on Th1/Th2 and Th17/Tregulatory in a mouse model of allergic asthma. Submitted to Forntiers in Pharmacology.ic & Appl Sci.
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Xio FY, Lu FE, Xu J. 2004. Mechanism of different parts of Portulaca oleracea in ameliorating lipid metabolic disorder in type 2 diabetic rats. Chine J Clin Rehabil, 8: 5042-5044.
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Yang Z, Liu C, Xiang L, Zheng Y. 2009. Phenolic alkaloids as a new class of antioxidants in Portulaca oleracea. Phytother Res, 23: 1032–1035.
41
Zakaria MNM, Islam MW, Radhakrishnan R, Habibullah M, Chan K. 1998. Evaluation of anti-inflammatory activity of Portulaca species. J Pharm Pharmacol, 50: 227-231.
42
ORIGINAL_ARTICLE
The antioxidant activity of Beta vulgaris leaf extract in improving scopolamine-induced spatial memory disorders in rats
Objective: Medicinal plants have attracted global attention due to their safety as well as their considerable antioxidant content that helps to prevent or ameliorate various disorders including memory impairments. This study was conducted to investigate the effect of beet root (Beta vulgaris) leaf extract on scopolamine-induced spatial memory impairments in male Wistar rats. Materials and Methods: Male Wistar rats were randomly divided into 5 groups (n=10): Control (C), scopolamine 1 mg/kg/day (S), scopolamine+50 mg/kg B. vulgaris leaf extract (S+B 50), scopolamine+100 mg/kg B. vulgaris leaf extract (S+B 100) and scopolamine+200 mg/kg B. vulgaris leaf extract (S+B 200). Morris water maze task was used to assess spatial memory. Serum antioxidant capacity and malondialdehyde (MDA) level were also measured. Results: Group S spent significantly less time in the target quadrant compared to the control group, and the administration of B. vulgaris leaf extract (100 and 200 mg/kg) significantly increased this time (p<0.05). Scopolamine decreased serum antioxidant capacity and increased serum MDA level yet insignificantly. B. vulgaris extract (200 mg/kg) significantly increased the antioxidant capacity and decreased serum MDA level in scopolamine-treated rats (p<0.05). Conclusion: Our results suggested that B. vulgaris leaf extract could ameliorate the memory impairments and exhibited protective effects against scopolamine-induced oxidation. Further investigation is needed to isolate specific antioxidant compounds from B. vulgaris leaf extract with protective effect against brain and memory impairments.
https://ajp.mums.ac.ir/article_8821_951878d51aec1d96e8c941cd509ee9f7.pdf
2017-09-01
417
425
10.22038/ajp.2017.8821
B. vulgaris
Leaf extract
Antioxidant activity
Spatial Memory
Shadie
Hajihosseini
sh_hajihoseini@gmail.com
1
Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj ,Iran
AUTHOR
Mahbubeh
Setorki
doctor.setorgi@gmail.com
2
Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran
LEAD_AUTHOR
Zahra
Hooshmandi
zhoushmani@yahoo.com
3
Department of Biology, Sanandaj Branch, Islamic Azad University, Sanandaj ,Iran
AUTHOR
Al-Jassabi S, Abdullah M. 2013. Purification and characterization of antioxidant fractions from Zizyphus spina-christi. Fruits, 5: 13-24.
1
Babu VA, Gowri R. 2010. Evaluation of antioxidant activity of Beta vulgaris root extract in rats. Asian J Chem, 22: 3385-90.
2
BiondoI PB, BoeingI SJ, BarizãoI EO, SouzaII NE, MatsushitaI M, OliveiraI C, BoroskiI M, VisentainerI JV. 2014. Evaluation of beetroot (Beta vulgaris L.) leaves during its developmental stages: a chemical composition study. Food Sci Technol, 34: 94-101.
3
Bolkent Ş, Yanardağ R, Tabakoğlu-Oğuz A, Özsoy-Saçan Ö. 2007. Effects of chard (Beta vulgaris L. var. cicla) extract on pancreatic B cells in streptozotocin-diabetic rats: a morphological and biochemical study. J Ethnopharmacol, 73: 251-259.
4
Chuong NN, Trung BH, Luan TC, Hung TM, Dang NH, Dat NT. 2014. Anti-amnesic effect of alkaloid fraction from Lycopodiella cernua (L.) Pic. Serm. on scopolamine-induced memory impairment in mice. Neurosci lett, 575:42-46.
5
El Gamal AA, AlSaid MS, Raish M, Al-Sohaibani M, Al-Massarani SM, Ahmad A, et al. 2014. Beetroot (Beta vulgaris L.) extract ameliorates gentamicin-induced nephrotoxicity associated oxidative stress, inflammation, and apoptosis in rodent model. Mediators Inflamm, 22: 133-145.
6
Gray C, Nukada H, Jackson DM, McMorran PD, Wu A, Ma F. 2003. Neuroprotective effects of nitrone radical scavenger S-PBN on reperfusion nerve injury in rats. Brain Res, 982:179-185.
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8
Hosseini M, Mohammadpour T, Karami R, Rajaei Z, Sadeghnia HR, Soukhtanloo M. 2015. Effects of the hydro-alcoholic extract of Nigella Sativa on scopolamine-induced spatial memory impairment in rats and its possible mechanism. Chinese J Integ Med, 21: 438-444.
9
Jain NK, Singhai AK. 2012. Protective role of Beta vulgaris L. leaves extract and fractions on ethanol-mediated hepatic toxicity. Acta Pol Pharm, 69: 945-950.
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11
Misane I, Ogren SO. 2003. Selective 5-HT1A antagonists WAY 100635 and NAD-299 attenuate the impairment of passive avoidance caused by scopolamine in the rat. Neuropsychopharmacol, 28:253-264.
12
Mokhtari-Dehkordi S, Hojjati M, Rouhi L, Rabiei Z, Alibabaei Z. 2014. Effect of ethanolic extract of beet roots and leaves on motor coordination in male Wistar rats. J Shahrekord Uni Med Sci, 16: 14-23.
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15
Rabiei Z, Alibabaei Z, Rafieian-Kopaei M. 2015. Determining the Antioxidant properties of chamomile and investigating the effects of chamomile ethanol extract on motor coordination disorders in rats. J Babol Univ Med Sci, 17:44-50.
16
Rabiei Z, Rafieian-kopaei M, Heidarian E, Saghaei E, Mokhtari S. 2014. Effects of Zizyphus jujube extract on memory and learning impairment induced by bilateral electric lesions of the nucleus basalis of meynert in rat. Neurochem Res, 39:353-360.
17
Rasoolijazi H, Mehdizadeh M, Soleimani M, Nikbakhte F, Farsani ME, Ababzadeh S. 2015. The effect of rosemary extract on spatial memory, learning and antioxidant enzymes activities in the hippocampus of middle-aged rats. Med J Islam Repub Iran, 29:187-193.
18
Sacan O, Yanardag R. 2010. Antioxidant and antiacetylcholinesterase activities of chard (Beta vulgaris L. var. cicla). Food Chem Toxicol, 48: 1275-1280.
19
Sulakhiya K, Patel VK, Saxena R, Dashore J, Srivastava AK, Rathore M. 2016. Effect of Beta vulgaris Linn. leaves extract on anxiety-and depressive-like behavior and oxidative stress in mice after acute restraint stress. Pharm Res, 8: 11-12.
20
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Yang MH, Yoon KD, Chin Y-W, Park JH, Kim SH, Kim YC, et al. 2009. Neuroprotective effects of Dioscorea opposita on scopolamine-induced memory impairment in in vivo behavioral tests and in vitro assays. J Ethnopharm, 121:130-134.
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26
ORIGINAL_ARTICLE
Effect of the methanolic extracts of different parts of Ferula assa-foetida on naloxone-induced withdrawal behavior in morphine-dependent mice
Objective: Ferula assa-foetida, a native species in Iran, is used for treatment of several diseases particularly for neurological disorders in Iranian Traditional Medicine. The aim of this study is to investigate the effect of methanolic roots, fruits, and aerial parts extracts of Ferula assa-foetida on withdrawal syndrome in morphine-dependent mice. Materials and Methods: Aerial parts, roots, and fruits of the plant were separately extracted with 80% MeOH. For induction of dependence, morphine (50, 50 and 75 mg/kg) was injected subcutaneously three times daily (10 am, 1 pm and 4 pm) for three days and a last dose of morphine (50 mg/kg) was administrated on the fourth day. Withdrawal syndrome was induced by injection of naloxone (5 mg/kg, intraperitoneal) 2 hr after the final dose of morphine. Different doses of the extracts were administered i.p. 60 minutes before naloxone injection and withdrawal sign was recorded 2 minutes after naloxone injection for a period of 60 minutes. Results: Pre-treatment of animals with different doses (2.5, 5, 10, 20 mg/kg) of methanolic extract of the aerial parts of F. assa-foetida caused a significant decrease in naloxone-induced behavior. Intraperitoneal administration of different doses (10, 15, 20, 25 mg/kg) of methanolic extract of the fruit significantly reduced the naloxone-induced withdrawal behavior (p<0.001). Conclusion: It might be concluded that the extracts of Ferula assa-foetida affect morphine withdrawal syndrome possibly via interference with the neurotransmitters in nervous system.
https://ajp.mums.ac.ir/article_8853_336ec608546c5deadb4bc57b3a44dceb.pdf
2017-09-01
426
435
10.22038/ajp.2017.17885.1696
Ferula assa-foetida
Extract
Gamma-aminobutyric acid (GABA)
Morphine dependence
Withdrawal syndrome
Mahnaz
Khanavi
khanavi@mail.ubc.ca
1
Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran.
AUTHOR
Sajad
Maadani
khanavim@tums.ac.ir
2
Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Behnaz
Farahanikia
bz_farahani@yahoo.com
3
Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Mahdieh
Eftekhari
mahdieh.eftekhari@gmail.com
4
Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Mohammad
Sharifzadeh
mahnazkhanavi@yahoo.ca
5
Department of Toxicology and Pharmacology and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.
LEAD_AUTHOR
Abd El‐Razek MH, Wu YC, Chang FR. 2007. Sesquiterpene coumarins from Ferulafoetida. J Chin Chem Soc, 54:235-238.
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40
ORIGINAL_ARTICLE
Evaluation of the effect of soybean diet on interferon-α-induced depression in male mice
Objective: Interferon-α (IFN) therapy can cause depressive symptom which may lead to drug discontinuation. By interfering with tryptophan pathway, the available level of tryptophan required for serotonin synthesis decreases which could be related to depression. The aim of this study was to evaluate whether soybean diet could improve IFN-induced depression. Materials and Methods: Male mice weighing 28±3 g were used in the forced swimming test (FST) as an animal model of depression; also, locomotor activity was recorded. IFN 16×105 IU/kg was injected subcutaneously for 6 days. Animals were fed with regular diet or soybean diet at 3 concentrations throughout the experiment. Fluoxetine was the reference drug. To check whether the tryptophan content in the soy bean diet was effective, a group of animals was injected with a single dose of tryptophan on the test day. Results: IFN-α increased the immobility time in the FST (192 sec ± 5.4), that denotes depression in mice. Soybean diets caused less immobility that was more profound with 50% soybean (26.4 sec ± 6). This diet overcame the depression caused by IFN in the FST (54 sec±18). This result was parallel with that of tryptophan injected to animals (38 sec±17). All the animals showed normal locomotor activity. Conclusion: For the first time, we showed that soybean diet could counteract with depression caused by IFN-α. Since tryptophan therapy had similar effects, possibly the tryptophan content of soybean had induced the serotonin synthesis. Thus, not only less harmful kynurenine was produced but also more serotonin was available in the brain to overcome depression. However, this interpretation needs further evaluations.
https://ajp.mums.ac.ir/article_8889_2a1679546dd677b519099e02c04416d6.pdf
2017-09-01
436
443
10.22038/ajp.2017.20914.1793
Interferon-α
Depression
Tryptophan
Soybean
Serotonin
Yazdan
Azimi Fashi
yazdan.azimi@yahoo.com
1
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical sciences, Isfahan university of Medical Sciences, Isfahan, Iran
AUTHOR
Azadeh
Mesripour
a_mesripour@yahoo.com
2
Isfahan Pharmaceutical Sciences Research Center, School of Pharmacy and Pharmaceutical sciences, Isfahan university of Medical Sciences, Isfahan, Iran
LEAD_AUTHOR
Valiollah
Hajhashemi
vhajhashemi@gmail.com
3
Department of Pharmacology and Toxicology, School of Pharmacy and Pharmaceutical sciences, Isfahan university of Medical Sciences, Isfahan, Iran
AUTHOR
Bale TL, Vale WW. 2003. Increased depression-like behaviors in corticotropin-releasing factor receptor-2-deficient mice: sexually dichotomous responses. J Neurosci, 23: 5295-301.
1
Banaszkiewicz T. 2011. Nutritional value of soybean meal. In: El-Shemy HA (Eds), Soybean and Nutrition, pp. 1-20, Croatia, InTech.
2
Baranyi A, Meinitzer A, Breitenecker RJ, Amouzadeh-Ghadikolai O, Stauber R, Rothenhäusler HB. 2015. Quinolinic acid responses during interferon-α-induced depressive symptomatology in patients with chronic hepatitis c infection-a novel aspect for depression and inflammatory hypothesis. PloS one, 10: p.e0137022.
3
Baranyi A, Meinitzer A, Stepan A, Putz-Bankuti C, Breitenecker RJ, Stauber R, Kapfhammer HP, Rothenhäusler HB. 2013. A biopsychosocial model of interferon-alpha-induced depression in patients with chronic hepatitis C infection. Psychother Psychosom, 82: 332-340.
4
Bonaccorso S, Marino V, Puzella A, Pasquini M, Biondi M, Artini M, Almerighi C, Verkerk R, Meltzer H, Maes M. 2002. Increased depressive ratings in patients with hepatitis C receiving interferon-α–based immunotherapy are related to interferon-α–induced changes in the serotonergic system. J Clin Psychopharmacol, 22:86-90.
5
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6
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7
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Kraus MR, Schäfer A, Al‐Taie O, Scheurlen M. 2005. Prophylactic SSRI during interferon alpha re‐therapy in patients with chronic hepatitis C and a history of interferon‐induced depression. J Viral Hepat, 12:96-100.
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36
ORIGINAL_ARTICLE
A simple, sensitive and rapid isocratic reversed-phase high-performance liquid chromatography method for determination and stability study of curcumin in pharmaceutical samples
Objective: This study was designed to develop and validate a new reversed-phase high-performance liquid chromatography (RP-HPLC) method based on Q2 (R1) International Conference on Harmonization (ICH) guideline for determination of curcumin in pharmaceutical samples. Materials and Methods: The HPLC instrument method was optimized with isocratic elution with acetonitrile: ammonium acetate (45:55, v/v, pH 3.5), C18 column (150 mm×4.6 mm×5 µm particle size) and a flow rate of 1 ml/min in ambient condition and total retention time of 17 min. The volume of injection was set at 20 µl and detection was recorded at 425 nm. The robustness of the method was examined by changing the mobile phase composition, mobile phase pH, and flow rate. Results: The method was validated with respect to precision, accuracy and linearity in a concentration range of 2-100 µg/ml. The limit of detection (LOD) and limit of quantification (LOQ) were 0.25 and 0.5 µg/ml, respectively. The percentage of recovery was 98.9 to 100.5 with relative standard deviation (RSD) < 0.638%. Conclusion: The method was found to be simple, sensitive and rapid for determination of curcumin in pharmaceutical samples and had enough sensitivity to detect degradation product of curcumin produced under photolysis and hydrolysis stress condition.
https://ajp.mums.ac.ir/article_8861_aa821fbce1601a51434b6ee1e91059f6.pdf
2017-09-01
444
453
10.22038/ajp.2017.20890.1790
Curcumin
Hydrolysis
Photostability
RP-HPLC
Farjad
Amanolahi
f-amanolahi@tums.ac.ir
1
Department of Drug and Food Control, School of Pharmacy, Tehran University of Medical Science, Tehran, Iran
AUTHOR
Ali
Mohammadi
alimohammadi@tums.ac.ir
2
Department of Drug and Food Control, School of Pharmacy, Tehran University of Medical Science, Tehran, Iran
AUTHOR
Reza
Kazemi Oskuee
oskueekr@mums.ac.ir
3
Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Hooriyeh
Nassirli
nasirleeh1@mums.ac.ir
4
Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Bizhan
Malaekeh-Nikouei
malaekehb@mums.ac.ir
5
Nanotechnology Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Aggarwal BA, Kumar A, Aggarwal MS, Shishodia S. 2005. Curcumin derived from turmeric (Curcuma longa): a spice for all seasons. In: Phytopharmaceuticals in Cancer Chemoprevention. CRC Press LLC, pp. 349–387
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Aggarwal BB, Kumar A, Bharti AC. 2003. Anticancer potential of curcumin: preclinical and clinical studies. Anticancer Res, 23:363–398
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9
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10
stability-indicating LC method for curcumin. Chromatographia, 69:871-877
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22
ORIGINAL_ARTICLE
Evaluation of the effects of the hydroalcoholic extract of Terminalia chebula fruits on diazinon-induced liver toxicity and oxidative stress in rats
Objective: Diazinon causes oxidative stress and dysfunction of the liver. This study was undertaken to evaluate the effects of the hydroalcoholic extract of Terminalia chebula, on some biochemical and histopathological parameters of liver tissue in diazinon-administered rats. Materials and Methods: Wistar rats were orally administered with 25 mg/kg body weight diazinon. Vehicle (distilled water) and silymarin (50 mg/kg body weight) were used as the negative and positive control groups, respectively. Diazinon-administered groups were treated with T.chebula (Terminalia chebula) fruit extract (200, 400, and 800 mg/kg). After 15 days of treatment, the blood specimens and liver samples were examined. Results: In diazinon-treated group, the levels of serum urea, high density lipoprotein (HDL), and liver superoxide dismutase (SOD), catalase (CAT), and vitamin C significantly decreased (p<0.05) compared to control. Also, in this group, serum triglyceride (TG), total cholesterol (TC), very low density lipoprotein cholesterol (VLDL), protein carbonyl (PC), malondialdehyde, tumor necrosis factor-α (TNF-α), and TNF-α gene expression significantly increased (p<0.05) as compared to the control (vehicle-treated rats). Treatment with T. chebula resulted in a significant increase (p<0.05) in CAT, SOD, vitamin C, HDL and a significant decrease (p<0.05) in the level of urea, MDA, PC, TG, TC, VLDL, TNF-α protein, and the gene expression of TNF-α compared with test without treatment group. Histopathological evidence demonstrated that treatment with T. chebula extract could decrease liver lymphocyte infiltration. Conclusion: The present study suggests that T. chebula fruit extract has protective effects against diazinon-induced oxidative stress.
https://ajp.mums.ac.ir/article_8997_135191d06d17b386451504706d4fb7c6.pdf
2017-09-01
454
466
10.22038/ajp.2017.21401.1807
Terminalia chebula
Diazinon
Hepatotoxicity
Oxidative stress
TNF-α
Liver damage
Raheleh
Ahmadi-Naji
hadis.naji6565@gmail.com
1
Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran
AUTHOR
Esfandiar
Heidarian
heidarian46@yahoo.com
2
Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
LEAD_AUTHOR
Keyhan
Ghatreh-Samani
kgsamani@yahoo.com
3
Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
AUTHOR
Abdel-Daim MM. 2016. Synergistic protective role of ceftriaxone and ascorbic acid against subacute diazinon-induced nephrotoxicity in rats. Cytotechnology, 68: 279-289.
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20
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21
Heidarian E, Keloushadi M, Ghatreh-Samani K, Valipour P. 2016. The reduction of IL-6 gene expression, pAKT, pERK1/2, pSTAT3 signaling pathways and invasion activity by gallic acid in prostate cancer PC3 cells. Biomed Pharmacother, 84: 264-269.
22
Heidarian E, Rafieian-Kopaei M. 2012. Effect of silymarin on liver phoshpatidate phosphohydrolase in hyperlipidemic rats. Biosci Res, 9: 59-67.
23
Heidarian E, Rafieian-Kopaei M. 2013. Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat. Pharm Biol, 51: 1104-1109.
24
Heidarian E, Rafieian-Kopaei M, Khoshdel A, Bakhshesh M. 2014. Metabolic effects of berberine on liver phosphatidate phosphohydrolase in rats fed on high lipogenic diet: an additional mechanism for the hypolipidemic effects of berberine. Asian Pac J Trop Biomed, 4: S429-S435.
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Heidarian E, Saffari J, Jafari-Dehkordi E. 2014. Hepatoprotective action of Echinophora platyloba DC leaves against acute toxicity of acetaminophen in rats. J Diet Suppl, 11: 53-63.
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27
Kannan VR, Rajasekar GS, Rajesh P, Balasubramanian V, Ramesh N, Solomon EK, Nivas D, Chandru S. 2012. Anti-diabetic activity on ethanolic extracts of fruits of Terminalia chebula Retz. Alloxan induced diabetic rats. Am J Drug Discov Dev, 2: 135-142.
28
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Lari P, Abnous K, Imenshahidi M, Rashedinia M, Razavi M, Hosseinzadeh H. 2015. Evaluation of diazinon-induced hepatotoxicity and protective effects of crocin. Toxicol Ind Health, 31: 367-376.
32
Lee H-S, Won NH, Kim KH, Lee H, Jun W, Lee K-W. 2005. Antioxidant effects of aqueous extract of Terminalia chebula in vivo and in vitro. Biol Pharm Bull, 28: 1639-1644.
33
Lichter-Konecki U. 2016. Defects of the urea cycle. Transl Sci Rare Dis, 1: 23-43.
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Lukaszewicz-Hussain A. 2010. Role of oxidative stress in organophosphate insecticide toxicity–Short review. Pest Biochem Physiol, 98: 145-150.
35
McDonald S, Prenzler PD, Antolovich M, Robards K. 2001. Phenolic content and antioxidant activity of olive extracts. Food Chem, 73: 73-84.
36
Messarah M, Amamra W, Boumendjel A, Barkat L, Bouasla I, Abdennour C, Boulakoud MS, El Feki A. 2013. Ameliorating effects of curcumin and vitamin E on diazinon-induced oxidative damage in rat liver and erythrocytes. Toxicol Ind Health, 29: 77-88.
37
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41
Rezaei A, Heidarian E. 2013. Co-administration of trientine and flaxseed oil on oxidative stress, serum lipids and heart structure in diabetic rats. Indian. J Exp Biol, 51:646-652.
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46
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47
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48
ORIGINAL_ARTICLE
Acute effects of thermally processed pili (Canarium ovatum, Engl.) pomace drink on plasma antioxidant and polyphenol status in humans
Objective: Pili (Canarium ovatum, Engl.) pomace is an underutilized agricultural waste that possesses great potential to be regarded as a functional food ingredient. The aim of this study was to measure the polyphenol content and antioxidant activity of pili pomace drink and determine the influence of heating on these parameters. Moreover, it sought to assess the acute effects of thermally processed pili pomace drink on plasma antioxidant and polyphenol status in humans. Material and Methods: Ten healthy adults received a single dose (130 ml) of pili pomace drink following an overnight fasting, and blood was collected at 0, 30, 60, 120 and 240 min after ingestion of pili pomace. Plasma total polyphenol content was measured using Folin-Ciocalteu method, while total antioxidant capacity (TAC) was determined using ferric reducing antioxidant power (FRAP) assay in uricase-treated and untreated plasma samples. Results: Significant changes in plasma antioxidant and polyphenol levels were observed, reaching maximum levels at 120 and between 30 – 60 min, respectively (p<0.05). Both plasma polyphenols and TAC remained significantly above baseline values throughout the entire test period (p<0.05). Conclusion: Results raised the possibility that an acute consumption of this phenolic-rich pili pomace drink may enhance plasma antioxidant and polyphenol status in humans. Future studies on other unidentified metabolites from pili pomace that may have enhanced the antioxidant activity of plasma should be done.
https://ajp.mums.ac.ir/article_8814_4dce3d8d414a9bea54cab3e3913d7d81.pdf
2017-09-01
467
476
10.22038/ajp.2017.8814
Polyphenols
Plasma
Antioxidant capacity
Canarium ovatum
Elizabeth
Arenas
betharenas@yahoo.com
1
The Graduate School University of Santo Tomas Espana, Manila Philippines
LEAD_AUTHOR
Trinidad
Trinidad
trinidadtp@yahoo.com.ph
2
The Graduate School University of Santo Tomas Espana, Manila Philippines
AUTHOR
Cassidy A, Brown J, Hawdon A, Faughnan M, King L, Millward J, Zimmer-Nechemias L, Wolfe B, Setchell K. 2006. Factors Affecting the Bioavailability of Soy Isoflavones in Humans after Ingestion of Physiologically Relevant Levels from Different Soy Foods. J Nutr, 136: 45-51.
1
Chew L, Prasad N, Amin I, Azrina A, Lau C. 2011. Nutritional composition and antioxidant properties of Canarium odontophyllum Miq. (dabai) fruits. J Food Compos Anal, 24: 670-677.
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Ghiselli A, Serafini M, Scaccini C. 2000b. Total antioxidant capacity as a tool to assess redox status: critical view and experimental data. Free Radical Biol Med, 29: 1106-1114.
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