ORIGINAL_ARTICLE
Gustav III’s risk assessment on coffee consumption; A medical history report
https://ajp.mums.ac.ir/article_7870_20a0972baf06cd217911e655328d64c8.pdf
2017-03-01
99
100
10.22038/ajp.2016.7870
Coffee
Heart
medical history
Reza
Afshari
afsharir@mums.ac.ir
1
Environmental Health Services, BC Centre for Disease Control, Vancouver, Canada
LEAD_AUTHOR
Brown OI, Allgar V, Wong KY. 2016. Coffee reduces the risk of death after acute myocardial infarction: a meta-analysis. Coron Artery Dis. Jun 16 [Epub ahead of print].
1
Giesinger K, Hamilton DF, Erschbamer M, Jost B, Giesinger JM. 2015. Black medicine: an observational study of doctors' coffee purchasing patterns at work. BMJ. 16; 351:h6446.
2
Encyclopædia Britannica. 2016. Gustav III King of Sweden.Encyclopedia Britannica. ©Encyclopædia Britannica, Inc. http://www.britannica.com/biography/Gustav-III (Retrieved 16 June 2016).
3
International Agency for Research on Cancer (IARC). 1991. Coffee, tea, mate, methylxanthines and methylglyoxal. IARC Monogr Eval Carcinog Risks Hum. 51: 1–513.
4
Loomis D, Guyton K Z, Grosse Y, Lauby-Secretan B, Ghissassi F EI, Bouvard V, and others. Carcinogenicity of drinking coffee, mate, and very hot beverages. Lancet Oncology. Published online: June 15, 2016.
5
Weinberg BA, Bealer BK. 2001. The world of caffeine: the science and culture of the world's most popular drug. pp. 92. Psychology Press.
6
Cultural Heritage Group. 2013. Behind the scene. Uppsala University Library. https://uppsalalibraryculturalheritage.wordpress.com/tag/gustav-iii/ (Retrieved 16 June 2016).
7
ORIGINAL_ARTICLE
In vitro and in vivo assessment of inhibitory effect of stevioside on pro-inflammatory cytokines
Objective: Stevioside is a natural non-caloric sweetener which has been reported to have anti-inflammatory activity. The aim of the present study was to examine in vitro and in vivo effects of stevioside on rats plasma levels of tumor necrosis factor- α (TNF-α), interleukin-1β (IL-1β), TNF-α and IL-1β release from lipopolysaccharide(LPS)-stimulated rat peripheral blood mononuclear cells (PBMCs). Materials and Methods: Male wistar rats weighing between 170-220 g were given stevioside (0, 500 and 1000 mg/kg BW/day) for 6 weeks. Mononuclear cells were separated from peripheral blood samples. TNF-α and IL-1β levels in plasma and the release of TNF-α and IL-1β from PBMCs were determined using rat enzyme-linked immunosorbent assay (ELISA) kits. Results: Plasma levels of TNF-α and IL-1β were found to be non-detectable in control and groups treated with 500 and 1000 mg/kg of stevioside. Regarding TNF-α release from LPS-stimulated PBMCs, rats that were orally fed with 500 and 1000 mg/kg of stevioside were significantly different (p<0.05) from those in LPS-treated control group (186.8+18.6 and 151.4 + 15.4 vs 248.6+21.4 pg/ml). Additionally, IL-1β levels in rats treated with 500 and 1000 mg/kg of stevioside were significantly different (p<0.05) from those in LPS-treated control group (220.0+12.1 and 158.1 + 22.6 vs 294.4+16.1 pg/ml). Conclusion: Consumption of stevioside has an inhibitory effect on the release of TNF-α and IL-1β from LPS-stimulated PBMCs in rats.
https://ajp.mums.ac.ir/article_6599_ccd21beb18f0196952f100e27acd74e4.pdf
2017-03-01
101
106
10.22038/ajp.2016.6599
Stevioside
TNF- α
IL-1β
Peripheral blood mononuclear cells
Jatuporn
Noosud
fvetjpn@ku.ac.th
1
Department of Companion Animal Clinical Science, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand
AUTHOR
Narissara
Lailerd
naressara.lailerd@cmu.ac.th
2
Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
AUTHOR
Autchara
Kayan
fagrark@ku.ac.th
3
Department of Animal Science, Faculty of Agriculture, Kasetsart University, Bangkok, Thailand
AUTHOR
Chaiwat
Boonkaewwan
agrcwb@ku.ac.th
4
Department of Animal Science, Faculty of Agriculture, Kasetsart University, Bangkok, Thailand
LEAD_AUTHOR
Hanson JR, De Oliveira BH. 1993. Stevioside and related sweet diterpenoid glycosides. Nat Prod Rep, 10: 301-309.
1
Koyama E, Sakai N, Ohori Y, Kitazawa K, Izawa O, Kakekawa K, Fujino A, Ui M. 2003. Absorption and metabolism of glycosidic sweeteners of stevia mixture and their aglycone, steviol , in rats and humans. Food Chem Toxicol, 41: 875-883.
2
Mosetting E. 1995. Stevioside II. The structure of the aglycone. J Org Chem, 20: 884-899.
3
Koyama E, Kitazawa K, Ohori Y, Izawa O, Kakegawa K, Fujino A, Ui M. 2003. In vitro metabolism of the glycosidic sweeteners, stevia in human intestinal microflora. Food Chem Toxicol, 41 : 359-374.
4
Geuns JM, Buyse J, Vankeirsbilck A, Temme EH. 2007. Metabolism of stevioside by healthy subjects. Exp Biol Med, 232: 164-173.
5
Chatsudthipong V, Muanprasat C. 2009. Stevioside and related compounds: therapeutic benefit beyond sweetness. Pharmacol Ther, 121: 41-54.
6
Jeppesen PB, Kyrskog SE, Agger A, Gregersen XJ, Hermansen K. 2006. Can stevioside in combination with a soy-based dietary supplement be a new useful treatment of type 2 diabetes? An in vivo Studies in the diabetic goto-Kakizaki Rat. Rev Diabet Stud, 3: 189-199.
7
Lee CN, Wong K, Liu J, Chen Y, Chen J, Chan P. 2001. Inhibitory effect of stevioside on calcium influx to produce antihypertension. Planta Med, 67: 796-799.
8
Boonkaewwan C, Toskulkao C, Vongsakul M. 2006. Anti-inflammatory and Immunomodulatory Activities of Stevioside and Its Metabolite Steviol on THP-1 Cells. J Agric Food Chem, 54: 785-789.
9
Boonkaewwan C, Ao M, Toskulkao C, Rao MC. 2008. Specific immunomodulatory and secretory activities of stevioside and steviol in intestinal cells. J Agric Food Chem, 56: 3777-3784.
10
Boonkaewwan C, Burodom A. 2013. Anti-inflammatory and immunomodulatory activities of stevioside and steviol on colonic epithelial cells. J Sci Food Agric , 93: 3820–3825.
11
Pariwat P, Homvisasevongsa S, Muanprasa C, Chatsudthipong V. 2008. A natural plant-derived . dihydroisosteviol prevents cholera toxin-induced intestinal fluid secretion. J Pharmcol Exp Ther, 324: 798-805.
12
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18
JECTA. 2008. Steviol glycosides. In: Compendium of Food Additive Specifications FAO/WHO Expert Committee on Food Additives (JECFA), 69th Meeting, 17-26 June FAO/JECFA monographs no 5) Rome: Food and Agriculture Organization of the United Nations/World Health Oraganization; 75-78.
19
ORIGINAL_ARTICLE
Cassia fistula: A remedy from Traditional Persian Medicine for treatment of cutaneous lesions of pemphigus vulgaris
Objective: Pemphigus is a rare autoimmune disease that may be fatal without proper medical intervention. It is a blistering disease that involves both the skin and mucus membranes, in which the most important causes of death comprise superimposed opportunistic infections and complications of long-term high-dose corticosteroid therapy or prolonged consumption of immune suppressant drugs. Skin lesions are the most important sources of infection, and any local treatment decreasing the healing time of lesions and reducing the total dosage of drugs is favorable. Materials and Methods: Here, we review the probable mechanism of action of a traditional formulary of Cassia fistula (C. fistula) fruit extract in almond oil as a new topical medication for reducing the duration of treatment of pemphigus vulgaris erosions. Result: C. fistula fruit oil has lupeol, anthraquinone compounds as rhein and flavonoids. Previous in vitro and animal studies on C. fistula fruit have demonstrated wound healing, antioxidative, anti-leukotrienes, anti-inflammatory, antibacterial and antifungal effects of this plant. Conclusion: It is hypothesized that C. fistula L. can be a botanical therapeutic choice for treatment of pemphigus erosions.
https://ajp.mums.ac.ir/article_6629_3b5f91813f5cb87dbf8f3d847fe9abe1.pdf
2017-03-01
107
115
10.22038/ajp.2016.6629
Pemphigus vulgaris
Cassia fistula L
Traditional Persian Medicine (TPM)
Topical therapy
Fatemh
Atarzadeh
dr.atarzadeh@gmail.com
1
Department of Traditional Iranian Medicine, School of Traditional Medicine, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Amir
Jaladat
drjaladat@gmail.com
2
Department of Traditional Persian Medicine, School of Medicine, Shiraz, Iran
AUTHOR
Ladan
Dastgheib
dastghl@sums.ac.ir
3
Molecular Dermatology Research Center, Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, Iran
AUTHOR
Gholamreza
Amin
amin@tums.ac.ir
4
Department of Traditional Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Majid
Nimrouzi
mnimruzi@yahoo.com
5
Department of Traditional Persian Medicine, School of Medicine, Shiraz, Iran
AUTHOR
Mohammad
Kamalinejad
mkamalinejad@yahoo.com
6
Department of Pharmacognosy, School of Pharmacy, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
Abida O, Ben Mansour R, Gargouri B, Ben Ayed M, Masmoudi A, Turki H, Masmoudi H, Lassoued S. 2012. Catalase and Lipid Peroxidation Values in Serum of Tunisian Patients with Pemphigus Vulgaris and Foliaceus. Biol Trace Elem Res, 150: 74-80.
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Almugairen N, Hospital V, Bedane C, Duvert-Lehembre S, Picard D, Tronquoy AF, Houivet E, D'Incan M, Joly P. 2013. Assessment of the rate of long-term complete remission off therapy in patients with pemphigus treated with different regimens including medium- and high-dose corticosteroids. J Am Acad Dermatol, 69: 583-588.
4
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10
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Tsang SW, Zhang H, Lin C, Xiao H, Wong M, Shang H, Yang Z-J, Lu A, Yung KK-L, Bian Z. 2013. Rhein, a Natural Anthraquinone Derivative, Attenuates the Activation of Pancreatic Stellate Cells and Ameliorates Pancreatic Fibrosis in Mice with Experimental Chronic Pancreatitis. PloS one, 8: e82201.
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55
ORIGINAL_ARTICLE
Preventive effect of Coriandrum sativum on neuronal damages in pentylentetrazole-induced seizure in rats
Objective:Coriandrum sativum (C. sativum) as a medicinal plant has been pointed to have analgesic, hypnotic and anti-oxidant effects. In the current study, a possible preventive effect of the hydro-alcoholic extract of the plant on neuronal damages was examined in pentylenetetrazole (PTZ) rat model of seizure.Materials and Methods: Forty male rats were divided into five main groups and treated by (1) saline, (2) PTZ: 100 mg/kg PTZ (i.p) and (3-5) 50, 100 and 200 mg/kg of hydro-alcoholic extract of C. sativum during seven consecutive days before PTZ injection. After electrocorticography (ECoG), the brains were removed to use for histological examination.Results: All doses of the extract reduced duration, frequency and amplitude of the burst discharges while prolonged the latency of the seizure attacks (p<0.05, p<0.01, and p<0.001). Administration of all 3 doses of the extract significantly prevented from production of dark neurons (p<0.01, and p<0.001) and apoptotic cells (p<0.05, p<0.01, and p<0.001) in different areas of the hippocampus compared to PTZ group.Conclusion: The results of this study allow us to conclude that C. sativum,because of its antioxidant properties, prevents from neuronal damages in PTZ rat model of seizure.
https://ajp.mums.ac.ir/article_7757_06062e445614ed2f7d8ad7a3d39cf88c.pdf
2017-03-01
116
128
10.22038/ajp.2016.7757
Coriandrum sativum
Seizure
Apoptosis
Neuronal damage
Hippocampus
Mojtaba
Pourzaki
pourzakim911@mums.ac.ir
1
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mansour
Homayoun
mansour.homayoun@yahoo.com
2
Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Saeed
Sadeghi
sadeghis912@mums.ac.ir
3
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Masoumeh
seghatoleslam
seghatoleslamm@mums.ac.ir
4
Department of Anatomy and Cell Biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. Microanatomy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
LEAD_AUTHOR
Mahmoud
Hosseini
hosseinim@mums.ac.ir
5
Neurocognitive Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Alireza
Ebrahimzadeh Bideskan
ebrahimzadehba@mums.ac.ir
6
Department of Anatomy and Cell Biology, Microanatomy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Ataei ML and Ebrahimzadeh-Bideskan AR. 2014. The effects of nano-silver and garlic administration during pregnancy on neuron apoptosis in rat offspring hippocampus. Iran J Basic Med Sci, 17: 411-418.
1
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2
Baracskay P , Szepesi Z , Orbán G , Juhász G , Czurkó A. 2008. Generalization of seizures parallels the formation of “dark” neurons in the hippocampus and pontine reticular formation after focal–cortical application of 4-aminopyridine (4-AP) in the rat. Brain res, 1228: 217-228.
3
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58
ORIGINAL_ARTICLE
A comparison of the efficacy of metronidazole vaginal gel and Myrtus (Myrtus communis) extract combination and metronidazole vaginal gel alone in the treatment of recurrent bacterial vaginosis
Objective: Due to the high incidence of bacterial vaginosis (BV) and its resistance to chemical medications and considering the anti-bacterial and anti-fungal effects of Myrtus communis, the present study aimed to compare the therapeutic effects of the vaginal gel of M. communis 2% (in metronidazole base) with metronidazole vaginal gel 0.75% alone on BV.Materials and Methods: This research was a randomized controlled clinical trial conducted on 80 women of 18-40 years old with BV. Patients were divided into two groups of 40 women. Diagnostic criteria were Amsel's criteria and Gram staining. The first group received vaginal gel of metronidazole plus M. communis 2% and the second group received metronidazole vaginal gel alone for five consecutive nights. Therapeutic effects and Amsel’s criteria were assessed after one week. Finally, the data were analyzed by SPSS 16 using t-test and Chi square tests.Results: There was a significant difference in the therapeutic response between the two groups. The results demonstrated that the combination of metronidazole and M. communis had a higher efficiency (p<0.05). The patients receiving M. communis in metronidazole gel base did not experience any recurrent BV, but 30% of patients taking metronidazole alone faced recurrent BV after three weeks of follow up.Conclusion: Findings of the study suggested that adding M. communis extract to metronidazole increases the efficiency of BV treatment.
https://ajp.mums.ac.ir/article_7286_1bfc4e3f99077ce92b410a986f10a0af.pdf
2017-03-01
129
136
10.22038/ajp.2016.7286
Myrtus Communis
Metronidazole
Bacterial vaginosis
Mansoure
Masoudi
masoudim2014@gmail.com
1
Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
AUTHOR
Mahmoud
Rafieian
rafieian@yahoo.com
2
Medicinal Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
AUTHOR
Sepide
Miraj
kiani.sandra@yahoo.com
3
Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
LEAD_AUTHOR
Al-Saimary IE, Bakr SS, Jaffar T, Al-Saimary AE, Salim H, Al-Muosawi R. 2002. Effects of some plant extracts and antibiotics on Pseudomonas aeruginosa isolated from various burn cases. Saudi Med J,7: 802-805.
1
Alipour G, Dashti S, Hosseinzadeh H. 2014. Review of pharmacological effects of Myrtus communis L. and its active constituents. Phytother Res, 8: 1125-1136.
2
Allsworth JE. 2010. Bacterial vaginosis-race and sexual transmission: issues of causation. Sex Transm Dis,3: 137-139.
3
Amirmohammadi M, Khajoenia S, Bahmani M, Rafieian-Kopaei M, Eftekhari Z, Qorbani M. 2014. In vivo evaluation of antiparasitic effects of Artemisia abrotanum and Salvia officinalis extracts on Syphacia obvelata, Aspiculoris tetrapetra and Hymenolepis nana parasites. Asian Pac J Trop Dis, 4: S250-S254.
4
Bahmani M, Rafieian-Kopaei M. 2014. Medicinal plants and secondary metabolites for leech control. Asian Pac J Trop Dis , 4: 315-316.
5
Brandt M, Abels C, May T, Lohmann K, Schmidts-Winkler I, Hoyme U. 2008. Intravaginally applied metronidazole is as effective as orally applied in the treatment of bacterial vaginosis, but exhibits significantly less side effects. Eur J Obstet Gynecol Reprod Biol, 2: 158-162.
6
Danforth DN, Gibbs S. 2008. Danforth's obstetrics and gynecology, pp.112. Lippincott Williams & Wilkins.
7
Donders GG, Zodzika J, Rezeberga D. 2014. Treatment of bacterial vaginosis: what we have and what we miss. Expert Opin Pharmacother ,5: 645-657.
8
Farage MA, Miller KW, Ledger WJ. 2008. Determining the cause of vulvovaginal symptoms. Obstet Gynecol Surv,63: 445-464.
9
Ghasemi Dehkordi N, Sajadi S, Ghanadi A, Amanzadeh Y, Azadbakht M, Asghari GR, et al. 2003. Iranian herbal pharmacopoeia (IHP). Hakim Res J, 63-69.
10
Hosseinzadeh H, Khoshdel M, Ghorbani M. 2011. Antinociceptive, anti-inflammatory effects and acute toxicity of aqueous and ethanolic extracts of Myrtus communis L. aerial parts in mice. J Acupunct Meridian Stud, 4: 242-247.
11
Houshmand B, Mortazavi H, Alikhani Y, Abdolsamadi H, AhmadiMotemayel F, ZareMahmoudabadi R. 2011. In Vitro Evaluation of Antibacterial Effect of Myrtus Extract with Different Concentrations on Some Oral Bacteria. J Mashad Dent Sch, 35: 123-130.
12
Klebanoff MA, Nansel TR, Brotman RM, Zhang J, Yu K-F, Schwebke JR, et al.2010. Personal hygienic behaviors and bacterial vaginosis. Sex Transm Dis, 2: 94.
13
Koumans EH, Sternberg M, Bruce C, McQuillan G, Kendrick J, Sutton M, et al. 2007. The prevalence of bacterial vaginosis in the United States, 2001–2004; associations with symptoms, sexual behaviors, and reproductive health. Sex Transm Dis , 34: 864-869.
14
de Figueiredo Leite SR, de Amorim MM, Calábria WB, de Figueiredo Leite TN, de Oliveira VS, Ferreira Júnior JA, et al.2010. Clinical and microbiological profile of women with bacterial vaginosis. Revista Brasileira de Ginecologia e Obstetrícia ,2: 82-87.
15
Löfmark S, Edlund C, Nord CE. 2010. Metronidazole is still the drug of choice for treatment of anaerobic infections. Clin Infect Dis, 1: S16-S23.
16
Mashburn J. 2012. Vaginal infections update. J Midwifery Womens Health,6: 629-634.
17
Masoudi M, Miraj S, Rafieian-Kopaei M. 2016 .Comparison of the Effects of Myrtus Communis L, Berberis Vulgaris and Metronidazole Vaginal Gel alone for the Treatment of Bacterial Vaginosis. J clin diag res, 3.
18
Ness RB, Hillier SL, Kip KE, Soper DE, Stamm CA, McGregor JA, et al. 2004. "Bacterial vaginosis and risk of pelvic inflammatory disease. Obstet Gynecol ,4: 761-769.
19
Novak E , Berek S . 2007. Berek & Novak's gynecology, Lippincott Williams & Wilkins.
20
Rabiei Z, Rafieian-Kopaei M, Heidarian E, Saghaei E, Mokhtari S. 2014. Effects of Zizyphus jujube extract on memory and learning impairment induced by bilateral electric lesions of the nucleus Basalis of Meynert in rat. Neurochem res , 2: 353-360.
21
Rafiean-Kopaei M, Baradaran A, Maghsoudi AR, Ghobadi Sh, Nasri H. Nasri. 2012. Helicobacter pylori infection and serum homocysteine in hemodialysis patient. Life Sci J ,4.
22
Reichman O, Akins R, Sobel JD. 2009. Boric acid addition to suppressive antimicrobial therapy for recurrent bacterial vaginosis. Sex Transm Dis, 11: 732-734.
23
Riggs M, Klebanoff M, Nansel T, Zhang J, Schwebke J, Andrews W. 2007. Longitudinal association between hormonal contraceptives and bacterial vaginosis in women of reproductive age. Sex Transm Dis, 12: 954-959.
24
Rossi A, Di Paola R, Mazzon E, Genovese T, Caminiti R, Bramanti P, et al. 2009. Myrtucommulone from Myrtus communis exhibits potent anti-inflammatory effectiveness in vivo. J Pharmacol ExpTher, 1: 76-86.
25
Schwebke JR, Desmond RA, Oh MK. 2004. Predictors of bacterial vaginosis in adolescent women who douche. Sex Transm Dis ,7: 433-436.
26
Sharafati-chaleshtori R, Mahmoud Rafieian-kopaei M. 2014. Screening of antibacterial effect of the Scrophularia Striata against E. coli in vitro. J HerbMed Pharmacol , 3:31-34.
27
Shirzad H, Taji F, Rafieian-Kopaei M. 2011. Correlation between antioxidant activity of garlic extracts and WEHI-164 fibrosarcoma tumor growth in BALB/c mice. J Med Food, 9: 969-974.
28
Simbar M, Azarbad Z, Mojab F, Alavi Majd H. 2008. A comparative study of the therapeutic effects of the Zataria multiflora vaginal cream and metronidazole vaginal gel on bacterial vaginosis. Phytomedicine , 12: 1025-1031.
29
Sobel JD. 2000. Bacterial vaginosis. Annu Rev Med, 1: 349-356.
30
Sobel JD, Ferris D, Schwebke J, Nyirjesy P, Wiesenfeld HC, Peipert J, et al. 2006. Suppressive antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis. Am J Obstet Gynecol , 5: 1283-1289.
31
Seyyedi F, Rafiean-Kopaei M, Miraj S. 2016. Comparison of the Effects of Vaginal Royal Jelly and Vaginal Estrogen on Quality of Life, Sexual and Urinary Function in Postmenopausal Women. J Clin Diag Res, 10.
32
Verstraelen H, Verhelst R. 2009. Bacterial vaginosis: an update on diagnosis and treatment. Expert Rev Anti Infect Ther, 9: 1109-1124.
33
ORIGINAL_ARTICLE
Kelussia odoratissima potentiates cytotoxic effects of radiation in HeLa cancer cell line
Objective: Cervical cancer is the second most common cause of death from cancer in women throughout the world. The aim of this study was to evaluate the cytotoxic activity of Kelussia odoratissima (K. odoratissima) extract associated with radiotherapy in cervical cancer cells (HeLa cell line).Materials and Methods: Different concentration of the extract (25-500µg/ml) was tested in HeLa cell lines. Cell cytotoxicity of the extract and the effects of the extract on radiation (2Gy/min)-induced damages were assessed by MTT assay. Apoptosis was assessed using flow cytometric analysis.Result: K. odoratissima decreased cell viability in HeLa cell line in a concentration and time-dependent manner. When compared to the control,K. odoratissima induced a sub-G1 peak in the flow cytometry histogram of treated cells, indicating that apoptotic cell death is involved in K. odoratissima-induced toxicity. It was also shown that K. odoratissima sensitizes cells to radiation-induced toxicity.Conclusion: Our result showed the extract increased the radiation effect. This observation may be related to the presence of active compounds such as phthalides and ferulic acid.
https://ajp.mums.ac.ir/article_7759_369738cc6cc78a4f3cabae713fffd7fd.pdf
2017-03-01
137
144
10.22038/ajp.2016.7759
HeLa cell line
Kelussia odoratissima
Cytotoxicity
Radiotherapy
Apoptosis
Azar
Hosseini
hoseiniaz@mums.ac.ir
1
Pharmacological Research Center of Medicinal Plants, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Shima
Saeidi Javadi
saeidi s@google.com
2
Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Azar
Fani Pakdel
fani pa@mums.ac.ir
3
Department of Oncology, Omid Hospitsal, Mashhad, Iran
AUTHOR
Seyed Hadi
Mousavi
mousavih@mums.ac.ir
4
Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Ahmadi F, Kadima M, Shahedi M. 2007. Antioxidant activity of Kelussia odoratissima Mozaff in model and food systems. Food chem, 105: 57–64.
1
Alexandre J, Batteux F, Nicco C. 2006. Accumulation of hydrogen peroxide is an early and crucial step for paclitaxel-induced cancer cell death both in vitro and in vivo. Int J Cancer, 119: 41-48.
2
Alexandre J, Hu Y, Lu W, Pelicano H, Huang P. 2007. Novel action of paclitaxel against cancer cells: bystander effect mediated by reactive oxygen species. Cancer Res, 67: 3512-3517.
3
Bandugula VR, Prasad R. 2013. 2-Deoxy-D-glucose and ferulic acid modulates radiation response signaling in non-small cell lung cancer cells. Tumor Biol, 34:251–259.
4
Bhoslea SM, Huilgola NG, Mishra KP. 2005. Enhancement of radiation-induced oxidative stress and cytotoxicity in tumor cells by ellagic acid. Clin Chim Acta, 359:89-100.
5
Bosch FX, Lorincz A, Munoz N. 2002. The casual relation between human papilloma virus and cervical cancer. J Clin Pathol, 55: 244-65.
6
Cragg GM, Newman DJ. 2005. Plants as a source of anti-cancer agents. J Ethnopharmacol, 100: 72-79.
7
Dal-Pizzol F, Ritter C, Klamt F, Andrades M, da Frota ML Jr, Diel C. 2003. Modulation of oxidative stress in response to γ-radiation in human glioma cell lines. J Neurooncol, 61:89-94.
8
Dewick PM. 2011. Medicinal Natural Products: A Biosynthetic Approach . West Sussex: pp: 539, John Wiley & Sons.
9
Dropcho EJ. 2011. The neurologic side effects of chemotherapeutic agents. Continuum, (Minneap Minn) 17: 95-112.
10
Dunne-Daly CF.1999. Principles of radiotherapy and radiobiology. Semin Oncol Nurs, 15:250-259.
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Garg AK, Buchholz TA, Aggarwal BB. 2005. Chemosensitization and radiosensitization of tumors by plant polyphenols. Antioxid Redox Signal, 7:1630 – 1647.
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15
Lopez-Lazaro M. 2007. Dual role of hydrogen peroxide in cancer: Possible relevance to cancer chemoprevention and therapy. Cancer Lett, 252: 1-8.
16
Magné N, Fischel JL,Dubreuil A, Formento P, Marcié S, Lagrange JL, and Milano G. 2002. Sequence-dependent effects of ZD1839 (‘Iressa’) in combination with cytotoxic treatment in human head and neck cancer. Br J Cancer, 86: 819-827.
17
Monsuez J, Charniot JC, Vignat N, Artigou JY. 2010. Cardiac side-effects of cancer chemotherapy. Inter J Cardiol, 144: 3–15.
18
Mozaffarian V. 2003. Two new genera of Iranian Umbellifera. Bot Zhurn, 88: 88–94.
19
Nussbaumer S, Bonnabry P, Veuthey JL, Sandrine F. 2011. Analysis of anticancer drugs: A review. Talanta, 85: 2265-2289.
20
Olive PL.1998. The role of DNA single and double strand breaks in cell killing by ionizing radiation. Radiat Res, 150:S42-S51.
21
Pelicano H, Carney D, Huang P. 2004. ROS stress in cancer cells and therapeutic implications. Drug Resist Updat, 7: 97-110.
22
Qi F, Zhao L, Zhou A, Zhang B, Li A, Wang Z, Han J. 2015. The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer. BioScience Trends, 9:16-34.
23
Reddy BV, Prasad NR . 2011. 2-deoxy-D-glucose combined with ferulic acid enhances radiation response in non-small cell lung carcinoma cells. Cent Eur J Biol, 6:743 – 755.
24
Renschler MF. 2004. The emerging role of reactive oxygen species in cancer therapy. Eur J Cancer, 40: 1934-40.
25
Sajjadi SE, Shokoohinia Y, Moayedi NS. 2012. Isolation and Identification of Ferulic Acid From Aerial Parts of Kelussia odoratissima Mozaff. Jundishapur J Nat Pharm Prod, 7:159-162.
26
Schumacker PT. 2006. Reactive oxygen species in cancer cells: live by the sword, die by the sword. Cancer Cell, 10: 175-176.
27
She M, Pu F, Pan Z. 2005. "Apiaceae". Flora of China. Vol 14.Page1
28
Torres MA, Raju U, Molkentine D, Riesterer O, Milas L, Ang KK. 2011. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest. New Drugs,29: 554-561.
29
Trachootham D, Alexandre J, Huang P. 2009. Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov, 8:579 – 591.
30
Wardman P. 2007. Chemical Radiosensitizers for use in radiotherapy. Clin Oncol, 19:397-417.
31
Zoberi I, Bradbury CM, Curry HA. 2002. Radiosensitizing and antiproliferative effects of resveratrol in two human cervical tumor cell lines. Cancer Lett, 175:65-173.
32
ORIGINAL_ARTICLE
Anti-carcinogenic and anti-angiogenic properties of the extracts of Acorus calamus on gastric cancer cells
Objective: Acorus calamus (A. calamus) has been used as a medicinal plant in Asia for its effects on digestive system for the last 2000 years. To investigate the anti-cancer activity of rhizome of A. calamus, the ethanolic and methanolic extracts and essential oil of the rhizome were prepared and their effects were assessed on human gastric cancer cell line (AGS). Materials and Methods: The viability of cells which were treated with the extracts and the essential oil was assessed by MTT assay. To evaluate the anti-angiogenic property of the extracts, in vitro tube formation assay was done. Cell cycle distribution and the expression of Oct4 and Nucleostemin, after treatments, were checked by flowcytometry and quantitative RT-PCR, respectively. Furthermore, analysis of essential oil from A.calamus was done by GC-MS. Results: Our results showed that the growth of AGS cells was inhibited by the extracts and essential oil and the extracts inhibited the angiogenesis in HUVEC cells. Our data revealed that the extracts and essential oil of A. calamus caused G1 arrest in AGS cells and downregulation of Oct4 and NS after treatment. By GC-MS analysis, we found new compoundssuch as epiprezizaene, valencene and isocyclocitral in essential oil of A. Conclusions: All together, our results showed that the extracts of A. calamus have anti-proliferative and anti-angiogenic effects on cancer cells.
https://ajp.mums.ac.ir/article_7485_649faba38a889b3c2d7b98ad8af98cb8.pdf
2017-03-01
145
156
10.22038/ajp.2016.7485
Acorus calamus
Gastric cancer
Anti-proliferative
Angiogenesis
Oct4
Nucleostemin
Samaneh
Rahamoz Haghighi
samane_rahamoz@yahoo.com
1
Department of Plant Breeding, Faculty of New Sciences and Technologies, Graduate University of Advanced Technology, Kerman, Iran
AUTHOR
Malek Hossein
Asadi
hossein_a1359@yahoo.com
2
Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
LEAD_AUTHOR
Hassan
Akrami
hassan_akrami@yahoo.com
3
Department of Biology, Faculty of Basic Science, Razi University, Kermanshah, Iran
AUTHOR
Amin
Baghizadeh
amin_4156@yahoo.com
4
Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran
AUTHOR
Agarwal SL, Arora RB, Dandiya PC, Singh KP. 1956. A note on the preliminary studies of certain pharmacological actions of Acorus calamus L. J Am Pharm Assoc Am Pharm Assoc, 45:655-656.
1
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Balakumbahan R, Rajamani K, Kumanan K. 2010. Acorus calamus: An overview. J Med Plants Res, 4:2740-2745.
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Palani S, Raja S, Praveen kumar R, Venkadesan D, Devi K, Sivaraj A, Senthilkumar B. 2009. Therapeutic efficacy of antihepatotoxic and antioxidant activities of Acorus calamus on acetaminophen induced toxicity in rat. Int J Int Biol, 7:39-44.
20
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Rajkumar V, Gunjan G, Ashok KR, Lazar M. 2009. Evaluation of Cytotoxic Potential of Acorus calamus Rhizome. Ethnobotanical Leaflets, 13:832-839.
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Rajput SB, Karuppayil SM. 2013. beta-Asarone, an active principle of Acorus calamus rhizome, inhibits morphogenesis, biofilm formation and ergosterol biosynthesis in Candida albicans. Phytomedicine, 20:139-142.
23
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26
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27
ORIGINAL_ARTICLE
Antioxidant, cytotoxic and DNA protective properties of Achillea eriophora DC. and Achillea biebersteinii Afan. extracts: A comparative study
Objective: Achillea is a traditional medicinal herb which contains different phenol and flavonoid compounds that are responsible for Achillea pharmacological effects. We aimed to determine phenol and flavonoid contents, besides antioxidant activities of different extracts from Achillea eriophoraa (A. eriophora) DC. and Achillea biebersteinii (A. biebersteinii) Afan. (endemic species in Iran) and to investigate their effects on human cells.Materials and Methods: Achillea extracts, were prepared by maceration and shaking methods, from different parts (aerial parts, stem, leaves and inflorescence) of two species using methanol and ethanol as solvents. Total phenol and flavonoid contents were measured by spectrophotometry, and antioxidant activities of the extracts were determined by DPPH radical scavenging, BCB and TBARS assays. Cytotoxicity and antioxidant activities of the extracts were investigated in Human Foreskin Fibroblast (HFF3) cells using MTT, comet and H2O2 assays.Results: Methanol extracts of A. biebersteinii prepared from leaves and inflorescence by maceration method exhibited maximum phenol (1657.58 ± 36.45 mg GAE/100 g DW) and flavonoid (264.00 ± 62.16 mg QUE/100 g DW) contents. Leaf methanol extract showed significantly higher antioxidant activity (0.0276 ± 0.003, 0.16 ± 0.016 and 13.96 ± 0.26 mg/ml for DPPH, BCB and TBARS IC50s, respectively) than those of the other extracts. Leaf extract of A. biebersteinii was not cytotoxic even at the highest examined dose (512 µg/ml) and inhibited cell toxicity induced by H2O2 (98% viability for the cells pretreated with plant extract in the presence of H2O2). Comet assay also confirmed high DNA protective activity of leaf extracts.Conclusion: Achillea extracts possess remarkable antioxidant activity, and could be good natural alternatives to synthetic antioxidants in pharmaceutical and food industries.
https://ajp.mums.ac.ir/article_7756_d9047c55aa95180b095645e2ea2c86e0.pdf
2017-03-01
157
168
10.22038/ajp.2016.7756
extraction
Flavonoids
DPPH
MTT Assay
Comet
HFF3 cells
Maryam
Varasteh-kojourian
ma.varasteh@stu.um.ac.ir
1
Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran
AUTHOR
Parvaneh
Abrishamchi
abrisham@ferdowsi.um.ac.ir
2
Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran
LEAD_AUTHOR
Maryam
Matin
matin@um.ac.ir
3
Cell and Molecular Biotechnology Research Group, Institute of Biotechnology, Ferdowsi University of Mashhad, Mashhad, Iran
AUTHOR
Javad
Asili
asilij@mums.ac.ir
4
Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Hamid
Ejtehadi
hejtehadi@yahoo.com
5
Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran
AUTHOR
Fatemeh
Khosravitabar
khosravi.fa28@yahoo.com
6
Department of Biology, Faculty of Science, Ferdowsi University of Mashhad, Mashhad, Iran
AUTHOR
Adetutu A, Morgan WA, Corcoran O. 2011. Antibacterial, antioxidant and fibroblast growth stimulation activity of crude extracts of Bridelia ferruginea leaf, a wound-healing plant of Nigeria. J Ethnopharmacol, 133: 116-119.
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62
ORIGINAL_ARTICLE
Antidiabetic, hypolipidemic and hepatoprotective effects of Arctium lappa root’s hydro-alcoholic extract on nicotinamide-streptozotocin induced type 2 model of diabetes in male mice
Objective: Arctium lappa (burdock), (A. lappa) root has hypoglycemic and antioxidative effects, and has been used for treatment of diabetes in tradition medicine. This study was conducted to evaluate the antidiabetic and hypolipidemic properties of A. lappa root extract on nicotinamide-streptozotocin (NA-STZ)-induced type2 diabetes in mice.Materials and Methods: In this investigation, 70 adult male NMRI mice (30-35g) randomly divided into 7 groups (n=10) as follow: 1-control, 2-type 2 diabetic mice, 3-diabetic mice that received glibenclamide (0.25 mg/kg) as an anti-diabetic drug, 4, 5, 6 and 7- diabetic and normal animals that were pre-treated with 200 and 300 mg/kg A. lappa root extract, respectively, for 28 days. Diabetes has been induced by intraperitoneal injection of NA and STZ. Finally, the blood sample was taken and insulin, glucose, SGOT, SGPT, alkaline phosphatase, leptin and lipid levels was evaluated.Results: Induction of diabetes decreased the level of insulin, leptin and high density lipoprotein (HDL) and increased the level of other lipids, glucose, and hepatic enzymes significantly (p<0.05). Administration of both doses of the extract significantly decreased the level of triglyceride, very low density lipoprotein, glucose and alkaline phosphatase in diabetic mice (p<0.05). Insulin levels increased in animals treated with 200 mg/kg (p<0.05) and HDL and leptin levels increased in animals treated with 300 mg/kg of the extract (p<0.01).Conclusion: The results showed that A. lappa root extract, at specific doses, has an anti-diabetic effect through its hypolipidemic and insulinotropic properties. Hence, this plant extract may be beneficial in the treatment of diabetes.
https://ajp.mums.ac.ir/article_7843_f33f9f412b79d15636bdcea6bd0ece98.pdf
2017-03-01
169
179
10.22038/ajp.2016.7843
Arctium Lappa
Type 2 diabetes
Insulin
lipid profile
Hepatic enzyme
Akram
Ahangarpour
akramahangarpour@gmail.com
1
Health Research Institute, Diabetes Research Center, Department of Physiology, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
AUTHOR
Hamid
Heidari
physiology_86@yahoo.com
2
Department of Physiology, Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. Department of Physiology, School of Medicine, Qom University of Medical Sciences, Qom, Iran
LEAD_AUTHOR
Ali Akbar
Oroojan
aliakbar_oroojan@yahoo.com
3
Department of Physiology, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
AUTHOR
Farhang
Mirzavandi
farhangmirfm@yahoo.com
4
Department of Nutrition, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
AUTHOR
Khalil
Nasr Esfehani
khnesf@gmail.com
5
Department of Nutrition, Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
AUTHOR
Zienab
Dehghan Mohammadi
mohamadif37@yahoo.com
6
Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
AUTHOR
Abbasnezhad AA, Hayatdavoudi P, Niazmand S, Mahmoudabady M. 2015. The effects of hydroalcoholic extract of Nigella sativa seed on oxidative stress in hippocampus of STZ-induced diabetic rats. Avicenna J Phytomed, 5: 333-340.
1
Ahangarpour A, Heidari H, Mard SA, Hashemitabar M, Khodadadi A. 2014. Progesterone and cilostazol protect mice pancreatic islets from oxidative stress induced by hydrogen peroxide. Iran J Pharm Res, 13: 937-944.
2
Ahangarpour A, Mohaghegh M, Asadinia E, Ramazani Ali-Akbari F. 2013. Effect of Arctium Lappa Root Extract on Glucose Levels and Insulin Resistance in Rats with High Sucrose Diet. J Shahid Sadoughi Uni, 21: 179-188. [Persian]
3
Ahangarpour A, Oroojan AA, Heidari H, Ehsan G, Rashidi Nooshabadi MR. 2014. Effects of Hydro-Alcoholic Extract of Rhus coriaria (Sumac) Seeds on Reproductive Complications of Nicotinamide-Streptozotocin Induced Type-2 Diabetes in Male Mice. World J Mens Health, 32: 151-158.
4
Ahangarpour A, Oroojan AA, Heidari H, Ghaedi E, Taherkhani R. 2015. Effects of Hydro-alcoholic Extract from Arctium lappa L. (Burdock) Root on Gonadotropins, Testosterone, and Sperm Count and Viability in Male Mice with Nicotinamide/ Streptozotocin-Induced Type 2 Diabetes. Malays J Med Sci, 22: 25-32.
5
Ahangarpour A, Oroojan AA, Ramezani Aliakbari F. 2014. Effects of C-peptide and Nicotinamide on serum LH, FSH, testosterone levels and sperm count in nicotinamide/STZ induced diabetic mice. Acta Endocrinologica (Buc), 4: 588-594.
6
Ahangarpour A, Teymuri Zamaneh H, Jabari A, Malekshahinia H, Heidari H. 2014. Antidiabetic and hypolipidemic effects of Dorema aucheri hydro alcoholic leave extract in streptozotocin-nicotinamide induced type 2 diabetes in male rats. Iran J Basic Med Sci, 17: 808-814.
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43
ORIGINAL_ARTICLE
Kidney stone formation and antioxidant effects of Cynodon dactylon decoction in male Wistar rats
Objectives: The antioxidant capacity impairs in kidney and urinary bladder of animals with stone disease. Herbal medicine can improve the antioxidant condition of renal tissue. Cynodon dactylon (C. dactylon) is a medicinal plant with antioxidative and diuretic properties and different preparations of this plant have shown promising effects in stone disease. Assessment of the whole plant decoction to prevent kidney stone disease as well as its antioxidant effects was the aim of this paper.Materials and Methods: Fifty male Wistar rats were randomly divided into 5 experimental groups (n=10). One group was left without treatment and four groups received ethylene glycol (1% v/v) in drinking water for 6 weeks. Three doses of Cynodon dactylon aqueous decoction (12.5, 50 and 200 mg/kg BW) were added to the drinking water of groups 3-5. Finally, water intake, 24-hour urine volume, MDA, total thiol concentration and FRAP value were measured in the serum and kidney tissues. The CaOx depositions were evaluated by hematoxylin and eosin staining.Results: Compared to the ethylene glycol-treated group, 200 mg/kg C. dactylon, lowered stone incidents, decreased urine volume, increased FRAP/g Cr (43%) and thiol content (p<0.05) with no significant alteration of water intake, MDA decreased significantly compared to C. dactylon 12.5 (p<0.01). Kidney weight increased and body weight decreased in ethylene glycol-treated group compared to the control group (p<0.05). Conclusion: A minimum dose of 200 mg/kg C. dactylon reduced stone formation and simultaneously increased total antioxidant power of serum and preserved MDA content and water.
https://ajp.mums.ac.ir/article_7844_809ce8160bc420d029e5b9faef8ff333.pdf
2017-03-01
180
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10.22038/ajp.2016.7844
Cynodon dactylon decoction
FRAP
MDA
nephrolithiasis
Antioxidant
Ethylene glycol
Alireza
Golshan
golshanalirezag@gmail.com
1
School of Medicine, North Khorasan University of Medical sciences, Bojnurd, Iran
AUTHOR
Parichehr
Hayatdavoudi
hayatdp891@mums.ac.ir
2
Neurocognitive Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mousa AL-Reza
Hadjzadeh
hajzadehmr@mums.ac.ir
3
Neurocognitive Research Center, Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Abolfazl
Khajavi Rad
khajavirada@mums.ac.ir
4
Neurogenic Inflammation Research Center,Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Nema
Mohamadian Roshan
roshann@mums.ac.ir
5
Department of Pathology, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhd, Iran
AUTHOR
Abbasali
Abbasnezhad
abbasnezhad.abbasali@gmail.com
6
Department of Basic Sciences, Faculty of Medicine, Gonabad University of Medical Sciences, Gonabad,Iran
AUTHOR
Seyed Mojtaba
Mousavi
smousavy@yahoo.com
7
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad,Iran
AUTHOR
Roghayeh
Pakdel
pakdelr901@mums.ac.ir
8
Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad,Iran
AUTHOR
Batool
Zarei
9
Department of physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Azita
Aghaee
aghaeea1@mums.ac.ir
10
Pharmacological Research Center of Medicinal Plants, Department of Pharmacology, School of Medicine, Mashhad University of Medical Sciences, Mashhad,Iran
AUTHOR
Alex M, Varghese MV, Abhilash M, Paul MVS. 2013. Effect of astaxanthin on ethylene glycol induced nephrolithiasis. IOSR-JPBS, 7: 42–47.
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38
ORIGINAL_ARTICLE
Capparis spinosa L. aqueous extract evokes antidiabetic effect in streptozotocin-induced diabetic mice
Objective: As the aqueous extract of Capparis spinosa (CS) possess antidiabetic effect, he present study aims to reveal the possible mechanism of action of CS in diabetic mice.Materials and Methods: Both single and repeated oral administrations of aqueous extract of CS were performed in multi-low dose streptozotocin-induced (MLDS) diabetic mice. Euglycemic hyperinsulinemic clamp was used in association with the endogenous glucose production (perfusion rate of 3-3H glucose) to evaluate the effect of CS aqueous extract on insulin sensitivity.Results: Our study showed that aqueous extract of CS possess a potent hypoglycaemic activity in MLDS diabetic mice. Furthermore, the analysis perfusion of 3-3H glucose demonstrated the parallel decrease of basal endogenous glucose production (EGP) with the hypoglycaemic activity. EGP was lower in CS-Treated group when compared to the control group (p<0.001). The euglycemic hyperinsulinemic clamp technique demonstrated that CS treatment improves insulin sensitivity in peripheral tissues.Conclusion: We conclude that the antihyperglycemic effet CS is probably due to the inhibition of basal endogenous glucose production and the improvement of insulin sensitivity in MLDS diabetic mice.
https://ajp.mums.ac.ir/article_7761_b203ca4b3cb6490d2d1155e2946bd6b4.pdf
2017-03-01
191
198
10.22038/ajp.2016.7761
Diabetes
Streptozotocin
Insulin sensitivity
Mice
Mohamed
Eddouks
mohamed.eddouks@laposte.net
1
Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco
LEAD_AUTHOR
Ahmed
Lemhadri
2
Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco
AUTHOR
Morad
Hebi
hebimorad@gmail.com
3
Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco
AUTHOR
Ahmed EL
Hidani
4
Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco
AUTHOR
Naoufel Ali
Zeggwagh
5
ISPITS Rabat, Avenue Hassan II Km 4,5 Route de Casa, Rabat Maroc
AUTHOR
Bachir
EL Bouhali
6
Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco
AUTHOR
Lhoussaine
Hajji
7
Faculty of Sciences and Tecniques Errachidia, Moulay Ismail University, BP 509, Boutalamine, Errachidia, 52000, Morocco
AUTHOR
Remy
Burcelin
burcelinremy@gmail.com
8
2UMR 5018 CNRS-UPS and IFR 31, Rangueil Hospital, L1 Bldg, BP 84225 Toulouse 31432 Cedex 4, France
AUTHOR
Adeneye AA. 2012. The leaf and seed aqueous extract of Phyllanthus amarus improves insulin resistance diabetes in experimental animal studies. J Ethnopharmacol, 144: 705-711.
1
American Diabetes Association. Diagnosis and Classification of Diabetes Mellitus. 2014. Diabetes Care, 37: 81-90.
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3
Chen YI, Cheng YW, Tzeng CY, Lee YC, Chang YN, Lee SC, Tsai CC, Chen JC, Tzen JT, Chang SL. 2014. Peroxisome proliferator-activated receptor activating hypoglycemic effect of Gardenia jasminoides Ellis aqueous extract and improvement of insulin sensitivity in steroid induced insulin resistant rats. BMCComplementar Altern Med,14 : 10-18
4
Eddouks M, Maghrani M, Lemhadri A, Ouahidi ML, Jouad H. 2002. Ethnopharmacological survey of medicinal plants used for the treatment of diabetes mellitus, hypertension and cardiac diseases in the south-east region of Morocco (Tafilalet). J Ethnopharmacol, 82: 97-103.
5
Eddouks M, Jouad H, Maghrani M, Lemhadri A, Burcelin R. 2003. Inhibition of endogenous glucose production accounts for hypoglycemic effect of Spergularia purpurea in streptozotocin mice. Phytomedicine,10: 594-599.
6
Eddouks M, Lemhadri A, Michel JB. 2004. Caraway and caper: potential antihyperglycaemic plants in diabetic rats. J Ethnopharmacol, 94: 143-148.
7
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8
Eddouks M, Bidi A, El Bouhali B, et al. 2014. Antidiabetic plants improving insulin sensitivity. J Pharm Pharmacol, 66: 1197-214.
9
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26