%0 Journal Article %T Antinociceptive effect of extracts of Marrubium astracanicum Jacq. aerial parts %J Avicenna Journal of Phytomedicine %I Mashhad University of Medical Sciences %Z 2228-7930 %A Kahkeshani, Niloofar %A Gharedaghi, Milad %A Hadjiakhoondi, Abbas %A Sharifzadeh, Mohammad %A Khanavi, Mahnaz %D 2017 %\ 01/01/2017 %V 7 %N 1 %P 73-79 %! Antinociceptive effect of extracts of Marrubium astracanicum Jacq. aerial parts %K Marrubium astracanicum %K Pain measurment %K Analgesic %R 10.22038/ajp.2016.7073 %X Objective: The genus Marrubium is used for treatment of joint pain, gout, stomach-ache and colic in Iranian Traditional Medicine. Marrubium astracanicum Jacq. (M. astracanicum) is a native species in the flora of Iran. The aim of this study was to evaluate the antinociceptive properties of various extracts of aerial parts of M. astracanicum.Materials and Methods: Antinociceptive activities of total hydroalcoholic extract (THE) and its n-hexane (non-polar) and residual partition (polar) fractions were analyzed using formalin test in mice. Morphine (5 mg/kg) and normal saline were used as positive and negative controls, respectively.Results: Intraperitoneal administration of THE (50, 100 and 200 mg/kg), non-polar fraction (200 mg/kg) and polar fraction (100 and 200 mg/kg), 30 min before formalin injection, caused significant analgesic activity in acute phase (0-5 min after formalin injection) of formalin test (p0.05 in comparison with morphine).  In chronic phase (15–60 min after formalin injection), non-polar and polar fractions (50, 100 and 200 mg/kg) showed significant analgesic activity (p0.05 in comparison with morphine).Conclusion: Different extracts of M. astracanicum demonstrated antinociceptive activity that support the traditional usage of Marrubium genus for the treatment of arthritis, gout and other inflammatory diseases. %U https://ajp.mums.ac.ir/article_7073_99ed75e0ba13f29aed48fadd9603f491.pdf