%0 Journal Article %T Neuro-pharmacological effects of Crinum zeylanicum in mice %J Avicenna Journal of Phytomedicine %I Mashhad University of Medical Sciences %Z 2228-7930 %A Tijani, Adeniyi Yahaya %A Salawu, Oluwakanyinsola Adeola %A Jaiyeoba, Good-luck %A Akponso Anuka, Joseph %A Hussaini, Isah Marte %D 2012 %\ 06/01/2012 %V 2 %N 3 %P 162-168 %! Neuro-pharmacological effects of Crinum zeylanicum in mice %K Crinum Zeylanicum %K Pentobarbitone %K Psychosis %K Sleep %K Stereotype Behaviour %R 10.22038/ajp.2012.104 %X Objectives: The aim of present study was to evaluate some effects of Crinum zeylanicum (C. zeylanicum) on central nervous system. Materials and Methods: C. zeylanicum methanolic bulb extract (250-1000 mg/kg orally), 2 mg chlorpromazine and 4 mg diazepam /kg body weight intraperitoneally respectively were tested in mice using Irwin test, pentobarbitone-induced sleep test, spontaneous motor activity, apomorphine-induced stereotype behaviour, and rota-rod performance. Results: The C. zeylanicum bulb extract significantly and dose-dependently decreased apomorphine-induced hyperactivity in mice (p<0.001). The Irwin test revealed dose-dependent central depressant effect of the extract, shortened (p<0.05-0.01) the onset of sleep and prolonged the duration of sleep. The extract produced significant (p<0.05-0.001) and dose- dependent reduction in spontaneous motor activity and apomorphine-induced stereotype behaviours in mice. The extract had no effect on performance of mice on rotarod.   Conclusion: The results suggest that the extract may possess sedative principles with potential neuroleptic properties. %U https://ajp.mums.ac.ir/article_104_8831c98b733c5858c85a34ddd60cb1e7.pdf