@article { author = {Eddouks, Mohamed and Lemhadri, Ahmed and Hebi, Morad and Hidani, Ahmed EL and Zeggwagh, Naoufel Ali and EL Bouhali, Bachir and Hajji, Lhoussaine and Burcelin, Remy}, title = {Capparis spinosa L. aqueous extract evokes antidiabetic effect in streptozotocin-induced diabetic mice}, journal = {Avicenna Journal of Phytomedicine}, volume = {7}, number = {2}, pages = {191-198}, year = {2017}, publisher = {Mashhad University of Medical Sciences}, issn = {2228-7930}, eissn = {2228-7949}, doi = {10.22038/ajp.2016.7761}, abstract = {Objective: As the aqueous extract of Capparis spinosa (CS) possess antidiabetic effect, he present study aims to reveal the possible  mechanism of action of CS in diabetic mice.Materials and Methods: Both single and repeated oral administrations of aqueous extract of CS were performed in multi-low dose streptozotocin-induced (MLDS) diabetic mice. Euglycemic hyperinsulinemic clamp was used in association with the endogenous glucose production (perfusion rate of 3-3H glucose) to evaluate the effect of CS aqueous extract on insulin sensitivity.Results: Our study showed that aqueous extract of CS possess a potent hypoglycaemic activity in MLDS diabetic mice. Furthermore, the analysis perfusion of 3-3H glucose demonstrated  the parallel decrease of basal endogenous glucose production (EGP) with the hypoglycaemic activity. EGP was lower in CS-Treated group when compared to the control group (p<0.001). The euglycemic hyperinsulinemic clamp technique demonstrated that CS treatment improves insulin sensitivity in peripheral tissues.Conclusion: We conclude that the antihyperglycemic effet CS is probably due to the inhibition of basal endogenous glucose production and the improvement of insulin sensitivity in MLDS diabetic mice.}, keywords = {Diabetes,Streptozotocin,Insulin sensitivity,Mice}, url = {https://ajp.mums.ac.ir/article_7761.html}, eprint = {https://ajp.mums.ac.ir/article_7761_b203ca4b3cb6490d2d1155e2946bd6b4.pdf} }