@article { author = {Nesa, Luthfun and Munira, Shirajum and Mollika, Shabnam and Islam, Md. Monirul and choin, Habibullah and Uzzaman Chouduri, Aktar and Naher, Nazmun}, title = {Evaluation of analgesic, anti-inflammatory and CNS depressant activities of methanolic extract of Lawsonia inermis barks in mice}, journal = {Avicenna Journal of Phytomedicine}, volume = {4}, number = {4}, pages = {287-296}, year = {2014}, publisher = {Mashhad University of Medical Sciences}, issn = {2228-7930}, eissn = {2228-7949}, doi = {10.22038/ajp.2014.2347}, abstract = {Objectives: The study was carried out to assess the analgesic, anti-inflammatory, and CNS depressant activity of the methanolic extract of  the Lawsonia inermis barks(MELIB). Materials and Methods: Anti-inflammatory effects of MEBLI were studied using carrageenan-induced inflammatory method at the dose of 300 and 500 mg/kg b.wt., p.o. Analgesic activity was measured using acetic acid-induced writhing model and formalin-induced licking and biting in mice. The CNS depressant activity was evaluated by observing the reduction of locomotor and exploratory activities in the open field and hole cross tests at a dose of 300 and 500 mg/kg body weight. Results: Statistical analysis showed that dose  of 500 mg/kg  exhibited higher analgesic activity against acetic acid-induced pain in mice than the standard drug diclofenac sodium. Furthermore, doses of 300 and 500 mg/kg caused higher percent of protection (91.16% and 95.03%, respectively) of licking and biting of formalin-induced mice than diclophenac sodium (70.72%). The Lawsonia inemis methanolic extract (300 and 500 mg/kg) alsoexhibited sustained inhibition (54.97% and 65.56%) of paw edema at the 4th hour compared with standard indomethacin (74.17%). Besides, the plant extract also had significant (p<0.05) dose-dependent CNS depressant activity. Conclusion: this study recommends that the methanolic extract of  Lawsonia inermis barks has significant analgesic, anti-inflammatory, and CNS depressant properties.}, keywords = {Analgesic,Anti-inflammatory,Carrageenan,CNS depressant,Formalin induced pain Methanolic,extract of Lawsonia inermis barks,Writhing}, url = {https://ajp.mums.ac.ir/article_2347.html}, eprint = {https://ajp.mums.ac.ir/article_2347_a033f38b6bd2e1a3c89c725079726a43.pdf} }